Gene HSPG2 - ENSG00000142798 | NCBI Gene ID: 3339

Details for: HSPG2

Gene ID: 3339

Symbol: HSPG2

Ensembl ID: ENSG00000142798

Description: heparan sulfate proteoglycan 2

Associated with

Amyloid fiber formation
(R-HSA-977225)
A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Attachment and entry
(R-HSA-9694614)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective ext1 causes exostoses 1, trps2 and chds
(R-HSA-3656253)
Defective ext2 causes exostoses 2
(R-HSA-3656237)
Degradation of the extracellular matrix
(R-HSA-1474228)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Early sars-cov-2 infection events
(R-HSA-9772572)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Hs-gag biosynthesis
(R-HSA-2022928)
Hs-gag degradation
(R-HSA-2024096)
Infectious disease
(R-HSA-5663205)
Integrin cell surface interactions
(R-HSA-216083)
Laminin interactions
(R-HSA-3000157)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of proteins
(R-HSA-392499)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Non-integrin membrane-ecm interactions
(R-HSA-3000171)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Retinoid metabolism and transport
(R-HSA-975634)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Sensory perception
(R-HSA-9709957)
Viral infection pathways
(R-HSA-9824446)
Visual phototransduction
(R-HSA-2187338)
Amyloid-beta binding
(GO:0001540)
Angiogenesis
(GO:0001525)
Animal organ regeneration
(GO:0031100)
Basement membrane
(GO:0005604)
Brain development
(GO:0007420)
Calcium ion binding
(GO:0005509)
Cell differentiation
(GO:0030154)
Circulatory system development
(GO:0072359)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen v binding
(GO:0070052)
Embryo implantation
(GO:0007566)
Extracellular exosome
(GO:0070062)
Extracellular matrix structural constituent conferring compression resistance
(GO:0030021)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
Golgi lumen
(GO:0005796)
Inflammatory response
(GO:0006954)
Lipid metabolic process
(GO:0006629)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Lysosomal lumen
(GO:0043202)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of cell population proliferation
(GO:0008285)
Plasma membrane
(GO:0005886)
Plasma membrane protein complex
(GO:0098797)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Protein binding
(GO:0005515)
Receptor-mediated endocytosis
(GO:0006898)
Response to hypoxia
(GO:0001666)
Response to xenobiotic stimulus
(GO:0009410)
Smoothened signaling pathway
(GO:0007224)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: endocardial cell (CL0002350)
Fold Change: 8.66
Marker Score: 4892
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.98
Marker Score: 3609
Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.93
Marker Score: 3656
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.8
Marker Score: 6151.5
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.72
Marker Score: 48302.5
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.64
Marker Score: 3547
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.6
Marker Score: 604
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.6
Marker Score: 2444
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.48
Marker Score: 1632
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.43
Marker Score: 10119
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.35
Marker Score: 741
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.34
Marker Score: 1368
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.31
Marker Score: 4614
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.08
Marker Score: 3017
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.05
Marker Score: 2081
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.02
Marker Score: 738
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 2
Marker Score: 486
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.98
Marker Score: 619
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.97
Marker Score: 542
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.96
Marker Score: 2102
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.96
Marker Score: 417
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.89
Marker Score: 534
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.79
Marker Score: 392
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.78
Marker Score: 1534
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.78
Marker Score: 8754.5
Cell Name: fat cell (CL0000136)
Fold Change: 1.77
Marker Score: 987
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.76
Marker Score: 2119
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.74
Marker Score: 1563
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.71
Marker Score: 1630
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.7
Marker Score: 1538
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7
Marker Score: 58847
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.69
Marker Score: 655
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.68
Marker Score: 404.5
Cell Name: keratocyte (CL0002363)
Fold Change: 1.67
Marker Score: 385
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.65
Marker Score: 483
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.62
Marker Score: 55255
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.55
Marker Score: 1034
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.54
Marker Score: 34407
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.52
Marker Score: 1312
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167864
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.45
Marker Score: 844
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.44
Marker Score: 336
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.43
Marker Score: 363
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.39
Marker Score: 1502
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.39
Marker Score: 343
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.38
Marker Score: 443
Cell Name: lactocyte (CL0002325)
Fold Change: 1.38
Marker Score: 22136
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.33
Marker Score: 760
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.33
Marker Score: 20820.5
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.33
Marker Score: 1825
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.3
Marker Score: 1311
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.3
Marker Score: 3283
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.26
Marker Score: 2433
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.26
Marker Score: 3290
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.25
Marker Score: 4437.5
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.24
Marker Score: 825
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.22
Marker Score: 1317
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.18
Marker Score: 8754
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.16
Marker Score: 1038
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.16
Marker Score: 1505
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.16
Marker Score: 2189
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.15
Marker Score: 477
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.15
Marker Score: 435
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 1.14
Marker Score: 302
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.14
Marker Score: 810
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.14
Marker Score: 1214
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.13
Marker Score: 1177
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.11
Marker Score: 1261
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.09
Marker Score: 12275
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.08
Marker Score: 7033
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.07
Marker Score: 3968.5
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.07
Marker Score: 478
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.06
Marker Score: 280
Cell Name: contractile cell (CL0000183)
Fold Change: 1.05
Marker Score: 570
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.05
Marker Score: 6285
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251739
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.04
Marker Score: 653.5
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.03
Marker Score: 681
Cell Name: neural cell (CL0002319)
Fold Change: 1.03
Marker Score: 497
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.03
Marker Score: 772
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.03
Marker Score: 2414
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1
Marker Score: 2511
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1
Marker Score: 624
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71757
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47981.5
Cell Name: decidual cell (CL2000002)
Fold Change: 0.99
Marker Score: 4285
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.99
Marker Score: 2019.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: fibroblast (CL0000057)
Fold Change: 0.98
Marker Score: 943
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2406
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.95
Marker Score: 2972
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.94
Marker Score: 220
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.94
Marker Score: 325
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.93
Marker Score: 554
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1502
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.91
Marker Score: 1294
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.91
Marker Score: 324
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2721

