Details for: IDE

Gene ID: 3416

Symbol: IDE

Ensembl ID: ENSG00000119912

Description: insulin degrading enzyme

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.5970
    Cell Significance Index: -26.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.4199
    Cell Significance Index: -27.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.5155
    Cell Significance Index: -29.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.6174
    Cell Significance Index: -24.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.3576
    Cell Significance Index: -24.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.6285
    Cell Significance Index: -27.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3701
    Cell Significance Index: -27.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2176
    Cell Significance Index: -25.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2199
    Cell Significance Index: -28.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9771
    Cell Significance Index: -15.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.7944
    Cell Significance Index: 71.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7153
    Cell Significance Index: 169.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6264
    Cell Significance Index: 22.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.5438
    Cell Significance Index: 33.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3309
    Cell Significance Index: 266.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1860
    Cell Significance Index: 235.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9729
    Cell Significance Index: 672.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9722
    Cell Significance Index: 74.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9461
    Cell Significance Index: 102.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7956
    Cell Significance Index: 129.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7895
    Cell Significance Index: 47.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7850
    Cell Significance Index: 281.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7463
    Cell Significance Index: 47.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7037
    Cell Significance Index: 133.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6859
    Cell Significance Index: 30.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6739
    Cell Significance Index: 78.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6599
    Cell Significance Index: 24.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6531
    Cell Significance Index: 17.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5801
    Cell Significance Index: 14.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5267
    Cell Significance Index: 11.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4938
    Cell Significance Index: 13.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4916
    Cell Significance Index: 5.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4824
    Cell Significance Index: 86.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4639
    Cell Significance Index: 32.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4530
    Cell Significance Index: 23.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4147
    Cell Significance Index: 6.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3947
    Cell Significance Index: 9.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3672
    Cell Significance Index: 45.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3484
    Cell Significance Index: 19.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3233
    Cell Significance Index: 21.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2787
    Cell Significance Index: 8.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2567
    Cell Significance Index: 5.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2318
    Cell Significance Index: 126.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2118
    Cell Significance Index: 191.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2006
    Cell Significance Index: 23.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1697
    Cell Significance Index: 7.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1349
    Cell Significance Index: 1.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1251
    Cell Significance Index: 56.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1153
    Cell Significance Index: 217.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1129
    Cell Significance Index: 19.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1129
    Cell Significance Index: 49.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0978
    Cell Significance Index: 150.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0876
    Cell Significance Index: 55.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0825
    Cell Significance Index: 112.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0766
    Cell Significance Index: 141.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0601
    Cell Significance Index: 8.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0492
    Cell Significance Index: 1.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0296
    Cell Significance Index: 0.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0210
    Cell Significance Index: 0.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0093
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0045
    Cell Significance Index: 0.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0088
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0144
    Cell Significance Index: -8.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0227
    Cell Significance Index: -17.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0270
    Cell Significance Index: -19.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0378
    Cell Significance Index: -21.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0845
    Cell Significance Index: -24.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0863
    Cell Significance Index: -1.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0920
    Cell Significance Index: -13.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0925
    Cell Significance Index: -19.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1137
    Cell Significance Index: -6.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1140
    Cell Significance Index: -11.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1144
    Cell Significance Index: -5.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1183
    Cell Significance Index: -15.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1188
    Cell Significance Index: -6.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1262
    Cell Significance Index: -13.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1438
    Cell Significance Index: -10.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1565
    Cell Significance Index: -2.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1819
    Cell Significance Index: -23.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1857
    Cell Significance Index: -8.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2025
    Cell Significance Index: -23.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2055
    Cell Significance Index: -13.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2535
    Cell Significance Index: -18.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2789
    Cell Significance Index: -5.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3063
    Cell Significance Index: -18.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3073
    Cell Significance Index: -2.8300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3120
    Cell Significance Index: -3.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3184
    Cell Significance Index: -4.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3255
    Cell Significance Index: -25.7800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3510
    Cell Significance Index: -5.0400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3570
    Cell Significance Index: -5.7600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3696
    Cell Significance Index: -5.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3806
    Cell Significance Index: -10.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4012
    Cell Significance Index: -9.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4115
    Cell Significance Index: -9.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4283
    Cell Significance Index: -13.6400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4415
    Cell Significance Index: -5.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4562
    Cell Significance Index: -23.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IDE is a secreted protein that is primarily expressed in the brain, pancreas, and other tissues. Its primary function is to degrade insulin and IGF-1, which are key players in glucose homeostasis and cell growth. IDE is a zinc-dependent enzyme that exhibits a unique substrate specificity, targeting insulin and IGF-1 for degradation. Its activity is regulated by various post-translational modifications, including ubiquitination and proteolytic processing. **Pathways and Functions** IDE's primary function is to regulate insulin and IGF-1 signaling through degradation of these peptides. This process is crucial for maintaining glucose homeostasis and preventing insulin resistance. IDE's activity is also linked to various signaling pathways, including: 1. **Insulin signaling pathway**: IDE regulates insulin signaling by degrading insulin, thereby modulating its half-life and biological activity. 2. **IGF-1 signaling pathway**: IDE also degrades IGF-1, which is involved in cell growth and differentiation. 3. **Amyloid-beta clearance pathway**: IDE has been implicated in the clearance of amyloid-beta peptides, which are associated with Alzheimer's disease. 4. **Cellular catabolic process**: IDE is involved in the degradation of various peptides, including bradykinin and peptide hormones. **Clinical Significance** Dysregulation of IDE has been implicated in various metabolic disorders, including: 1. **Type 2 diabetes**: Elevated IDE activity has been linked to insulin resistance and impaired glucose homeostasis. 2. **Obesity**: IDE's dysregulation has been associated with obesity and metabolic syndrome. 3. **Alzheimer's disease**: IDE's role in amyloid-beta clearance has been implicated in the pathogenesis of Alzheimer's disease. 4. **Cancer**: IDE's activity has been linked to cancer progression and metastasis. In conclusion, the insulin-degrading enzyme (IDE) gene plays a critical role in regulating insulin and IGF-1 signaling, as well as amyloid-beta clearance. Its dysregulation has been implicated in various metabolic disorders, including type 2 diabetes, obesity, and Alzheimer's disease. Further research is needed to fully elucidate the mechanisms underlying IDE's functions and its clinical significance.

