Details for: HSF4

Gene ID: 3299

Symbol: HSF4

Ensembl ID: ENSG00000102878

Description: heat shock transcription factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.2269
    Cell Significance Index: -12.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.7405
    Cell Significance Index: -12.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.3816
    Cell Significance Index: -12.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5579
    Cell Significance Index: -12.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2852
    Cell Significance Index: -7.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.6668
    Cell Significance Index: 40.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1988
    Cell Significance Index: 26.2500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.0630
    Cell Significance Index: 6.3700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.0338
    Cell Significance Index: 16.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7009
    Cell Significance Index: 36.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6710
    Cell Significance Index: 66.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5741
    Cell Significance Index: 115.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4729
    Cell Significance Index: 426.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4376
    Cell Significance Index: 5.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4068
    Cell Significance Index: 18.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3632
    Cell Significance Index: 4.5100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3435
    Cell Significance Index: 5.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3417
    Cell Significance Index: 9.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3397
    Cell Significance Index: 7.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3305
    Cell Significance Index: 53.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2929
    Cell Significance Index: 4.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2745
    Cell Significance Index: 7.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2614
    Cell Significance Index: 93.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2527
    Cell Significance Index: 19.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2366
    Cell Significance Index: 25.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2267
    Cell Significance Index: 10.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1747
    Cell Significance Index: 328.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1209
    Cell Significance Index: 4.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1153
    Cell Significance Index: 0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1106
    Cell Significance Index: 150.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1004
    Cell Significance Index: 6.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0890
    Cell Significance Index: 2.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0852
    Cell Significance Index: 58.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0829
    Cell Significance Index: 10.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0759
    Cell Significance Index: 1.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0745
    Cell Significance Index: 14.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0687
    Cell Significance Index: 4.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0543
    Cell Significance Index: 3.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0489
    Cell Significance Index: 26.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0432
    Cell Significance Index: 27.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0412
    Cell Significance Index: 18.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0384
    Cell Significance Index: 16.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0309
    Cell Significance Index: 0.8400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0274
    Cell Significance Index: 0.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0225
    Cell Significance Index: 0.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0221
    Cell Significance Index: 1.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0158
    Cell Significance Index: 0.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0133
    Cell Significance Index: 24.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0107
    Cell Significance Index: 1.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0079
    Cell Significance Index: 12.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0009
    Cell Significance Index: -0.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0104
    Cell Significance Index: -0.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0106
    Cell Significance Index: -7.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0116
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0122
    Cell Significance Index: -9.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0132
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0204
    Cell Significance Index: -12.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0286
    Cell Significance Index: -0.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0289
    Cell Significance Index: -0.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0295
    Cell Significance Index: -4.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0361
    Cell Significance Index: -10.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0376
    Cell Significance Index: -4.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0470
    Cell Significance Index: -9.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0482
    Cell Significance Index: -3.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0533
    Cell Significance Index: -3.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0544
    Cell Significance Index: -6.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0546
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0552
    Cell Significance Index: -11.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0563
    Cell Significance Index: -2.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0601
    Cell Significance Index: -7.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0613
    Cell Significance Index: -2.8800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0626
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0720
    Cell Significance Index: -8.2500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0721
    Cell Significance Index: -0.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0735
    Cell Significance Index: -1.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0769
    Cell Significance Index: -5.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0835
    Cell Significance Index: -1.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0908
    Cell Significance Index: -3.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0971
    Cell Significance Index: -2.0700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0987
    Cell Significance Index: -1.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1029
    Cell Significance Index: -12.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1058
    Cell Significance Index: -3.3700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1093
    Cell Significance Index: -2.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1096
    Cell Significance Index: -1.5700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1186
    Cell Significance Index: -2.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1224
    Cell Significance Index: -3.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1254
    Cell Significance Index: -1.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1391
    Cell Significance Index: -11.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1397
    Cell Significance Index: -9.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1399
    Cell Significance Index: -2.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1546
    Cell Significance Index: -3.3400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1598
    Cell Significance Index: -2.3900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1701
    Cell Significance Index: -5.3800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1708
    Cell Significance Index: -2.7400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1716
    Cell Significance Index: -2.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1754
    Cell Significance Index: -5.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1847
    Cell Significance Index: -9.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSF4 is a transcription factor that belongs to the HSF family, which consists of four members: HSF1, HSF2, HSF3, and HSF4. HSF4 is specifically expressed in lens fiber cells, retinal ganglion cells, and cardiac muscle myoblasts, among other cell types. It is a DNA-binding transcription factor that recognizes specific DNA sequences, including the heat shock element (HSE), and regulates the expression of heat shock proteins (HSPs) and other target genes. **Pathways and Functions:** HSF4 is involved in various cellular processes, including: 1. **Lens fiber cell differentiation**: HSF4 regulates the expression of genes involved in lens fiber cell differentiation, including the production of crystallins and other lens-specific proteins. 2. **Neuroprotection**: HSF4 has been shown to have neuroprotective effects in retinal ganglion cells, where it regulates the expression of genes involved in survival and differentiation. 3. **Cardiac muscle myoblast differentiation**: HSF4 plays a crucial role in regulating the expression of genes involved in cardiac muscle myoblast differentiation and cardiac function. 4. **Stress response**: HSF4 is involved in the regulation of the heat shock response, including the expression of HSPs and other stress-related genes. **Clinical Significance:** HSF4 has been implicated in various diseases, including: 1. **Cataracts**: Mutations in the HSF4 gene have been associated with congenital cataracts and other lens-related disorders. 2. **Glaucoma**: HSF4 has been shown to have neuroprotective effects in glaucoma, where it regulates the expression of genes involved in retinal ganglion cell survival. 3. **Cardiac disease**: HSF4 has been implicated in cardiac disease, including heart failure and cardiac arrhythmias. 4. **Neurodegenerative diseases**: HSF4 has been shown to have neuroprotective effects in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, HSF4 is a critical transcription factor involved in various cellular processes, including differentiation, proliferation, and survival. Its dysregulation has been implicated in various diseases, including cataracts, glaucoma, cardiac disease, and neurodegenerative diseases. Further studies are needed to fully understand the role of HSF4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 799801136

