Details for: CFI

Gene ID: 3426

Symbol: CFI

Ensembl ID: ENSG00000205403

Description: complement factor I

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.8796
    Cell Significance Index: -19.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.3894
    Cell Significance Index: -19.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9543
    Cell Significance Index: -19.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.9014
    Cell Significance Index: 300.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0186
    Cell Significance Index: 69.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.7427
    Cell Significance Index: 46.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4999
    Cell Significance Index: 28.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1902
    Cell Significance Index: 57.5900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3470
    Cell Significance Index: 17.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1759
    Cell Significance Index: 20.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9042
    Cell Significance Index: 46.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7644
    Cell Significance Index: 45.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7509
    Cell Significance Index: 410.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7255
    Cell Significance Index: 71.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6818
    Cell Significance Index: 615.5900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6793
    Cell Significance Index: 9.7700
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.6281
    Cell Significance Index: 3.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5877
    Cell Significance Index: 14.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5806
    Cell Significance Index: 8.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5735
    Cell Significance Index: 78.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5731
    Cell Significance Index: 62.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4894
    Cell Significance Index: 10.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3984
    Cell Significance Index: 64.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3385
    Cell Significance Index: 23.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2456
    Cell Significance Index: 5.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2145
    Cell Significance Index: 40.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2131
    Cell Significance Index: 6.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1937
    Cell Significance Index: 38.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1583
    Cell Significance Index: 18.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1460
    Cell Significance Index: 3.9800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1344
    Cell Significance Index: 2.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1181
    Cell Significance Index: 1.7800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1058
    Cell Significance Index: 0.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0805
    Cell Significance Index: 2.8300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0688
    Cell Significance Index: 0.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0585
    Cell Significance Index: 44.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0576
    Cell Significance Index: 7.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0263
    Cell Significance Index: 4.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0196
    Cell Significance Index: 0.4900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0139
    Cell Significance Index: 0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0139
    Cell Significance Index: 1.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0090
    Cell Significance Index: 0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0026
    Cell Significance Index: 1.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0022
    Cell Significance Index: 0.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0006
    Cell Significance Index: 0.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0020
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -20.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0110
    Cell Significance Index: -16.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0118
    Cell Significance Index: -7.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0163
    Cell Significance Index: -22.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0289
    Cell Significance Index: -1.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0309
    Cell Significance Index: -1.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0320
    Cell Significance Index: -3.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0370
    Cell Significance Index: -7.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0431
    Cell Significance Index: -19.5600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0434
    Cell Significance Index: -0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0470
    Cell Significance Index: -16.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0507
    Cell Significance Index: -14.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0582
    Cell Significance Index: -8.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0647
    Cell Significance Index: -8.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0748
    Cell Significance Index: -15.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0956
    Cell Significance Index: -10.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1048
    Cell Significance Index: -1.4300
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.1061
    Cell Significance Index: -0.9000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1248
    Cell Significance Index: -0.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1425
    Cell Significance Index: -7.2000
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.1501
    Cell Significance Index: -0.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1571
    Cell Significance Index: -4.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1872
    Cell Significance Index: -19.5000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1953
    Cell Significance Index: -2.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2044
    Cell Significance Index: -16.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2324
    Cell Significance Index: -17.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2461
    Cell Significance Index: -18.3400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2509
    Cell Significance Index: -0.9500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2628
    Cell Significance Index: -4.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2732
    Cell Significance Index: -8.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2842
    Cell Significance Index: -17.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2972
    Cell Significance Index: -13.9700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3343
    Cell Significance Index: -2.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3354
    Cell Significance Index: -18.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3505
    Cell Significance Index: -9.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3541
    Cell Significance Index: -21.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3670
    Cell Significance Index: -19.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3965
    Cell Significance Index: -6.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4193
    Cell Significance Index: -17.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4247
    Cell Significance Index: -8.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4303
    Cell Significance Index: -11.5300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4310
    Cell Significance Index: -5.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4360
    Cell Significance Index: -8.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4530
    Cell Significance Index: -16.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4604
    Cell Significance Index: -4.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4721
    Cell Significance Index: -6.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4780
    Cell Significance Index: -14.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4910
    Cell Significance Index: -9.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4915
    Cell Significance Index: -21.7400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4926
    Cell Significance Index: -6.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CFI is a serine protease that inhibits the activation of the classical pathway of complement, which is initiated by the binding of C1q to antigens. CFI achieves this by binding to C1q and inhibiting the formation of C1r and C1s, the enzymes responsible for the activation of the classical pathway. This inhibition prevents the amplification of the complement cascade, thereby preventing excessive activation and tissue damage. CFI is also involved in the regulation of proteolysis, as it inhibits the activity of serine proteases. **Pathways and Functions** The complement system is a complex network of proteins that work together to eliminate pathogens from the body. The classical pathway is one of the three main pathways of complement activation, and it is initiated by the binding of C1q to antigens. CFI plays a crucial role in regulating this pathway, preventing excessive activation and subsequent tissue damage. The pathways and functions of CFI include: * Regulation of the classical pathway of complement activation * Inhibition of serine proteases * Maintenance of immune homeostasis * Regulation of proteolysis **Clinical Significance** Dysregulation of the complement system has been implicated in various diseases, including autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). CFI has been shown to be involved in the pathogenesis of these diseases, as impaired CFI function can lead to excessive activation of the classical pathway and subsequent tissue damage. Additionally, CFI has been implicated in the regulation of inflammation, and its dysregulation has been linked to various inflammatory disorders. Furthermore, CFI has been shown to have a role in the regulation of angiogenesis, and its dysregulation has been linked to various angiogenic disorders, such as cancer. In addition, CFI has been implicated in the regulation of the innate immune response, and its dysregulation has been linked to various infectious diseases. In conclusion, CFI is a critical gene that plays a vital role in the regulation of the complement system and the maintenance of immune homeostasis. Its dysregulation has been implicated in various diseases, including autoimmune disorders, inflammatory disorders, and angiogenic disorders. Further research is needed to fully understand the role of CFI in human disease and to develop therapeutic strategies to modulate its activity.

