Details for: HTR3A

Gene ID: 3359

Symbol: HTR3A

Ensembl ID: ENSG00000166736

Description: 5-hydroxytryptamine receptor 3A

Associated with

  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Chemical synaptic transmission
    (GO:0007268)
  • Cleavage furrow
    (GO:0032154)
  • Excitatory extracellular ligand-gated monoatomic ion channel activity
    (GO:0005231)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Identical protein binding
    (GO:0042802)
  • Inorganic cation transmembrane transport
    (GO:0098662)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Nervous system process
    (GO:0050877)
  • Neuron projection
    (GO:0043005)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein binding
    (GO:0005515)
  • Regulation of membrane potential
    (GO:0042391)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Serotonin-activated cation-selective channel complex
    (GO:1904602)
  • Serotonin-gated monoatomic cation channel activity
    (GO:0022850)
  • Serotonin binding
    (GO:0051378)
  • Serotonin receptor signaling pathway
    (GO:0007210)
  • Synapse
    (GO:0045202)
  • Transmembrane transporter complex
    (GO:1902495)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.74
    Marker Score: 3305
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7499
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.07
    Marker Score: 358
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16357
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2572
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.91
    Marker Score: 2693
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1791
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 648.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.73
    Marker Score: 1547
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.73
    Marker Score: 173
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.66
    Marker Score: 325
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.65
    Marker Score: 898
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 309
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 380
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.63
    Marker Score: 654
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.62
    Marker Score: 380
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.55
    Marker Score: 322
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.53
    Marker Score: 305
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.51
    Marker Score: 575
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.39
    Marker Score: 205
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.36
    Marker Score: 1023
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 183
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.31
    Marker Score: 162
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.3
    Marker Score: 176
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 131
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.26
    Marker Score: 3514
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.25
    Marker Score: 252.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 517
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.24
    Marker Score: 912
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.23
    Marker Score: 148
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.21
    Marker Score: 204
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.16
    Marker Score: 1251
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.16
    Marker Score: 189
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.16
    Marker Score: 273
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.14
    Marker Score: 33
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.14
    Marker Score: 68
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.14
    Marker Score: 318
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.14
    Marker Score: 48
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.13
    Marker Score: 125
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.12
    Marker Score: 94
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.12
    Marker Score: 172
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.12
    Marker Score: 90.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.11
    Marker Score: 106
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.11
    Marker Score: 155
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.11
    Marker Score: 96
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.11
    Marker Score: 129
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 69.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.09
    Marker Score: 112
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.08
    Marker Score: 305
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.08
    Marker Score: 19070
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 138
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.06
    Marker Score: 32

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The HTR3A protein is a transmembrane protein that is localized to the plasma membrane. - It is a member of the 5-HT3 family of G protein-coupled receptors. - The protein is a ligand-gated monoatomic ion channel, which means that it opens when a ligand binds to it. - The HTR3A protein is expressed in cells that are involved in synaptic transmission, including cardiac endothelial cells, goblet cells, and primary sensory neurons. **Pathways and functions:** - The HTR3A protein is involved in the regulation of presynaptic membrane potential. - It is a ligand-gated monoatomic ion channel, which means that it opens when a ligand binds to it. - When the HTR3A protein is activated, it opens a monoatomic ion channel in the presynaptic terminal, which allows sodium ions to flow into the cell. - This increase in intracellular sodium concentration depolarizes the presynaptic membrane, which can lead to the release of neurotransmitters from the presynaptic terminal. **Clinical significance:** The HTR3A gene has been linked to a number of psychiatric disorders, including depression and schizophrenia. Mutations in the HTR3A gene have been found to be associated with these disorders. These findings suggest that the HTR3A protein is a potential target for therapy in these disorders.

