Details for: IARS1

Gene ID: 3376

Symbol: IARS1

Ensembl ID: ENSG00000196305

Description: isoleucyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 236.5871
    Cell Significance Index: -36.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.5891
    Cell Significance Index: -37.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 94.5214
    Cell Significance Index: -38.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.4088
    Cell Significance Index: -38.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.1050
    Cell Significance Index: -42.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9806
    Cell Significance Index: -43.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9415
    Cell Significance Index: -30.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0280
    Cell Significance Index: -17.5700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 2.0934
    Cell Significance Index: 66.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0096
    Cell Significance Index: 403.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7761
    Cell Significance Index: 352.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2952
    Cell Significance Index: 140.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2438
    Cell Significance Index: 202.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1826
    Cell Significance Index: 33.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0529
    Cell Significance Index: 377.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0454
    Cell Significance Index: 58.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7632
    Cell Significance Index: 33.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7331
    Cell Significance Index: 27.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6572
    Cell Significance Index: 454.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5766
    Cell Significance Index: 44.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5662
    Cell Significance Index: 102.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5643
    Cell Significance Index: 69.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5402
    Cell Significance Index: 37.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5338
    Cell Significance Index: 15.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5312
    Cell Significance Index: 62.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5026
    Cell Significance Index: 13.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4869
    Cell Significance Index: 66.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4391
    Cell Significance Index: 29.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4263
    Cell Significance Index: 12.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4186
    Cell Significance Index: 228.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4047
    Cell Significance Index: 19.0200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3743
    Cell Significance Index: 5.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3699
    Cell Significance Index: 36.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3584
    Cell Significance Index: 16.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3458
    Cell Significance Index: 17.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3456
    Cell Significance Index: 25.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3405
    Cell Significance Index: 21.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3309
    Cell Significance Index: 146.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3046
    Cell Significance Index: 275.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2742
    Cell Significance Index: 35.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2561
    Cell Significance Index: 18.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2323
    Cell Significance Index: 5.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2232
    Cell Significance Index: 303.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2228
    Cell Significance Index: 11.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1804
    Cell Significance Index: 3.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1404
    Cell Significance Index: 4.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1320
    Cell Significance Index: 8.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1116
    Cell Significance Index: 3.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1108
    Cell Significance Index: 5.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1000
    Cell Significance Index: 184.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0815
    Cell Significance Index: 153.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0734
    Cell Significance Index: 12.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0696
    Cell Significance Index: 107.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0658
    Cell Significance Index: 12.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0521
    Cell Significance Index: 1.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0352
    Cell Significance Index: 22.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0195
    Cell Significance Index: 8.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0163
    Cell Significance Index: 2.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0079
    Cell Significance Index: 5.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0012
    Cell Significance Index: 0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0211
    Cell Significance Index: -15.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0431
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0472
    Cell Significance Index: -34.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0741
    Cell Significance Index: -41.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0782
    Cell Significance Index: -48.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0929
    Cell Significance Index: -9.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1316
    Cell Significance Index: -37.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1362
    Cell Significance Index: -2.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1542
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1622
    Cell Significance Index: -18.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1721
    Cell Significance Index: -2.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1942
    Cell Significance Index: -3.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2183
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2291
    Cell Significance Index: -48.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2518
    Cell Significance Index: -6.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2518
    Cell Significance Index: -13.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2753
    Cell Significance Index: -3.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2876
    Cell Significance Index: -6.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3400
    Cell Significance Index: -35.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3520
    Cell Significance Index: -5.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3585
    Cell Significance Index: -21.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3781
    Cell Significance Index: -9.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4060
    Cell Significance Index: -5.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4292
    Cell Significance Index: -9.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4648
    Cell Significance Index: -11.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4809
    Cell Significance Index: -10.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4851
    Cell Significance Index: -38.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5025
    Cell Significance Index: -5.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5542
    Cell Significance Index: -17.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5778
    Cell Significance Index: -8.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6115
    Cell Significance Index: -20.0200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6445
    Cell Significance Index: -9.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6673
    Cell Significance Index: -9.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6709
    Cell Significance Index: -19.7100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6934
    Cell Significance Index: -13.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7249
    Cell Significance Index: -4.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7391
    Cell Significance Index: -17.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7433
    Cell Significance Index: -16.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7785
    Cell Significance Index: -15.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IARS1 gene is a single-copy gene located on chromosome 11q13.3. It encodes a cytoplasmic isoleucyl-tRNA synthetase enzyme, which is responsible for the aminoacylation of isoleucine-containing tRNA molecules. The IARS1 protein shares high sequence identity with other aminoacyl-tRNA synthetases, suggesting that it plays a conserved role in protein synthesis. The IARS1 enzyme has been shown to possess isoleucyl-tRNA ligase activity, which is essential for the efficient and accurate transfer of amino acids to tRNA molecules. **Pathways and Functions:** The IARS1 gene is involved in several critical pathways, including: 1. **Aminoacyl-tRNA editing activity**: IARS1 is responsible for the editing of isoleucine-containing tRNA molecules, ensuring that the correct amino acid is incorporated into proteins during translation. 2. **Aminoacyl-tRNA metabolism involved in translational fidelity**: IARS1 plays a key role in maintaining translational fidelity by ensuring that tRNA molecules are accurately charged with the correct amino acids. 3. **Aminoacyl-tRNA synthetase multienzyme complex**: IARS1 is part of a larger complex that includes other aminoacyl-tRNA synthetases, which work together to ensure the accurate charging of tRNA molecules. 4. **Translation**: IARS1 is essential for protein synthesis, as it ensures that tRNA molecules are accurately charged with the correct amino acids. **Clinical Significance:** Dysregulation of the IARS1 gene has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in the IARS1 gene have been associated with neurodegenerative disorders such as Huntington's disease and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: Alterations in the IARS1 gene have been observed in certain types of cancer, including breast cancer and prostate cancer. 3. **Metabolic disorders**: IARS1 has been implicated in metabolic disorders such as type 2 diabetes and obesity. In conclusion, the IARS1 gene plays a critical role in protein synthesis and translation fidelity. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 1080684635

