Details for: HSPA1L

Gene ID: 3305

Symbol: HSPA1L

Ensembl ID: ENSG00000204390

Description: heat shock protein family A (Hsp70) member 1 like

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.01
    Marker Score: 319
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5327
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.86
    Marker Score: 579
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.85
    Marker Score: 266
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 269
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.83
    Marker Score: 1141
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.78
    Marker Score: 968
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.77
    Marker Score: 1343
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.77
    Marker Score: 5105
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 546.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.69
    Marker Score: 1616
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.56
    Marker Score: 806
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 321
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.43
    Marker Score: 112
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.4
    Marker Score: 144
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 254
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.37
    Marker Score: 529
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.29
    Marker Score: 83
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.24
    Marker Score: 300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 97
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.23
    Marker Score: 95
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 122
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.19
    Marker Score: 294
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 48
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.18
    Marker Score: 70
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.16
    Marker Score: 62
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.16
    Marker Score: 90
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.15
    Marker Score: 152
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.15
    Marker Score: 248
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.14
    Marker Score: 105
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.14
    Marker Score: 1187
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.13
    Marker Score: 26
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.13
    Marker Score: 4508.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.13
    Marker Score: 266
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.13
    Marker Score: 122
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 25
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.12
    Marker Score: 346
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.12
    Marker Score: 128
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.12
    Marker Score: 151
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 134
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 114
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.11
    Marker Score: 123
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.11
    Marker Score: 87.5
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.11
    Marker Score: 283
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.11
    Marker Score: 103
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.1
    Marker Score: 151
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1
    Marker Score: 122
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.1
    Marker Score: 25

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Other Information

**Key characteristics:** - HSPA1L is a chaperone protein that binds to unfolded or misfolded proteins. - It is a key regulator of the heat shock response by promoting the folding and stability of heat shock proteins. - It also plays a role in the regulation of apoptosis. - It is a key regulator of the immune response, where it is involved in the regulation of inflammation and immune cell activation. **Pathways and functions:** - HSPA1L binds to unfolded or misfolded proteins and helps to refold them. - It also binds to the heat shock factor HSF1 and activates its transactivation. - This leads to the expression of a number of heat shock genes, which help to protect cells from damage caused by heat stress. - HSPA1L also plays a role in the regulation of inflammation and immune cell activation. - It is involved in the regulation of the immune response to viral infection, where it helps to protect cells from infection. - It is also involved in the regulation of the immune response to stress, where it helps to protect cells from damage caused by heat stress. **Clinical significance:** - Mutations in HSPA1L have been linked to a number of human diseases, including amyotrophic lateral sclerosis (ALS), heat stress-related disorders, and cancer. - HSPA1L is a potential therapeutic target for these diseases, as it is a key regulator of the heat shock response and plays a role in protecting cells from damage caused by heat stress.

Genular Protein ID: 1647726801

Symbol: HS71L_HUMAN

Name: Heat shock 70 kDa protein 1-like

UniProtKB Accession Codes:

P34931 A6NNB0 B0UXW8 O75634 Q2HXR3 Q8NE72 Q96QC9 Q9UQM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1700760

Title: Structure and expression of the three MHC-linked HSP70 genes.

PubMed ID: 1700760

DOI: 10.1007/bf00187095

PubMed ID: 9685725

Title: Genomic structure of the spermatid-specific HSP70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man.

PubMed ID: 9685725

DOI: 10.1093/oxfordjournals.jbchem.a022118

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24270810

Title: High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

PubMed ID: 24270810

DOI: 10.1038/nature12748

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

PubMed ID: 1356099

Title: Polymorphic analysis of the three MHC-linked HSP70 genes.

PubMed ID: 1356099

DOI: 10.1007/bf00218042

Sequence Information:

  • Length: 641
  • Mass: 70375
  • Checksum: A9339D7657166FF7
  • Sequence:
    • MATAKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ 
VAMNPQNTVF DAKRLIGRKF NDPVVQADMK LWPFQVINEG GKPKVLVSYK GENKAFYPEE 
ISSMVLTKLK ETAEAFLGHP VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA 
AAIAYGLDKG GQGERHVLIF DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV 
SHFVEEFKRK HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT 
RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR LLQDYFNGRD 
LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP LSLGLETAGG VMTALIKRNS 
TIPTKQTQIF TTYSDNQPGV LIQVYEGERA MTKDNNLLGR FDLTGIPPAP RGVPQIEVTF 
DIDANGILNV TATDKSTGKV NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA 
KNALESYAFN MKSVVSDEGL KGKISESDKN KILDKCNELL SWLEVNQLAE KDEFDHKRKE 
LEQMCNPIIT KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.