Details for: NDST1

Gene ID: 3340

Symbol: NDST1

Ensembl ID: ENSG00000070614

Description: N-deacetylase and N-sulfotransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.43
    Marker Score: 9412
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.52
    Marker Score: 1831
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.45
    Marker Score: 3404
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.35
    Marker Score: 28849
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20206
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.28
    Marker Score: 5513
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.26
    Marker Score: 8126
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.24
    Marker Score: 5181
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.2
    Marker Score: 6477
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1834
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.18
    Marker Score: 370
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.17
    Marker Score: 11074
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.16
    Marker Score: 1282
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.12
    Marker Score: 9604
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.1
    Marker Score: 2234.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.07
    Marker Score: 40574
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.04
    Marker Score: 622
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63560
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.02
    Marker Score: 9574
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.02
    Marker Score: 15213
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71771
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47996
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.98
    Marker Score: 920
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.95
    Marker Score: 3690
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.95
    Marker Score: 7280
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.95
    Marker Score: 3102
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.94
    Marker Score: 3904
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.92
    Marker Score: 848
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.92
    Marker Score: 9476
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.9
    Marker Score: 966
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.89
    Marker Score: 32838
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5308
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5019
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.82
    Marker Score: 1865
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.81
    Marker Score: 872
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.79
    Marker Score: 3220
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.79
    Marker Score: 1889
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.79
    Marker Score: 849
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.78
    Marker Score: 454
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.77
    Marker Score: 527
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 245
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3128
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 355
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.73
    Marker Score: 983
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.72
    Marker Score: 14406
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.7
    Marker Score: 1342
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.69
    Marker Score: 280
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.67
    Marker Score: 1344
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.67
    Marker Score: 582
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.67
    Marker Score: 249
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.66
    Marker Score: 297
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.66
    Marker Score: 553
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.66
    Marker Score: 593
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.66
    Marker Score: 959
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.65
    Marker Score: 747
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.65
    Marker Score: 10395
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.64
    Marker Score: 5524
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.64
    Marker Score: 767
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.63
    Marker Score: 819
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.63
    Marker Score: 347
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.63
    Marker Score: 279
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.63
    Marker Score: 237
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.62
    Marker Score: 562
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.62
    Marker Score: 302
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.62
    Marker Score: 241
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.61
    Marker Score: 635
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 364.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.6
    Marker Score: 146
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.59
    Marker Score: 717
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.59
    Marker Score: 257
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.58
    Marker Score: 3436
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.57
    Marker Score: 709
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.57
    Marker Score: 132
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.56
    Marker Score: 534
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.56
    Marker Score: 279
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.55
    Marker Score: 292
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.55
    Marker Score: 143
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.53
    Marker Score: 308
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.53
    Marker Score: 923
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.52
    Marker Score: 743
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.52
    Marker Score: 2179.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.51
    Marker Score: 5148
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.51
    Marker Score: 348
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.51
    Marker Score: 122

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Other Information

**Key characteristics:** - NDST1 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in various cell types, including neural progenitor cells, type I pneumocytes, kidney proximal straight tubule epithelial cells, astrocytes, cardiac muscle myoblasts, midzonal region hepatocytes, centrilobular region hepatocytes, GABAergic neurons, and periportal region hepatocytes. - It is involved in the deacetylation of N-acetylglucosamine and the sulfotransferase activity of heparan sulfate. **Pathways and functions:** - **Cardiac septum development:** Through the regulation of FGFR signaling, NDST1 is involved in the development and maintenance of the cardiac septum, a structure that forms around the heart during embryonic development. - **Cell population proliferation:** It contributes to cell cycle regulation and proliferation in various cell types. - **Deacetylase activity:** NDST1 is an enzyme that deacetylates N-acetylglucosamine, influencing the availability of this sugar for various cellular processes. - **FGFR pathway regulation:** By deacetylating N-acetylglucosamine, NDST1 positively regulates the FGFR signaling pathway, which is crucial for cell proliferation and survival. - **Heparan sulfate metabolism:** It participates in the metabolism of heparan sulfate, a vital component of the extracellular matrix, by deacetylating it and facilitating its transfer to other proteins. - **Other functions:** NDST1 also plays roles in wound healing, inflammation, metabolism of carbohydrates, and respiratory gas exchange. **Clinical significance:** - Mutations in NDST1 have been linked to various human diseases, including heart failure, stroke, and cancer. - Understanding the role of NDST1 in these diseases could lead to the development of novel therapeutic strategies.

Genular Protein ID: 1459161897

Symbol: NDST1_HUMAN

Name: Glucosaminyl N-deacetylase/N-sulfotransferase 1

UniProtKB Accession Codes:

P52848 B7Z1Q0 E7EVJ3 Q96E57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 13 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7601448

Title: Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1.

PubMed ID: 7601448

DOI: 10.1016/0888-7543(95)80206-2

PubMed ID: 9230113

Title: Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network.

PubMed ID: 9230113

DOI: 10.1042/bj3250351

PubMed ID: 19880432

Title: Identification and functional analyses of 11,769 full-length human cDNAs focused on alternative splicing.

PubMed ID: 19880432

DOI: 10.1093/dnares/dsp022

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9744796

Title: A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase.

PubMed ID: 9744796

DOI: 10.1016/s0014-5793(98)00913-2

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 35137078

Title: A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation.

