Details for: HSPG2

Gene ID: 3339

Symbol: HSPG2

Ensembl ID: ENSG00000142798

Description: heparan sulfate proteoglycan 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 298.4984
    Cell Significance Index: -46.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.5434
    Cell Significance Index: -45.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 120.1730
    Cell Significance Index: -49.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.0235
    Cell Significance Index: -42.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.6331
    Cell Significance Index: -46.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.5334
    Cell Significance Index: -34.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.3222
    Cell Significance Index: -43.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.7611
    Cell Significance Index: -46.4100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 8.1630
    Cell Significance Index: 48.2000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 5.4039
    Cell Significance Index: 18.8000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.1319
    Cell Significance Index: 73.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.1195
    Cell Significance Index: 58.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.3370
    Cell Significance Index: 84.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.2062
    Cell Significance Index: 85.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.0656
    Cell Significance Index: 78.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.2299
    Cell Significance Index: 171.1200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.7439
    Cell Significance Index: 21.9600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.3649
    Cell Significance Index: 19.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2758
    Cell Significance Index: 696.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1002
    Cell Significance Index: 218.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0485
    Cell Significance Index: 30.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0344
    Cell Significance Index: 52.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.9158
    Cell Significance Index: 13.5200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.9026
    Cell Significance Index: 8.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7802
    Cell Significance Index: 704.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7801
    Cell Significance Index: 100.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5478
    Cell Significance Index: 3.3100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.5136
    Cell Significance Index: 3.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5110
    Cell Significance Index: 83.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4870
    Cell Significance Index: 48.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4758
    Cell Significance Index: 12.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4602
    Cell Significance Index: 208.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4436
    Cell Significance Index: 12.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3971
    Cell Significance Index: 611.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3611
    Cell Significance Index: 44.4000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3442
    Cell Significance Index: 3.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3324
    Cell Significance Index: 36.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2855
    Cell Significance Index: 39.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2611
    Cell Significance Index: 481.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2566
    Cell Significance Index: 11.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2563
    Cell Significance Index: 113.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2456
    Cell Significance Index: 5.3200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.2274
    Cell Significance Index: 0.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2213
    Cell Significance Index: 300.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2182
    Cell Significance Index: 138.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1319
    Cell Significance Index: 7.9200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.0942
    Cell Significance Index: 0.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0830
    Cell Significance Index: 14.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0642
    Cell Significance Index: 12.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0632
    Cell Significance Index: 1.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0591
    Cell Significance Index: 4.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0524
    Cell Significance Index: 5.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0445
    Cell Significance Index: 83.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0182
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0305
    Cell Significance Index: -23.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0416
    Cell Significance Index: -30.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0537
    Cell Significance Index: -37.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0673
    Cell Significance Index: -49.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0725
    Cell Significance Index: -45.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0840
    Cell Significance Index: -47.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0918
    Cell Significance Index: -32.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1217
    Cell Significance Index: -14.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1239
    Cell Significance Index: -35.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1279
    Cell Significance Index: -25.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1799
    Cell Significance Index: -8.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1996
    Cell Significance Index: -25.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2010
    Cell Significance Index: -3.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2070
    Cell Significance Index: -30.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2204
    Cell Significance Index: -37.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2309
    Cell Significance Index: -23.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2423
    Cell Significance Index: -51.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2487
    Cell Significance Index: -28.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3133
    Cell Significance Index: -16.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3186
    Cell Significance Index: -22.5300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3348
    Cell Significance Index: -2.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3671
    Cell Significance Index: -43.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4424
    Cell Significance Index: -14.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4437
    Cell Significance Index: -7.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4489
    Cell Significance Index: -20.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4626
    Cell Significance Index: -28.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4777
    Cell Significance Index: -37.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4835
    Cell Significance Index: -10.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4936
    Cell Significance Index: -8.2600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4943
    Cell Significance Index: -3.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5319
    Cell Significance Index: -39.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5774
    Cell Significance Index: -37.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5822
    Cell Significance Index: -12.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6082
    Cell Significance Index: -26.4500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6158
    Cell Significance Index: -4.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6426
    Cell Significance Index: -43.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6973
    Cell Significance Index: -39.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7035
    Cell Significance Index: -44.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7113
    Cell Significance Index: -43.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7126
    Cell Significance Index: -37.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8467
    Cell Significance Index: -23.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8515
    Cell Significance Index: -29.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9249
    Cell Significance Index: -9.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9371
    Cell Significance Index: -49.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9581
    Cell Significance Index: -12.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HSPG2 is a transmembrane proteoglycan with a molecular weight of approximately 130-140 kDa. It is composed of a single extracellular domain, which is rich in sulfated amino acids, particularly glutamic acid and aspartic acid. The extracellular domain of HSPG2 is highly glycosylated, with a significant portion of it being composed of heparan sulfate. This unique glycosylation pattern allows HSPG2 to bind to a wide range of proteins, including growth factors, cytokines, and adhesion molecules. HSPG2 is also highly phosphorylated, with several tyrosine and serine residues being post-translationally modified. **Pathways and Functions** HSPG2 plays a critical role in various biological processes, including: 1. **Angiogenesis**: HSPG2 is involved in the regulation of angiogenesis, a process by which new blood vessels form from pre-existing vessels. HSPG2 binds to vascular endothelial growth factor (VEGF) and other angiogenic factors, promoting the formation of new vessels. 2. **Cell Differentiation**: HSPG2 is involved in the regulation of cell differentiation, particularly in the development of the nervous system and the formation of the ECM. 3. **Immune Responses**: HSPG2 is involved in the regulation of immune responses, particularly in the context of viral infections. HSPG2 binds to viral proteins, such as the respiratory syncytial virus (RSV) attachment protein, facilitating the entry of viruses into host cells. 4. **ECM Organization**: HSPG2 is involved in the organization of the ECM, particularly in the context of basement membrane formation. **Clinical Significance** Dysregulation of HSPG2 has been implicated in various diseases, including: 1. **Cancer**: HSPG2 is involved in the regulation of angiogenesis and metastasis in cancer. Altered expression of HSPG2 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders**: HSPG2 is involved in the regulation of neuronal development and function. Altered expression of HSPG2 has been observed in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Infectious Diseases**: HSPG2 is involved in the regulation of immune responses to viral infections. Altered expression of HSPG2 has been observed in various infectious diseases, including respiratory syncytial virus (RSV) and influenza virus infections. In conclusion, HSPG2 is a critical component of the ECM that plays a significant role in various biological processes, including cell differentiation, angiogenesis, and immune responses. Dysregulation of HSPG2 has been implicated in various diseases, highlighting the importance of further research into the role of HSPG2 in human health and disease.