Genular Protein ID: 4205728107

Symbol: IDE_HUMAN

Name: Abeta-degrading protease

UniProtKB Accession Codes:

P14735 B2R721 B7ZAU2 D3DR35 Q5T5N2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 1 EMBL 9 EMDB 13 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 3 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 61 PDBsum 61 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3059494

Title: Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III.

PubMed ID: 3059494

DOI: 10.1126/science.3059494

PubMed ID: 2293021

Title: Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.

PubMed ID: 2293021

DOI: 10.1210/mend-4-8-1125

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9830016

Title: Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

PubMed ID: 9830016

DOI: 10.1074/jbc.273.49.32730

PubMed ID: 10684867

Title: Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

PubMed ID: 10684867

DOI: 10.1523/jneurosci.20-05-01657.2000

PubMed ID: 17055432

Title: Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread.

PubMed ID: 17055432

DOI: 10.1016/j.cell.2006.08.046

PubMed ID: 17553876

Title: The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor.

PubMed ID: 17553876

DOI: 10.1128/jvi.00286-07

PubMed ID: 20364150

Title: Production of an antigenic peptide by insulin-degrading enzyme.

PubMed ID: 20364150

DOI: 10.1038/ni.1862

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26968463

Title: Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation states.

PubMed ID: 26968463

DOI: 10.1016/j.bbagen.2016.03.010

PubMed ID: 17051221

Title: Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.

PubMed ID: 17051221

DOI: 10.1038/nature05143

PubMed ID: 17613531

Title: Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.

PubMed ID: 17613531

DOI: 10.1074/jbc.m701590200

PubMed ID: 18986166

Title: Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.

PubMed ID: 18986166

DOI: 10.1021/bi801192h

PubMed ID: 19321446

Title: Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.

PubMed ID: 19321446

DOI: 10.1074/jbc.m900068200

PubMed ID: 21098034

Title: Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.

PubMed ID: 21098034

DOI: 10.1074/jbc.m110.173252

PubMed ID: 23922390

Title: Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.

PubMed ID: 23922390

DOI: 10.1073/pnas.1304575110

PubMed ID: 24847884

Title: Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

PubMed ID: 24847884

DOI: 10.1038/nature13297

PubMed ID: 26394692

Title: Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.

PubMed ID: 26394692

DOI: 10.1038/ncomms9250

PubMed ID: 29596046

Title: Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.