Hover over a box to see details here...

**Key characteristics:** - It is a large protein with a molecular weight of approximately 140 kDa. - It is composed of two glycosaminoglycan chains, linked by a disulfide bond. - It is expressed in high levels in various cell types, including endothelial cells, epithelial cells, and cardiac cells. **Pathways and functions:** - HSPG2 is involved in the formation of amyloid fibers, which are a hallmark feature of several diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. - It also plays a role in the degradation of the ECM through a process called pericellular proteolysis. - It is involved in disease processes such as disease of glycosylation, which is characterized by the accumulation of abnormal glycoproteins in the ECM. - HSPG2 is also involved in the regulation of cell adhesion and migration, and it is important for the maintenance of tissue integrity. **Clinical significance:** - Mutations in HSPG2 have been linked to several human diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, and cardiovascular diseases. - Targeting HSPG2 with antibodies has been explored as a potential therapeutic strategy for these diseases. **Additional information:** - HSPG2 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. - It is a transmembrane protein that is expressed on the surface of cells. - It is a key regulator of cell adhesion and migration.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Basement membrane-specific heparan sulfate proteoglycan core protein

Genular Protein ID: 2834000091

Symbol: PGBM_HUMAN

Name: Basement membrane-specific heparan sulfate proteoglycan core protein

UniProtKB Accession Codes:

P98160 Q16287 Q5SZI3 Q9H3V5

Database IDs:

Citations:

PubMed ID: 1569102

Title: Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.

PubMed ID: 1569102

DOI: 10.1016/s0021-9258(18)42478-7

PubMed ID: 1730768

Title: Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.

PubMed ID: 1730768

DOI: 10.1083/jcb.116.2.559

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8234307

Title: Structural characterization of the complete human perlecan gene and its promoter.

PubMed ID: 8234307

DOI: 10.1073/pnas.90.21.10404

PubMed ID: 11101850

Title: Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia).

PubMed ID: 11101850

DOI: 10.1038/82638

PubMed ID: 1685141

Title: Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1-->p35 and identification of a BamHI restriction fragment length polymorphism.

PubMed ID: 1685141

DOI: 10.1016/0888-7543(91)90147-7

PubMed ID: 1679749

Title: Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1.

PubMed ID: 1679749

DOI: 10.1016/0888-7543(91)90451-j

PubMed ID: 2687294

Title: Matrix-associated heparan sulfate proteoglycan: core protein-specific monoclonal antibodies decorate the pericellular matrix of connective tissue cells and the stromal side of basement membranes.

PubMed ID: 2687294

DOI: 10.1083/jcb.109.6.3199

PubMed ID: 15591058

Title: BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan.

PubMed ID: 15591058

DOI: 10.1074/jbc.m409841200

PubMed ID: 12435733

Title: Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan.

PubMed ID: 12435733

DOI: 10.1074/jbc.m210445200

PubMed ID: 11148217

Title: Fibroblast growth factor-binding protein is a novel partner for perlecan protein core.

