Details for: HTR3A

Gene ID: 3359

Symbol: HTR3A

Ensembl ID: ENSG00000166736

Description: 5-hydroxytryptamine receptor 3A

Associated with

  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Chemical synaptic transmission
    (GO:0007268)
  • Cleavage furrow
    (GO:0032154)
  • Excitatory extracellular ligand-gated monoatomic ion channel activity
    (GO:0005231)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Identical protein binding
    (GO:0042802)
  • Inorganic cation transmembrane transport
    (GO:0098662)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Neuron projection
    (GO:0043005)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein binding
    (GO:0005515)
  • Regulation of membrane potential
    (GO:0042391)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Serotonin-activated cation-selective channel complex
    (GO:1904602)
  • Serotonin-gated cation-selective signaling pathway
    (GO:0140227)
  • Serotonin-gated monoatomic cation channel activity
    (GO:0022850)
  • Serotonin binding
    (GO:0051378)
  • Serotonin receptor signaling pathway
    (GO:0007210)
  • Synapse
    (GO:0045202)
  • Transmembrane transporter complex
    (GO:1902495)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.1229
    Cell Significance Index: 79.2600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.3947
    Cell Significance Index: 7.9200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.8631
    Cell Significance Index: 45.1300
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.0833
    Cell Significance Index: 3.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8799
    Cell Significance Index: 103.7700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.5296
    Cell Significance Index: 5.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0418
    Cell Significance Index: 1.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0299
    Cell Significance Index: 10.7400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0296
    Cell Significance Index: 0.4200
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.0235
    Cell Significance Index: 0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0121
    Cell Significance Index: 2.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0060
    Cell Significance Index: 1.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0041
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0046
    Cell Significance Index: -0.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0062
    Cell Significance Index: -2.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0072
    Cell Significance Index: -0.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0096
    Cell Significance Index: -0.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0096
    Cell Significance Index: -2.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0103
    Cell Significance Index: -0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0111
    Cell Significance Index: -2.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0128
    Cell Significance Index: -0.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0150
    Cell Significance Index: -2.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0151
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0152
    Cell Significance Index: -3.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0172
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0179
    Cell Significance Index: -2.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0216
    Cell Significance Index: -2.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0241
    Cell Significance Index: -3.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0257
    Cell Significance Index: -0.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0280
    Cell Significance Index: -0.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0281
    Cell Significance Index: -0.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0285
    Cell Significance Index: -0.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0368
    Cell Significance Index: -0.6300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0411
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0415
    Cell Significance Index: -2.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0416
    Cell Significance Index: -1.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0418
    Cell Significance Index: -0.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0420
    Cell Significance Index: -3.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0432
    Cell Significance Index: -2.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0459
    Cell Significance Index: -0.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0489
    Cell Significance Index: -2.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0537
    Cell Significance Index: -3.0100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0540
    Cell Significance Index: -0.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0613
    Cell Significance Index: -2.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0655
    Cell Significance Index: -1.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0673
    Cell Significance Index: -3.1700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0678
    Cell Significance Index: -0.9300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0697
    Cell Significance Index: -0.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0728
    Cell Significance Index: -2.5500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0733
    Cell Significance Index: -0.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0737
    Cell Significance Index: -1.9800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0740
    Cell Significance Index: -0.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0748
    Cell Significance Index: -3.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0757
    Cell Significance Index: -2.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0772
    Cell Significance Index: -2.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0773
    Cell Significance Index: -2.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0777
    Cell Significance Index: -1.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0786
    Cell Significance Index: -2.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0790