Genular Protein ID: 2834000091

Symbol: PGBM_HUMAN

Name: Basement membrane-specific heparan sulfate proteoglycan core protein

UniProtKB Accession Codes:

P98160 Q16287 Q5SZI3 Q9H3V5

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 7 CTD 1 CarbonylDB 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 11 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 2 SIGNOR 1 SMART 10 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1569102

Title: Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.

PubMed ID: 1569102

DOI: 10.1016/s0021-9258(18)42478-7

PubMed ID: 1730768

Title: Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.

PubMed ID: 1730768

DOI: 10.1083/jcb.116.2.559

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8234307

Title: Structural characterization of the complete human perlecan gene and its promoter.

PubMed ID: 8234307

DOI: 10.1073/pnas.90.21.10404

PubMed ID: 11101850

Title: Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia).

PubMed ID: 11101850

DOI: 10.1038/82638

PubMed ID: 1685141

Title: Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1-->p35 and identification of a BamHI restriction fragment length polymorphism.

PubMed ID: 1685141

DOI: 10.1016/0888-7543(91)90147-7

PubMed ID: 1679749

Title: Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1.

PubMed ID: 1679749

DOI: 10.1016/0888-7543(91)90451-j

PubMed ID: 2687294

Title: Matrix-associated heparan sulfate proteoglycan: core protein-specific monoclonal antibodies decorate the pericellular matrix of connective tissue cells and the stromal side of basement membranes.

PubMed ID: 2687294

DOI: 10.1083/jcb.109.6.3199

PubMed ID: 15591058

Title: BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan.