PubMed ID: 29596046

DOI: 10.7554/elife.33572

Sequence Information:

  • Length: 1019
  • Mass: 117968
  • Checksum: 8A28AEF75EDA0EDA
  • Sequence:
    • MRYRLAWLLH PALPSTFRSV LGARLPPPER LCGFQKKTYS KMNNPAIKRI GNHITKSPED 
KREYRGLELA NGIKVLLISD PTTDKSSAAL DVHIGSLSDP PNIAGLSHFC EHMLFLGTKK 
YPKENEYSQF LSEHAGSSNA FTSGEHTNYY FDVSHEHLEG ALDRFAQFFL CPLFDESCKD 
REVNAVDSEH EKNVMNDAWR LFQLEKATGN PKHPFSKFGT GNKYTLETRP NQEGIDVRQE 
LLKFHSAYYS SNLMAVCVLG RESLDDLTNL VVKLFSEVEN KNVPLPEFPE HPFQEEHLKQ 
LYKIVPIKDI RNLYVTFPIP DLQKYYKSNP GHYLGHLIGH EGPGSLLSEL KSKGWVNTLV 
GGQKEGARGF MFFIINVDLT EEGLLHVEDI ILHMFQYIQK LRAEGPQEWV FQECKDLNAV 
AFRFKDKERP RGYTSKIAGI LHYYPLEEVL TAEYLLEEFR PDLIEMVLDK LRPENVRVAI 
VSKSFEGKTD RTEEWYGTQY KQEAIPDEVI KKWQNADLNG KFKLPTKNEF IPTNFEILPL 
EKEATPYPAL IKDTAMSKLW FKQDDKFFLP KACLNFEFFS PFAYVDPLHC NMAYLYLELL 
KDSLNEYAYA AELAGLSYDL QNTIYGMYLS VKGYNDKQPI LLKKIIEKMA TFEIDEKRFE 
IIKEAYMRSL NNFRAEQPHQ HAMYYLRLLM TEVAWTKDEL KEALDDVTLP RLKAFIPQLL 
SRLHIEALLH GNITKQAALG IMQMVEDTLI EHAHTKPLLP SQLVRYREVQ LPDRGWFVYQ 
QRNEVHNNCG IEIYYQTDMQ STSENMFLEL FCQIISEPCF NTLRTKEQLG YIVFSGPRRA 
NGIQGLRFII QSEKPPHYLE SRVEAFLITM EKSIEDMTEE AFQKHIQALA IRRLDKPKKL 
SAECAKYWGE IISQQYNFDR DNTEVAYLKT LTKEDIIKFY KEMLAVDAPR RHKVSVHVLA 
REMDSCPVVG EFPCQNDINL SQAPALPQPE VIQNMTEFKR GLPLFPLVKP HINFMAAKL

Genular Protein ID: 3305734147

Symbol: A0A7I2V2P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V2P6

Database IDs:

ARBA 5 AlphaFoldDB 1 Bgee 1 CTD 1 DisGeNET 1 EMBL 1 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 7 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 978
  • Mass: 113174
  • Checksum: BF612FD9EE4CFC80
  • Sequence:
    • MNNPAIKRIG NHITKSPEDK REYRGLELAN GIKVLLISDP TTDKSSAALD VHIGSLSDPP 
NIAGLSHFCE HMLFLGTKKY PKENEYSQFL SEHAGSSNAF TSGEHTNYYF DVSHEHLEGA 
LDRFAQFFLC PLFDESCKDR EVNAVDSEHE KNVMNDAWRL FQLEKATGNP KHPFSKFGTG 
NKYTLETRPN QEGIDVRQEL LKFHSAYYSS NLMAVCVLGR ESLDDLTNLV VKLFSEVENK 
NVPLPEFPEH PFQEEHLKQL YKIVPIKDIR NLYVTFPIPD LQKYYKSNPG HYLGHLIGHE 
GPGSLLSELK SKGWVNTLVG GQKEGARGFM FFIINVDLTE EGLLHVEDII LHMFQYIQKL 
RAEGPQEWVF QECKDLNAVA FRFKDKERPR GYTSKIAGIL HYYPLEEVLT AEYLLEEFRP 
DLIEMVLDKL RPENVRVAIV SKSFEGKTDR TEEWYGTQYK QEAIPDEVIK KWQNADLNGK 
FKLPTKNEFI PTNFEILPLE KEATPYPALI KDTAMSKLWF KQDDKFFLPK ACLNFEFFSR 
YIYADPLHCN MTYLFIRLLK DDLKEYTYAA RLSGLSYGIA SGMNAILLSV KGYNDKQPIL 
LKKIIEKMAT FEIDEKRFEI IKEAYMRSLN NFRAEQPHQH AMYYLRLLMT EVAWTKDELK 
EALDDVTLPR LKAFIPQLLS RLHIEALLHG NITKQAALGI MQMVEDTLIE HAHTKPLLPS 
QLVRYREVQL PDRGWFVYQQ RNEVHNNCGI EIYYQTDMQS TSENMFLELF CQIISEPCFN 
TLRTKEQLGY IVFSGPRRAN GIQGLRFIIQ SEKPPHYLES RVEAFLITME KSIEDMTEEA 
FQKHIQALAI RRLDKPKKLS AECAKYWGEI ISQQYNFDRD NTEVAYLKTL TKEDIIKFYK 
EMLAVDAPRR HKVSVHVLAR EMDSCPVVGE FPCQNDINLS QAPALPQPEV IQNMTEFKRG 
LPLFPLVKPH INFMAAKL

