Details for: HRC

Gene ID: 3270

Symbol: HRC

Ensembl ID: ENSG00000130528

Description: histidine rich calcium binding protein

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Atpase binding
    (GO:0051117)
  • Calcium ion binding
    (GO:0005509)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Muscle contraction
    (GO:0006936)
  • Positive regulation of heart contraction
    (GO:0045823)
  • Positive regulation of heart rate
    (GO:0010460)
  • Positive regulation of relaxation of cardiac muscle
    (GO:1901899)
  • Protein binding
    (GO:0005515)
  • Regulation of calcium ion transmembrane transport
    (GO:1903169)
  • Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    (GO:0010881)
  • Regulation of cell communication by electrical coupling involved in cardiac conduction
    (GO:1901844)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Regulation of heart rate
    (GO:0002027)
  • Regulation of peptidyl-serine phosphorylation
    (GO:0033135)
  • Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    (GO:0010880)
  • Regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060314)
  • Sarcoplasmic reticulum lumen
    (GO:0033018)
  • Sarcoplasmic reticulum membrane
    (GO:0033017)
  • Transmembrane transporter binding
    (GO:0044325)
  • Z disc
    (GO:0030018)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.4762
    Cell Significance Index: 20.8000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.5707
    Cell Significance Index: 13.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3472
    Cell Significance Index: 32.8700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.1317
    Cell Significance Index: 18.2600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1268
    Cell Significance Index: 14.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9899
    Cell Significance Index: 26.5300
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.8359
    Cell Significance Index: 3.7000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.7858
    Cell Significance Index: 9.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7733
    Cell Significance Index: 147.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5703
    Cell Significance Index: 8.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5428
    Cell Significance Index: 41.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5285
    Cell Significance Index: 11.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4496
    Cell Significance Index: 20.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4176
    Cell Significance Index: 41.3100
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.4124
    Cell Significance Index: 1.9100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3923
    Cell Significance Index: 5.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3741
    Cell Significance Index: 22.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3404
    Cell Significance Index: 307.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3148
    Cell Significance Index: 34.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2331
    Cell Significance Index: 37.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1700
    Cell Significance Index: 9.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1519
    Cell Significance Index: 10.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1337
    Cell Significance Index: 7.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1336
    Cell Significance Index: 3.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1257
    Cell Significance Index: 3.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1177
    Cell Significance Index: 2.0800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1010
    Cell Significance Index: 0.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0860
    Cell Significance Index: 17.0700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0786
    Cell Significance Index: 1.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0745
    Cell Significance Index: 0.8100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0680
    Cell Significance Index: 0.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0632
    Cell Significance Index: 1.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0314
    Cell Significance Index: 1.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0313
    Cell Significance Index: 0.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0152
    Cell Significance Index: 10.5300
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.0149
    Cell Significance Index: 0.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0146
    Cell Significance Index: 0.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0083
    Cell Significance Index: 0.2900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0094
    Cell Significance Index: -5.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0119
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0130
    Cell Significance Index: -1.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0167
    Cell Significance Index: -5.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0168
    Cell Significance Index: -3.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0189
    Cell Significance Index: -5.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0237
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0301
    Cell Significance Index: -6.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0306
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0323
    Cell Significance Index: -5.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0346
    Cell Significance Index: -4.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0362
    Cell Significance Index: -2.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0378
    Cell Significance Index: -4.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0378
    Cell Significance Index: -1.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0389
    Cell Significance Index: -5.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0399
    Cell Significance Index: -5.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0481
    Cell Significance Index: -5.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0534
    Cell Significance Index: -2.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0540
    Cell Significance Index: -5.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0548
    Cell Significance Index: -1.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0566
    Cell Significance Index: -0.8100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0584
    Cell Significance Index: -0.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0592
