Details for: IFI35

Gene ID: 3430

Symbol: IFI35

Ensembl ID: ENSG00000068079

Description: interferon induced protein 35

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2
    Marker Score: 2900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.81
    Marker Score: 2182
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.6
    Marker Score: 18587
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.55
    Marker Score: 86521
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.4
    Marker Score: 1925
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.39
    Marker Score: 6652
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.38
    Marker Score: 13633
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.36
    Marker Score: 8690
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.35
    Marker Score: 3726
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.35
    Marker Score: 5804
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.31
    Marker Score: 11458
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.29
    Marker Score: 1711
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.26
    Marker Score: 2455
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.23
    Marker Score: 680
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.2
    Marker Score: 3061
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.16
    Marker Score: 485
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.16
    Marker Score: 1153
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.16
    Marker Score: 29713
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.16
    Marker Score: 404
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.12
    Marker Score: 1124.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.11
    Marker Score: 1128
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.05
    Marker Score: 239
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.03
    Marker Score: 752
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.01
    Marker Score: 1489
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.01
    Marker Score: 227
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71670
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1
    Marker Score: 1535
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47895
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30388
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.98
    Marker Score: 1599
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.96
    Marker Score: 696
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2394
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.93
    Marker Score: 2922
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.92
    Marker Score: 344
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.91
    Marker Score: 941
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2710
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.88
    Marker Score: 2293
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5212
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.86
    Marker Score: 2035
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.86
    Marker Score: 5465
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.85
    Marker Score: 1675
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.85
    Marker Score: 490
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.85
    Marker Score: 732
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.85
    Marker Score: 3469
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.85
    Marker Score: 2659
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.84
    Marker Score: 814
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4699
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.82
    Marker Score: 700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.81
    Marker Score: 426
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.81
    Marker Score: 9104
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.8
    Marker Score: 210
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.8
    Marker Score: 2325
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.79
    Marker Score: 196
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.79
    Marker Score: 881
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.79
    Marker Score: 298
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.78
    Marker Score: 697
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.78
    Marker Score: 1871
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.76
    Marker Score: 193
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.76
    Marker Score: 444
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.75
    Marker Score: 248
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.75
    Marker Score: 523
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.75
    Marker Score: 634
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.74
    Marker Score: 654
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.74
    Marker Score: 345.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.73
    Marker Score: 1180
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.73
    Marker Score: 5439
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.73
    Marker Score: 375
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.73
    Marker Score: 1786.5
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.73
    Marker Score: 251
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.73
    Marker Score: 184
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.72
    Marker Score: 7346
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.72
    Marker Score: 2669
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.72
    Marker Score: 215
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.72
    Marker Score: 1054
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.71
    Marker Score: 680
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.71
    Marker Score: 175
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.71
    Marker Score: 579
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.7
    Marker Score: 1243
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.69
    Marker Score: 620
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.69
    Marker Score: 222
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.69
    Marker Score: 36591
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.69
    Marker Score: 165
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.69
    Marker Score: 666
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.69
    Marker Score: 1095
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 452
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.68
    Marker Score: 1663
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.67
    Marker Score: 1531
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.67
    Marker Score: 135
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.66
    Marker Score: 1513

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Other Information

**Key characteristics:** * IFI35 is a protein that is involved in the regulation of the immune response. * It is a member of the interferon-beta family of proteins. * It is expressed in a variety of cell types, including endothelial cells, myeloid cells, blood cells, and immune cells. * It is known to play a role in the regulation of inflammation and immune responses. **Pathways and functions:** * IFI35 is involved in the regulation of the innate immune response. * It is a key regulator of macrophage activation. * It is involved in the regulation of the activation of dendritic cells. * It is involved in the regulation of the activation of T cells. * It is involved in the regulation of the activation of natural killer cells. **Clinical significance:** * Mutations in the IFI35 gene have been linked to the development of several autoimmune diseases, including lupus and rheumatoid arthritis. * IFI35 is a potential therapeutic target for these diseases. **Additional information:** * IFI35 is a highly conserved protein. * It is expressed in high levels in healthy individuals. * It is expressed in lower levels in individuals with autoimmune diseases. * IFI35 is a key regulator of inflammation and immune responses. * It is a potential therapeutic target for inflammatory diseases.

Genular Protein ID: 1233328162

Symbol: IN35_HUMAN

Name: N/A

UniProtKB Accession Codes:

P80217 C9JGX1 Q92984 Q99537 Q9BV98

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8288566

Title: IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution.

PubMed ID: 8288566

DOI: 10.1016/s0021-9258(17)42225-3

PubMed ID: 8954125

Title: IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors.

PubMed ID: 8954125

DOI: 10.1006/bbrc.1996.1799

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8938427

Title: Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.

PubMed ID: 8938427

DOI: 10.1101/gr.6.11.1029

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 10779520

Title: Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35.

PubMed ID: 10779520

DOI: 10.1074/jbc.m003177200

PubMed ID: 10950963

Title: Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35.

PubMed ID: 10950963

DOI: 10.1074/jbc.m006975200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26342464

Title: Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.

PubMed ID: 26342464

DOI: 10.1016/j.virol.2015.08.013

PubMed ID: 29038465

Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.

PubMed ID: 29038465

DOI: 10.1038/s41467-017-00930-9

PubMed ID: 29350881

Title: Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.

PubMed ID: 29350881

DOI: 10.1111/apha.13037

Sequence Information:

  • Length: 286
  • Mass: 31546
  • Checksum: 3FCAB26E97317508
  • Sequence:
    • MSAPLDAALH ALQEEQARLK MRLWDLQQLR KELGDSPKDK VPFSVPKIPL VFRGHTQQDP 
EVPKSLVSNL RIHCPLLAGS ALITFDDPKV AEQVLQQKEH TINMEECRLR VQVQPLELPM 
VTTIQMSSQL SGRRVLVTGF PASLRLSEEE LLDKLEIFFG KTRNGGGDVD VRELLPGSVM 
LGFARDGVAQ RLCQIGQFTV PLGGQQVPLR VSPYVNGEIQ KAEIRSQPVP RSVLVLNIPD 
ILDGPELHDV LEIHFQKPTR GGGEVEALTV VPQGQQGLAV FTSESG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.