Details for: HUS1

Gene ID: 3364

Symbol: HUS1

Ensembl ID: ENSG00000136273

Description: HUS1 checkpoint clamp component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.7179
    Cell Significance Index: -16.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.7292
    Cell Significance Index: -17.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.1667
    Cell Significance Index: -20.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.9202
    Cell Significance Index: -20.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6291
    Cell Significance Index: -19.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0739
    Cell Significance Index: -18.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0025
    Cell Significance Index: -19.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7558
    Cell Significance Index: -8.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0598
    Cell Significance Index: 304.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9113
    Cell Significance Index: 54.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8440
    Cell Significance Index: 91.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6858
    Cell Significance Index: 111.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5257
    Cell Significance Index: 11.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4959
    Cell Significance Index: 13.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4390
    Cell Significance Index: 30.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4285
    Cell Significance Index: 6.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4240
    Cell Significance Index: 12.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4085
    Cell Significance Index: 11.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4023
    Cell Significance Index: 20.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3980
    Cell Significance Index: 78.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3965
    Cell Significance Index: 358.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3587
    Cell Significance Index: 16.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3203
    Cell Significance Index: 4.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2632
    Cell Significance Index: 52.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2468
    Cell Significance Index: 24.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2465
    Cell Significance Index: 6.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2189
    Cell Significance Index: 25.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2036
    Cell Significance Index: 111.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2019
    Cell Significance Index: 24.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1890
    Cell Significance Index: 34.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1759
    Cell Significance Index: 2.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1751
    Cell Significance Index: 62.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1697
    Cell Significance Index: 23.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1516
    Cell Significance Index: 7.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1469
    Cell Significance Index: 9.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1394
    Cell Significance Index: 10.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1303
    Cell Significance Index: 24.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1286
    Cell Significance Index: 4.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0995
    Cell Significance Index: 2.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0933
    Cell Significance Index: 1.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0932
    Cell Significance Index: 11.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0911
    Cell Significance Index: 40.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0727
    Cell Significance Index: 4.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0624
    Cell Significance Index: 0.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0414
    Cell Significance Index: 1.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0388
    Cell Significance Index: 0.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0292
    Cell Significance Index: 0.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0251
    Cell Significance Index: 1.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0206
    Cell Significance Index: 3.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0166
    Cell Significance Index: 0.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0130
    Cell Significance Index: 0.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0090
    Cell Significance Index: 6.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0119
    Cell Significance Index: -7.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0182
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0213
    Cell Significance Index: -15.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0228
    Cell Significance Index: -10.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0257
    Cell Significance Index: -3.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0294
    Cell Significance Index: -16.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0356
    Cell Significance Index: -22.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0364
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0396
    Cell Significance Index: -4.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0466
    Cell Significance Index: -0.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0570
    Cell Significance Index: -1.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0674
    Cell Significance Index: -7.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0682
    Cell Significance Index: -9.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0866
    Cell Significance Index: -4.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1002
    Cell Significance Index: -7.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1021
    Cell Significance Index: -21.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1057
    Cell Significance Index: -1.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1103
    Cell Significance Index: -1.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1657
    Cell Significance Index: -4.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1739
    Cell Significance Index: -3.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1743
    Cell Significance Index: -11.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1751
    Cell Significance Index: -4.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1826
    Cell Significance Index: -19.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1903
    Cell Significance Index: -2.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1918
    Cell Significance Index: -4.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1942
    Cell Significance Index: -6.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1981
    Cell Significance Index: -6.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2109
    Cell Significance Index: -3.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2116
    Cell Significance Index: -11.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2127
    Cell Significance Index: -5.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2212
    Cell Significance Index: -17.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2316
    Cell Significance Index: -6.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2411
    Cell Significance Index: -5.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2876
    Cell Significance Index: -4.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2944
    Cell Significance Index: -8.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3324
    Cell Significance Index: -20.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3492
    Cell Significance Index: -8.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3774
    Cell Significance Index: -9.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4298
    Cell Significance Index: -7.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4427
    Cell Significance Index: -16.2500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4451
    Cell Significance Index: -6.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4607
    Cell Significance Index: -11.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Checkpoint Clamp Component**: HUS1 is a component of the checkpoint clamp complex, which is a multi-subunit protein complex that regulates the activity of ATR kinase in response to DNA damage. 2. **DNA Damage Response**: HUS1 is involved in the response to DNA damage, including replication stress, DNA double-strand breaks, and other forms of DNA damage. 3. **Homologous Recombination Repair**: HUS1 is also involved in the homologous recombination repair (HRR) pathway, which is a critical mechanism for repairing DNA double-strand breaks. 4. **TP53 Regulation**: HUS1 is a regulator of TP53 activity, which is a key tumor suppressor protein that plays a central role in DNA damage response. **Pathways and Functions:** 1. **Activation of ATR**: HUS1 is involved in the activation of ATR kinase in response to DNA damage, which leads to the initiation of DNA repair processes. 2. **Homologous Recombination Repair**: HUS1 is involved in the HRR pathway, which is a critical mechanism for repairing DNA double-strand breaks. 3. **Cell Cycle Checkpoints**: HUS1 is involved in the regulation of cell cycle checkpoints, which ensure that cells can properly repair DNA damage before proceeding with cell division. 4. **DNA Damage Response**: HUS1 is involved in the response to various forms of DNA damage, including replication stress, DNA double-strand breaks, and other forms of DNA damage. **Clinical Significance:** Dysregulation of the HUS1 gene has been implicated in various diseases, including: 1. **Cancer**: Mutations in the HUS1 gene have been found in several types of cancer, including breast, lung, and colon cancer. 2. **Genetic Disorders**: Mutations in the HUS1 gene have also been found in genetic disorders, including ataxia-telangiectasia and Fanconi anemia. 3. **Immunodeficiency**: HUS1 is also involved in the regulation of immune responses, and dysregulation of the HUS1 gene has been implicated in immunodeficiency disorders. 4. **Neurological Disorders**: HUS1 is also involved in the regulation of neuronal development and function, and dysregulation of the HUS1 gene has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the HUS1 gene plays a crucial role in DNA damage response and checkpoint clamp complex, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of HUS1 in human disease and to develop therapeutic strategies for the treatment of HUS1-related disorders.

