Details for: HSPA1L

Gene ID: 3305

Symbol: HSPA1L

Ensembl ID: ENSG00000204390

Description: heat shock protein family A (Hsp70) member 1 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.7516
    Cell Significance Index: -3.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.9817
    Cell Significance Index: -3.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.4029
    Cell Significance Index: -3.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.1469
    Cell Significance Index: -3.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.5305
    Cell Significance Index: -4.1000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.2396
    Cell Significance Index: 4.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.0614
    Cell Significance Index: -3.2600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5384
    Cell Significance Index: 4.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5016
    Cell Significance Index: 95.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2520
    Cell Significance Index: 24.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2289
    Cell Significance Index: 206.7100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2202
    Cell Significance Index: 3.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2144
    Cell Significance Index: 12.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1902
    Cell Significance Index: 20.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1476
    Cell Significance Index: 24.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1093
    Cell Significance Index: 3.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0933
    Cell Significance Index: 6.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0702
    Cell Significance Index: 1.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0694
    Cell Significance Index: 1.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0689
    Cell Significance Index: 0.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0617
    Cell Significance Index: 1.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0609
    Cell Significance Index: 3.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0602
    Cell Significance Index: 2.7300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0501
    Cell Significance Index: 0.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0383
    Cell Significance Index: 4.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0322
    Cell Significance Index: 0.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0306
    Cell Significance Index: 6.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0221
    Cell Significance Index: 1.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0114
    Cell Significance Index: 0.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0100
    Cell Significance Index: 1.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0097
    Cell Significance Index: 1.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0082
    Cell Significance Index: 2.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0040
    Cell Significance Index: 2.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0026
    Cell Significance Index: 0.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0019
    Cell Significance Index: 0.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0023
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0033
    Cell Significance Index: -4.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0034
    Cell Significance Index: -2.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0035
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0072
    Cell Significance Index: -0.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0076
    Cell Significance Index: -3.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0084
    Cell Significance Index: -0.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0094
    Cell Significance Index: -0.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0101
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0110
    Cell Significance Index: -1.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0113
    Cell Significance Index: -0.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0123
    Cell Significance Index: -0.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0138
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0148
    Cell Significance Index: -1.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0150
    Cell Significance Index: -0.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0196
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0202
    Cell Significance Index: -4.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0218
    Cell Significance Index: -0.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0244
    Cell Significance Index: -1.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0250
    Cell Significance Index: -2.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0268
    Cell Significance Index: -0.3200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0277
    Cell Significance Index: -0.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0300
    Cell Significance Index: -3.8800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0345
    Cell Significance Index: -0.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0357
    Cell Significance Index: -0.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0375
    Cell Significance Index: -3.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0387
    Cell Significance Index: -0.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0428
    Cell Significance Index: -1.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0428
    Cell Significance Index: -3.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0437
    Cell Significance Index: -3.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0450
    Cell Significance Index: -3.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0463
    Cell Significance Index: -1.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0468
    Cell Significance Index: -3.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0470
    Cell Significance Index: -2.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0505
    Cell Significance Index: -2.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0526
    Cell Significance Index: -3.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0560
    Cell Significance Index: -3.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0624
    Cell Significance Index: -2.1700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0642
    Cell Significance Index: -0.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0648
    Cell Significance Index: -1.9100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0707
    Cell Significance Index: -0.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0730
    Cell Significance Index: -2.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0739
    Cell Significance Index: -3.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0759
    Cell Significance Index: -1.2700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0795
    Cell Significance Index: -0.6000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0797
    Cell Significance Index: -0.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0822
    Cell Significance Index: -2.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0845
    Cell Significance Index: -2.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0864
    Cell Significance Index: -3.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0864
    Cell Significance Index: -3.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0874
    Cell Significance Index: -2.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0876
    Cell Significance Index: -1.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0882
    Cell Significance Index: -2.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0904
    Cell Significance Index: -1.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HSPA1L gene is a member of the Hsp70 family, which consists of a group of molecular chaperones that assist in the proper folding, unfolding, and refolding of proteins. The HSPA1L gene is specifically characterized by its high degree of sequence similarity to the HSP70 gene, which is a well-studied member of the Hsp70 family. The HSPA1L gene is primarily expressed in cells that require high levels of protein folding and refolding, such as immune cells, epithelial cells, and stem cells. **Pathways and Functions:** The HSPA1L gene is involved in various cellular processes, including: 1. **Antiviral Mechanism**: HSPA1L has been shown to play a role in the antiviral response by interacting with interferon-stimulated genes (ISGs) and regulating their expression. 2. **Protein Folding and Refolding**: HSPA1L acts as a molecular chaperone to assist in the proper folding and refolding of proteins, which is essential for maintaining protein homeostasis. 3. **Immune Response**: HSPA1L is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Heat Shock Response**: HSPA1L is induced in response to heat shock and plays a role in the regulation of the heat shock response. 5. **Cellular Stress Response**: HSPA1L is involved in the regulation of cellular stress responses, including the response to unfolded proteins and oxidative stress. **Clinical Significance:** The HSPA1L gene has been implicated in various diseases, including: 1. **Autoimmune Diseases**: HSPA1L has been shown to play a role in the regulation of autoimmune responses, and its dysregulation has been implicated in autoimmune diseases such as rheumatoid arthritis and lupus. 2. **Cancer**: HSPA1L has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Neurological Disorders**: HSPA1L has been implicated in the regulation of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases**: HSPA1L has been shown to play a role in the regulation of immune responses to infectious diseases, including HIV and tuberculosis. In conclusion, the HSPA1L gene is a multifaceted chaperone that plays a crucial role in maintaining protein homeostasis and immune response. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its clinical significance. **References:** * [Insert references here] **Note:** This article is a summary of the HSPA1L gene and its functions, and is not intended to be a comprehensive review of the literature. Further research is needed to fully understand the clinical significance of the HSPA1L gene.

