Details for: HSF4

Gene ID: 3299

Symbol: HSF4

Ensembl ID: ENSG00000102878

Description: heat shock transcription factor 4

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Identical protein binding
    (GO:0042802)
  • Lens fiber cell differentiation
    (GO:0070306)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear speck
    (GO:0016607)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.75
    Marker Score: 1024
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.69
    Marker Score: 709
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.62
    Marker Score: 6787
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169408
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.44
    Marker Score: 393
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.14
    Marker Score: 663
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17006
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.04
    Marker Score: 507
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2012.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1802
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.94
    Marker Score: 2074
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.93
    Marker Score: 3308
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.92
    Marker Score: 1427
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.92
    Marker Score: 622
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.91
    Marker Score: 599.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5201
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.9
    Marker Score: 20189
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.89
    Marker Score: 281
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.84
    Marker Score: 2114
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.84
    Marker Score: 7964
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.83
    Marker Score: 51169
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.82
    Marker Score: 538
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.82
    Marker Score: 17411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.75
    Marker Score: 902
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.75
    Marker Score: 27491
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.74
    Marker Score: 6974
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3062
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.7
    Marker Score: 384
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.69
    Marker Score: 1412
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.69
    Marker Score: 655
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5802
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.62
    Marker Score: 6443
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.61
    Marker Score: 1032
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 293
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.61
    Marker Score: 3661
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.59
    Marker Score: 11796
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.59
    Marker Score: 2277
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.59
    Marker Score: 171
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.58
    Marker Score: 21905
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 346
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.57
    Marker Score: 8503
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 362
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.53
    Marker Score: 2229
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.52
    Marker Score: 293
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.5
    Marker Score: 3830
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.48
    Marker Score: 151
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.46
    Marker Score: 185
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 438
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.43
    Marker Score: 370
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1003
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.42
    Marker Score: 1747
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.42
    Marker Score: 153
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.4
    Marker Score: 162
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 165
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.39
    Marker Score: 170
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.38
    Marker Score: 415
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.37
    Marker Score: 423
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 162
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.36
    Marker Score: 840
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.35
    Marker Score: 985
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.34
    Marker Score: 117
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.34
    Marker Score: 1574
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.34
    Marker Score: 1381
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.33
    Marker Score: 446
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 212
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.31
    Marker Score: 115
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.29
    Marker Score: 776
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.28
    Marker Score: 693
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.28
    Marker Score: 9555
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.28
    Marker Score: 9449
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.27
    Marker Score: 4320
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.26
    Marker Score: 171
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.25
    Marker Score: 578
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.25
    Marker Score: 182
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.25
    Marker Score: 347
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.25
    Marker Score: 262
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.24
    Marker Score: 582

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Other Information

**Key characteristics:** - HSF4 is a highly conserved protein that is found in all eukaryotic cells. - It is a chaperone protein that helps to protect other proteins from degradation. - HSF4 is a key regulator of heat shock responses. - It is also involved in the regulation of apoptosis, cell cycle regulation, and inflammation. **Pathways and functions:** - HSF4 is a key regulator of heat shock responses. It is induced by heat stress and helps to protect cells from damage caused by heat shock proteins (HSPs). - It also plays a role in the regulation of cell cycle progression and apoptosis. - HSF4 is involved in the development and maintenance of tissues, including the lens, skin, and heart. - It is also involved in the regulation of cell proliferation, differentiation, and apoptosis. **Clinical significance:** - Mutations in the HSF4 gene have been linked to a number of human diseases, including heat shock, cancer, and neurodegenerative diseases. - HSF4 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** - HSF4 is a highly overexpressed protein in many human tumors. - It is a target for cancer immunotherapy. - HSF4 is a promising target for the treatment of a variety of human diseases.

Genular Protein ID: 799801136

Symbol: HSF4_HUMAN

Name: Heat shock factor protein 4

UniProtKB Accession Codes:

Q9ULV5 Q99472 Q9ULV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8972228

Title: HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator.

PubMed ID: 8972228

DOI: 10.1128/mcb.17.1.469

PubMed ID: 10488131

Title: The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing.

PubMed ID: 10488131

DOI: 10.1074/jbc.274.39.27845

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 16581800

Title: Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26.

PubMed ID: 16581800

DOI: 10.1128/mcb.26.8.3282-3294.2006

PubMed ID: 16371476

Title: PDSM, a motif for phosphorylation-dependent SUMO modification.

PubMed ID: 16371476

DOI: 10.1073/pnas.0503698102

PubMed ID: 22587838

Title: HSF4 is involved in DNA damage repair through regulation of Rad51.

PubMed ID: 22587838

DOI: 10.1016/j.bbadis.2012.05.005

PubMed ID: 23145062

Title: Human ALKBH4 interacts with proteins associated with transcription.

PubMed ID: 23145062

DOI: 10.1371/journal.pone.0049045

PubMed ID: 23507146

Title: HSF4 regulates DLAD expression and promotes lens de-nucleation.

PubMed ID: 23507146

DOI: 10.1016/j.bbadis.2013.03.007

PubMed ID: 28981088

Title: HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.

PubMed ID: 28981088

DOI: 10.1038/cddis.2017.478

PubMed ID: 12089525

Title: Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract.

PubMed ID: 12089525

DOI: 10.1038/ng921

PubMed ID: 16876512

Title: Novel HSF4 mutation causes congenital total white cataract in a Chinese family.

PubMed ID: 16876512

DOI: 10.1016/j.ajo.2006.03.056

PubMed ID: 19182255

Title: Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract.

PubMed ID: 19182255

DOI: 10.1167/iovs.08-3149

Sequence Information:

  • Length: 492
  • Mass: 53011
  • Checksum: D5F1C0D68014BC2E
  • Sequence:
    • MQEAPAALPT EPGPSPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD QSRFAKEVLP 
QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE FQHPSFVRGR EQLLERVRRK 
VPALRGDDGR WRPEDLGRLL GEVQALRGVQ ESTEARLREL RQQNEILWRE VVTLRQSHGQ 
QHRVIGKLIQ CLFGPLQAGP SNAGGKRKLS LMLDEGSSCP TPAKFNTCPL PGALLQDPYF 
IQSPLPETNL GLSPHRARGP IISDIPEDSP SPEGTRLSPS SDGRREKGLA LLKEEPASPG 
GDGEAGLALA PNECDFCVTA PPPLPVAVVQ AILEGKGSFS PEGPRNAQQP EPGDPREIPD 
RGPLGLESGD RSPESLLPPM LLQPPQESVE PAGPLDVLGP SLQGREWTLM DLDMELSLMQ 
PLVPERGEPE LAVKGLNSPS PGKDPTLGAP LLLDVQAALG GPALGLPGAL TIYSTPESRT 
ASYLGPEASP SP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.