Details for: IFNG

Gene ID: 3458

Symbol: IFNG

Ensembl ID: ENSG00000111537

Description: interferon gamma

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
    (R-HSA-8950505)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Ifng signaling activates mapks
    (R-HSA-9732724)
  • Immune system
    (R-HSA-168256)
  • Interferon gamma signaling
    (R-HSA-877300)
  • Interferon signaling
    (R-HSA-913531)
  • Interleukin-12 family signaling
    (R-HSA-447115)
  • Interleukin-12 signaling
    (R-HSA-9020591)
  • Regulation of ifng signaling
    (R-HSA-877312)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
    (R-HSA-8877330)
  • Signaling by interleukins
    (R-HSA-449147)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • Adaptive immune response
    (GO:0002250)
  • Apoptotic process
    (GO:0006915)
  • Astrocyte activation
    (GO:0048143)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to virus
    (GO:0098586)
  • Cytokine activity
    (GO:0005125)
  • Defense response to virus
    (GO:0051607)
  • Extracellular region
    (GO:0005576)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Humoral immune response
    (GO:0006959)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Macrophage differentiation
    (GO:0030225)
  • Microglial cell activation
    (GO:0001774)
  • Negative regulation of amyloid-beta clearance
    (GO:1900222)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epithelial cell differentiation
    (GO:0030857)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of tau-protein kinase activity
    (GO:1902948)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuroinflammatory response
    (GO:0150076)
  • Positive regulation of amyloid-beta formation
    (GO:1902004)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of calcidiol 1-monooxygenase activity
    (GO:0060559)
  • Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation involved in immune response
    (GO:0032834)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cellular respiration
    (GO:1901857)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of core promoter binding
    (GO:1904798)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of epithelial cell migration
    (GO:0010634)
  • Positive regulation of exosomal secretion
    (GO:1903543)
  • Positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
    (GO:0060550)
  • Positive regulation of fructose 1,6-bisphosphate metabolic process
    (GO:0060552)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-23 production
    (GO:0032747)
  • Positive regulation of iron ion import across plasma membrane
    (GO:1904440)
  • Positive regulation of killing of cells of another organism
    (GO:0051712)
  • Positive regulation of membrane protein ectodomain proteolysis
    (GO:0051044)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of neurogenesis
    (GO:0050769)
  • Positive regulation of nitric-oxide synthase biosynthetic process
    (GO:0051770)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of nitrogen compound metabolic process
    (GO:0051173)
  • Positive regulation of nmda glutamate receptor activity
    (GO:1904783)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of peptidyl-serine phosphorylation of stat protein
    (GO:0033141)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of protein deacetylation
    (GO:0090312)
  • Positive regulation of protein import into nucleus
    (GO:0042307)
  • Positive regulation of protein localization to plasma membrane
    (GO:1903078)
  • Positive regulation of protein serine/threonine kinase activity
    (GO:0071902)
  • Positive regulation of signaling receptor activity
    (GO:2000273)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
    (GO:2000309)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of vitamin d biosynthetic process
    (GO:0060557)
  • Protein binding
    (GO:0005515)
  • Receptor signaling pathway via jak-stat
    (GO:0007259)
  • Regulation of insulin secretion
    (GO:0050796)
  • Response to virus
    (GO:0009615)
  • Type iii interferon-mediated signaling pathway
    (GO:0038196)
  • Type ii interferon-mediated signaling pathway
    (GO:0060333)
  • Type ii interferon receptor binding
    (GO:0005133)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.8
    Marker Score: 772
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.79
    Marker Score: 5029
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.69
    Marker Score: 4934
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.23
    Marker Score: 1811
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.2
    Marker Score: 692
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.19
    Marker Score: 1002
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.19
    Marker Score: 1041
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.1
    Marker Score: 802
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7264
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.09
    Marker Score: 790
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1
    Marker Score: 9884
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2432
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5299
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.92
    Marker Score: 1491
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.67
    Marker Score: 209
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.66
    Marker Score: 1482
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.63
    Marker Score: 823
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 373
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.61
    Marker Score: 842
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.61
    Marker Score: 263
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.6
    Marker Score: 404
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.58
    Marker Score: 1841
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.57
    Marker Score: 449
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.57
    Marker Score: 293
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.51
    Marker Score: 454
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.49
    Marker Score: 1204
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.48
    Marker Score: 406
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 197
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.47
    Marker Score: 287
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.46
    Marker Score: 261
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.44
    Marker Score: 2831
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.43
    Marker Score: 141
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.42
    Marker Score: 472
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.42
    Marker Score: 96
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.42
    Marker Score: 344
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.42
    Marker Score: 245
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.42
    Marker Score: 146
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.41
    Marker Score: 297
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.39
    Marker Score: 743
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.38
    Marker Score: 190
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 208
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.34
    Marker Score: 262
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.32
    Marker Score: 149
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.31
    Marker Score: 171
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.3
    Marker Score: 173
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.3
    Marker Score: 217
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.29
    Marker Score: 74
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.29
    Marker Score: 794
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.27
    Marker Score: 180
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.27
    Marker Score: 552
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.26
    Marker Score: 117
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.25
    Marker Score: 398
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.24
    Marker Score: 264
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 487
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.23
    Marker Score: 71
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.23
    Marker Score: 213
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.22
    Marker Score: 167
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.22
    Marker Score: 3436.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.21
    Marker Score: 206
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.21
    Marker Score: 198
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.2
    Marker Score: 124
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.2
    Marker Score: 110
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.19
    Marker Score: 253
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 181
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.19
    Marker Score: 370
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.19
    Marker Score: 37
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 118
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.17
    Marker Score: 176
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.17
    Marker Score: 185
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 182
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.16
    Marker Score: 111
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.16
    Marker Score: 134
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.16
    Marker Score: 40.5
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.16
    Marker Score: 150
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.15
    Marker Score: 40