PubMed ID: 11148217

DOI: 10.1074/jbc.m011493200

PubMed ID: 11279527

Title: Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.

PubMed ID: 11279527

DOI: 10.1038/86941

PubMed ID: 11956183

Title: The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin.

PubMed ID: 11956183

DOI: 10.1074/jbc.m107583200

PubMed ID: 12604605

Title: Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis.

PubMed ID: 12604605

DOI: 10.1074/jbc.m210529200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17105986

Title: Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism.

PubMed ID: 17105986

DOI: 10.1093/jnci/djj441

PubMed ID: 18024432

Title: Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity.

PubMed ID: 18024432

DOI: 10.1074/jbc.m708364200

PubMed ID: 19789387

Title: Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.

PubMed ID: 19789387

DOI: 10.1182/blood-2009-02-207134

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 21996443

Title: Crystal structure of the LG3 domain of endorepellin, an angiogenesis inhibitor.

PubMed ID: 21996443

DOI: 10.1016/j.jmb.2011.09.048

Sequence Information:

Length: 4391
Mass: 468830
Checksum: C587660E24C83324
Sequence:

MGWRAAGALL LALLLHGRLL AVTHGLRAYD GLSLPEDIET VTASQMRWTH SYLSDDEDML 
ADSISGDDLG SGDLGSGDFQ MVYFRALVNF TRSIEYSPQL EDAGSREFRE VSEAVVDTLE 
SEYLKIPGDQ VVSVVFIKEL DGWVFVELDV GSEGNADGAQ IQEMLLRVIS SGSVASYVTS 
PQGFQFRRLG TVPQFPRACT EAEFACHSYN ECVALEYRCD RRPDCRDMSD ELNCEEPVLG 
ISPTFSLLVE TTSLPPRPET TIMRQPPVTH APQPLLPGSV RPLPCGPQEA ACRNGHCIPR 
DYLCDGQEDC EDGSDELDCG PPPPCEPNEF PCGNGHCALK LWRCDGDFDC EDRTDEANCP 
TKRPEEVCGP TQFRCVSTNM CIPASFHCDE ESDCPDRSDE FGCMPPQVVT PPRESIQASR 
GQTVTFTCVA IGVPTPIINW RLNWGHIPSH PRVTVTSEGG RGTLIIRDVK ESDQGAYTCE 
AMNARGMVFG IPDGVLELVP QRGPCPDGHF YLEHSAACLP CFCFGITSVC QSTRRFRDQI 
RLRFDQPDDF KGVNVTMPAQ PGTPPLSSTQ LQIDPSLHEF QLVDLSRRFL VHDSFWALPE 
QFLGNKVDSY GGSLRYNVRY ELARGMLEPV QRPDVVLMGA GYRLLSRGHT PTQPGALNQR 
QVQFSEEHWV HESGRPVQRA ELLQVLQSLE AVLIQTVYNT KMASVGLSDI AMDTTVTHAT 
SHGRAHSVEE CRCPIGYSGL SCESCDAHFT RVPGGPYLGT CSGCNCNGHA SSCDPVYGHC 
LNCQHNTEGP QCNKCKAGFF GDAMKATATS CRPCPCPYID ASRRFSDTCF LDTDGQATCD 
ACAPGYTGRR CESCAPGYEG NPIQPGGKCR PVNQEIVRCD ERGSMGTSGE ACRCKNNVVG 
RLCNECADGS FHLSTRNPDG CLKCFCMGVS RHCTSSSWSR AQLHGASEEP GHFSLTNAAS 
THTTNEGIFS PTPGELGFSS FHRLLSGPYF WSLPSRFLGD KVTSYGGELR FTVTQRSQPG 
STPLHGQPLV VLQGNNIILE HHVAQEPSPG QPSTFIVPFR EQAWQRPDGQ PATREHLLMA 
LAGIDTLLIR ASYAQQPAES RVSGISMDVA VPEETGQDPA LEVEQCSCPP GYRGPSCQDC 
DTGYTRTPSG LYLGTCERCS CHGHSEACEP ETGACQGCQH HTEGPRCEQC QPGYYGDAQR 
GTPQDCQLCP CYGDPAAGQA AHTCFLDTDG HPTCDACSPG HSGRHCERCA PGYYGNPSQG 
QPCQRDSQVP GPIGCNCDPQ GSVSSQCDAA GQCQCKAQVE GLTCSHCRPH HFHLSASNPD 
GCLPCFCMGI TQQCASSAYT RHLISTHFAP GDFQGFALVN PQRNSRLTGE FTVEPVPEGA 
