Gene IGLC2 - ENSG00000211677 | NCBI Gene ID: 3538

Details for: IGLC2

Gene ID: 3538

Symbol: IGLC2

Ensembl ID: ENSG00000211677

Description: immunoglobulin lambda constant 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Blood microparticle
(GO:0072562)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Igg immunoglobulin complex
(GO:0071735)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 9.57
Marker Score: 97011
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.44
Marker Score: 3782
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.23
Marker Score: 1613
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.81
Marker Score: 871
Cell Name: germinal center B cell (CL0000844)
Fold Change: 2.8
Marker Score: 1703
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 2.66
Marker Score: 3821
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 2.19
Marker Score: 576
Cell Name: naive B cell (CL0000788)
Fold Change: 2.13
Marker Score: 1903
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.09
Marker Score: 2510.5
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 2.06
Marker Score: 567
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.03
Marker Score: 2001
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.95
Marker Score: 910
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.86
Marker Score: 643
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.74
Marker Score: 4505
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.7
Marker Score: 10822
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.68
Marker Score: 732
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.67
Marker Score: 962
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.67
Marker Score: 629
Cell Name: follicular B cell (CL0000843)
Fold Change: 1.66
Marker Score: 1799
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.61
Marker Score: 2805
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.57
Marker Score: 557
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.52
Marker Score: 3450
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.47
Marker Score: 888
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.45
Marker Score: 329
Cell Name: immature B cell (CL0000816)
Fold Change: 1.42
Marker Score: 938
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4
Marker Score: 1397
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 1.39
Marker Score: 716
Cell Name: memory T cell (CL0000813)
Fold Change: 1.35
Marker Score: 579
Cell Name: mature B cell (CL0000785)
Fold Change: 1.29
Marker Score: 948
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.23
Marker Score: 1686
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.22
Marker Score: 633
Cell Name: plasmablast (CL0000980)
Fold Change: 1.15
Marker Score: 1524.5
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.15
Marker Score: 2402
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.14
Marker Score: 476
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.14
Marker Score: 291
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.13
Marker Score: 821
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.12
Marker Score: 4715
Cell Name: goblet cell (CL0000160)
Fold Change: 1.09
Marker Score: 7276
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 1.09
Marker Score: 840.5
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.09
Marker Score: 378
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 1.07
Marker Score: 283
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.05
Marker Score: 4351
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.03
Marker Score: 529
Cell Name: neutrophil (CL0000775)
Fold Change: 1
Marker Score: 611
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71682
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47907
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.99
Marker Score: 778
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30396
Cell Name: peptic cell (CL0000155)
Fold Change: 0.97
Marker Score: 407
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.97
Marker Score: 637
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.97
Marker Score: 655.5
Cell Name: mature T cell (CL0002419)
Fold Change: 0.96
Marker Score: 9464.5
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2402
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.94
Marker Score: 307
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 485
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 444
Cell Name: plasma cell (CL0000786)
Fold Change: 0.92
Marker Score: 1029
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5217
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2725
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 361
Cell Name: ionocyte (CL0005006)
Fold Change: 0.9
Marker Score: 272
Cell Name: memory B cell (CL0000787)
Fold Change: 0.89
Marker Score: 674
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.87
Marker Score: 1980
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.87
Marker Score: 737.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5264
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.86
Marker Score: 173
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.85
Marker Score: 717
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.85
Marker Score: 305
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.84
Marker Score: 193
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.83
Marker Score: 4361
Cell Name: B cell (CL0000236)
Fold Change: 0.82
Marker Score: 783
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.82
Marker Score: 2031
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.8
Marker Score: 2251
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.8
Marker Score: 170
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.8
Marker Score: 252
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 607
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.78
Marker Score: 455
Cell Name: fibroblast (CL0000057)
Fold Change: 0.78
Marker Score: 749
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: T cell (CL0000084)
Fold Change: 0.77
Marker Score: 1335
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.77
Marker Score: 2092
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.76
Marker Score: 296
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.76
Marker Score: 429
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1205
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.74
Marker Score: 167
Cell Name: blood cell (CL0000081)
Fold Change: 0.74
Marker Score: 8625
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.74
Marker Score: 1937
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 382
Cell Name: platelet (CL0000233)
Fold Change: 0.74
Marker Score: 334
Cell Name: mast cell (CL0000097)
Fold Change: 0.73
Marker Score: 426
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.73
Marker Score: 301
Cell Name: enterocyte (CL0000584)
Fold Change: 0.72
Marker Score: 3465
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.71
Marker Score: 172
Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 649
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.71
Marker Score: 668
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.71
Marker Score: 183
Cell Name: keratocyte (CL0002363)
Fold Change: 0.7
Marker Score: 162
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.7
Marker Score: 163

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Other Information

Description

**Key characteristics:** - IGLC2 is a type I membrane protein that is expressed on the surface of immune cells. - It is a member of the immunoglobulin lambda superfamily. - IGLC2 is a part of the cell surface receptor complex for complement proteins. **Pathways and functions:** - IGLC2 is involved in the activation of the complement cascade. - It is expressed on macrophages and dendritic cells, which are key cells in the immune response. - IGLC2 is also expressed on B cells, where it is involved in the regulation of immune responses. **Clinical significance:** - Mutations in the IGLC2 gene have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, lupus, and scleroderma. - IGLC2 is a potential target for therapeutic intervention in these diseases. **Other important points:** - IGLC2 is a highly conserved protein, with a similar sequence found in mammals and birds. - It is a key component of the immune system, and its dysfunction can lead to immune deficiencies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.