Symbol: HSF4_HUMAN

Name: Heat shock factor protein 4

UniProtKB Accession Codes:

Q9ULV5 Q99472 Q9ULV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8972228

Title: HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator.

PubMed ID: 8972228

DOI: 10.1128/mcb.17.1.469

PubMed ID: 10488131

Title: The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing.

PubMed ID: 10488131

DOI: 10.1074/jbc.274.39.27845

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 16581800

Title: Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26.

PubMed ID: 16581800

DOI: 10.1128/mcb.26.8.3282-3294.2006

PubMed ID: 16371476

Title: PDSM, a motif for phosphorylation-dependent SUMO modification.

PubMed ID: 16371476

DOI: 10.1073/pnas.0503698102

PubMed ID: 22587838

Title: HSF4 is involved in DNA damage repair through regulation of Rad51.

PubMed ID: 22587838

DOI: 10.1016/j.bbadis.2012.05.005

PubMed ID: 23145062

Title: Human ALKBH4 interacts with proteins associated with transcription.

PubMed ID: 23145062

DOI: 10.1371/journal.pone.0049045

PubMed ID: 23507146

Title: HSF4 regulates DLAD expression and promotes lens de-nucleation.

PubMed ID: 23507146

DOI: 10.1016/j.bbadis.2013.03.007

PubMed ID: 28981088

Title: HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.

PubMed ID: 28981088

DOI: 10.1038/cddis.2017.478

PubMed ID: 12089525

Title: Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract.

PubMed ID: 12089525

DOI: 10.1038/ng921

PubMed ID: 16876512

Title: Novel HSF4 mutation causes congenital total white cataract in a Chinese family.

PubMed ID: 16876512

DOI: 10.1016/j.ajo.2006.03.056

PubMed ID: 19182255

Title: Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract.

PubMed ID: 19182255

DOI: 10.1167/iovs.08-3149

Sequence Information:

  • Length: 492
  • Mass: 53011
  • Checksum: D5F1C0D68014BC2E
  • Sequence:
    • MQEAPAALPT EPGPSPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD QSRFAKEVLP 
QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE FQHPSFVRGR EQLLERVRRK 
VPALRGDDGR WRPEDLGRLL GEVQALRGVQ ESTEARLREL RQQNEILWRE VVTLRQSHGQ 
QHRVIGKLIQ CLFGPLQAGP SNAGGKRKLS LMLDEGSSCP TPAKFNTCPL PGALLQDPYF 
IQSPLPETNL GLSPHRARGP IISDIPEDSP SPEGTRLSPS SDGRREKGLA LLKEEPASPG 
GDGEAGLALA PNECDFCVTA PPPLPVAVVQ AILEGKGSFS PEGPRNAQQP EPGDPREIPD 
RGPLGLESGD RSPESLLPPM LLQPPQESVE PAGPLDVLGP SLQGREWTLM DLDMELSLMQ 
PLVPERGEPE LAVKGLNSPS PGKDPTLGAP LLLDVQAALG GPALGLPGAL TIYSTPESRT 
ASYLGPEASP SP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.