Details for: HRC

Gene ID: 3270

Symbol: HRC

Ensembl ID: ENSG00000130528

Description: histidine rich calcium binding protein

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Atpase binding
    (GO:0051117)
  • Calcium ion binding
    (GO:0005509)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Muscle contraction
    (GO:0006936)
  • Positive regulation of heart contraction
    (GO:0045823)
  • Positive regulation of heart rate
    (GO:0010460)
  • Positive regulation of relaxation of cardiac muscle
    (GO:1901899)
  • Protein binding
    (GO:0005515)
  • Regulation of calcium ion transmembrane transport
    (GO:1903169)
  • Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    (GO:0010881)
  • Regulation of cell communication by electrical coupling involved in cardiac conduction
    (GO:1901844)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Regulation of heart rate
    (GO:0002027)
  • Regulation of peptidyl-serine phosphorylation
    (GO:0033135)
  • Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    (GO:0010880)
  • Regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060314)
  • Sarcoplasmic reticulum lumen
    (GO:0033018)
  • Sarcoplasmic reticulum membrane
    (GO:0033017)
  • Transmembrane transporter binding
    (GO:0044325)
  • Z disc
    (GO:0030018)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.1
    Marker Score: 1635
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.51
    Marker Score: 2858
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19687
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.18
    Marker Score: 2014
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.16
    Marker Score: 879
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2327
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.85
    Marker Score: 405
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.8
    Marker Score: 1497
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.74
    Marker Score: 524
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.73
    Marker Score: 16273
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 473
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.71
    Marker Score: 4602
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 373
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.61
    Marker Score: 577
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 239
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 224
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.51
    Marker Score: 168
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.43
    Marker Score: 403
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.42
    Marker Score: 5644
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 229
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 233
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.38
    Marker Score: 111
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.38
    Marker Score: 199
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 589
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.37
    Marker Score: 1298
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.36
    Marker Score: 382
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.33
    Marker Score: 403
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 311.5
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.26
    Marker Score: 79
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.25
    Marker Score: 105
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.25
    Marker Score: 265
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.24
    Marker Score: 160
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.24
    Marker Score: 293
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.24
    Marker Score: 67
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.22
    Marker Score: 454
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2
    Marker Score: 170
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.19
    Marker Score: 51
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.19
    Marker Score: 148
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.18
    Marker Score: 3241
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.18
    Marker Score: 554
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.18
    Marker Score: 42
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.17
    Marker Score: 1001
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.16
    Marker Score: 275
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 96
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.15
    Marker Score: 169
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.14
    Marker Score: 100
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 282
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.13
    Marker Score: 166
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 136
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.13
    Marker Score: 1753
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 122
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 85
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.12
    Marker Score: 191
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.12
    Marker Score: 131
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.12
    Marker Score: 812
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.12
    Marker Score: 113
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.11
    Marker Score: 36

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Other Information

**Key characteristics** * SRCH is a transmembrane protein with a molecular weight of approximately 140 kDa. * SRCH is a calcium-binding protein that is expressed in high levels in cardiac muscle. * SRCH is involved in regulating cardiac muscle contraction and relaxation. * SRCH is also involved in regulating cell communication by electrical coupling involved in cardiac conduction. **Pathways and functions** * SRCH is involved in the regulation of cardiac muscle contraction and relaxation. * SRCH binds to the ryanodine-sensitive calcium-release channel, which is responsible for releasing calcium ions into the cytosol. * When SRCH binds to the ryanodine-sensitive calcium-release channel, it induces the release of calcium ions, which leads to cardiac contraction. * SRCH also regulates the release of calcium ions from the sarcoplasmic reticulum into the cytosol. * SRCH is also involved in the regulation of cell communication by electrical coupling involved in cardiac conduction. **Clinical significance** * Mutations in the SRCH gene have been linked to a number of human diseases, including hypertrophic cardiomyopathy, heart failure, and arrhythmias. * SRCH is a potential target for the treatment of these diseases. **Additional information** * SRCH is a member of the SRCL family of calcium-binding proteins. * SRCH is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * SRCH is a well-studied protein that has been extensively characterized in both animal and human systems.

Genular Protein ID: 700519483

Symbol: SRCH_HUMAN

Name: Sarcoplasmic reticulum histidine-rich calcium-binding protein

UniProtKB Accession Codes:

P23327 Q504Y6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2037293

Title: cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7.

PubMed ID: 2037293

DOI: 10.1016/0888-7543(91)90359-m

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 699
  • Mass: 80244
  • Checksum: 9922EEDF012C61DD
  • Sequence:
    • MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS EEASAELRHH 
LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG HLLPGHRSQD HKVGDEGVSG 
EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH HLPSHRSHSH QDEDEDEVVS SEHHHHILRH 
GHRGHDGEDD EGEEEEEEEE EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH 
QGHEEDDDDD DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH 
EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD EEEDEDVSTE 
RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK SDEEDFQDEY KTEVPHHHHH 
RVPREEDEEV SAELGHQAPS HRQSHQDEET GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD 
DSEEEKEKEE DPGSHEEDDE SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK 
EEEEEEEDEE RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA 
SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNRCTECE SCHCDEENMG EHCDQCQHCQ 
FCYLCPLVCE TVCAPGSYVD YFSSSLYQAL ADMLETPEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.