Details for: IFNG

Gene ID: 3458

Symbol: IFNG

Ensembl ID: ENSG00000111537

Description: interferon gamma

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
    (R-HSA-8950505)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Ifng signaling activates mapks
    (R-HSA-9732724)
  • Immune system
    (R-HSA-168256)
  • Interferon gamma signaling
    (R-HSA-877300)
  • Interferon signaling
    (R-HSA-913531)
  • Interleukin-12 family signaling
    (R-HSA-447115)
  • Interleukin-12 signaling
    (R-HSA-9020591)
  • Regulation of ifng signaling
    (R-HSA-877312)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
    (R-HSA-8877330)
  • Signaling by interleukins
    (R-HSA-449147)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • Adaptive immune response
    (GO:0002250)
  • Apoptotic process
    (GO:0006915)
  • Astrocyte activation
    (GO:0048143)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cell surface receptor signaling pathway via jak-stat
    (GO:0007259)
  • Cell surface receptor signaling pathway via stat
    (GO:0097696)
  • Cellular response to virus
    (GO:0098586)
  • Cytokine activity
    (GO:0005125)
  • Defense response to virus
    (GO:0051607)
  • Extracellular region
    (GO:0005576)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Humoral immune response
    (GO:0006959)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Macrophage differentiation
    (GO:0030225)
  • Microglial cell activation
    (GO:0001774)
  • Negative regulation of amyloid-beta clearance
    (GO:1900222)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epithelial cell differentiation
    (GO:0030857)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of tau-protein kinase activity
    (GO:1902948)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuroinflammatory response
    (GO:0150076)
  • Positive regulation of amyloid-beta formation
    (GO:1902004)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of calcidiol 1-monooxygenase activity
    (GO:0060559)
  • Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation involved in immune response
    (GO:0032834)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cellular respiration
    (GO:1901857)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of core promoter binding
    (GO:1904798)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of epithelial cell migration
    (GO:0010634)
  • Positive regulation of exosomal secretion
    (GO:1903543)
  • Positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
    (GO:0060550)
  • Positive regulation of fructose 1,6-bisphosphate metabolic process
    (GO:0060552)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-23 production
    (GO:0032747)
  • Positive regulation of iron ion import across plasma membrane
    (GO:1904440)
  • Positive regulation of killing of cells of another organism
    (GO:0051712)
  • Positive regulation of membrane protein ectodomain proteolysis
    (GO:0051044)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of neurogenesis
    (GO:0050769)
  • Positive regulation of nitric-oxide synthase biosynthetic process
    (GO:0051770)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of nmda glutamate receptor activity
    (GO:1904783)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of peptidyl-serine phosphorylation of stat protein
    (GO:0033141)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of protein deacetylation
    (GO:0090312)
  • Positive regulation of protein import into nucleus
    (GO:0042307)
  • Positive regulation of protein localization to plasma membrane
    (GO:1903078)
  • Positive regulation of protein serine/threonine kinase activity
    (GO:0071902)
  • Positive regulation of signaling receptor activity
    (GO:2000273)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
    (GO:2000309)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of vitamin d biosynthetic process
    (GO:0060557)
  • Protein binding
    (GO:0005515)
  • Regulation of insulin secretion
    (GO:0050796)
  • Regulation of metabolic process
    (GO:0019222)
  • Response to virus
    (GO:0009615)
  • Type iii interferon-mediated signaling pathway
    (GO:0038196)
  • Type ii interferon-mediated signaling pathway
    (GO:0060333)
  • Type ii interferon receptor binding
    (GO:0005133)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.3838
    Cell Significance Index: -11.0400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.7103
    Cell Significance Index: 20.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0930
    Cell Significance Index: -9.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.3890
    Cell Significance Index: 21.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.7578
    Cell Significance Index: -2.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4359
    Cell Significance Index: 11.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4091
    Cell Significance Index: 12.0200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.3544
    Cell Significance Index: 3.6800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.1118
    Cell Significance Index: 1.0900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0584
    Cell Significance Index: 0.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0012
    Cell Significance Index: -0.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0025
    Cell Significance Index: -0.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0046
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0061
    Cell Significance Index: -11.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0084
    Cell Significance Index: -6.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0277
    Cell Significance Index: -12.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0531
    Cell Significance Index: -6.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0594
    Cell Significance Index: -11.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0604
    Cell Significance Index: -11.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0626
    Cell Significance Index: -11.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0784
    Cell Significance Index: -3.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0813
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0818
    Cell Significance Index: -13.9700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0820
    Cell Significance Index: -0.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0845
    Cell Significance Index: -12.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0865
    Cell Significance Index: -11.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0896
    Cell Significance Index: -12.3000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0909
    Cell Significance Index: -1.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0935
    Cell Significance Index: -11.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0946
    Cell Significance Index: -12.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0948
    Cell Significance Index: -9.6800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0963
    Cell Significance Index: -1.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0984
    Cell Significance Index: -11.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1022
    Cell Significance Index: -2.8600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1351
    Cell Significance Index: -1.5100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1587
    Cell Significance Index: -1.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1638
    Cell Significance Index: -12.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1681
    Cell Significance Index: -12.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1923
    Cell Significance Index: -12.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2005
    Cell Significance Index: -12.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2211
    Cell Significance Index: -2.6100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2213