Symbol: SYIC_HUMAN

Name: Isoleucine--tRNA ligase, cytoplasmic

UniProtKB Accession Codes:

P41252 A8KAE9 Q5TCD0 Q7Z3T4 Q9H588

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 6 Ensembl 6 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8052601

Title: Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit.

PubMed ID: 8052601

DOI: 10.1073/pnas.91.16.7435

PubMed ID: 7721108

Title: Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension.

PubMed ID: 7721108

DOI: 10.1016/0378-1119(94)00634-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19131329

Title: Dissection of the structural organization of the aminoacyl-tRNA synthetase complex.

PubMed ID: 19131329

DOI: 10.1074/jbc.m809636200

PubMed ID: 19289464

Title: Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.

PubMed ID: 19289464

DOI: 10.1074/jbc.m900480200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 24706940

Title: Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia.

PubMed ID: 24706940

DOI: 10.1136/jmedgenet-2013-102218

PubMed ID: 27426735

Title: Biallelic IARS mutations cause growth retardation with prenatal onset, intellectual disability, muscular hypotonia, and infantile hepatopathy.

PubMed ID: 27426735

DOI: 10.1016/j.ajhg.2016.05.027

Sequence Information:

  • Length: 1262
  • Mass: 144498
  • Checksum: 73CB3967A6868005
  • Sequence:
    • MLQQVPENIN FPAEEEKILE FWTEFNCFQE CLKQSKHKPK FTFYDGPPFA TGLPHYGHIL 
AGTIKDIVTR YAHQSGFHVD RRFGWDCHGL PVEYEIDKTL GIRGPEDVAK MGITEYNNQC 
RAIVMRYSAE WKSTVSRLGR WIDFDNDYKT LYPQFMESVW WVFKQLYDKG LVYRGVKVMP 
FSTACNTPLS NFESHQNYKD VQDPSVFVTF PLEEDETVSL VAWTTTPWTL PSNLAVCVNP 
EMQYVKIKDV ARGRLLILME ARLSALYKLE SDYEILERFP GAYLKGKKYR PLFDYFLKCK 
ENGAFTVLVD NYVKEEEGTG VVHQAPYFGA EDYRVCMDFN IIRKDSLPVC PVDASGCFTT 
EVTDFAGQYV KDADKSIIRT LKEQGRLLVA TTFTHSYPFC WRSDTPLIYK AVPSWFVRVE 
NMVDQLLRNN DLCYWVPELV REKRFGNWLK DARDWTISRN RYWGTPIPLW VSDDFEEVVC 
IGSVAELEEL SGAKISDLHR ESVDHLTIPS RCGKGSLHRI SEVFDCWFES GSMPYAQVHY 
PFENKREFED AFPADFIAEG IDQTRGWFYT LLVLATALFG QPPFKNVIVN GLVLASDGQK 
MSKRKKNYPD PVSIIQKYGA DALRLYLINS PVVRAENLRF KEEGVRDVLK DVLLPWYNAY 
RFLIQNVLRL QKEEEIEFLY NENTVRESPN ITDRWILSFM QSLIGFFETE MAAYRLYTVV 
PRLVKFVDIL TNWYVRMNRR RLKGENGMED CVMALETLFS VLLSLCRLMA PYTPFLTELM 
YQNLKVLIDP VSVQDKDTLS IHYLMLPRVR EELIDKKTES AVSQMQSVIE LGRVIRDRKT 
IPIKYPLKEI VVIHQDPEAL KDIKSLEKYI IEELNVRKVT LSTDKNKYGI RLRAEPDHMV 
LGKRLKGAFK AVMTSIKQLS SEELEQFQKT GTIVVEGHEL HDEDIRLMYT FDQATGGTAQ 
FEAHSDAQAL VLLDVTPDQS MVDEGMAREV INRIQKLRKK CNLVPTDEIT VYYKAKSEGT 
YLNSVIESHT EFIFTTIKAP LKPYPVSPSD KVLIQEKTQL KGSELEITLT RGSSLPGPAC 
AYVNLNICAN GSEQGGVLLL ENPKGDNRLD LLKLKSVVTS IFGVKNTELA VFHDETEIQN 
QTDLLSLSGK TLCVTAGSAP SLINSSSTLL CQYINLQLLN AKPQECLMGT VGTLLLENPL 
GQNGLTHQGL LYEAAKVFGL RSRKLKLFLN ETQTQEITED IPVKTLNMKT VYVSVLPTTA 
DF

