Gene IL1R1 - ENSG00000115594 | NCBI Gene ID: 3554

Details for: IL1R1

Gene ID: 3554

Symbol: IL1R1

Ensembl ID: ENSG00000115594

Description: interleukin 1 receptor type 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-10 signaling
(R-HSA-6783783)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Viral infection pathways
(R-HSA-9824446)
Cell surface receptor signaling pathway
(GO:0007166)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Interleukin-1 binding
(GO:0019966)
Interleukin-1 receptor activity
(GO:0004908)
Interleukin-1, type i, activating receptor activity
(GO:0004909)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Membrane
(GO:0016020)
Nad+ nucleotidase, cyclic adp-ribose generating
(GO:0061809)
Nadp+ nucleosidase activity
(GO:0050135)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor binding
(GO:0005161)
Positive regulation of interleukin-1-mediated signaling pathway
(GO:2000661)
Positive regulation of neutrophil extravasation
(GO:2000391)
Positive regulation of t-helper 1 cell cytokine production
(GO:2000556)
Positive regulation of type ii interferon production
(GO:0032729)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Regulation of inflammatory response
(GO:0050727)
Response to interleukin-1
(GO:0070555)
Transmembrane signaling receptor activity
(GO:0004888)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.4
Marker Score: 28762
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 3.31
Marker Score: 1842
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.25
Marker Score: 110632
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.93
Marker Score: 1673
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.5
Marker Score: 2670
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.44
Marker Score: 5991
Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.2
Marker Score: 6308
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.19
Marker Score: 911
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.17
Marker Score: 1852
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.09
Marker Score: 3030
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.08
Marker Score: 23371
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.99
Marker Score: 2285
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.84
Marker Score: 539
Cell Name: lactocyte (CL0002325)
Fold Change: 1.79
Marker Score: 28667
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.71
Marker Score: 967
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.67
Marker Score: 4376
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.67
Marker Score: 2295
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.64
Marker Score: 348
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.6
Marker Score: 1717
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.6
Marker Score: 933
Cell Name: decidual cell (CL2000002)
Fold Change: 1.57
Marker Score: 6758
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.55
Marker Score: 53857
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.54
Marker Score: 383
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.53
Marker Score: 383
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.5
Marker Score: 338
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.48
Marker Score: 2852
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.48
Marker Score: 760
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.41
Marker Score: 340
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.4
Marker Score: 1450
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.38
Marker Score: 500
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.33
Marker Score: 385
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.33
Marker Score: 427
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.32
Marker Score: 326
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.32
Marker Score: 8476
Cell Name: keratocyte (CL0002363)
Fold Change: 1.31
Marker Score: 301
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3
Marker Score: 1368
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.29
Marker Score: 403
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.27
Marker Score: 799
Cell Name: secretory cell (CL0000151)
Fold Change: 1.25
Marker Score: 2289
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.25
Marker Score: 324
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.23
Marker Score: 1107
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.22
Marker Score: 2874
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.21
Marker Score: 5242
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.2
Marker Score: 344.5
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.17
Marker Score: 2338
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.16
Marker Score: 296
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.15
Marker Score: 432
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4765
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.13
Marker Score: 7374
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.13
Marker Score: 6051
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.08
Marker Score: 1834.5
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.08
Marker Score: 720
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.07
Marker Score: 346
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.06
Marker Score: 673.5
Cell Name: stromal cell (CL0000499)
Fold Change: 1.06
Marker Score: 1241
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.06
Marker Score: 949
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251738
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.03
Marker Score: 1659
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.03
Marker Score: 1273.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.02
Marker Score: 16029
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.01
Marker Score: 6054
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1
Marker Score: 1077
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71756
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47980
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.99
Marker Score: 2247
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30402
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.97
Marker Score: 4058.5
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.97
Marker Score: 212
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 498
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.96
Marker Score: 264
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: fibroblast (CL0000057)
Fold Change: 0.95
Marker Score: 915
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2407
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.93
Marker Score: 804
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.92
Marker Score: 625
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 366
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2726
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.91
Marker Score: 365
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: club cell (CL0000158)
Fold Change: 0.89
Marker Score: 1035
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.89
Marker Score: 1408
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.88
Marker Score: 2209
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.88
Marker Score: 4634
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.87
Marker Score: 407
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4953
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.86
Marker Score: 293
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.86
Marker Score: 514
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.86
Marker Score: 218
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.83
Marker Score: 579
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.83
Marker Score: 322
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 626
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.82
Marker Score: 198
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.81
Marker Score: 350
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.81
Marker Score: 388
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.81
Marker Score: 790
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.8
Marker Score: 321
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.79
Marker Score: 1158
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.78
Marker Score: 747
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.78
Marker Score: 292.5

