Details for: IFI35

Gene ID: 3430

Symbol: IFI35

Ensembl ID: ENSG00000068079

Description: interferon induced protein 35

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.0914
    Cell Significance Index: -16.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.4689
    Cell Significance Index: -24.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.4514
    Cell Significance Index: -20.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.1048
    Cell Significance Index: -21.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.0040
    Cell Significance Index: -22.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.0481
    Cell Significance Index: -21.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.3356
    Cell Significance Index: -20.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7159
    Cell Significance Index: -20.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2686
    Cell Significance Index: -20.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8576
    Cell Significance Index: -14.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5276
    Cell Significance Index: -9.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1299
    Cell Significance Index: -6.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5145
    Cell Significance Index: 78.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4764
    Cell Significance Index: 43.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2782
    Cell Significance Index: 23.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0629
    Cell Significance Index: 27.9500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.9234
    Cell Significance Index: 7.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7820
    Cell Significance Index: 10.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7235
    Cell Significance Index: 37.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6798
    Cell Significance Index: 613.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6447
    Cell Significance Index: 9.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6326
    Cell Significance Index: 86.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5162
    Cell Significance Index: 66.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5076
    Cell Significance Index: 32.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4592
    Cell Significance Index: 12.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4137
    Cell Significance Index: 11.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4062
    Cell Significance Index: 18.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4030
    Cell Significance Index: 8.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4007
    Cell Significance Index: 49.2700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3512
    Cell Significance Index: 2.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3360
    Cell Significance Index: 9.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3195
    Cell Significance Index: 3.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2813
    Cell Significance Index: 50.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2358
    Cell Significance Index: 104.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2251
    Cell Significance Index: 22.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2205
    Cell Significance Index: 16.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2004
    Cell Significance Index: 38.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1907
    Cell Significance Index: 22.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1712
    Cell Significance Index: 3.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1480
    Cell Significance Index: 3.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1292
    Cell Significance Index: 25.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1209
    Cell Significance Index: 5.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0948
    Cell Significance Index: 51.7500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0721
    Cell Significance Index: 0.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0720
    Cell Significance Index: 1.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0574
    Cell Significance Index: 39.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0377
    Cell Significance Index: 4.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0247
    Cell Significance Index: 0.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0244
    Cell Significance Index: 0.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0215
    Cell Significance Index: 0.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0073
    Cell Significance Index: 5.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0034
    Cell Significance Index: -0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0075
    Cell Significance Index: -0.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0136
    Cell Significance Index: -18.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0139
    Cell Significance Index: -21.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0180
    Cell Significance Index: -11.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0208
    Cell Significance Index: -15.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0215
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0271
    Cell Significance Index: -20.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0362
    Cell Significance Index: -7.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0390
    Cell Significance Index: -24.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0400
    Cell Significance Index: -18.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0443
    Cell Significance Index: -15.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0494
    Cell Significance Index: -5.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0499
    Cell Significance Index: -2.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0536
    Cell Significance Index: -15.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0650
    Cell Significance Index: -7.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0687
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0709
    Cell Significance Index: -12.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0931
    Cell Significance Index: -13.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1180
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1193
    Cell Significance Index: -25.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1976
    Cell Significance Index: -20.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2315
    Cell Significance Index: -9.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2395
    Cell Significance Index: -18.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2437
    Cell Significance Index: -18.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2700
    Cell Significance Index: -2.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3316
    Cell Significance Index: -22.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3510
    Cell Significance Index: -21.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3535
    Cell Significance Index: -21.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3567
    Cell Significance Index: -22.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3979
    Cell Significance Index: -22.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4108
    Cell Significance Index: -6.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4137
    Cell Significance Index: -3.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4367
    Cell Significance Index: -19.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4615
    Cell Significance Index: -24.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4626
    Cell Significance Index: -13.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4840
    Cell Significance Index: -10.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4964
    Cell Significance Index: -12.7600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4970
    Cell Significance Index: -7.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5004
    Cell Significance Index: -14.7400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5024
    Cell Significance Index: -8.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5126
    Cell Significance Index: -4.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5143
    Cell Significance Index: -8.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5216
    Cell Significance Index: -19.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFI35 is a member of the interferon-induced protein family, which is primarily induced by interferons (IFNs) in response to viral infections and other immune stimuli. It is characterized by its ability to bind to various cellular proteins, including membrane-bound receptors, cytoplasmic signaling molecules, and nuclear components. IFI35 is highly expressed in cells of the innate immune system, including myeloid leukocytes, macrophages, and dendritic cells, where it plays a crucial role in the regulation of immune responses. **Pathways and Functions:** IFI35 is involved in several key pathways that regulate immune responses, including: 1. **Interferon alpha/beta signaling:** IFI35 is induced by IFNs and plays a crucial role in the regulation of interferon signaling pathways, which are essential for the induction of an antiviral state in cells. 2. **Cytokine signaling in the immune system:** IFI35 interacts with various cytokines, including TNF-α, IL-1β, and IL-6, to modulate immune responses and regulate inflammation. 3. **Macrophage activation:** IFI35 is required for the activation of macrophages, which are key players in the innate immune response, and promotes their ability to phagocytose pathogens and produce pro-inflammatory cytokines. 4. **Negative regulation of cell population proliferation:** IFI35 has been shown to inhibit the proliferation of various cell types, including cancer cells, by regulating cell cycle progression and apoptosis. 5. **Regulation of non-canonical NF-κB signaling:** IFI35 interacts with components of the NF-κB signaling pathway, which is essential for the regulation of inflammation and immune responses. **Clinical Significance:** IFI35 has significant clinical implications in various diseases, including: 1. **Viral infections:** IFI35 plays a crucial role in the regulation of immune responses to viral infections, such as influenza and HIV. 2. **Cancer:** IFI35 has been shown to inhibit the proliferation of cancer cells and promote apoptosis, making it a potential therapeutic target for cancer treatment. 3. **Autoimmune diseases:** IFI35 has been implicated in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Infectious diseases:** IFI35 has been shown to regulate the activation of macrophages and the production of pro-inflammatory cytokines, making it a potential therapeutic target for the treatment of infectious diseases. In conclusion, IFI35 is a complex protein that plays a crucial role in the regulation of immune responses, particularly in the innate immune system. Its involvement in various pathways and functions makes it a significant player in the regulation of immune responses and has significant clinical implications in various diseases. Further research is needed to fully elucidate the mechanisms of action of IFI35 and its potential therapeutic applications.