Genular Protein ID: 1118483889

Symbol: Q7L4K8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7L4K8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 481
  • Mass: 53578
  • Checksum: A22A0779D3C61D7C
  • Sequence:
    • QNLKVLIDPV SVQDKDTLSI HYLMLPRVRE ELIDKKTESA VSQMQSVIEL GRVIRDRKTI 
PIKYPLKEIV VIHQDPEALK DIKSLEKYII EELNVRKVTL STDKNKYGIR LRAEPDHMVL 
GKRLKGAFKA VMTSIKQLSS EELEQFQKTG TIVVEGHELH DEDIRLMYTF DQATGGTAQF 
EAHSDAQALV LLDVTPDQSM VDEGMAREVI NRIQKLRKKC NLVPTDEITV YYKAKSEGTY 
LNSVIESHTE FIFTTIKAPL KPYPVSPSDK VLIQEKTQLK GSELEITLTR GSSLPGPACA 
YVNLNICANG SEQGGVLLLE NPKGDNRLDL LKLKSVVTSI FGVKNTELAV FHDETEIQNQ 
TDLLSLSGKT LCVTAGSAPS LINSSSTLLC QYINLQLLNA KPQECLMGTV GTLLLENPLG 
QNGLTHQGLL YEAAKVFGLR SRKLKLFLNE TQTQEITEDI PVKTLNMKTV YVSVLPTTAD 
F

Genular Protein ID: 3863134767

Symbol: Q6P0M4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P0M4

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 5 RefSeq 1 Rhea 3 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1055
  • Mass: 120627
  • Checksum: 14E54F1D7332CBE2
  • Sequence:
    • MESVWWVFKQ LYDKGLVYRG VKVMPFSTAC NTPLSNFESH QNYKDVQDPS VFVTFPLEED 
ETVSLVAWTT TPWTLPSNLA VCVNPEMQYV KIKDVARGRL LILMEARLSA LYKLESDYEI 
LERFPGAYLK GKKYRPLFDY FLKCKENGAF TVLVDNYVKE EEGTGVVHQA PYFGAEDYRV 
CMDFNIIRKD SLPVCPVDAS GCFTTEVTDF AGQYVKDADK SIIRTLKEQG RLLVATTFTH 
SYPFCWRSDT PLIYKAVPSW FVRVENMVDQ LLRNNDLCYW VPELVREKRF GNWLKDARDW 
TISRNRYWGT PIPLWVSDDF EEVVCIGSVA ELEELSGAKI SDLHRESVDH LTIPSRCGKG 
SLHRISEVFD CWFESGSMPY AQVHYPFENK REFEDAFPAD FIAEGIDQTR GWFYTLLVLA 
TALFGQPPFK NVIVNGLVLA SDGQKMSKRK KNYPDPVSII QKYGADALRL YLINSPVVRA 
ENLRFKEEGV RDVLKDVLLP WYNAYRFLIQ NVLRLQKEEE IEFLYNENTV RESPNITDRW 
ILSFMQSLIG FFETEMAAYR LYTVVPRLVK FVDILTNWYV RMNRRRLKGE NGMEDCVMAL 
ETLFSVLLSL CRLMAPYTPF LTELMYQNLK VLIDPVSVQD KDTLSIHYLM LPRVREELID 
KKTESAVSQM QSVIELGRVI RDRKTIPIKY PLKEIVVIHQ DPEALKDIKS LEKYIIEELN 
VRKVTLSTDK NKYGIRLRAE PDHMVLGKRL KGAFKAVMTS IKQLSSEELE QFQKTGTIVA 
EGHELHDEDI RLMYTFDQAT GGTAQFEAHS DAQALVLLDV TPDQSMVDEG MAREVINRIQ 
KLRKKCNLVP TDEITVYYKA KSEGTYLNSV IESHTEFIFT TIKAPLKPYP VSPSDKVLIQ 
EKTQLKGSEL EITLTRGSSL PGPACAYVNL NICANGSEQG GVLLLENPKG SAPSLINSSS 
TLLCQYINLQ LLNAKPQECL MGTVGTLLLE NPLGQNGLTH QGLLYEAAKV FGLRSRKLKL 
FLNETQTQEI TEDIPVKTLN MKTVYVSVLP TTADF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.