QLSFGNFAQL GHESFYWQLP ETYQGDKVAA YGGKLRYTLS YTAGPQGSPL SDPDVQITGN 
NIMLVASQPA LQGPERRSYE IMFREEFWRR PDGQPATREH LLMALADLDE LLIRATFSSV 
PLAASISAVS LEVAQPGPSN RPRALEVEEC RCPPGYIGLS CQDCAPGYTR TGSGLYLGHC 
ELCECNGHSD LCHPETGACS QCQHNAAGEF CELCAPGYYG DATAGTPEDC QPCACPLTNP 
ENMFSRTCES LGAGGYRCTA CEPGYTGQYC EQCGPGYVGN PSVQGGQCLP ETNQAPLVVE 
VHPARSIVPQ GGSHSLRCQV SGSPPHYFYW SREDGRPVPS GTQQRHQGSE LHFPSVQPSD 
AGVYICTCRN LHQSNTSRAE LLVTEAPSKP ITVTVEEQRS QSVRPGADVT FICTAKSKSP 
AYTLVWTRLH NGKLPTRAMD FNGILTIRNV QLSDAGTYVC TGSNMFAMDQ GTATLHVQAS 
GTLSAPVVSI HPPQLTVQPG QLAEFRCSAT GSPTPTLEWT GGPGGQLPAK AQIHGGILRL 
PAVEPTDQAQ YLCRAHSSAG QQVARAVLHV HGGGGPRVQV SPERTQVHAG RTVRLYCRAA 
GVPSATITWR KEGGSLPPQA RSERTDIATL LIPAITTADA GFYLCVATSP AGTAQARIQV 
VVLSASDASP PPVKIESSSP SVTEGQTLDL NCVVAGSAHA QVTWYRRGGS LPPHTQVHGS 
RLRLPQVSPA DSGEYVCRVE NGSGPKEASI TVSVLHGTHS GPSYTPVPGS TRPIRIEPSS 
SHVAEGQTLD LNCVVPGQAH AQVTWHKRGG SLPARHQTHG SLLRLHQVTP ADSGEYVCHV 
VGTSGPLEAS VLVTIEASVI PGPIPPVRIE SSSSTVAEGQ TLDLSCVVAG QAHAQVTWYK 
RGGSLPARHQ VRGSRLYIFQ ASPADAGQYV CRASNGMEAS ITVTVTGTQG ANLAYPAGST 
QPIRIEPSSS QVAEGQTLDL NCVVPGQSHA QVTWHKRGGS LPVRHQTHGS LLRLYQASPA 
DSGEYVCRVL GSSVPLEASV LVTIEPAGSV PALGVTPTVR IESSSSQVAE GQTLDLNCLV 
AGQAHAQVTW HKRGGSLPAR HQVHGSRLRL LQVTPADSGE YVCRVVGSSG TQEASVLVTI 
QQRLSGSHSQ GVAYPVRIES SSASLANGHT LDLNCLVASQ APHTITWYKR GGSLPSRHQI 
VGSRLRIPQV TPADSGEYVC HVSNGAGSRE TSLIVTIQGS GSSHVPSVSP PIRIESSSPT 
VVEGQTLDLN CVVARQPQAI ITWYKRGGSL PSRHQTHGSH LRLHQMSVAD SGEYVCRANN 
NIDALEASIV ISVSPSAGSP SAPGSSMPIR IESSSSHVAE GETLDLNCVV PGQAHAQVTW 
HKRGGSLPSH HQTRGSRLRL HHVSPADSGE YVCRVMGSSG PLEASVLVTI EASGSSAVHV 
PAPGGAPPIR IEPSSSRVAE GQTLDLKCVV PGQAHAQVTW HKRGGNLPAR HQVHGPLLRL 
NQVSPADSGE YSCQVTGSSG TLEASVLVTI EPSSPGPIPA PGLAQPIYIE ASSSHVTEGQ 
TLDLNCVVPG QAHAQVTWYK RGGSLPARHQ THGSQLRLHL VSPADSGEYV CRAASGPGPE 
QEASFTVTVP PSEGSSYRLR SPVISIDPPS STVQQGQDAS FKCLIHDGAA PISLEWKTRN 
QELEDNVHIS PNGSIITIVG TRPSNHGTYR CVASNAYGVA QSVVNLSVHG PPTVSVLPEG 
PVWVKVGKAV TLECVSAGEP RSSARWTRIS STPAKLEQRT YGLMDSHAVL QISSAKPSDA 
GTYVCLAQNA LGTAQKQVEV IVDTGAMAPG APQVQAEEAE LTVEAGHTAT LRCSATGSPA 
PTIHWSKLRS PLPWQHRLEG DTLIIPRVAQ QDSGQYICNA TSPAGHAEAT IILHVESPPY 
ATTVPEHASV QAGETVQLQC LAHGTPPLTF QWSRVGSSLP GRATARNELL HFERAAPEDS 
GRYRCRVTNK VGSAEAFAQL LVQGPPGSLP ATSIPAGSTP TVQVTPQLET KSIGASVEFH 
CAVPSDRGTQ LRWFKEGGQL PPGHSVQDGV LRIQNLDQSC QGTYICQAHG PWGKAQASAQ 
LVIQALPSVL INIRTSVQTV VVGHAVEFEC LALGDPKPQV TWSKVGGHLR PGIVQSGGVV 
RIAHVELADA GQYRCTATNA AGTTQSHVLL LVQALPQISM PQEVRVPAGS AAVFPCIASG 
YPTPDISWSK LDGSLPPDSR LENNMLMLPS VRPQDAGTYV CTATNRQGKV KAFAHLQVPE 
RVVPYFTQTP YSFLPLPTIK DAYRKFEIKI TFRPDSADGM LLYNGQKRVP GSPTNLANRQ 
PDFISFGLVG GRPEFRFDAG SGMATIRHPT PLALGHFHTV TLLRSLTQGS LIVGDLAPVN 