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**Key characteristics:** - The IL1R1 gene is located on chromosome 1. - It is a single-exon gene encoding a 33-kD protein. - It is expressed in a variety of cell types, including immune cells, endothelial cells, and fibroblasts. - It is a key regulator of inflammation and immune responses. **Pathways and functions:** - The IL1R1 gene is a key regulator of the cytokine interleukin-1 (IL-1). - IL-1 is a pro-inflammatory cytokine that plays a role in a variety of immune responses, including inflammation, infection, and tissue remodeling. - IL1R1 binds to IL-1 and activates its signaling pathway. - The signaling pathway leads to the activation of various transcription factors, which regulate the expression of inflammatory genes. - IL-1R1 also plays a role in the regulation of platelet-derived growth factor (PDGF) signaling. - IL-1R1 signaling can be inhibited by the cytokine IL-10, which is a regulatory cytokine. **Clinical significance:** - Mutations in the IL1R1 gene have been linked to a number of inflammatory diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. - IL1R1 agonists are being investigated as potential treatments for these diseases. **Additional notes:** - The IL1R1 gene is also known as CD124. - It is a member of the interleukin-1 receptor family of receptors. - It is expressed in high levels in the lungs, skin, and gut.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-1 receptor type 1
B8ZZW4_HUMAN

Genular Protein ID: 3358848327

Symbol: IL1R1_HUMAN

Name: Interleukin-1 receptor type 1

UniProtKB Accession Codes:

P14778 Q587I7

Database IDs:

Citations:

PubMed ID: 2532321

Title: Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.

PubMed ID: 2532321

DOI: 10.1093/nar/17.23.10114

PubMed ID: 2530587

Title: Cloning the interleukin 1 receptor from human T cells.

PubMed ID: 2530587

DOI: 10.1073/pnas.86.22.8946

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2950091

Title: The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

PubMed ID: 2950091

DOI: 10.1016/s0021-9258(18)61450-4

PubMed ID: 8142597

Title: Specific binding of interleukin 1 (IL-1) beta and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I.

PubMed ID: 8142597

DOI: 10.1016/1043-4666(93)90032-z

PubMed ID: 7989776

Title: Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.

PubMed ID: 7989776

PubMed ID: 9371760

Title: Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.

PubMed ID: 9371760

DOI: 10.1073/pnas.94.24.12829

PubMed ID: 9821957

Title: Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I.

PubMed ID: 9821957

DOI: 10.1016/s0014-5793(98)01270-8

PubMed ID: 10653850

Title: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

PubMed ID: 10653850

DOI: 10.1093/intimm/12.2.151

PubMed ID: 10671496

Title: Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.

PubMed ID: 10671496

DOI: 10.1074/jbc.275.7.4670

PubMed ID: 9062193

Title: Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.

PubMed ID: 9062193

DOI: 10.1038/386190a0

PubMed ID: 9062194

Title: A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist.

PubMed ID: 9062194

DOI: 10.1038/386194a0

PubMed ID: 10903327

Title: X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1.

PubMed ID: 10903327

DOI: 10.1074/jbc.m006071200

Sequence Information:

Length: 569
Mass: 65402
Checksum: 5BAA83F8F0225C25
Sequence:

MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD 
DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL 
CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR 
LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL 
GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE 
IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK 
IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST SDCDIFVFKV LPEVLEKQCG 
YKLFIYGRDD YVGEDIVEVI NENVKKSRRL IIILVRETSG FSWLGGSSEE QIAMYNALVQ 
DGIKVVLLEL EKIQDYEKMP ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV 
QRRSPSSKHQ LLSPATKEKL QREAHVPLG

Genular Protein ID: 582624846

Symbol: B8ZZW4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B8ZZW4

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 538
Mass: 62029
Checksum: DDBACC413E9618E5
Sequence:

MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD 
DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL 
CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR 
LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL 
GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE 
IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK 
IDIVLWYRDS CYDFLPIKVL PEVLEKQCGY KLFIYGRDDY VGEDIVEVIN ENVKKSRRLI 
IILVRETSGF SWLGGSSEEQ IAMYNALVQD GIKVVLLELE KIQDYEKMPE SIKFIKQKHG 
AIRWSGDFTQ GPQSAKTRFW KNVRYHMPVQ RRSPSSKHQL LSPATKEKLQ REAHVPLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL1R1

Associated with

Cells (max top 100)

Other Information

Sequence of the cDNA for the human fibroblast type interleukin-1 receptor. PubMed ID: 2532321

Cloning the interleukin 1 receptor from human T cells. PubMed ID: 2530587

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. PubMed ID: 2950091

Specific binding of interleukin 1 (IL-1) beta and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I. PubMed ID: 8142597

Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. PubMed ID: 7989776

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. PubMed ID: 9371760

Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I. PubMed ID: 9821957

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. PubMed ID: 10653850

Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. PubMed ID: 10671496

Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. PubMed ID: 9062193

A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. PubMed ID: 9062194

X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. PubMed ID: 10903327

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Database document:

PubMed ID: 2532321

PubMed ID: 2530587

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 2950091

PubMed ID: 8142597

PubMed ID: 7989776

PubMed ID: 9371760

PubMed ID: 9821957

PubMed ID: 10653850

PubMed ID: 10671496

PubMed ID: 9062193

PubMed ID: 9062194

PubMed ID: 10903327

PubMed ID: 15815621