Details for: PRMT2

Gene ID: 3275

Symbol: PRMT2

Ensembl ID: ENSG00000160310

Description: protein arginine methyltransferase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.76
    Marker Score: 8709
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.62
    Marker Score: 1132
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.39
    Marker Score: 126513
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.35
    Marker Score: 27347
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.32
    Marker Score: 6769
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.29
    Marker Score: 9593
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.24
    Marker Score: 5461.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.21
    Marker Score: 3945.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.18
    Marker Score: 1090
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.18
    Marker Score: 2105
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.09
    Marker Score: 20740
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.08
    Marker Score: 1705
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.07
    Marker Score: 1819
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.06
    Marker Score: 1207
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.04
    Marker Score: 4894.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.03
    Marker Score: 2986
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.01
    Marker Score: 3946
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.01
    Marker Score: 2255
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.01
    Marker Score: 2701
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2
    Marker Score: 1010
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2
    Marker Score: 2418
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.99
    Marker Score: 2481
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.99
    Marker Score: 655
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.96
    Marker Score: 973
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.95
    Marker Score: 3551
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.9
    Marker Score: 64228
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.9
    Marker Score: 8131
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.87
    Marker Score: 2587
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.87
    Marker Score: 1363.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.86
    Marker Score: 445.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.83
    Marker Score: 5145.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.83
    Marker Score: 1628
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.82
    Marker Score: 11819.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.81
    Marker Score: 1693
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.8
    Marker Score: 558
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.79
    Marker Score: 38247
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.79
    Marker Score: 62014
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.78
    Marker Score: 11373
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.77
    Marker Score: 385.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.77
    Marker Score: 16621
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.75
    Marker Score: 2267
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.75
    Marker Score: 712
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.74
    Marker Score: 1464
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.74
    Marker Score: 4800.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.73
    Marker Score: 2972
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.72
    Marker Score: 696
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.72
    Marker Score: 577
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.71
    Marker Score: 619.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.71
    Marker Score: 1861
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.71
    Marker Score: 632
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.7
    Marker Score: 642
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.69
    Marker Score: 2037
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.68
    Marker Score: 63917
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.68
    Marker Score: 14504
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.68
    Marker Score: 3946.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.67
    Marker Score: 13072
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.67
    Marker Score: 583
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.65
    Marker Score: 419
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.65
    Marker Score: 1515
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.64
    Marker Score: 1421
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.64
    Marker Score: 16474
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.64
    Marker Score: 794
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.63
    Marker Score: 3321
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.63
    Marker Score: 373.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.63
    Marker Score: 897
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.62
    Marker Score: 970
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.62
    Marker Score: 460
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.61
    Marker Score: 2366
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.6
    Marker Score: 1162
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.6
    Marker Score: 31906.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13753
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6
    Marker Score: 6167.5
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.59
    Marker Score: 418.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.59
    Marker Score: 552
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.59
    Marker Score: 15066
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.58
    Marker Score: 1020
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.58
    Marker Score: 1707
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.58
    Marker Score: 6446
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.57
    Marker Score: 446.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.57
    Marker Score: 966
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.56
    Marker Score: 1685
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.56
    Marker Score: 456
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.56
    Marker Score: 925
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.54
    Marker Score: 1695
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.54
    Marker Score: 354
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 1.54
    Marker Score: 712
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.54
    Marker Score: 382.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.53
    Marker Score: 1540
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.53
    Marker Score: 843
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.53
    Marker Score: 464
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.53
    Marker Score: 2506
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.53
    Marker Score: 404.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.52
    Marker Score: 1045
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.52
    Marker Score: 437
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.52
    Marker Score: 418.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.51
    Marker Score: 1140
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.5
    Marker Score: 429
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.5
    Marker Score: 1011.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.5
    Marker Score: 1180
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.5
    Marker Score: 383.5

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Other Information

**Key characteristics:** * PRMT2 is a protein with a molecular weight of approximately 120 kDa. * It is a histone methyltransferase, meaning that it adds methyl groups to the histone proteins, which are essential for the structure and function of chromatin. * PRMT2 is found in both nuclear and cytoplasmic locations. * It is a key regulator of gene expression by modifying the methylation status of DNA, which can affect the accessibility of genes to transcription factors. **Pathways and functions:** * PRMT2 is involved in several important pathways, including chromatin remodeling, transcription, and signal transduction. * It is a key regulator of T cell development and function. * It is involved in the regulation of immune responses and inflammation. * It is also involved in cell cycle regulation and apoptosis. **Clinical significance:** * Mutations in PRMT2 have been linked to several human diseases, including cancer and autoimmune disorders. * Targeting PRMT2 has emerged as a promising therapeutic strategy for these diseases. **Additional points:** * PRMT2 is a highly conserved protein with homologs in other species. * It is a regulated by various factors, including growth factors, cytokines, and hormones. * It is a potential target for cancer immunotherapy.

Genular Protein ID: 1457025690

Symbol: ANM2_HUMAN

Name: Protein arginine N-methyltransferase 2

UniProtKB Accession Codes:

P55345 B7U630 B7U631 B7U632 P78350 Q498Y5 Q5U7D4 Q6FHF0 Q99781 Q9BW15 Q9UMC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 2 CORUM 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 16 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 RefSeq 11 Rhea 3 SABIO-RK 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9545638

Title: Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).

PubMed ID: 9545638

DOI: 10.1006/geno.1997.5190

PubMed ID: 9196002

Title: Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene.

PubMed ID: 9196002

DOI: 10.1007/s003359900491

PubMed ID: 21820040

Title: Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer.

PubMed ID: 21820040

DOI: 10.1016/j.gene.2011.06.022

PubMed ID: 22093364

Title: Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma.

PubMed ID: 22093364

DOI: 10.1111/j.1742-4658.2011.08426.x

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11513728

Title: Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1.

PubMed ID: 11513728

DOI: 10.1042/0264-6021:3580305

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 16648481

Title: Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis.

PubMed ID: 16648481

DOI: 10.1128/mcb.26.10.3864-3874.2006

PubMed ID: 17925405

Title: Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.

PubMed ID: 17925405

DOI: 10.1074/jbc.m704650200

PubMed ID: 17587566

Title: PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.

PubMed ID: 17587566

DOI: 10.1016/j.jsbmb.2007.05.006

PubMed ID: 19405910

Title: Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4.

PubMed ID: 19405910

DOI: 10.1042/bj20090268

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 433
  • Mass: 49042
  • Checksum: 6DEE0350C15ECD4F
  • Sequence:
    • MATSGDCPRS ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL 
RQTTADWWWG ERAGCCGYIP ANHVGKHVDE YDPEDTWQDE EYFGSYGTLK LHLEMLADQP 
RTTKYHSVIL QNKESLTDKV ILDVGCGTGI ISLFCAHYAR PRAVYAVEAS EMAQHTGQLV 
LQNGFADIIT VYQQKVEDVV LPEKVDVLVS EWMGTCLLFE FMIESILYAR DAWLKEDGVI 
WPTMAALHLV PCSADKDYRS KVLFWDNAYE FNLSALKSLA VKEFFSKPKY NHILKPEDCL 
SEPCTILQLD MRTVQISDLE TLRGELRFDI RKAGTLHGFT AWFSVHFQSL QEGQPPQVLS 
TGPFHPTTHW KQTLFMMDDP VPVHTGDVVT GSVVLQRNPV WRRHMSVALS WAVTSRQDPT 
SQKVGEKVFP IWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.