GTSQGKFQGL DLNEELYLGG YPDYGAIPKA GLSSGFIGCV RELRIQGEEI VFHDLNLTAH 
GISHCPTCRD RPCQNGGQCH DSESSSYVCV CPAGFTGSRC EHSQALHCHP EACGPDATCV 
NRPDGRGYTC RCHLGRSGLR CEEGVTVTTP SLSGAGSYLA LPALTNTHHE LRLDVEFKPL 
APDGVLLFSG GKSGPVEDFV SLAMVGGHLE FRYELGSGLA VLRSAEPLAL GRWHRVSAER 
LNKDGSLRVN GGRPVLRSSP GKSQGLNLHT LLYLGGVEPS VPLSPATNMS AHFRGCVGEV 
SVNGKRLDLT YSFLGSQGIG QCYDSSPCER QPCQHGATCM PAGEYEFQCL CRDGFKGDLC 
EHEENPCQLR EPCLHGGTCQ GTRCLCLPGF SGPRCQQGSG HGIAESDWHL EGSGGNDAPG 
QYGAYFHDDG FLAFPGHVFS RSLPEVPETI ELEVRTSTAS GLLLWQGVEV GEAGQGKDFI 
SLGLQDGHLV FRYQLGSGEA RLVSEDPIND GEWHRVTALR EGRRGSIQVD GEELVSGRSP 
GPNVAVNAKG SVYIGGAPDV ATLTGGRFSS GITGCVKNLV LHSARPGAPP PQPLDLQHRA 
QAGANTRPCP S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HSPG2

Associated with

Cells (max top 100)

Other Information

Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. PubMed ID: 1569102

Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. PubMed ID: 1730768

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Structural characterization of the complete human perlecan gene and its promoter. PubMed ID: 8234307

Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). PubMed ID: 11101850

Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1--&gt;p35 and identification of a BamHI restriction fragment length polymorphism. PubMed ID: 1685141

Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1. PubMed ID: 1679749

Matrix-associated heparan sulfate proteoglycan: core protein-specific monoclonal antibodies decorate the pericellular matrix of connective tissue cells and the stromal side of basement membranes. PubMed ID: 2687294

BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. PubMed ID: 15591058

Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. PubMed ID: 12435733

Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. PubMed ID: 11148217

Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene. PubMed ID: 11279527

The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin. PubMed ID: 11956183

Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. PubMed ID: 12604605

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism. PubMed ID: 17105986

Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. PubMed ID: 18024432

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. PubMed ID: 19789387

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. PubMed ID: 22171320

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans. PubMed ID: 25326458

An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. PubMed ID: 32337544

Mass spectrometric analysis of chondroitin sulfate-linked peptides. PubMed ID: 36213313

Crystal structure of the LG3 domain of endorepellin, an angiogenesis inhibitor. PubMed ID: 21996443