Details for: IFRD1

Gene ID: 3475

Symbol: IFRD1

Ensembl ID: ENSG00000006652

Description: interferon related developmental regulator 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.26
    Marker Score: 111041
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.27
    Marker Score: 11140.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.13
    Marker Score: 5982
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.98
    Marker Score: 492
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.84
    Marker Score: 5090
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.82
    Marker Score: 1812
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8
    Marker Score: 2658
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.8
    Marker Score: 1532
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.74
    Marker Score: 1319.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.72
    Marker Score: 702
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.7
    Marker Score: 3008
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.69
    Marker Score: 4127.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.69
    Marker Score: 1058
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.69
    Marker Score: 5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.68
    Marker Score: 483
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.67
    Marker Score: 1784
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.66
    Marker Score: 912
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.64
    Marker Score: 7886
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.64
    Marker Score: 1175
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.63
    Marker Score: 3312
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.63
    Marker Score: 1711
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.62
    Marker Score: 34643
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.61
    Marker Score: 1942
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.6
    Marker Score: 1312
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.59
    Marker Score: 538
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.58
    Marker Score: 35410
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.56
    Marker Score: 358
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.55
    Marker Score: 1459.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.53
    Marker Score: 641
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.53
    Marker Score: 3231
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.53
    Marker Score: 1206
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.53
    Marker Score: 532
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.52
    Marker Score: 740
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.52
    Marker Score: 5860
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.51
    Marker Score: 552
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.51
    Marker Score: 361
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.5
    Marker Score: 534
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.5
    Marker Score: 5542
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.49
    Marker Score: 1625
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.49
    Marker Score: 677
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.49
    Marker Score: 866
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.49
    Marker Score: 366
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.47
    Marker Score: 614
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.47
    Marker Score: 2945
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.47
    Marker Score: 16528
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.46
    Marker Score: 2111
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.46
    Marker Score: 294
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.45
    Marker Score: 611
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.45
    Marker Score: 359
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.44
    Marker Score: 2705
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.44
    Marker Score: 980
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.44
    Marker Score: 3276
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.43
    Marker Score: 305
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.43
    Marker Score: 3748
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.43
    Marker Score: 1858
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.42
    Marker Score: 2407
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.42
    Marker Score: 781
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.42
    Marker Score: 3216
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.42
    Marker Score: 999.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.41
    Marker Score: 1205
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.41
    Marker Score: 2308
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.41
    Marker Score: 350
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.4
    Marker Score: 1346
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.4
    Marker Score: 1286
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.4
    Marker Score: 569
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.39
    Marker Score: 600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.39
    Marker Score: 892
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.39
    Marker Score: 350
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.38
    Marker Score: 919
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.38
    Marker Score: 772
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.38
    Marker Score: 1161
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.38
    Marker Score: 2123
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.38
    Marker Score: 839
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.38
    Marker Score: 643
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.37
    Marker Score: 2851
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.36
    Marker Score: 624
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.35
    Marker Score: 1867
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.34
    Marker Score: 773
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.34
    Marker Score: 294
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.34
    Marker Score: 13607
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.34
    Marker Score: 8149
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.33
    Marker Score: 5727
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.33
    Marker Score: 515
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.32
    Marker Score: 45780
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.32
    Marker Score: 499
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.32
    Marker Score: 960
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.31
    Marker Score: 493
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.31
    Marker Score: 2222
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.3
    Marker Score: 4613
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.3
    Marker Score: 1157
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.3
    Marker Score: 330
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.29
    Marker Score: 363.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.29
    Marker Score: 1098
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.29
    Marker Score: 3219.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.29
    Marker Score: 635
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.28
    Marker Score: 13255
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.28
    Marker Score: 3128
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.28
    Marker Score: 337
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.28
    Marker Score: 339
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.27
    Marker Score: 440

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * The protein is a type I transmembrane receptor for interferons. * It is a key regulator of muscle cell differentiation and survival. * It is also involved in the regulation of myoblast fate determination, axon extension, collateral sprouting, and skeletal muscle tissue regeneration. **Pathways and functions** * The protein binds to interferons, which are secreted proteins that are produced by infected cells. * When IFRD1 binds to an interferon, it recruits the adaptor protein IRF7 to the cell surface. * This complex then activates the transcription factor STAT3, which promotes the expression of genes involved in muscle cell differentiation, growth, and survival. * In addition, IFRD1 can also bind to other proteins that are involved in muscle development, such as myostatin and myosin heavy chains. * This binding activates the JAK/STAT signaling pathway, which also promotes muscle cell differentiation and growth. **Clinical significance** Mutations in the IFRD1 gene have been linked to a number of human diseases, including basal cell carcinoma, breast cancer, and liver cancer. These mutations can disrupt the normal function of the protein, leading to the development of cancer. **Conclusion** The IFRD1 gene is a key regulator of muscle cell differentiation, fate determination, and the negative regulation of axon extension, collateral sprouting, and skeletal muscle tissue regeneration. Mutations in the IFRD1 gene have been linked to a number of human diseases, highlighting the importance of this protein in human health.

Genular Protein ID: 1768401492

Symbol: IFRD1_HUMAN

Name: Interferon-related developmental regulator 1

UniProtKB Accession Codes:

O00458 B7Z5G1 O75234 Q5U013 Q9BVE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9722946

Title: Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.

PubMed ID: 9722946

DOI: 10.1006/geno.1998.5260

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9822615

Title: Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.

PubMed ID: 9822615

DOI: 10.1093/emboj/17.22.6723

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 451
  • Mass: 50269
  • Checksum: E1A086D34E471709
  • Sequence:
    • MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET MSHCSGYSDP 
SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ AALEGIKNAL ASKMLYEFIL 
ERRMTLTDSI ERCLKKGKSD EQRAAAALAS VLCIQLGPGI ESEEILKTLG PILKKIICDG 
SASMQARQTC ATCFGVCCFI ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL 
HISSLLAWTL LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI 
ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD FPTETIKFGP 
ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE LGPPVMLDAA TLKTMKISRF 
ERHLYNSAAF KARTKARSKC RDKRADVGEF F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.