Details for: IDE

Gene ID: 3416

Symbol: IDE

Ensembl ID: ENSG00000119912

Description: insulin degrading enzyme

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.7
    Marker Score: 3735
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.57
    Marker Score: 921
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.54
    Marker Score: 94601
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.53
    Marker Score: 14545
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56331
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5
    Marker Score: 15464
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.48
    Marker Score: 13898
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.46
    Marker Score: 613
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.44
    Marker Score: 12405
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.44
    Marker Score: 2215
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.4
    Marker Score: 53235
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.36
    Marker Score: 5545
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.33
    Marker Score: 5158
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.33
    Marker Score: 19929
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.31
    Marker Score: 10073
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.3
    Marker Score: 25925
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.3
    Marker Score: 1573.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.29
    Marker Score: 1426.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.28
    Marker Score: 5291
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.23
    Marker Score: 2503
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.18
    Marker Score: 1358
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.15
    Marker Score: 669
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.15
    Marker Score: 4793
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.14
    Marker Score: 1532
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.13
    Marker Score: 1974
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.12
    Marker Score: 306
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.12
    Marker Score: 23808
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.11
    Marker Score: 324
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17323
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.1
    Marker Score: 349
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.07
    Marker Score: 2689
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.04
    Marker Score: 23157
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.04
    Marker Score: 3681
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47961
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.97
    Marker Score: 478
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.94
    Marker Score: 564
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9
    Marker Score: 5791
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.89
    Marker Score: 621
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.88
    Marker Score: 1696
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4924
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.86
    Marker Score: 3339
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 516
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.84
    Marker Score: 3625
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.8
    Marker Score: 204
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.8
    Marker Score: 535
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.79
    Marker Score: 3303
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.79
    Marker Score: 2717
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1278
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.78
    Marker Score: 821
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.78
    Marker Score: 246
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.77
    Marker Score: 230
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.77
    Marker Score: 831
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.77
    Marker Score: 447
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.77
    Marker Score: 372
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.76
    Marker Score: 347
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.75
    Marker Score: 666
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3145
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.75
    Marker Score: 1701
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.74
    Marker Score: 4447
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.74
    Marker Score: 413
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.74
    Marker Score: 2107
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.73
    Marker Score: 361
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.72
    Marker Score: 3341
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1694
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.71
    Marker Score: 12690
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.71
    Marker Score: 950
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.71
    Marker Score: 228
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7
    Marker Score: 1038
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.7
    Marker Score: 194
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.7
    Marker Score: 201
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7
    Marker Score: 3739
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.69
    Marker Score: 468
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.69
    Marker Score: 531
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.69
    Marker Score: 218
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.68
    Marker Score: 775
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 624
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.67
    Marker Score: 335
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.67
    Marker Score: 809
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.67
    Marker Score: 859
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.66
    Marker Score: 1116
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.66
    Marker Score: 937
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.66
    Marker Score: 224
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.65
    Marker Score: 700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.65
    Marker Score: 243
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.65
    Marker Score: 1594.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.64
    Marker Score: 10307
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.64
    Marker Score: 792

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Other Information

**Key characteristics:** * Protein type: Enzyme * Ensembl ID: ENSG00000119912 * Protein size: 135 amino acids * Subcellular location: Cytoplasm * Cellular source: Various cell types **Pathways and functions:** * IDE is involved in the degradation of insulin through a process called ubiquitination-mediated proteolysis. * It is a key regulator of insulin signaling by deubiquitinating and recycling insulin molecules. * IDE also plays a role in the metabolism of proteins, including the degradation of damaged or misfolded proteins. **Clinical significance:** * Mutations in the IDE gene have been linked to a number of human diseases, including diabetes. * In type 1 diabetes, mutations in the IDE gene lead to the production of a non-functional IDE protein that cannot be degraded properly. This results in high levels of free insulin in the blood, which can lead to hyperglycemia. * In type 2 diabetes, mutations in the IDE gene can also lead to the production of a protein that is less effective at inhibiting insulin signaling. This results in low blood sugar levels and can lead to hypoglycemia. **Additional notes:** * IDE is a member of the DegP family of protein deubiquitinases. * It is a highly conserved protein with a similar sequence in mammals and humans. * IDE is a target for therapeutic antibodies in the treatment of diabetes.

