Details for: HOXB3

Gene ID: 3213

Symbol: HOXB3

Ensembl ID: ENSG00000120093

Description: homeobox B3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.71
    Marker Score: 2340
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.29
    Marker Score: 1330
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.25
    Marker Score: 2281
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.18
    Marker Score: 1680
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.84
    Marker Score: 63704
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.76
    Marker Score: 551
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.73
    Marker Score: 1381
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.64
    Marker Score: 866
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.53
    Marker Score: 1639
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.49
    Marker Score: 350
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.49
    Marker Score: 1673
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.49
    Marker Score: 3754
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.42
    Marker Score: 1338
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.41
    Marker Score: 2028
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.35
    Marker Score: 846
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.34
    Marker Score: 3581
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.32
    Marker Score: 267
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.29
    Marker Score: 764
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4799
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.08
    Marker Score: 510
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251791
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.03
    Marker Score: 1089
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.02
    Marker Score: 13488
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.02
    Marker Score: 2395
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.01
    Marker Score: 2116
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1
    Marker Score: 316
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.98
    Marker Score: 1624
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.97
    Marker Score: 327
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.96
    Marker Score: 1363
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.96
    Marker Score: 642
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5285
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.89
    Marker Score: 2178.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.89
    Marker Score: 1679
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.87
    Marker Score: 1526
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.87
    Marker Score: 1665
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.84
    Marker Score: 802
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.83
    Marker Score: 1689
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.79
    Marker Score: 154
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.78
    Marker Score: 433
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 245
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.75
    Marker Score: 702
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 676
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.72
    Marker Score: 771
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.71
    Marker Score: 268
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.65
    Marker Score: 157
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.64
    Marker Score: 1512
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.64
    Marker Score: 222
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.62
    Marker Score: 216
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.56
    Marker Score: 832
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.54
    Marker Score: 738
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 320
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.5
    Marker Score: 622
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.5
    Marker Score: 258
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.49
    Marker Score: 115
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.49
    Marker Score: 307
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 232
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.48
    Marker Score: 685
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.47
    Marker Score: 532
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.46
    Marker Score: 710
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.45
    Marker Score: 1177
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 196
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 182
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.43
    Marker Score: 1041
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.42
    Marker Score: 838
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.42
    Marker Score: 245
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.42
    Marker Score: 223
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.41
    Marker Score: 220.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.41
    Marker Score: 499
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.39
    Marker Score: 189
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.39
    Marker Score: 141
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5904.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.38
    Marker Score: 268
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.37
    Marker Score: 359
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.37
    Marker Score: 86
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.36
    Marker Score: 865
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.35
    Marker Score: 133
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.35
    Marker Score: 241
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.35
    Marker Score: 221
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.34
    Marker Score: 340
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.34
    Marker Score: 170

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Other Information

**Key characteristics:** - HOXB3 is a homeobox gene, a family of transcription factors that regulate gene expression through a specific DNA-binding domain known as the homeodomain. - It is expressed in a wide range of cell types in the developing brain, including neural crest cells, progenitor cells, and differentiated neurons. - It is involved in the specification of the anterior/posterior axis in the hindbrain. **Pathways and functions:** - Activation of anterior hox genes: HOXB3 is a key factor in the activation of several anterior hox genes, including Hox1, Hox3, and Hox5. - Angiogenesis: HOXB3 is involved in the regulation of blood vessel development, including the formation of the cerebral vasculature. - Cartilage development: HOXB3 is essential for the development of the cartilage layer of the neural tube. - Definitive hemopoiesis: HOXB3 is involved in the development of the definitive haematopoietic tissue in the bone marrow. - Regulation of neurogenesis: HOXB3 is a key regulator of neurogenesis, promoting the proliferation and survival of neural stem cells and the differentiation of neural progenitor cells into various neuronal subtypes. **Clinical significance:** - HOXB3 mutations have been linked to various human diseases, including lissencephaly, a neural tube defect associated with severe intellectual disability. - Understanding the role of HOXB3 in brain development and disease has potential implications for the development of new therapeutic strategies for these conditions.

Genular Protein ID: 1363601956

Symbol: HXB3_HUMAN

Name: Homeobox protein Hox-B3

UniProtKB Accession Codes:

P14651 A8K567 B7Z5N8 B7Z5P8 B7ZAD0 D3DTV3 O95615 P17484

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 13 Ensembl 7 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 10 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 431
  • Mass: 44340
  • Checksum: 56D39C0C9496E65A
  • Sequence:
    • MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS ACSLQSLGNA 
APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT SNSSNGGGPS KSGPPKCGPG 
TNSTLTKQIF PWMKESRQTS KLKNNSPGTA EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK 
SPPGSAASKR ARTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR 
MKYKKDQKAK GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN 
AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP VYVGGGGYAD 
PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP CEPHPTYTDL SSHHAPPPQG 
RIQEAPKLTH L

Genular Protein ID: 2974209028

Symbol: B3KNJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNJ7

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 431
  • Mass: 44413
  • Checksum: 80339E87D43C485A
  • Sequence:
    • MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS ACSLQSLGNA 
APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT SNSSNGGGPS KSGPPKCGPG 
TNSTLTKQIF PWMKESRQTS KLKNNSPGTA EGCGGGGGGG GGGGSGGSGG GGGGGEGGDK 
SPPGSAASER ARTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR 
MKYKKDQKAK GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN 
AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP VYVGGGGYAD 
PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP CEPHPTYTDL SSHHAPPPQG 
RIQEAPKLTH L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.