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Other Information

**Key characteristics:** * IFNG is a cytokine that is produced and secreted by immune cells. * It is a potent activator of the Jak/STAT signaling pathway. * It plays a role in the regulation of inflammation and immune responses. **Pathways and functions:** * IFNG binds to its receptor, IFNAR1, on immune cells. * Binding of IFNG to IFNAR1 triggers the Jak/STAT signaling pathway. * This pathway phosphorylates STAT1 and STAT3 proteins, which are key regulators of gene expression. * Phosphorylation of STAT1 and STAT3 leads to the expression of a variety of target genes, including those involved in immune regulation, cell growth, and differentiation. **Clinical significance:** * Mutations in the IFNG gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, lupus, and psoriasis. * IFNG is a potential therapeutic target for these diseases. **Other relevant information:** * IFNG is a highly conserved cytokine that is expressed in humans, mice, and other animals. * It is a potent cytokine that can have both pro- and anti-inflammatory effects depending on the context. * It is a key cytokine in the regulation of innate and adaptive immune responses.

Genular Protein ID: 4163287280

Symbol: IFNG_HUMAN

Name: Interferon gamma

UniProtKB Accession Codes:

P01579 B5BU88 Q53ZV4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 72 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6180322

Title: Structure of the human immune interferon gene.

PubMed ID: 6180322

DOI: 10.1038/298859a0

PubMed ID: 6173769

Title: Expression of human immune interferon cDNA in E. coli and monkey cells.

PubMed ID: 6173769

DOI: 10.1038/295503a0

PubMed ID: 2860101

Title: Cloning and expression of a novel variant of human interferon-gamma cDNA.

PubMed ID: 2860101

DOI: 10.1093/oxfordjournals.jbchem.a135039

PubMed ID: 6329718

Title: Cloning and structure of the human immune interferon-gamma chromosomal gene.

PubMed ID: 6329718

DOI: 10.1002/j.1460-2075.1982.tb01277.x

PubMed ID: 6176945

Title: Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.

PubMed ID: 6176945

DOI: 10.1093/nar/10.8.2487

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6427223

Title: Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation.

PubMed ID: 6427223

DOI: 10.1016/s0021-9258(17)39797-1

PubMed ID: 3109913

Title: Structural characterization of human interferon gamma. Heterogeneity of the carboxyl terminus.

PubMed ID: 3109913

DOI: 10.1111/j.1432-1033.1987.tb13494.x

PubMed ID: 2504704

Title: Studies on the sugar chains of interferon-gamma from human peripheral-blood lymphocytes.

PubMed ID: 2504704

DOI: 10.1093/oxfordjournals.jbchem.a122762

PubMed ID: 8349687

Title: Interferon-gamma induces receptor dimerization in solution and on cells.

PubMed ID: 8349687

DOI: 10.1016/s0021-9258(17)46817-7

PubMed ID: 8163024

Title: Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing.

PubMed ID: 8163024

DOI: 10.1016/0014-5793(94)80612-8

PubMed ID: 7729559

Title: Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages.

PubMed ID: 7729559

DOI: 10.1016/0014-5793(95)00287-j

PubMed ID: 8666937

Title: Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.

PubMed ID: 8666937

DOI: 10.1084/jem.183.4.1807

PubMed ID: 9643557

Title: The regulation and biological activity of interleukin 12.

PubMed ID: 9643557

DOI: 10.3109/10428199809050903

PubMed ID: 11112687

Title: Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies.

PubMed ID: 11112687

DOI: 10.1242/jcs.114.1.29

PubMed ID: 16914093

Title: Arsenic enhances the apoptosis induced by interferon gamma: key role of IRF-1.

PubMed ID: 16914093

PubMed ID: 32163377

Title: Inherited human IFN-gamma deficiency underlies mycobacterial disease.

PubMed ID: 32163377

DOI: 10.1172/jci135460

PubMed ID: 1902591

Title: Three-dimensional structure of recombinant human interferon-gamma.

PubMed ID: 1902591

DOI: 10.1126/science.1902591

PubMed ID: 7617032

Title: Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

PubMed ID: 7617032

DOI: 10.1038/376230a0

PubMed ID: 10860730

Title: Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma.

PubMed ID: 10860730

DOI: 10.1006/jmbi.2000.3734

PubMed ID: 10986460

Title: Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.

PubMed ID: 10986460

DOI: 10.1016/s0969-2126(00)00184-2

PubMed ID: 1525157

Title: 1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma.

PubMed ID: 1525157

DOI: 10.1021/bi00150a009

PubMed ID: 15327519

Title: Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population.

PubMed ID: 15327519

DOI: 10.1111/j.1365-2141.2004.05102.x

Sequence Information:

  • Length: 166
  • Mass: 19348
  • Checksum: 1514E8F785FD81AA
  • Sequence:
    • MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GHSDVADNGT LFLGILKNWK 
EESDRKIMQS QIVSFYFKLF KNFKDDQSIQ KSVETIKEDM NVKFFNSNKK KRDDFEKLTN 
YSVTDLNVQR KAIHELIQVM AELSPAAKTG KRKRSQMLFR GRRASQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.