Genular Protein ID: 4205728107

Symbol: IDE_HUMAN

Name: Abeta-degrading protease

UniProtKB Accession Codes:

P14735 B2R721 B7ZAU2 D3DR35 Q5T5N2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 1 EMBL 9 EMDB 13 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 3 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 95 PDBsum 61 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3059494

Title: Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III.

PubMed ID: 3059494

DOI: 10.1126/science.3059494

PubMed ID: 2293021

Title: Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.

PubMed ID: 2293021

DOI: 10.1210/mend-4-8-1125

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9830016

Title: Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

PubMed ID: 9830016

DOI: 10.1074/jbc.273.49.32730

PubMed ID: 10684867

Title: Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

PubMed ID: 10684867

DOI: 10.1523/jneurosci.20-05-01657.2000

PubMed ID: 17055432

Title: Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread.

PubMed ID: 17055432

DOI: 10.1016/j.cell.2006.08.046

PubMed ID: 17553876

Title: The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor.

PubMed ID: 17553876

DOI: 10.1128/jvi.00286-07

PubMed ID: 20364150

Title: Production of an antigenic peptide by insulin-degrading enzyme.

PubMed ID: 20364150

DOI: 10.1038/ni.1862

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26968463

Title: Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation states.

PubMed ID: 26968463

DOI: 10.1016/j.bbagen.2016.03.010

PubMed ID: 17051221

Title: Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.

PubMed ID: 17051221

DOI: 10.1038/nature05143

PubMed ID: 17613531

Title: Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.

PubMed ID: 17613531

DOI: 10.1074/jbc.m701590200

PubMed ID: 18986166

Title: Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.

PubMed ID: 18986166

DOI: 10.1021/bi801192h

PubMed ID: 19321446

Title: Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.

PubMed ID: 19321446

DOI: 10.1074/jbc.m900068200

PubMed ID: 21098034

Title: Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.

PubMed ID: 21098034

DOI: 10.1074/jbc.m110.173252

PubMed ID: 23922390

Title: Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.

PubMed ID: 23922390

DOI: 10.1073/pnas.1304575110

PubMed ID: 24847884

Title: Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

PubMed ID: 24847884

DOI: 10.1038/nature13297

PubMed ID: 26394692

Title: Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.

PubMed ID: 26394692

DOI: 10.1038/ncomms9250

PubMed ID: 29596046

Title: Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.

PubMed ID: 29596046

DOI: 10.7554/elife.33572

Sequence Information:

  • Length: 1019
  • Mass: 117968
  • Checksum: 8A28AEF75EDA0EDA
  • Sequence:
    • MRYRLAWLLH PALPSTFRSV LGARLPPPER LCGFQKKTYS KMNNPAIKRI GNHITKSPED 
KREYRGLELA NGIKVLLISD PTTDKSSAAL DVHIGSLSDP PNIAGLSHFC EHMLFLGTKK 
YPKENEYSQF LSEHAGSSNA FTSGEHTNYY FDVSHEHLEG ALDRFAQFFL CPLFDESCKD 
REVNAVDSEH EKNVMNDAWR LFQLEKATGN PKHPFSKFGT GNKYTLETRP NQEGIDVRQE 
LLKFHSAYYS SNLMAVCVLG RESLDDLTNL VVKLFSEVEN KNVPLPEFPE HPFQEEHLKQ 
LYKIVPIKDI RNLYVTFPIP DLQKYYKSNP GHYLGHLIGH EGPGSLLSEL KSKGWVNTLV 
GGQKEGARGF MFFIINVDLT EEGLLHVEDI ILHMFQYIQK LRAEGPQEWV FQECKDLNAV 
AFRFKDKERP RGYTSKIAGI LHYYPLEEVL TAEYLLEEFR PDLIEMVLDK LRPENVRVAI 
VSKSFEGKTD RTEEWYGTQY KQEAIPDEVI KKWQNADLNG KFKLPTKNEF IPTNFEILPL 
EKEATPYPAL IKDTAMSKLW FKQDDKFFLP KACLNFEFFS PFAYVDPLHC NMAYLYLELL 
KDSLNEYAYA AELAGLSYDL QNTIYGMYLS VKGYNDKQPI LLKKIIEKMA TFEIDEKRFE 
IIKEAYMRSL NNFRAEQPHQ HAMYYLRLLM TEVAWTKDEL KEALDDVTLP RLKAFIPQLL 
SRLHIEALLH GNITKQAALG IMQMVEDTLI EHAHTKPLLP SQLVRYREVQ LPDRGWFVYQ 
QRNEVHNNCG IEIYYQTDMQ STSENMFLEL FCQIISEPCF NTLRTKEQLG YIVFSGPRRA 
NGIQGLRFII QSEKPPHYLE SRVEAFLITM EKSIEDMTEE AFQKHIQALA IRRLDKPKKL 
SAECAKYWGE IISQQYNFDR DNTEVAYLKT LTKEDIIKFY KEMLAVDAPR RHKVSVHVLA 
REMDSCPVVG EFPCQNDINL SQAPALPQPE VIQNMTEFKR GLPLFPLVKP HINFMAAKL