Genular Protein ID: 1647726801

Symbol: HS71L_HUMAN

Name: Heat shock 70 kDa protein 1-like

UniProtKB Accession Codes:

P34931 A6NNB0 B0UXW8 O75634 Q2HXR3 Q8NE72 Q96QC9 Q9UQM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1700760

Title: Structure and expression of the three MHC-linked HSP70 genes.

PubMed ID: 1700760

DOI: 10.1007/bf00187095

PubMed ID: 9685725

Title: Genomic structure of the spermatid-specific HSP70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man.

PubMed ID: 9685725

DOI: 10.1093/oxfordjournals.jbchem.a022118

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24270810

Title: High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

PubMed ID: 24270810

DOI: 10.1038/nature12748

PubMed ID: 26865365

Title: The human HSP70 family of chaperones: where do we stand?

PubMed ID: 26865365

DOI: 10.1007/s12192-016-0676-6

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

PubMed ID: 1356099

Title: Polymorphic analysis of the three MHC-linked HSP70 genes.

PubMed ID: 1356099

DOI: 10.1007/bf00218042

Sequence Information:

  • Length: 641
  • Mass: 70375
  • Checksum: A9339D7657166FF7
  • Sequence:
    • MATAKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ 
VAMNPQNTVF DAKRLIGRKF NDPVVQADMK LWPFQVINEG GKPKVLVSYK GENKAFYPEE 
ISSMVLTKLK ETAEAFLGHP VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA 
AAIAYGLDKG GQGERHVLIF DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV 
SHFVEEFKRK HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT 
RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR LLQDYFNGRD 
LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP LSLGLETAGG VMTALIKRNS 
TIPTKQTQIF TTYSDNQPGV LIQVYEGERA MTKDNNLLGR FDLTGIPPAP RGVPQIEVTF 
DIDANGILNV TATDKSTGKV NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA 
KNALESYAFN MKSVVSDEGL KGKISESDKN KILDKCNELL SWLEVNQLAE KDEFDHKRKE 
LEQMCNPIIT KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.