Genular Protein ID: 1233328162

Symbol: IN35_HUMAN

Name: N/A

UniProtKB Accession Codes:

P80217 C9JGX1 Q92984 Q99537 Q9BV98

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8288566

Title: IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution.

PubMed ID: 8288566

DOI: 10.1016/s0021-9258(17)42225-3

PubMed ID: 8954125

Title: IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors.

PubMed ID: 8954125

DOI: 10.1006/bbrc.1996.1799

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8938427

Title: Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.

PubMed ID: 8938427

DOI: 10.1101/gr.6.11.1029

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 10779520

Title: Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35.

PubMed ID: 10779520

DOI: 10.1074/jbc.m003177200

PubMed ID: 10950963

Title: Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35.

PubMed ID: 10950963

DOI: 10.1074/jbc.m006975200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26342464

Title: Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.

PubMed ID: 26342464

DOI: 10.1016/j.virol.2015.08.013

PubMed ID: 29038465

Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.

PubMed ID: 29038465

DOI: 10.1038/s41467-017-00930-9

PubMed ID: 29350881

Title: Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.

PubMed ID: 29350881

DOI: 10.1111/apha.13037

Sequence Information:

  • Length: 286
  • Mass: 31546
  • Checksum: 3FCAB26E97317508
  • Sequence:
    • MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL VFRGHTQQDP 
EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH TINMEECRLR VQVQPLELPM 
VTTIQMSSQL SGRRVLVTGF PASLRLSEEE LLDKLEIFFG KTRNGGGDVD VRELLPGSVM 
LGFARDGVAQ RLCQIGQFTV PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD 
ILDGPELHDV LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.