Genular Protein ID: 1774643328

Symbol: B3KSB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSB8

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MEROPS 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 4 Proteomes 2 RefSeq 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 464
  • Mass: 54214
  • Checksum: AC406B169DD3E1BA
  • Sequence:
    • MSKLWFKQDD KFFLPKACLN FEFFSRYIYA DPLHCNMTYL FIRLLKDDLK EYTYAARLSG 
LSYGIASGMN AILLSVKGYN DKQPILLKKI IEKMATFEID EKRFEIIKEA YMRSLNNFRA 
EQPHQHAMYY LRLLMTEVAW TKDELKEALD DVTLPRLKAF IPQLLSRLHI EALLHGNITK 
QAALGIMQMV EDTLIEHAHT KPLLPSQLVR YREVQLPDRG WFVYQQRNEV HNNCGIEIYY 
QTDMQSTSEN MFLELFCQII SEPCFNTLRT KEQLGYIVFS GPRRANGIQG LRFIIQSEKP 
PHYLESRVEA FLITMEKSIE DMTEEAFQKH IQALAIRRLD KPKKLSAECA KYWGEIISQQ 
YNFDRDNTEV AYLKTLTKED IIKFYKEMLA VDAPRRHKVS VHVLAREMDS CPVVGEFPCQ 
NDINLSQAPA LPQPEVIQNM TEFKRGLPLF PLVKPHINFM AAKL

Genular Protein ID: 3281158603

Symbol: A0A3B3ISG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3ISG5

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 6 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 1019
  • Mass: 117943
  • Checksum: F37486BBC1B3A652
  • Sequence:
    • MRYRLAWLLH PALPSTFRSV LGARLPPPER LCGFQKKTYS KMNNPAIKRI GNHITKSPED 
KREYRGLELA NGIKVLLISD PTTDKSSAAL DVHIGSLSDP PNIAGLSHFC EHMLFLGTKK 
YPKENEYSQF LSEHAGSSNA FTSGEHTNYY FDVSHEHLEG ALDRFAQFFL CPLFDESCKD 
REVNAVDSEH EKNVMNDAWR LFQLEKATGN PKHPFSKFGT GNKYTLETRP NQEGIDVRQE 
LLKFHSAYYS SNLMAVCVLG RESLDDLTNL VVKLFSEVEN KNVPLPEFPE HPFQEEHLKQ 
LYKIVPIKDI RNLYVTFPIP DLQKYYKSNP GHYLGHLIGH EGPGSLLSEL KSKGWVNTLV 
GGQKEGARGF MFFIINVDLT EEGLLHVEDI ILHMFQYIQK LRAEGPQEWV FQECKDLNAV 
AFRFKDKERP RGYTSKIAGI LHYYPLEEVL TAEYLLEEFR PDLIEMVLDK LRPENVRVAI 
VSKSFEGKTD RTEEWYGTQY KQEAIPDEVI KKWQNADLNG KFKLPTKNEF IPTNFEILPL 
EKEATPYPAL IKDTAMSKLW FKQDDKFFLP KACLNFEFFS RYIYADPLHC NMTYLFIRLL 
KDDLKEYTYA ARLSGLSYGI ASGMNAILLS VKGYNDKQPI LLKKIIEKMA TFEIDEKRFE 
IIKEAYMRSL NNFRAEQPHQ HAMYYLRLLM TEVAWTKDEL KEALDDVTLP RLKAFIPQLL 
SRLHIEALLH GNITKQAALG IMQMVEDTLI EHAHTKPLLP SQLVRYREVQ LPDRGWFVYQ 
QRNEVHNNCG IEIYYQTDMQ STSENMFLEL FCQIISEPCF NTLRTKEQLG YIVFSGPRRA 
NGIQGLRFII QSEKPPHYLE SRVEAFLITM EKSIEDMTEE AFQKHIQALA IRRLDKPKKL 
SAECAKYWGE IISQQYNFDR DNTEVAYLKT LTKEDIIKFY KEMLAVDAPR RHKVSVHVLA 
REMDSCPVVG EFPCQNDINL SQAPALPQPE VIQNMTEFKR GLPLFPLVKP HINFMAAKL