    Cell Significance Index: -2.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2462
    Cell Significance Index: -12.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2574
    Cell Significance Index: -12.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2648
    Cell Significance Index: -3.0100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.2935
    Cell Significance Index: -2.5000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3021
    Cell Significance Index: -2.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3241
    Cell Significance Index: -7.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3299
    Cell Significance Index: -12.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3525
    Cell Significance Index: -13.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3687
    Cell Significance Index: -12.0700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.3700
    Cell Significance Index: -1.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3707
    Cell Significance Index: -9.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3712
    Cell Significance Index: -11.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3865
    Cell Significance Index: -12.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4132
    Cell Significance Index: -12.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4140
    Cell Significance Index: -11.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4148
    Cell Significance Index: -10.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4186
    Cell Significance Index: -12.0000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4358
    Cell Significance Index: -3.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4373
    Cell Significance Index: -11.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4494
    Cell Significance Index: -12.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4531
    Cell Significance Index: -12.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4629
    Cell Significance Index: -11.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4660
    Cell Significance Index: -11.6200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4737
    Cell Significance Index: -12.0700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4764
    Cell Significance Index: -4.0200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4805
    Cell Significance Index: -2.6200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.4907
    Cell Significance Index: -8.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.5007
    Cell Significance Index: -5.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5176
    Cell Significance Index: -12.6300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.5179
    Cell Significance Index: -5.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5231
    Cell Significance Index: -11.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5265
    Cell Significance Index: -7.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5376
    Cell Significance Index: -12.4200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.5483
    Cell Significance Index: -4.4400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5557
    Cell Significance Index: -9.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5707
    Cell Significance Index: -12.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.5770
    Cell Significance Index: -8.4100
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.5792
    Cell Significance Index: -4.7200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5807
    Cell Significance Index: -11.5800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.5815
    Cell Significance Index: -5.4400
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.5898
    Cell Significance Index: -1.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6035
    Cell Significance Index: -11.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6054
    Cell Significance Index: -12.8500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.6059
    Cell Significance Index: -6.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6074
    Cell Significance Index: -7.8600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6079
    Cell Significance Index: -10.4800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.6088
    Cell Significance Index: -7.5300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.6144
    Cell Significance Index: -4.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6166
    Cell Significance Index: -12.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6275
    Cell Significance Index: -10.5700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6419
    Cell Significance Index: -6.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6428
    Cell Significance Index: -11.8800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.6521
    Cell Significance Index: -5.4500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.6540
    Cell Significance Index: -13.6400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.6718
    Cell Significance Index: -7.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6743
    Cell Significance Index: -13.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IFNG is a single-chain polypeptide consisting of 154 amino acids, with a molecular weight of approximately 17 kDa. It is produced by various immune cells, including T cells, macrophages, and natural killer cells, in response to viral infections, bacterial infections, and other inflammatory stimuli. IFNG is characterized by its ability to bind to the interferon gamma receptor (IFN-γR) on the surface of target cells, triggering a signaling cascade that leads to the activation of transcription factors, such as STAT1 and STAT2. **Pathways and Functions** IFNG exerts its effects through the IFN-γR, which is composed of two subunits, IFN-γR1 and IFN-γR2. Upon binding of IFNG to the IFN-γR, the receptor undergoes dimerization, leading to the activation of the JAK-STAT signaling pathway. The activated JAK-STAT pathway phosphorylates and activates transcription factors, such as STAT1 and STAT2, which regulate the expression of genes involved in immune responses. IFNG regulates various immune responses, including: 1. **Activation of immune cells**: IFNG activates immune cells, such as T cells, macrophages, and natural killer cells, enhancing their ability to recognize and eliminate pathogens. 2. **Antigen presentation**: IFNG regulates the expression of major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells (APCs), which is essential for the activation of T cells. 3. **Regulation of immune responses**: IFNG regulates the expression of cytokines, chemokines, and other immune-related genes, modulating the intensity and duration of immune responses. 4. **Cytotoxicity**: IFNG induces the production of reactive oxygen species (ROS) and nitric oxide (NO) by macrophages and other immune cells, which are essential for the elimination of pathogens. **Clinical Significance** IFNG plays a crucial role in the immune response to viral infections, bacterial infections, and other inflammatory stimuli. Dysregulation of IFNG signaling has been implicated in various diseases, including: 1. **Autoimmune diseases**: IFNG dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: IFNG has been shown to have antitumor effects, and its dysregulation has been implicated in various types of cancer. 3. **Viral infections**: IFNG plays a crucial role in the immune response to viral infections, such as HIV and herpes simplex virus. 4. **Inflammatory disorders**: IFNG dysregulation has been implicated in inflammatory disorders, such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, IFNG is a critical cytokine that plays a pivotal role in the adaptive immune response, particularly in the activation of immune cells, enhancement of antigen presentation, and regulation of immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of IFNG signaling in the immune response.

