Details for: IFRD1

Gene ID: 3475

Symbol: IFRD1

Ensembl ID: ENSG00000006652

Description: interferon related developmental regulator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 375.3249
    Cell Significance Index: -58.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 212.5622
    Cell Significance Index: -53.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 142.1783
    Cell Significance Index: -58.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.8347
    Cell Significance Index: -52.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 128.5683
    Cell Significance Index: -60.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 116.6635
    Cell Significance Index: -60.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 90.4888
    Cell Significance Index: -60.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.3971
    Cell Significance Index: -52.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.8176
    Cell Significance Index: -60.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.5722
    Cell Significance Index: -55.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.4560
    Cell Significance Index: -60.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5701
    Cell Significance Index: -41.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2937
    Cell Significance Index: -20.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.5621
    Cell Significance Index: 130.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.2091
    Cell Significance Index: 78.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9433
    Cell Significance Index: 133.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.5543
    Cell Significance Index: 327.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3769
    Cell Significance Index: 111.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.8679
    Cell Significance Index: 537.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7318
    Cell Significance Index: 281.6700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.6290
    Cell Significance Index: 10.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5654
    Cell Significance Index: 42.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2956
    Cell Significance Index: 259.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2885
    Cell Significance Index: 98.8800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.2800
    Cell Significance Index: 7.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2336
    Cell Significance Index: 159.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1310
    Cell Significance Index: 30.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1102
    Cell Significance Index: 38.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0922
    Cell Significance Index: 70.4600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9897
    Cell Significance Index: 10.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9875
    Cell Significance Index: 436.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9317
    Cell Significance Index: 101.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8814
    Cell Significance Index: 65.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8689
    Cell Significance Index: 61.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8351
    Cell Significance Index: 82.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8322
    Cell Significance Index: 454.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8024
    Cell Significance Index: 41.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7671
    Cell Significance Index: 105.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6913
    Cell Significance Index: 118.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6870
    Cell Significance Index: 12.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6617
    Cell Significance Index: 19.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6557
    Cell Significance Index: 30.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6445
    Cell Significance Index: 38.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6249
    Cell Significance Index: 124.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6236
    Cell Significance Index: 32.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.6229
    Cell Significance Index: 9.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5575
    Cell Significance Index: 68.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4413
    Cell Significance Index: 158.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4207
    Cell Significance Index: 29.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3817
    Cell Significance Index: 68.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2723
    Cell Significance Index: 4.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2628
    Cell Significance Index: 17.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2609
    Cell Significance Index: 49.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2270
    Cell Significance Index: 5.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2256
    Cell Significance Index: 26.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1909
    Cell Significance Index: 5.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1668
    Cell Significance Index: 9.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1149
    Cell Significance Index: 2.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1113
    Cell Significance Index: 2.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0614
    Cell Significance Index: 55.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0131
    Cell Significance Index: 0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0086
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0241
    Cell Significance Index: -45.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0267
    Cell Significance Index: -41.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0283
    Cell Significance Index: -2.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0284
    Cell Significance Index: -18.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0293
    Cell Significance Index: -22.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0317
    Cell Significance Index: -19.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0330
    Cell Significance Index: -24.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0388
    Cell Significance Index: -28.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0406
    Cell Significance Index: -55.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0709
    Cell Significance Index: -1.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0800
    Cell Significance Index: -45.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0941
    Cell Significance Index: -2.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1159
    Cell Significance Index: -0.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1301
    Cell Significance Index: -59.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1488
    Cell Significance Index: -16.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1579
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1846
    Cell Significance Index: -38.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2679
    Cell Significance Index: -5.7100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.2821
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2884
    Cell Significance Index: -33.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3034
    Cell Significance Index: -34.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3297
    Cell Significance Index: -3.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3846
    Cell Significance Index: -24.2400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3855
    Cell Significance Index: -6.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3985
    Cell Significance Index: -57.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4102
    Cell Significance Index: -25.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4542
    Cell Significance Index: -23.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4673
    Cell Significance Index: -7.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4763
    Cell Significance Index: -21.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4960
    Cell Significance Index: -9.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5081
    Cell Significance Index: -12.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5255
    Cell Significance Index: -7.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5330
    Cell Significance Index: -17.0700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5362
    Cell Significance Index: -9.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5908
    Cell Significance Index: -61.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6115
    Cell Significance Index: -17.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6282
    Cell Significance Index: -23.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFRD1 is a protein-coding gene that belongs to the interferon-related developmental regulator family. It is characterized by its ability to regulate various cellular processes, including muscle cell differentiation, axon extension, and immune response. The gene is expressed in a wide range of cell types, including fibroblasts, myoepithelial cells, T cells, and natural killer cells. IFRD1's expression is also observed in several types of cancer cells, including bladder urothelial cells and pancreatic cancer cells. **Pathways and Functions:** IFRD1's pathways and functions are multifaceted and involve various cellular processes. The gene's involvement in negative regulation of axon extension and collateral sprouting suggests its potential role in modulating neural development and function. IFRD1's expression in skeletal muscle tissue regeneration and striated muscle development highlights its importance in muscle biology. Additionally, the gene's involvement in muscle cell differentiation and myoblast fate determination suggests its role in regulating muscle development and function. In the context of the immune system, IFRD1's expression in T cells and natural killer cells suggests its potential role in regulating immune responses. The gene's involvement in negative regulation of axon extension and collateral sprouting may also contribute to its immunomodulatory functions. **Clinical Significance:** IFRD1's clinical significance is multifaceted and involves various diseases and disorders. The gene's involvement in skeletal muscle tissue regeneration and striated muscle development suggests its potential role in treating muscle-related disorders, such as muscular dystrophy. IFRD1's expression in cancer cells, including bladder urothelial cells and pancreatic cancer cells, highlights its potential role in cancer therapy. Furthermore, the gene's involvement in immune regulation and development suggests its potential role in treating autoimmune disorders, such as multiple sclerosis. IFRD1's expression in T cells and natural killer cells also suggests its potential role in regulating immune responses and preventing immune-related disorders. In conclusion, IFRD1 is a gene that plays a critical role in regulating various cellular processes, including muscle cell differentiation, axon extension, and immune response. Its clinical significance is multifaceted and involves various diseases and disorders, including muscle-related disorders, cancer, and autoimmune disorders. Further research is needed to fully elucidate IFRD1's role in these processes and its potential therapeutic applications.

Genular Protein ID: 1768401492

Symbol: IFRD1_HUMAN

Name: Interferon-related developmental regulator 1

UniProtKB Accession Codes:

O00458 B7Z5G1 O75234 Q5U013 Q9BVE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 5 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9722946

Title: Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.

PubMed ID: 9722946

DOI: 10.1006/geno.1998.5260

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9822615

Title: Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.

PubMed ID: 9822615

DOI: 10.1093/emboj/17.22.6723

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 451
  • Mass: 50269
  • Checksum: E1A086D34E471709
  • Sequence:
    • MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET MSHCSGYSDP 
SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ AALEGIKNAL ASKMLYEFIL 
ERRMTLTDSI ERCLKKGKSD EQRAAAALAS VLCIQLGPGI ESEEILKTLG PILKKIICDG 
SASMQARQTC ATCFGVCCFI ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL 
HISSLLAWTL LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI 
ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD FPTETIKFGP 
ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE LGPPVMLDAA TLKTMKISRF 
ERHLYNSAAF KARTKARSKC RDKRADVGEF F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.