Genular Protein ID: 2818594775

Symbol: CFAI_HUMAN

Name: Complement factor I

UniProtKB Accession Codes:

P05156 O60442

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 3 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MEROPS 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2954545

Title: Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones.

PubMed ID: 2954545

DOI: 10.1042/bj2420849

PubMed ID: 2956252

Title: Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4.

PubMed ID: 2956252

DOI: 10.1016/s0021-9258(18)61076-2

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 9479036

Title: Cloning and characterization of the promoter for the human complement factor I (C3b/C4b inactivator) gene.

PubMed ID: 9479036

DOI: 10.1016/s0378-1119(97)00632-x

PubMed ID: 6444659

Title: Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes.

PubMed ID: 6444659

DOI: 10.1084/jem.151.3.501

PubMed ID: 7360115

Title: The physiological breakdown of the third component of human complement.

PubMed ID: 7360115

DOI: 10.1016/0161-5890(80)90119-4

PubMed ID: 6327681

Title: Biosynthesis and postsynthetic processing of human C3b/C4b inactivator (factor I) in three hepatoma cell lines.

PubMed ID: 6327681

DOI: 10.1016/s0021-9258(20)82168-1

PubMed ID: 2141838

Title: Regulation of proteolytic activity of complement factor I by pH: C3b/C4b receptor (CR1) and membrane cofactor protein (MCP) have different pH optima for factor I-mediated cleavage of C3b.

PubMed ID: 2141838

DOI: 10.1093/oxfordjournals.jbchem.a123044

PubMed ID: 7672128

Title: Beta-sheet secondary structure of an LDL receptor domain from complement factor I by consensus structure predictions and spectroscopy.

PubMed ID: 7672128

DOI: 10.1016/0014-5793(95)00916-w

PubMed ID: 9291131

Title: Interactions between human complement components factor H, factor I and C3b.