Genular Protein ID: 4163287280

Symbol: IFNG_HUMAN

Name: Interferon gamma

UniProtKB Accession Codes:

P01579 B5BU88 Q53ZV4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 72 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6180322

Title: Structure of the human immune interferon gene.

PubMed ID: 6180322

DOI: 10.1038/298859a0

PubMed ID: 6173769

Title: Expression of human immune interferon cDNA in E. coli and monkey cells.

PubMed ID: 6173769

DOI: 10.1038/295503a0

PubMed ID: 2860101

Title: Cloning and expression of a novel variant of human interferon-gamma cDNA.

PubMed ID: 2860101

DOI: 10.1093/oxfordjournals.jbchem.a135039

PubMed ID: 6329718

Title: Cloning and structure of the human immune interferon-gamma chromosomal gene.

PubMed ID: 6329718

DOI: 10.1002/j.1460-2075.1982.tb01277.x

PubMed ID: 6176945

Title: Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.

PubMed ID: 6176945

DOI: 10.1093/nar/10.8.2487

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6427223

Title: Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation.

PubMed ID: 6427223

DOI: 10.1016/s0021-9258(17)39797-1

PubMed ID: 3109913

Title: Structural characterization of human interferon gamma. Heterogeneity of the carboxyl terminus.

PubMed ID: 3109913

DOI: 10.1111/j.1432-1033.1987.tb13494.x

PubMed ID: 2504704

Title: Studies on the sugar chains of interferon-gamma from human peripheral-blood lymphocytes.

PubMed ID: 2504704

DOI: 10.1093/oxfordjournals.jbchem.a122762

PubMed ID: 8349687

Title: Interferon-gamma induces receptor dimerization in solution and on cells.

PubMed ID: 8349687

DOI: 10.1016/s0021-9258(17)46817-7

PubMed ID: 8163024

Title: Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing.

PubMed ID: 8163024

DOI: 10.1016/0014-5793(94)80612-8

PubMed ID: 7729559

Title: Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages.

PubMed ID: 7729559

DOI: 10.1016/0014-5793(95)00287-j

PubMed ID: 8666937

Title: Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.

PubMed ID: 8666937

DOI: 10.1084/jem.183.4.1807

PubMed ID: 9643557

Title: The regulation and biological activity of interleukin 12.

PubMed ID: 9643557

DOI: 10.3109/10428199809050903

PubMed ID: 11112687

Title: Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies.

PubMed ID: 11112687

DOI: 10.1242/jcs.114.1.29

PubMed ID: 16914093

Title: Arsenic enhances the apoptosis induced by interferon gamma: key role of IRF-1.

PubMed ID: 16914093

PubMed ID: 32163377

Title: Inherited human IFN-gamma deficiency underlies mycobacterial disease.

PubMed ID: 32163377

DOI: 10.1172/jci135460

PubMed ID: 1902591

Title: Three-dimensional structure of recombinant human interferon-gamma.

PubMed ID: 1902591

DOI: 10.1126/science.1902591

PubMed ID: 7617032

Title: Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

PubMed ID: 7617032

DOI: 10.1038/376230a0

PubMed ID: 10860730

Title: Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma.

PubMed ID: 10860730

DOI: 10.1006/jmbi.2000.3734

PubMed ID: 10986460

Title: Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.

PubMed ID: 10986460

DOI: 10.1016/s0969-2126(00)00184-2

PubMed ID: 1525157

Title: 1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma.

PubMed ID: 1525157

DOI: 10.1021/bi00150a009

PubMed ID: 15327519

Title: Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population.

PubMed ID: 15327519

DOI: 10.1111/j.1365-2141.2004.05102.x

Sequence Information:

  • Length: 166
  • Mass: 19348
  • Checksum: 1514E8F785FD81AA
  • Sequence:
    • MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GHSDVADNGT LFLGILKNWK 
EESDRKIMQS QIVSFYFKLF KNFKDDQSIQ KSVETIKEDM NVKFFNSNKK KRDDFEKLTN 
YSVTDLNVQR KAIHELIQVM AELSPAAKTG KRKRSQMLFR GRRASQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.