PubMed ID: 15591058

DOI: 10.1074/jbc.m409841200

PubMed ID: 12435733

Title: Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan.

PubMed ID: 12435733

DOI: 10.1074/jbc.m210445200

PubMed ID: 11148217

Title: Fibroblast growth factor-binding protein is a novel partner for perlecan protein core.

PubMed ID: 11148217

DOI: 10.1074/jbc.m011493200

PubMed ID: 11279527

Title: Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.

PubMed ID: 11279527

DOI: 10.1038/86941

PubMed ID: 11956183

Title: The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin.

PubMed ID: 11956183

DOI: 10.1074/jbc.m107583200

PubMed ID: 12604605

Title: Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis.

PubMed ID: 12604605

DOI: 10.1074/jbc.m210529200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17105986

Title: Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism.

PubMed ID: 17105986

DOI: 10.1093/jnci/djj441

PubMed ID: 18024432

Title: Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity.

PubMed ID: 18024432

DOI: 10.1074/jbc.m708364200

PubMed ID: 19789387

Title: Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.

PubMed ID: 19789387

DOI: 10.1182/blood-2009-02-207134

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 21996443

Title: Crystal structure of the LG3 domain of endorepellin, an angiogenesis inhibitor.

PubMed ID: 21996443

DOI: 10.1016/j.jmb.2011.09.048

Sequence Information:

