Details for: PRMT2

Gene ID: 3275

Symbol: PRMT2

Ensembl ID: ENSG00000160310

Description: protein arginine methyltransferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 441.3507
    Cell Significance Index: -68.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 252.0862
    Cell Significance Index: -63.9400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 173.4444
    Cell Significance Index: -71.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.4834
    Cell Significance Index: -62.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.8840
    Cell Significance Index: -72.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 137.0665
    Cell Significance Index: -70.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.2168
    Cell Significance Index: -63.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.2689
    Cell Significance Index: -70.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.8712
    Cell Significance Index: -58.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.2132
    Cell Significance Index: -71.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.6724
    Cell Significance Index: -54.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.5436
    Cell Significance Index: -31.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1043
    Cell Significance Index: 129.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5977
    Cell Significance Index: 288.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3286
    Cell Significance Index: 266.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2546
    Cell Significance Index: 154.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1549
    Cell Significance Index: 414.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1466
    Cell Significance Index: 626.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1062
    Cell Significance Index: 26.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0454
    Cell Significance Index: 27.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0117
    Cell Significance Index: 129.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0003
    Cell Significance Index: 198.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9745
    Cell Significance Index: 133.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8792
    Cell Significance Index: 25.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8616
    Cell Significance Index: 24.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8609
    Cell Significance Index: 40.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8592
    Cell Significance Index: 51.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7882
    Cell Significance Index: 50.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7545
    Cell Significance Index: 122.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6317
    Cell Significance Index: 48.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5442
    Cell Significance Index: 240.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5070
    Cell Significance Index: 22.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4288
    Cell Significance Index: 296.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4271
    Cell Significance Index: 42.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3889
    Cell Significance Index: 7.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3003
    Cell Significance Index: 16.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2488
    Cell Significance Index: 12.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2429
    Cell Significance Index: 457.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2130
    Cell Significance Index: 27.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1646
    Cell Significance Index: 19.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1532
    Cell Significance Index: 235.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1369
    Cell Significance Index: 252.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1229
    Cell Significance Index: 167.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1001
    Cell Significance Index: 2.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0902
    Cell Significance Index: 57.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0701
    Cell Significance Index: 3.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0310
    Cell Significance Index: 1.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0220
    Cell Significance Index: 3.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0131
    Cell Significance Index: 0.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0142
    Cell Significance Index: -2.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0295
    Cell Significance Index: -21.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0308
    Cell Significance Index: -23.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0324
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0365
    Cell Significance Index: -27.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0683
    Cell Significance Index: -42.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0698
    Cell Significance Index: -5.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0730
    Cell Significance Index: -7.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0826
    Cell Significance Index: -46.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0874
    Cell Significance Index: -39.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1090
    Cell Significance Index: -7.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1370
    Cell Significance Index: -9.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1787
    Cell Significance Index: -37.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1999
    Cell Significance Index: -3.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2180
    Cell Significance Index: -62.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2404
    Cell Significance Index: -34.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3142
    Cell Significance Index: -19.8000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3238
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3985
    Cell Significance Index: -45.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4115
    Cell Significance Index: -9.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4188
    Cell Significance Index: -48.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4950
    Cell Significance Index: -17.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5684
    Cell Significance Index: -38.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5715
    Cell Significance Index: -65.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5952
    Cell Significance Index: -61.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6011
    Cell Significance Index: -5.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6320
    Cell Significance Index: -18.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7472
    Cell Significance Index: -59.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7505
    Cell Significance Index: -15.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7644
    Cell Significance Index: -33.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9412
    Cell Significance Index: -35.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9501
    Cell Significance Index: -17.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9859
    Cell Significance Index: -60.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0047
    Cell Significance Index: -32.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0138
    Cell Significance Index: -25.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0838
    Cell Significance Index: -13.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1172
    Cell Significance Index: -16.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1263
    Cell Significance Index: -6.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1285
    Cell Significance Index: -28.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.1678
    Cell Significance Index: -26.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1756
    Cell Significance Index: -33.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1974
    Cell Significance Index: -32.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2436
    Cell Significance Index: -14.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2909
    Cell Significance Index: -42.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3002
    Cell Significance Index: -33.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3570
    Cell Significance Index: -43.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4612
    Cell Significance Index: -31.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4687
    Cell Significance Index: -31.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4997
    Cell Significance Index: -25.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5828
    Cell Significance Index: -55.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRMT2 is a member of the protein arginine methyltransferase (PRMT) family, enzymes responsible for the methylation of arginine residues on histones and non-histone proteins. PRMT2 specifically methylates histone H3 and H4, as well as non-histone proteins such as transcription factors and receptors. This post-translational modification plays a crucial role in various cellular processes, including: 1. **Chromatin remodeling**: PRMT2 facilitates the reorganization of chromatin structure, influencing gene expression and transcription. 2. **Transcription regulation**: PRMT2 modifies transcription factors, affecting their activity and binding to DNA. 3. **Immune response modulation**: PRMT2 is expressed in immune cells, where it regulates T cell development, function, and cytokine production. **Pathways and Functions:** PRMT2 is involved in several critical pathways, including: 1. **Chromatin remodeling**: PRMT2 interacts with chromatin remodeling complexes, such as SWI/SNF, to facilitate histone modification and chromatin reorganization. 2. **Histone modification**: PRMT2 methylates histone H3 and H4, influencing chromatin structure and gene expression. 3. **Transcription coactivation**: PRMT2 modifies transcription factors, enhancing their activity and binding to DNA. 4. **Signal transduction**: PRMT2 regulates signaling pathways, including the NF-κB and MAPK pathways, which are crucial for immune response and cell survival. 5. **Apoptosis regulation**: PRMT2 influences apoptosis by modifying pro-apoptotic and anti-apoptotic proteins. **Clinical Significance:** PRMT2's involvement in immune regulation and cancer highlights its potential as a therapeutic target: 1. **Autoimmune diseases**: PRMT2 inhibition may modulate immune responses in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: PRMT2 overexpression has been linked to cancer progression, making it a potential target for cancer therapy. 3. **Infectious diseases**: PRMT2 may play a role in the regulation of immune responses to infections, such as HIV and tuberculosis. 4. **Neurological disorders**: PRMT2's involvement in neuroinflammation and neurodegenerative diseases, such as Alzheimer's and Parkinson's, suggests its potential as a therapeutic target. In conclusion, PRMT2 is a complex gene with far-reaching implications in various cellular processes, including histone modification, transcription regulation, and immune response modulation. Further research is needed to fully elucidate its role in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1457025690