Genular Protein ID: 3281158603

Symbol: A0A3B3ISG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3ISG5

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 7 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 1019
  • Mass: 117943
  • Checksum: F37486BBC1B3A652
  • Sequence:
    • MRYRLAWLLH PALPSTFRSV LGARLPPPER LCGFQKKTYS KMNNPAIKRI GNHITKSPED 
KREYRGLELA NGIKVLLISD PTTDKSSAAL DVHIGSLSDP PNIAGLSHFC EHMLFLGTKK 
YPKENEYSQF LSEHAGSSNA FTSGEHTNYY FDVSHEHLEG ALDRFAQFFL CPLFDESCKD 
REVNAVDSEH EKNVMNDAWR LFQLEKATGN PKHPFSKFGT GNKYTLETRP NQEGIDVRQE 
LLKFHSAYYS SNLMAVCVLG RESLDDLTNL VVKLFSEVEN KNVPLPEFPE HPFQEEHLKQ 
LYKIVPIKDI RNLYVTFPIP DLQKYYKSNP GHYLGHLIGH EGPGSLLSEL KSKGWVNTLV 
GGQKEGARGF MFFIINVDLT EEGLLHVEDI ILHMFQYIQK LRAEGPQEWV FQECKDLNAV 
AFRFKDKERP RGYTSKIAGI LHYYPLEEVL TAEYLLEEFR PDLIEMVLDK LRPENVRVAI 
VSKSFEGKTD RTEEWYGTQY KQEAIPDEVI KKWQNADLNG KFKLPTKNEF IPTNFEILPL 
EKEATPYPAL IKDTAMSKLW FKQDDKFFLP KACLNFEFFS RYIYADPLHC NMTYLFIRLL 
KDDLKEYTYA ARLSGLSYGI ASGMNAILLS VKGYNDKQPI LLKKIIEKMA TFEIDEKRFE 
IIKEAYMRSL NNFRAEQPHQ HAMYYLRLLM TEVAWTKDEL KEALDDVTLP RLKAFIPQLL 
SRLHIEALLH GNITKQAALG IMQMVEDTLI EHAHTKPLLP SQLVRYREVQ LPDRGWFVYQ 
QRNEVHNNCG IEIYYQTDMQ STSENMFLEL FCQIISEPCF NTLRTKEQLG YIVFSGPRRA 
NGIQGLRFII QSEKPPHYLE SRVEAFLITM EKSIEDMTEE AFQKHIQALA IRRLDKPKKL 
SAECAKYWGE IISQQYNFDR DNTEVAYLKT LTKEDIIKFY KEMLAVDAPR RHKVSVHVLA 
REMDSCPVVG EFPCQNDINL SQAPALPQPE VIQNMTEFKR GLPLFPLVKP HINFMAAKL

Genular Protein ID: 1774643328

Symbol: B3KSB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSB8

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 464
  • Mass: 54214
  • Checksum: AC406B169DD3E1BA
  • Sequence:
    • MSKLWFKQDD KFFLPKACLN FEFFSRYIYA DPLHCNMTYL FIRLLKDDLK EYTYAARLSG 
LSYGIASGMN AILLSVKGYN DKQPILLKKI IEKMATFEID EKRFEIIKEA YMRSLNNFRA 
EQPHQHAMYY LRLLMTEVAW TKDELKEALD DVTLPRLKAF IPQLLSRLHI EALLHGNITK 
QAALGIMQMV EDTLIEHAHT KPLLPSQLVR YREVQLPDRG WFVYQQRNEV HNNCGIEIYY 
QTDMQSTSEN MFLELFCQII SEPCFNTLRT KEQLGYIVFS GPRRANGIQG LRFIIQSEKP 
PHYLESRVEA FLITMEKSIE DMTEEAFQKH IQALAIRRLD KPKKLSAECA KYWGEIISQQ 
YNFDRDNTEV AYLKTLTKED IIKFYKEMLA VDAPRRHKVS VHVLAREMDS CPVVGEFPCQ 
NDINLSQAPA LPQPEVIQNM TEFKRGLPLF PLVKPHINFM AAKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.