  • Length: 4391
  • Mass: 468830
  • Checksum: C587660E24C83324
  • Sequence:
    • MGWRAAGALL LALLLHGRLL AVTHGLRAYD GLSLPEDIET VTASQMRWTH SYLSDDEDML 
ADSISGDDLG SGDLGSGDFQ MVYFRALVNF TRSIEYSPQL EDAGSREFRE VSEAVVDTLE 
SEYLKIPGDQ VVSVVFIKEL DGWVFVELDV GSEGNADGAQ IQEMLLRVIS SGSVASYVTS 
PQGFQFRRLG TVPQFPRACT EAEFACHSYN ECVALEYRCD RRPDCRDMSD ELNCEEPVLG 
ISPTFSLLVE TTSLPPRPET TIMRQPPVTH APQPLLPGSV RPLPCGPQEA ACRNGHCIPR 
DYLCDGQEDC EDGSDELDCG PPPPCEPNEF PCGNGHCALK LWRCDGDFDC EDRTDEANCP 
TKRPEEVCGP TQFRCVSTNM CIPASFHCDE ESDCPDRSDE FGCMPPQVVT PPRESIQASR 
GQTVTFTCVA IGVPTPIINW RLNWGHIPSH PRVTVTSEGG RGTLIIRDVK ESDQGAYTCE 
AMNARGMVFG IPDGVLELVP QRGPCPDGHF YLEHSAACLP CFCFGITSVC QSTRRFRDQI 
RLRFDQPDDF KGVNVTMPAQ PGTPPLSSTQ LQIDPSLHEF QLVDLSRRFL VHDSFWALPE 
QFLGNKVDSY GGSLRYNVRY ELARGMLEPV QRPDVVLMGA GYRLLSRGHT PTQPGALNQR 
QVQFSEEHWV HESGRPVQRA ELLQVLQSLE AVLIQTVYNT KMASVGLSDI AMDTTVTHAT 
SHGRAHSVEE CRCPIGYSGL SCESCDAHFT RVPGGPYLGT CSGCNCNGHA SSCDPVYGHC 
LNCQHNTEGP QCNKCKAGFF GDAMKATATS CRPCPCPYID ASRRFSDTCF LDTDGQATCD 
ACAPGYTGRR CESCAPGYEG NPIQPGGKCR PVNQEIVRCD ERGSMGTSGE ACRCKNNVVG 
RLCNECADGS FHLSTRNPDG CLKCFCMGVS RHCTSSSWSR AQLHGASEEP GHFSLTNAAS 
THTTNEGIFS PTPGELGFSS FHRLLSGPYF WSLPSRFLGD KVTSYGGELR FTVTQRSQPG 
STPLHGQPLV VLQGNNIILE HHVAQEPSPG QPSTFIVPFR EQAWQRPDGQ PATREHLLMA 
LAGIDTLLIR ASYAQQPAES RVSGISMDVA VPEETGQDPA LEVEQCSCPP GYRGPSCQDC 
DTGYTRTPSG LYLGTCERCS CHGHSEACEP ETGACQGCQH HTEGPRCEQC QPGYYGDAQR 
GTPQDCQLCP CYGDPAAGQA AHTCFLDTDG HPTCDACSPG HSGRHCERCA PGYYGNPSQG 
QPCQRDSQVP GPIGCNCDPQ GSVSSQCDAA GQCQCKAQVE GLTCSHCRPH HFHLSASNPD 
GCLPCFCMGI TQQCASSAYT RHLISTHFAP GDFQGFALVN PQRNSRLTGE FTVEPVPEGA 
QLSFGNFAQL GHESFYWQLP ETYQGDKVAA YGGKLRYTLS YTAGPQGSPL SDPDVQITGN 
NIMLVASQPA LQGPERRSYE IMFREEFWRR PDGQPATREH LLMALADLDE LLIRATFSSV 
PLAASISAVS LEVAQPGPSN RPRALEVEEC RCPPGYIGLS CQDCAPGYTR TGSGLYLGHC 
ELCECNGHSD LCHPETGACS QCQHNAAGEF CELCAPGYYG DATAGTPEDC QPCACPLTNP 
ENMFSRTCES LGAGGYRCTA CEPGYTGQYC EQCGPGYVGN PSVQGGQCLP ETNQAPLVVE 
VHPARSIVPQ GGSHSLRCQV SGSPPHYFYW SREDGRPVPS GTQQRHQGSE LHFPSVQPSD 
AGVYICTCRN LHQSNTSRAE LLVTEAPSKP ITVTVEEQRS QSVRPGADVT FICTAKSKSP 
AYTLVWTRLH NGKLPTRAMD FNGILTIRNV QLSDAGTYVC TGSNMFAMDQ GTATLHVQAS 
GTLSAPVVSI HPPQLTVQPG QLAEFRCSAT GSPTPTLEWT GGPGGQLPAK AQIHGGILRL 
PAVEPTDQAQ YLCRAHSSAG QQVARAVLHV HGGGGPRVQV SPERTQVHAG RTVRLYCRAA 
GVPSATITWR KEGGSLPPQA RSERTDIATL LIPAITTADA GFYLCVATSP AGTAQARIQV 
VVLSASDASP PPVKIESSSP SVTEGQTLDL NCVVAGSAHA QVTWYRRGGS LPPHTQVHGS 
RLRLPQVSPA DSGEYVCRVE NGSGPKEASI TVSVLHGTHS GPSYTPVPGS TRPIRIEPSS 