    Cell Significance Index: -1.5600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0794
    Cell Significance Index: -1.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0829
    Cell Significance Index: -2.0700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0849
    Cell Significance Index: -0.6000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0859
    Cell Significance Index: -1.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0877
    Cell Significance Index: -3.3200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0881
    Cell Significance Index: -0.7600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0889
    Cell Significance Index: -1.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0892
    Cell Significance Index: -0.9700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0914
    Cell Significance Index: -1.1300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0955
    Cell Significance Index: -0.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0957
    Cell Significance Index: -2.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0967
    Cell Significance Index: -2.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0999
    Cell Significance Index: -2.1200
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1010
    Cell Significance Index: -0.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1034
    Cell Significance Index: -2.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1034
    Cell Significance Index: -2.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1034
    Cell Significance Index: -2.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1053
    Cell Significance Index: -2.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1064
    Cell Significance Index: -2.7100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1101
    Cell Significance Index: -1.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1110
    Cell Significance Index: -2.9700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1114
    Cell Significance Index: -0.8000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1128
    Cell Significance Index: -2.2500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1151
    Cell Significance Index: -3.6400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1172
    Cell Significance Index: -1.6200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1176
    Cell Significance Index: -1.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1180
    Cell Significance Index: -3.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1194
    Cell Significance Index: -2.5800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1196
    Cell Significance Index: -0.7400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1212
    Cell Significance Index: -1.1600
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1281
    Cell Significance Index: -1.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1286
    Cell Significance Index: -2.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HTR3A gene is a member of the G protein-coupled receptor (GPCR) family, which is involved in transmitting signals across cell membranes. The receptor is a serotonin-gated monoatomic cation channel complex that is activated by the neurotransmitter 5-hydroxytryptamine (5-HT). The receptor is composed of seven transmembrane domains and is characterized by its high affinity for 5-HT, which triggers a conformational change that opens the ion channel, allowing cations to flow through. **Pathways and Functions** The HTR3A gene is involved in various signaling pathways, including: 1. **Neurotransmission**: The receptor plays a crucial role in regulating neurotransmission, particularly in the central nervous system (CNS). It is involved in the transmission of excitatory signals across synapses, which can modulate neuronal excitability and synaptic plasticity. 2. **Membrane potential regulation**: The receptor helps regulate the resting membrane potential and action potential of neurons by modulating the flow of cations across the cell membrane. 3. **Serotonin signaling pathway**: The HTR3A gene is part of the serotonin signaling pathway, which is involved in various physiological processes, including mood regulation, appetite, and sleep. **Clinical Significance** Dysregulation of the HTR3A gene has been implicated in various neurological and psychiatric disorders, including: 1. **Migraine**: The HTR3A gene has been identified as a susceptibility gene for migraine, a complex neurological disorder characterized by recurrent headaches. 2. **Depression**: The receptor has been implicated in the pathophysiology of depression, particularly in the regulation of mood and appetite. 3. **Neurodegenerative diseases**: The HTR3A gene has been studied in the context of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may play a role in regulating neuronal excitability and synaptic plasticity. In conclusion, the HTR3A gene plays a crucial role in regulating neurotransmission, neuronal signaling, and membrane potential. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into the mechanisms underlying its function and the development of targeted therapies. **Significantly expressed cells** The HTR3A gene is significantly expressed in various cell types, including: 1. **Cardiac endothelial cell** 2. **Goblet cell** 3. **Primary sensory neuron (sensu Teleostei)** 4. **Cardiac muscle myoblast** 5. **Intestinal crypt stem cell of colon** 6. **Cerebral cortex GABAergic interneuron** 7. **Forebrain radial glial cell** 8. **Absorptive cell** 9. **Transit amplifying cell** These cell types suggest that the HTR3A gene is involved in various physiological processes, including cardiovascular function, immune response, and neural signaling. **Proteins** The HTR3A gene encodes a single protein, 5HT3A_HUMAN, which is a serotonin-gated monoatomic cation channel complex. The protein is composed of seven transmembrane domains and is characterized by its high affinity for 5-HT. In summary, the HTR3A gene plays a crucial role in regulating neurotransmission, neuronal signaling, and membrane potential, and its dysregulation has been implicated in various neurological and psychiatric disorders. Further research into the mechanisms underlying its function and the development of targeted therapies may provide new insights into the treatment of these disorders.