    Cell Significance Index: -6.0500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0674
    Cell Significance Index: -0.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0674
    Cell Significance Index: -1.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0682
    Cell Significance Index: -5.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0706
    Cell Significance Index: -2.2600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0729
    Cell Significance Index: -0.9400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0732
    Cell Significance Index: -0.7000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0769
    Cell Significance Index: -1.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0778
    Cell Significance Index: -2.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0793
    Cell Significance Index: -4.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0806
    Cell Significance Index: -5.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1018
    Cell Significance Index: -6.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1020
    Cell Significance Index: -6.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1042
    Cell Significance Index: -6.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1050
    Cell Significance Index: -1.8000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1083
    Cell Significance Index: -1.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1091
    Cell Significance Index: -1.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1117
    Cell Significance Index: -4.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1138
    Cell Significance Index: -5.3500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1172
    Cell Significance Index: -1.6800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1185
    Cell Significance Index: -1.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1201
    Cell Significance Index: -2.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1355
    Cell Significance Index: -3.6900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1374
    Cell Significance Index: -1.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1400
    Cell Significance Index: -1.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1417
    Cell Significance Index: -5.2000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1420
    Cell Significance Index: -1.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HRC is a calcium-binding protein that belongs to the histidine-rich calcium-binding protein family. It is characterized by its ability to bind calcium ions, which is crucial for its various functions. The protein is highly expressed in cells involved in immune responses, muscle development, and neuronal function. HRC has been shown to interact with various proteins and signaling pathways, including ATPase, protein kinases, and transcription factors. Its expression is tightly regulated by post-translational modifications, such as phosphorylation and acetylation, which affect its activity and localization within the cell. **Pathways and Functions** The HRC protein is involved in several key pathways and functions, including: 1. **Calcium homeostasis**: HRC regulates the concentration of calcium ions in the cytosol by binding and releasing calcium ions, which is essential for muscle contraction, neuronal signaling, and immune responses. 2. **Muscle contraction**: HRC plays a crucial role in regulating cardiac muscle contraction by controlling the release of sequestered calcium ions from the sarcoplasmic reticulum. 3. **Heart rate regulation**: HRC is involved in regulating heart rate by modulating the activity of the ryanodine-sensitive calcium-release channel. 4. **Insulin-like growth factor transport**: HRC binds to insulin-like growth factor-binding proteins (IGFBPs) and regulates the transport and uptake of insulin-like growth factors. 5. **Protein metabolism**: HRC interacts with various proteins involved in protein metabolism, including ATPases and protein kinases. 6. **Cell communication**: HRC regulates cell communication by electrical coupling involved in cardiac conduction. **Clinical Significance** Dysregulation of HRC has been implicated in various cardiovascular and metabolic disorders, including: 1. **Cardiac arrhythmias**: Alterations in HRC expression and function have been linked to cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 2. **Hypertension**: HRC has been shown to play a role in regulating blood pressure, and its dysregulation may contribute to hypertension. 3. **Diabetes**: HRC has been implicated in regulating insulin-like growth factor transport and metabolism, which may contribute to the development of diabetes. 4. **Muscle disorders**: HRC has been linked to muscle disorders, including muscular dystrophy and myasthenia gravis. In conclusion, the HRC gene plays a critical role in maintaining calcium homeostasis, regulating muscle contraction, and modulating cardiac function. Its dysregulation has been implicated in various cardiovascular and metabolic disorders, highlighting the importance of further research into the mechanisms underlying HRC function and its clinical significance.

Genular Protein ID: 700519483

Symbol: SRCH_HUMAN

Name: Sarcoplasmic reticulum histidine-rich calcium-binding protein

UniProtKB Accession Codes:

P23327 Q504Y6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2037293

Title: cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7.

PubMed ID: 2037293

DOI: 10.1016/0888-7543(91)90359-m

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 699
  • Mass: 80244
  • Checksum: 9922EEDF012C61DD
  • Sequence:
    • MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS EEASAELRHH 
LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG HLLPGHRSQD HKVGDEGVSG 
EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH HLPSHRSHSH QDEDEDEVVS SEHHHHILRH 
GHRGHDGEDD EGEEEEEEEE EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH 
QGHEEDDDDD DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH 
EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD EEEDEDVSTE 
RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK SDEEDFQDEY KTEVPHHHHH 
RVPREEDEEV SAELGHQAPS HRQSHQDEET GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD 
DSEEEKEKEE DPGSHEEDDE SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK 
EEEEEEEDEE RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA 
SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNRCTECE SCHCDEENMG EHCDQCQHCQ 
FCYLCPLVCE TVCAPGSYVD YFSSSLYQAL ADMLETPEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.