SHVAEGQTLD LNCVVPGQAH AQVTWHKRGG SLPARHQTHG SLLRLHQVTP ADSGEYVCHV 
VGTSGPLEAS VLVTIEASVI PGPIPPVRIE SSSSTVAEGQ TLDLSCVVAG QAHAQVTWYK 
RGGSLPARHQ VRGSRLYIFQ ASPADAGQYV CRASNGMEAS ITVTVTGTQG ANLAYPAGST 
QPIRIEPSSS QVAEGQTLDL NCVVPGQSHA QVTWHKRGGS LPVRHQTHGS LLRLYQASPA 
DSGEYVCRVL GSSVPLEASV LVTIEPAGSV PALGVTPTVR IESSSSQVAE GQTLDLNCLV 
AGQAHAQVTW HKRGGSLPAR HQVHGSRLRL LQVTPADSGE YVCRVVGSSG TQEASVLVTI 
QQRLSGSHSQ GVAYPVRIES SSASLANGHT LDLNCLVASQ APHTITWYKR GGSLPSRHQI 
VGSRLRIPQV TPADSGEYVC HVSNGAGSRE TSLIVTIQGS GSSHVPSVSP PIRIESSSPT 
VVEGQTLDLN CVVARQPQAI ITWYKRGGSL PSRHQTHGSH LRLHQMSVAD SGEYVCRANN 
NIDALEASIV ISVSPSAGSP SAPGSSMPIR IESSSSHVAE GETLDLNCVV PGQAHAQVTW 
HKRGGSLPSH HQTRGSRLRL HHVSPADSGE YVCRVMGSSG PLEASVLVTI EASGSSAVHV 
PAPGGAPPIR IEPSSSRVAE GQTLDLKCVV PGQAHAQVTW HKRGGNLPAR HQVHGPLLRL 
NQVSPADSGE YSCQVTGSSG TLEASVLVTI EPSSPGPIPA PGLAQPIYIE ASSSHVTEGQ 
TLDLNCVVPG QAHAQVTWYK RGGSLPARHQ THGSQLRLHL VSPADSGEYV CRAASGPGPE 
QEASFTVTVP PSEGSSYRLR SPVISIDPPS STVQQGQDAS FKCLIHDGAA PISLEWKTRN 
QELEDNVHIS PNGSIITIVG TRPSNHGTYR CVASNAYGVA QSVVNLSVHG PPTVSVLPEG 
PVWVKVGKAV TLECVSAGEP RSSARWTRIS STPAKLEQRT YGLMDSHAVL QISSAKPSDA 
GTYVCLAQNA LGTAQKQVEV IVDTGAMAPG APQVQAEEAE LTVEAGHTAT LRCSATGSPA 
PTIHWSKLRS PLPWQHRLEG DTLIIPRVAQ QDSGQYICNA TSPAGHAEAT IILHVESPPY 
ATTVPEHASV QAGETVQLQC LAHGTPPLTF QWSRVGSSLP GRATARNELL HFERAAPEDS 
GRYRCRVTNK VGSAEAFAQL LVQGPPGSLP ATSIPAGSTP TVQVTPQLET KSIGASVEFH 
CAVPSDRGTQ LRWFKEGGQL PPGHSVQDGV LRIQNLDQSC QGTYICQAHG PWGKAQASAQ 
LVIQALPSVL INIRTSVQTV VVGHAVEFEC LALGDPKPQV TWSKVGGHLR PGIVQSGGVV 
RIAHVELADA GQYRCTATNA AGTTQSHVLL LVQALPQISM PQEVRVPAGS AAVFPCIASG 
YPTPDISWSK LDGSLPPDSR LENNMLMLPS VRPQDAGTYV CTATNRQGKV KAFAHLQVPE 
RVVPYFTQTP YSFLPLPTIK DAYRKFEIKI TFRPDSADGM LLYNGQKRVP GSPTNLANRQ 
PDFISFGLVG GRPEFRFDAG SGMATIRHPT PLALGHFHTV TLLRSLTQGS LIVGDLAPVN 
GTSQGKFQGL DLNEELYLGG YPDYGAIPKA GLSSGFIGCV RELRIQGEEI VFHDLNLTAH 
GISHCPTCRD RPCQNGGQCH DSESSSYVCV CPAGFTGSRC EHSQALHCHP EACGPDATCV 
NRPDGRGYTC RCHLGRSGLR CEEGVTVTTP SLSGAGSYLA LPALTNTHHE LRLDVEFKPL 
APDGVLLFSG GKSGPVEDFV SLAMVGGHLE FRYELGSGLA VLRSAEPLAL GRWHRVSAER 
LNKDGSLRVN GGRPVLRSSP GKSQGLNLHT LLYLGGVEPS VPLSPATNMS AHFRGCVGEV 
SVNGKRLDLT YSFLGSQGIG QCYDSSPCER QPCQHGATCM PAGEYEFQCL CRDGFKGDLC 
EHEENPCQLR EPCLHGGTCQ GTRCLCLPGF SGPRCQQGSG HGIAESDWHL EGSGGNDAPG 
QYGAYFHDDG FLAFPGHVFS RSLPEVPETI ELEVRTSTAS GLLLWQGVEV GEAGQGKDFI 
SLGLQDGHLV FRYQLGSGEA RLVSEDPIND GEWHRVTALR EGRRGSIQVD GEELVSGRSP 
GPNVAVNAKG SVYIGGAPDV ATLTGGRFSS GITGCVKNLV LHSARPGAPP PQPLDLQHRA 
QAGANTRPCP S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.