Genular Protein ID: 3867788422

Symbol: 5HT3A_HUMAN

Name: 5-hydroxytryptamine receptor 3

UniProtKB Accession Codes:

P46098 B4DSY6 G5E986 O60854 Q7KZM7 Q99918 Q9BSZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 45 DrugCentral 1 EMBL 14 Ensembl 5 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7565620

Title: Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.

PubMed ID: 7565620

PubMed ID: 8848005

Title: Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.

PubMed ID: 8848005

PubMed ID: 9928262

Title: Molecular cloning of alternatively spliced human 5HT3 receptor cDNAs.

PubMed ID: 9928262

DOI: 10.1111/j.1749-6632.1998.tb10196.x

PubMed ID: 10670426

Title: Exon-intron organization of the human 5-HT3A receptor gene.

PubMed ID: 10670426

DOI: 10.1016/s0028-3908(99)00116-1

PubMed ID: 15028279

Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

PubMed ID: 15028279

DOI: 10.1016/j.ygeno.2003.09.023

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9950429

Title: The 5-HT3B subunit is a major determinant of serotonin-receptor function.

PubMed ID: 9950429

DOI: 10.1038/16941

PubMed ID: 10521471

Title: The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit.

PubMed ID: 10521471

DOI: 10.1074/jbc.274.43.30799

PubMed ID: 12867984

Title: A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.

PubMed ID: 12867984

DOI: 10.1038/nature01788

PubMed ID: 15809299

Title: Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3.

PubMed ID: 15809299

DOI: 10.1074/jbc.m414341200

PubMed ID: 17392525

Title: Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.

PubMed ID: 17392525

DOI: 10.1124/mol.106.032144

PubMed ID: 15293096

Title: Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients.

PubMed ID: 15293096

DOI: 10.1007/s10067-004-0927-2

PubMed ID: 16487942

Title: Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression.

PubMed ID: 16487942

DOI: 10.1016/j.biopsych.2005.11.008

Sequence Information:

  • Length: 478
  • Mass: 55280
  • Checksum: 24CA9A232286FBC9
  • Sequence:
    • MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT 
VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI 
LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQVVTACSLD IYNFPFDVQN CSLTFTSWLH 
TIQDINISLW RLPEKVKSDR SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR 
RPLFYVVSLL LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI 
GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER IAWLLCLREQ 
STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD RCSPPPPPRE ASLAVCGLLQ 
ELSSIRQFLE KRDEIREVAR DWLRVGSVLD KLLFHIYLLA VLAYSITLVM LWSIWQYA

Genular Protein ID: 3773548011

Symbol: B4E398_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E398

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 3 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 1 Pfam 4 PharmGKB 1 RefSeq 2 Rhea 3 RuleBase 1 SAM 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 484
  • Mass: 55922
  • Checksum: C941CD97007BCB4F
  • Sequence:
    • MLGKLAMLLW VQQALLALLL PTLLAQGEAR RSRNTTRPAL LRLSDYLLTN YRKGVRPVRD 
WRKPTTVSID VIVYAILNVD EKNQVLTTYI WYRQYWTDEF LQWNPEDFDN ITKLSIPTDS 
IWVPDILINE FVDVGKSPNI PYVYIRHQGE VQNYKPLQVV TACSLDIYNF PFDVQNCSLT 
FTSWLHTIQD INISLWRLPE KVKSDRSVFM NQGEWELLGV LPYFREFSME SSNYYAEMKF 
YVVIRRRPLF YVVSLLLPSI FLMVMDIVGF YLPPNSGERV SFKITLLLGY SVFLIIVSDT 
LPATAIGTPL IGVYFVVCMA LLVISLAETI FIVRLVHKQD LQQPVPAWLR HLVLERIAWL 
LCLREQSTSQ RPPATSQATK TDDCSAMGNH CSHMGGPQDF EKSPRDRCSP PPPPREASLA 
VCGLLQELSS IRQFLERRDE IREVARDWLR VGSVLDKLLF HIYLLAVLAY SITLVMLWSI 
WQYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.