Symbol: ANM2_HUMAN

Name: Protein arginine N-methyltransferase 2

UniProtKB Accession Codes:

P55345 B7U630 B7U631 B7U632 P78350 Q498Y5 Q5U7D4 Q6FHF0 Q99781 Q9BW15 Q9UMC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 2 CORUM 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 16 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 RefSeq 11 Rhea 3 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9545638

Title: Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).

PubMed ID: 9545638

DOI: 10.1006/geno.1997.5190

PubMed ID: 9196002

Title: Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene.

PubMed ID: 9196002

DOI: 10.1007/s003359900491

PubMed ID: 21820040

Title: Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer.

PubMed ID: 21820040

DOI: 10.1016/j.gene.2011.06.022

PubMed ID: 22093364

Title: Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma.

PubMed ID: 22093364

DOI: 10.1111/j.1742-4658.2011.08426.x

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11513728

Title: Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1.

PubMed ID: 11513728

DOI: 10.1042/0264-6021:3580305

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 16648481

Title: Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis.

PubMed ID: 16648481

DOI: 10.1128/mcb.26.10.3864-3874.2006

PubMed ID: 17925405

Title: Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.

PubMed ID: 17925405

DOI: 10.1074/jbc.m704650200

PubMed ID: 17587566

Title: PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.

PubMed ID: 17587566

DOI: 10.1016/j.jsbmb.2007.05.006

PubMed ID: 19405910

Title: Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4.

PubMed ID: 19405910

DOI: 10.1042/bj20090268

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 433
  • Mass: 49042
  • Checksum: 6DEE0350C15ECD4F
  • Sequence:
    • MATSGDCPRS ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL 
RQTTADWWWG ERAGCCGYIP ANHVGKHVDE YDPEDTWQDE EYFGSYGTLK LHLEMLADQP 
RTTKYHSVIL QNKESLTDKV ILDVGCGTGI ISLFCAHYAR PRAVYAVEAS EMAQHTGQLV 
LQNGFADIIT VYQQKVEDVV LPEKVDVLVS EWMGTCLLFE FMIESILYAR DAWLKEDGVI 
WPTMAALHLV PCSADKDYRS KVLFWDNAYE FNLSALKSLA VKEFFSKPKY NHILKPEDCL 
SEPCTILQLD MRTVQISDLE TLRGELRFDI RKAGTLHGFT AWFSVHFQSL QEGQPPQVLS 
TGPFHPTTHW KQTLFMMDDP VPVHTGDVVT GSVVLQRNPV WRRHMSVALS WAVTSRQDPT 
SQKVGEKVFP IWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.