PubMed ID: 35137078

DOI: 10.1093/glycob/cwac004

PubMed ID: 10196134

Title: Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/N-sulfotransferase 1.

PubMed ID: 10196134

DOI: 10.1074/jbc.274.16.10673

PubMed ID: 25125150

Title: NDST1 missense mutations in autosomal recessive intellectual disability.

PubMed ID: 25125150

DOI: 10.1002/ajmg.a.36723

Sequence Information:

  • Length: 882
  • Mass: 100868
  • Checksum: D4B716B84A0BF4C4
  • Sequence:
    • MPALACLRRL CRHVSPQAVL FLLFIFCLFS VFISAYYLYG WKRGLEPSAD APEPDCGDPP 
PVAPSRLLPL KPVQAATPSR TDPLVLVFVE SLYSQLGQEV VAILESSRFK YRTEIAPGKG 
DMPTLTDKGR GRFALIIYEN ILKYVNLDAW NRELLDKYCV AYGVGIIGFF KANENSLLSA 
QLKGFPLFLH SNLGLKDCSI NPKSPLLYVT RPSEVEKGVL PGEDWTVFQS NHSTYEPVLL 
AKTRSSESIP HLGADAGLHA ALHATVVQDL GLHDGIQRVL FGNNLNFWLH KLVFVDAVAF 
LTGKRLSLPL DRYILVDIDD IFVGKEGTRM KVEDVKALFD TQNELRAHIP NFTFNLGYSG 
KFFHTGTNAE DAGDDLLLSY VKEFWWFPHM WSHMQPHLFH NQSVLAEQMA LNKKFAVEHG 
IPTDMGYAVA PHHSGVYPVH VQLYEAWKQV WSIRVTSTEE YPHLKPARYR RGFIHNGIMV 
LPRQTCGLFT HTIFYNEYPG GSSELDKIIN GGELFLTVLL NPISIFMTHL SNYGNDRLGL 
YTFKHLVRFL HSWTNLRLQT LPPVQLAQKY FQIFSEEKDP LWQDPCEDKR HKDIWSKEKT 
CDRFPKLLII GPQKTGTTAL YLFLGMHPDL SSNYPSSETF EEIQFFNGHN YHKGIDWYME 
FFPIPSNTTS DFYFEKSANY FDSEVAPRRA AALLPKAKVL TILINPADRA YSWYQHQRAH 
DDPVALKYTF HEVITAGSDA SSKLRALQNR CLVPGWYATH IERWLSAYHA NQILVLDGKL 
LRTEPAKVMD MVQKFLGVTN TIDYHKTLAF DPKKGFWCQL LEGGKTKCLG KSKGRKYPEM 
DLDSRAFLKD YYRDHNIELS KLLYKMGQTL PTWLREDLQN TR

Genular Protein ID: 1776505003

Symbol: A8K8T3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8T3

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 8 DNASU 1 EC 1 EMBL 2 GO 5 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 4 SAM 1 SUPFAM 1 UniPathway 2

Sequence Information:

  • Length: 882
  • Mass: 100838
  • Checksum: 973888A8CDAFA604
  • Sequence:
    • MPALACLRRL CRHVSPQAVL FLLFIFCLFS VFISAYYLYG WKRGLEPSAD APEPDCGDPP 
PVAPSRLLPL KPVQAATPSR TDPLVLVFVE SLYSQLGQEV VAILESSRFK YRTEIAPGKG 
DMPTLTDKGR GRFALIIYEN ILKYVNLDAW DRELLDKYCV AYGVGIIGFF KANENSLLSA 
QLKGFPLFLH SNLGLKDCSI NPKSPLLYVT RPSEVEKGVL PGEDWTVFQS NHSTYEPVLL 
ARTRSSESIP HLGADAGLHA ALHATVVQDL GLHDGIQRVL FGNNLNFWLH KLVFVDAVAF 
LTGKRLSLPL DRYILVDIDD IFVGKEGTRM KVEDVKALFD TQNELRAHIP NFTFNLGYSG 
KFFHTGTNAE DAGDDLLLSY VKEFWWFPHM WSHMQPHLFH NQSVLAEQMA LNKKFAVEHG 
IPTDMGYAVA PHHSGVYPVH VQLYEAWKQV WSIRVTSTEE YPHLKPARYR RGFIHNGIMV 
LPRQTCGLFT HTIFYNEYPG GSSELDKIIN GGELSLTVLL NPISIFMTHL SNYGNDRLGL 
YTFKHLVRFL HSWTNLRLQT LPPVQLAQKY FQIFSEEKDP LWQDPCEDKR HEDIWSKEKT 
CDRFPKLLII GPQKTGTTAL YLFLGMHPDL SSNYPSSETF EEIQFFNGHN YHKGIDWYME 
FFPIPSNTTS DFYFEKSANY FDSEVAPRRA AALLPKAKVL TILINPADRA YSWYQHQRAH 
DDPVALKYTF HEVITAGSDA SSKLRALQNR CLVPGWYATH IERWLSAYHA NQILVLDGKL 
LRTEPAKVMD MVQKFLGVTN TIDYHKTLAF DPKKGFWCQL LEGGKTKCLG KSKGRKYPEM 
DLDSRAFLKD YYRDHNIELS KLLYKMGQTL PTWLREDLQN TR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.