Genular Protein ID: 3867788422

Symbol: 5HT3A_HUMAN

Name: 5-hydroxytryptamine receptor 3

UniProtKB Accession Codes:

P46098 B4DSY6 G5E986 O60854 Q7KZM7 Q99918 Q9BSZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 44 DrugCentral 1 EMBL 14 EMDB 4 Ensembl 5 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7565620

Title: Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.

PubMed ID: 7565620

PubMed ID: 8848005

Title: Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.

PubMed ID: 8848005

PubMed ID: 9928262

Title: Molecular cloning of alternatively spliced human 5HT3 receptor cDNAs.

PubMed ID: 9928262

DOI: 10.1111/j.1749-6632.1998.tb10196.x

PubMed ID: 10670426

Title: Exon-intron organization of the human 5-HT3A receptor gene.

PubMed ID: 10670426

DOI: 10.1016/s0028-3908(99)00116-1

PubMed ID: 15028279

Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

PubMed ID: 15028279

DOI: 10.1016/j.ygeno.2003.09.023

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9950429

Title: The 5-HT3B subunit is a major determinant of serotonin-receptor function.

PubMed ID: 9950429

DOI: 10.1038/16941

PubMed ID: 10521471

Title: The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit.

PubMed ID: 10521471

DOI: 10.1074/jbc.274.43.30799

PubMed ID: 12867984

Title: A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.

PubMed ID: 12867984

DOI: 10.1038/nature01788

PubMed ID: 15809299

Title: Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3.

PubMed ID: 15809299

DOI: 10.1074/jbc.m414341200

PubMed ID: 17392525

Title: Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.

PubMed ID: 17392525

DOI: 10.1124/mol.106.032144

PubMed ID: 15293096

Title: Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients.

PubMed ID: 15293096

DOI: 10.1007/s10067-004-0927-2

PubMed ID: 16487942

Title: Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression.

PubMed ID: 16487942

DOI: 10.1016/j.biopsych.2005.11.008

Sequence Information:

  • Length: 478
  • Mass: 55280
  • Checksum: 24CA9A232286FBC9
  • Sequence:
    • MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT 
VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI 
LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQVVTACSLD IYNFPFDVQN CSLTFTSWLH 
TIQDINISLW RLPEKVKSDR SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR 
RPLFYVVSLL LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI 
GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER IAWLLCLREQ 
STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD RCSPPPPPRE ASLAVCGLLQ 
ELSSIRQFLE KRDEIREVAR DWLRVGSVLD KLLFHIYLLA VLAYSITLVM LWSIWQYA

Genular Protein ID: 3773548011

Symbol: B4E398_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E398

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 3 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 10 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 1 Pfam 4 PharmGKB 1 RefSeq 2 Rhea 3 RuleBase 1 SAM 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 484
  • Mass: 55922
  • Checksum: C941CD97007BCB4F
  • Sequence:
    • MLGKLAMLLW VQQALLALLL PTLLAQGEAR RSRNTTRPAL LRLSDYLLTN YRKGVRPVRD 
WRKPTTVSID VIVYAILNVD EKNQVLTTYI WYRQYWTDEF LQWNPEDFDN ITKLSIPTDS 
IWVPDILINE FVDVGKSPNI PYVYIRHQGE VQNYKPLQVV TACSLDIYNF PFDVQNCSLT 
FTSWLHTIQD INISLWRLPE KVKSDRSVFM NQGEWELLGV LPYFREFSME SSNYYAEMKF 
YVVIRRRPLF YVVSLLLPSI FLMVMDIVGF YLPPNSGERV SFKITLLLGY SVFLIIVSDT 
LPATAIGTPL IGVYFVVCMA LLVISLAETI FIVRLVHKQD LQQPVPAWLR HLVLERIAWL 
LCLREQSTSQ RPPATSQATK TDDCSAMGNH CSHMGGPQDF EKSPRDRCSP PPPPREASLA 
VCGLLQELSS IRQFLERRDE IREVARDWLR VGSVLDKLLF HIYLLAVLAY SITLVMLWSI 
WQYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.