IGLC2 | ENSG00000211677 | NCBI 3538

Details for: IGLC2

Gene ID: 3538

Symbol: IGLC2

Ensembl ID: ENSG00000211677

Description: immunoglobulin lambda constant 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 59.5857
Cell Significance Index: -30.6500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 50.4530
Cell Significance Index: -23.8200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 36.0271
Cell Significance Index: -24.1800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.6057
Cell Significance Index: -31.0900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.6027
Cell Significance Index: -20.2800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 5.4860
Cell Significance Index: 192.7700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.5924
Cell Significance Index: 103.5100
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.0993
Cell Significance Index: 13.8600
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.9149
Cell Significance Index: 23.7600
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.6147
Cell Significance Index: 18.4000
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 2.3636
Cell Significance Index: 20.3100
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.7673
Cell Significance Index: 17.7200
Cell Name: odontoblast (CL0000060)
Fold Change: 1.5183
Cell Significance Index: 194.6400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7127
Cell Significance Index: 135.6300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.5315
Cell Significance Index: 8.0100
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.4798
Cell Significance Index: 49.0200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4449
Cell Significance Index: 44.0100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3576
Cell Significance Index: 322.8500
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.2770
Cell Significance Index: 3.8300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2080
Cell Significance Index: 33.8300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1963
Cell Significance Index: 2.2300
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1842
Cell Significance Index: 2.8500
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.1819
Cell Significance Index: 0.9100
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.1068
Cell Significance Index: 0.6400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0655
Cell Significance Index: 7.1300
Cell Name: keratocyte (CL0002363)
Fold Change: 0.0104
Cell Significance Index: 0.1600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0039
Cell Significance Index: -0.2000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0121
Cell Significance Index: -22.7800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0127
Cell Significance Index: -9.6500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0389
Cell Significance Index: -24.6800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0410
Cell Significance Index: -18.1200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0554
Cell Significance Index: -31.2300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0660
Cell Significance Index: -29.9500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0742
Cell Significance Index: -3.4600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0771
Cell Significance Index: -5.3300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0794
Cell Significance Index: -10.2600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0808
Cell Significance Index: -5.2100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0964
Cell Significance Index: -19.1400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1040
Cell Significance Index: -2.6000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1224
Cell Significance Index: -22.0600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1237
Cell Significance Index: -9.2200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1534
Cell Significance Index: -22.3100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1554
Cell Significance Index: -9.3300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1560
Cell Significance Index: -5.0000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1630
Cell Significance Index: -7.3900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1660
Cell Significance Index: -20.4100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1841
Cell Significance Index: -31.4400
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -0.1975
Cell Significance Index: -4.1200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2026
Cell Significance Index: -4.3900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2235
Cell Significance Index: -23.2700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2404
Cell Significance Index: -33.0200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2510
Cell Significance Index: -50.3600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2812
Cell Significance Index: -19.8900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2946
Cell Significance Index: -6.2800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3016
Cell Significance Index: -18.4900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3093
Cell Significance Index: -24.5000
Cell Name: peg cell (CL4033014)
Fold Change: -0.3281
Cell Significance Index: -7.5800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3483
Cell Significance Index: -26.7300
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.3713
Cell Significance Index: -3.8500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3801
Cell Significance Index: -43.5500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4064
Cell Significance Index: -8.4300
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4610
Cell Significance Index: -20.0500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4947
Cell Significance Index: -25.7000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5080