PubMed ID: 9291131

DOI: 10.1042/bj3260553

PubMed ID: 9605165

Title: Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway.

PubMed ID: 9605165

PubMed ID: 12055245

Title: Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells.

PubMed ID: 12055245

DOI: 10.4049/jimmunol.168.12.6298

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17320177

Title: Human keratinocytes produce the complement inhibitor factor I: Synthesis is regulated by interferon-gamma.

PubMed ID: 17320177

DOI: 10.1016/j.molimm.2007.01.007

PubMed ID: 18544012

Title: Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b.

PubMed ID: 18544012

DOI: 10.1086/588825

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 21768352

Title: Structural basis for complement factor I control and its disease-associated sequence polymorphisms.

PubMed ID: 21768352

DOI: 10.1073/pnas.1102167108

PubMed ID: 28671664

Title: Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.

PubMed ID: 28671664

DOI: 10.1038/nsmb.3427

PubMed ID: 8613545

Title: The molecular basis of hereditary complement factor I deficiency.

PubMed ID: 8613545

DOI: 10.1172/jci118515

PubMed ID: 12562389

Title: Molecular characterization of homozygous hereditary factor I deficiency.

PubMed ID: 12562389

DOI: 10.1046/j.1365-2249.2003.02077.x

PubMed ID: 15173250

Title: Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome.

PubMed ID: 15173250

DOI: 10.1136/jmg.2004.019083

PubMed ID: 16621965

Title: Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.

PubMed ID: 16621965

DOI: 10.1182/blood-2005-10-007252

PubMed ID: 17018561

Title: Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome.

PubMed ID: 17018561

DOI: 10.1136/jmg.2006.045328

PubMed ID: 17106690

Title: A missense mutation in factor I (IF) predisposes to atypical haemolytic uraemic syndrome.

PubMed ID: 17106690

DOI: 10.1007/s00467-006-0320-2

PubMed ID: 20513133

Title: Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.

PubMed ID: 20513133

DOI: 10.1002/humu.21256

PubMed ID: 23685748

Title: A functional variant in the CFI gene confers a high risk of age-related macular degeneration.

PubMed ID: 23685748

DOI: 10.1038/ng.2640

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 583
  • Mass: 65750
  • Checksum: F06070EFE6B572A1
  • Sequence:
    • MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP WQRCIEGTCV 
CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF LNNGTCTAEG KFSVSLKHGN 
TDSEGIVEVK LVDQDKTMFI CKSSWSMREA NVACLDLGFQ QGADTQRRFK LSDLSINSTE 
CLHVHCRGLE TSLAECTFTK RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA 
CDGINDCGDQ SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAGFASVT 
QEETEILTAD MDAERRRIKS LLPKLSCGVK NRMHIRRKRI VGGKRAQLGD LPWQVAIKDA 
SGITCGGIYI GGCWILTAAH CLRASKTHRY QIWTTVVDWI HPDLKRIVIE YVDRIIFHEN 
YNAGTYQNDI ALIEMKKDGN KKDCELPRSI PACVPWSPYL FQPNDTCIVS GWGREKDNER 
VFSLQWGEVK LISNCSKFYG NRFYEKEMEC AGTYDGSIDA CKGDSGGPLV CMDANNVTYV 
WGVVSWGENC GKPEFPGVYT KVANYFDWIS YHVGRPFISQ YNV

Genular Protein ID: 1790138657

Symbol: A8K3L0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3L0

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 4 InterPro 18 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 Pfam 5 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 1 SMART 4 SUPFAM 4

Sequence Information:

  • Length: 583
  • Mass: 65721
  • Checksum: 343FF30388AAE69F
  • Sequence:
    • MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP WQRCIEGTCV 
CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF LNNGTCTAEG KFSVSLKHGN 
TDSEGIVEVE LVDQDKTMFI CKSSWSMREA NVACLDLGFQ QGADTQRRFK LSDLSINSTE 
CLHVHCRGLE TSLAECTFTK RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA 
CDGINDCGDQ SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAGFASVA 
QEETEILTAD MDAERRRIKS LLPKLSCGVK NRMHIRRKRI VGGKRAQLGD LPWQVAIKDA 
SGITCGGIYI GGCWILTAAH CLRASKTHRY QIWTTVVDWI HPDLKRIVIE YVDRIIFHEN 
YNAGTYQNDI ALIEMKKDGN KKDCELPRSI PACVPWSPYL FQPNDTCIVS GWGREKDNER 
VFSLQWGEVK LISNCSKFYG NRFYEKEMEC AGTYDGSIDA CKGDSGGPLV CMDANNVTYV 
WGVVSWGENC GKPEFPGVYT KVANYFDWIS YHVGRPFISQ YNV

Genular Protein ID: 3308021736

Symbol: Q8WW88_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WW88

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 3 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 377
  • Mass: 42432
  • Checksum: D5B65AFBEEE9B86C
  • Sequence:
    • MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP WQRCIEGTCV 
CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF LNNGTCTAEG KFSVSLKHGN 
TDSEGIVEVK LVDQDKTMFI CKSSWSMREA NVACLDLGFQ QGADTQRRFK LSDLSINSTE 
CLHVHCRGLE TSLAECTFTK RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA 
CDGINDCGDQ SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAGFASVA 
QEETEILTAD MDAERRRIKS LLPKLSCGVK NRMHIRRKRI VGGKRAQLGK MKQISLDIFK 
GLHRVYAILE FCCIILK

Genular Protein ID: 2845088494

Symbol: G3XAM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3XAM2

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 3 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 18 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 576
  • Mass: 65060
  • Checksum: AB001AED6C1BF94A
  • Sequence:
    • MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP WQRCIEGTCV 
CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF LNNGTCTAEG KFSVSLKHGN 
TDSEGIVEVK LVDQDKTMFI CKSSWSMREA NVACLDLGFQ QGADTQRRFK LSDLSINSTE 
CLHVHCRGLE TSLAECTFTK RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA 
CDGINDCGDQ SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAEETEIL 
TADMDAERRR IKSLLPKLSC GVKNRMHIRR KRIVGGKRAQ LGDLPWQVAI KDASGITCGG 
IYIGGCWILT AAHCLRASKT HRYQIWTTVV DWIHPDLKRI VIEYVDRIIF HENYNAGTYQ 
NDIALIEMKK DGNKKDCELP RSIPACVPWS PYLFQPNDTC IVSGWGREKD NERVFSLQWG 
EVKLISNCSK FYGNRFYEKE MECAGTYDGS IDACKGDSGG PLVCMDANNV TYVWGVVSWG 
ENCGKPEFPG VYTKVANYFD WISYHVGRPF ISQYNV

Genular Protein ID: 1809831614

Symbol: B4DRF2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRF2

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 4 InterPro 18 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 Pfam 5 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 4

Sequence Information:

  • Length: 591
  • Mass: 66695
  • Checksum: CA49C95543EE7085
  • Sequence:
    • MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP WQRCIEGTCV 
CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF LNNGTCTAEG KFSVSLKHGN 
TDSEEIVEVK LVDQDKTMFI CKSSWSMREA NVACLDLGFQ QGADTQRRFK LSDLSINSTE 
CLHVHCRGLE TSLAECTFTK RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA 
CDGINDCGDQ SDELCCKACQ GRGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAAARHPT 
IQGFASVAQE ETEILTADMD AERRRIKSLL PKLSCGVKNR MHIRRKRIVG GKRAQLGDLP 
WQVAIKDASG ITCGGIYIGG CWILTAAHCL RASKTHRYQI WTTVVDWIHP DLKRIVIEYV 
DRIIFHENYN AGTYQNDIAL IEMKKDGNKK DCELPRSIPA CVPWSPYLFQ PNDTCIVSGW 
GREKDNERVF SLQWGEVKLI SNCSKFYGNR FYEKEMECAG TYDGSIDACK GDSGGPLVCM 
DANNVTYVWG VVSWGENCGK PEFPGVYTKV ANYFDWISYH VGRPFISQYN V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.