Genular Protein ID: 236535009

Symbol: HUS1_HUMAN

Name: Checkpoint protein HUS1

UniProtKB Accession Codes:

O60921 B4DFI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9524127

Title: Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage.

PubMed ID: 9524127

DOI: 10.1093/emboj/17.7.2055

PubMed ID: 9878245

Title: cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.

PubMed ID: 9878245

DOI: 10.1006/geno.1998.5587

PubMed ID: 10777662

Title: Physical interaction among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression.

PubMed ID: 10777662

DOI: 10.1006/geno.2000.6142

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10359610

Title: The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.

PubMed ID: 10359610

DOI: 10.1091/mbc.10.6.1985

PubMed ID: 10846170

Title: HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.

PubMed ID: 10846170

DOI: 10.1074/jbc.m000168200

PubMed ID: 10884395

Title: The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.

PubMed ID: 10884395

DOI: 10.1074/jbc.m005782200

PubMed ID: 11077446

Title: PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition.

PubMed ID: 11077446

DOI: 10.1038/sj.onc.1203901

PubMed ID: 11573955

Title: The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.

PubMed ID: 11573955

DOI: 10.1006/bbrc.2001.5685

PubMed ID: 14500360

Title: Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue.

PubMed ID: 14500360

PubMed ID: 14611806

Title: Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.

PubMed ID: 14611806

DOI: 10.1016/s0888-7543(03)00200-3

PubMed ID: 12578958

Title: Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro.

PubMed ID: 12578958

DOI: 10.1073/pnas.0437927100

PubMed ID: 15314187

Title: The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair.

PubMed ID: 15314187

DOI: 10.1093/nar/gkh652

PubMed ID: 15556996

Title: The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1.

PubMed ID: 15556996

DOI: 10.1073/pnas.0407686101

PubMed ID: 15871698

Title: The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.

PubMed ID: 15871698

DOI: 10.1042/bj20050211

PubMed ID: 16216273

Title: The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity.

PubMed ID: 16216273

DOI: 10.1016/j.jmb.2005.09.018

PubMed ID: 15897895

Title: Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells.

PubMed ID: 15897895

DOI: 10.1038/sj.onc.1208674

PubMed ID: 21659603

Title: A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.

PubMed ID: 21659603

DOI: 10.1126/science.1203430

PubMed ID: 31776186

Title: Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp.

PubMed ID: 31776186

DOI: 10.1074/jbc.ac119.011816

PubMed ID: 36841485

Title: The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO.

PubMed ID: 36841485

DOI: 10.1016/j.jbc.2023.103061

Sequence Information:

  • Length: 280
  • Mass: 31691
  • Checksum: 9C3ED2FD35C2ACB3
  • Sequence:
    • MKFRAKIVDG ACLNHFTRIS NMIAKLAKTC TLRISPDKLN FILCDKLANG GVSMWCELEQ 
ENFFNEFQME GVSAENNEIY LELTSENLSR ALKTAQNARA LKIKLTNKHF PCLTVSVELL 
SMSSSSRIVT HDIPIKVIPR KLWKDLQEPV VPDPDVSIYL PVLKTMKSVV EKMKNISNHL 
VIEANLDGEL NLKIETELVC VTTHFKDLGN PPLASESTHE DRNVEHMAEV HIDIRKLLQF 
LAGQQVNPTK ALCNIVNNKM VHFDLLHEDV SLQYFIPALS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.