Cell Significance Index: -28.5100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5096
Cell Significance Index: -23.9500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5548
Cell Significance Index: -34.1000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5827
Cell Significance Index: -21.3900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6744
Cell Significance Index: -18.0400
Cell Name: plasma cell (CL0000786)
Fold Change: -0.7008
Cell Significance Index: -7.8300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.7012
Cell Significance Index: -10.1800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7379
Cell Significance Index: -46.5100
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.7653
Cell Significance Index: -6.1500
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.7809
Cell Significance Index: -5.2000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8158
Cell Significance Index: -20.8400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8373
Cell Significance Index: -29.1000
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.9600
Cell Significance Index: -23.9400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.9829
Cell Significance Index: -28.1800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.9840
Cell Significance Index: -26.2800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9917
Cell Significance Index: -29.2100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.0296
Cell Significance Index: -24.9400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.0543
Cell Significance Index: -18.6300
Cell Name: leukocyte (CL0000738)
Fold Change: -1.0681
Cell Significance Index: -18.1400
Cell Name: lymphocyte (CL0000542)
Fold Change: -1.0857
Cell Significance Index: -14.7700
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -1.0890
Cell Significance Index: -11.5700
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.1006
Cell Significance Index: -28.9400
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -1.1573
Cell Significance Index: -7.5500
Cell Name: erythrocyte (CL0000232)
Fold Change: -1.1618
Cell Significance Index: -29.6000
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.1632
Cell Significance Index: -23.0000
Cell Name: precursor B cell (CL0000817)
Fold Change: -1.1863
Cell Significance Index: -15.3500
Cell Name: B cell (CL0000236)
Fold Change: -1.2990
Cell Significance Index: -15.3500
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -1.3302
Cell Significance Index: -10.1500
Cell Name: keratinocyte (CL0000312)
Fold Change: -1.3345
Cell Significance Index: -33.3300
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -1.3840
Cell Significance Index: -27.0600
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -1.3871
Cell Significance Index: -11.4500
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.3959
Cell Significance Index: -34.0600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.4063
Cell Significance Index: -23.5400
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -1.4179
Cell Significance Index: -19.9000
Cell Name: enterocyte (CL0000584)
Fold Change: -1.4346
Cell Significance Index: -8.9000
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.4360
Cell Significance Index: -24.1900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.4373
Cell Significance Index: -26.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGLC2 is a member of the immunoglobulin constant family, which is responsible for encoding the variable and constant regions of antibodies. The λ chain is distinct from the κ chain in terms of its structure and function, and IGLC2 is the only gene that encodes the λ chain. The gene is composed of three exons, which are spliced together to form the mature λ chain. IGLC2 is expressed in a variety of cell types, including B cells, T cells, and certain types of neurons. **Pathways and Functions** IGLC2 plays a critical role in the adaptive immune response, particularly in the recognition and binding of antigens. The λ chain is involved in the activation of B cells through the B cell receptor (BCR), which is a complex of the BCR and the immunoglobulin molecule. Upon antigen binding, the BCR triggers a signaling cascade that leads to the activation of B cells and the production of antibodies. IGLC2 is also implicated in various immune-related pathways, including: 1. Complement activation: IGLC2 is involved in the regulation of complement activation, which is a crucial component of the innate immune response. 2. Phagocytosis: The λ chain is involved in the recognition and binding of pathogens by phagocytic cells, such as neutrophils and macrophages. 3. Leishmania infection: IGLC2 is specifically implicated in the response to Leishmania parasites, which are a type of protozoan that causes leishmaniasis. 4. Antigen recognition: IGLC2 is involved in the recognition and binding of antigens by B cells, which is critical for the initiation of the adaptive immune response. **Clinical Significance** IGLC2 has significant clinical implications, particularly in the context of infectious diseases. Mutations in the IGLC2 gene have been associated with impaired antibody production and increased susceptibility to infections. Additionally, IGLC2 is implicated in various autoimmune diseases, including rheumatoid arthritis and lupus. The gene is also of interest in the context of cancer, as alterations in the λ chain have been observed in certain types of tumors. In conclusion, IGLC2 is a critical gene that plays a vital role in the adaptive immune response, particularly in the recognition and binding of antigens. Its dysregulation can have significant clinical implications, particularly in the context of infectious diseases and autoimmune disorders. Further research is needed to fully understand the mechanisms by which IGLC2 regulates the immune response and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.