Genular Protein ID: 3305734147

Symbol: A0A7I2V2P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V2P6

Database IDs:

ARBA 5 AlphaFoldDB 1 Bgee 1 CTD 1 EMBL 1 EPD 1 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 6 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 978
  • Mass: 113174
  • Checksum: BF612FD9EE4CFC80
  • Sequence:
    • MNNPAIKRIG NHITKSPEDK REYRGLELAN GIKVLLISDP TTDKSSAALD VHIGSLSDPP 
NIAGLSHFCE HMLFLGTKKY PKENEYSQFL SEHAGSSNAF TSGEHTNYYF DVSHEHLEGA 
LDRFAQFFLC PLFDESCKDR EVNAVDSEHE KNVMNDAWRL FQLEKATGNP KHPFSKFGTG 
NKYTLETRPN QEGIDVRQEL LKFHSAYYSS NLMAVCVLGR ESLDDLTNLV VKLFSEVENK 
NVPLPEFPEH PFQEEHLKQL YKIVPIKDIR NLYVTFPIPD LQKYYKSNPG HYLGHLIGHE 
GPGSLLSELK SKGWVNTLVG GQKEGARGFM FFIINVDLTE EGLLHVEDII LHMFQYIQKL 
RAEGPQEWVF QECKDLNAVA FRFKDKERPR GYTSKIAGIL HYYPLEEVLT AEYLLEEFRP 
DLIEMVLDKL RPENVRVAIV SKSFEGKTDR TEEWYGTQYK QEAIPDEVIK KWQNADLNGK 
FKLPTKNEFI PTNFEILPLE KEATPYPALI KDTAMSKLWF KQDDKFFLPK ACLNFEFFSR 
YIYADPLHCN MTYLFIRLLK DDLKEYTYAA RLSGLSYGIA SGMNAILLSV KGYNDKQPIL 
LKKIIEKMAT FEIDEKRFEI IKEAYMRSLN NFRAEQPHQH AMYYLRLLMT EVAWTKDELK 
EALDDVTLPR LKAFIPQLLS RLHIEALLHG NITKQAALGI MQMVEDTLIE HAHTKPLLPS 
QLVRYREVQL PDRGWFVYQQ RNEVHNNCGI EIYYQTDMQS TSENMFLELF CQIISEPCFN 
TLRTKEQLGY IVFSGPRRAN GIQGLRFIIQ SEKPPHYLES RVEAFLITME KSIEDMTEEA 
FQKHIQALAI RRLDKPKKLS AECAKYWGEI ISQQYNFDRD NTEVAYLKTL TKEDIIKFYK 
EMLAVDAPRR HKVSVHVLAR EMDSCPVVGE FPCQNDINLS QAPALPQPEV IQNMTEFKRG 
LPLFPLVKPH INFMAAKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.