Gene IL11 - ENSG00000095752 | NCBI Gene ID: 3589

Details for: IL11

Gene ID: 3589

Symbol: IL11

Ensembl ID: ENSG00000095752

Description: interleukin 11

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Il-6-type cytokine receptor ligand interactions
(R-HSA-6788467)
Immune system
(R-HSA-168256)
Interleukin-6 family signaling
(R-HSA-6783589)
Signaling by interleukins
(R-HSA-449147)
B cell differentiation
(GO:0030183)
Cell population proliferation
(GO:0008283)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fat cell differentiation
(GO:0045444)
Growth factor activity
(GO:0008083)
Interleukin-11 receptor binding
(GO:0005142)
Interleukin-11-mediated signaling pathway
(GO:0038154)
Megakaryocyte differentiation
(GO:0030219)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of hormone secretion
(GO:0046888)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of complement-dependent cytotoxicity
(GO:1903659)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1171
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 796
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251814
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71831
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48056
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.95
Marker Score: 600
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.94
Marker Score: 596
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.94
Marker Score: 211
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5320
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.89
Marker Score: 370
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.88
Marker Score: 597
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5289
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.81
Marker Score: 792
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.81
Marker Score: 370.5
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.78
Marker Score: 3263
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1262
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 709
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.69
Marker Score: 287
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.54
Marker Score: 346
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 276
Cell Name: mast cell (CL0000097)
Fold Change: 0.45
Marker Score: 259
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 438
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.43
Marker Score: 108
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.43
Marker Score: 187
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.43
Marker Score: 108
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.37
Marker Score: 361
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.32
Marker Score: 463
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.32
Marker Score: 202
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.31
Marker Score: 589
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.29
Marker Score: 289.5
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.28
Marker Score: 109
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.28
Marker Score: 74
Cell Name: germ cell (CL0000586)
Fold Change: 0.24
Marker Score: 417
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.23
Marker Score: 237.5
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.22
Marker Score: 77
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.19
Marker Score: 393.5
Cell Name: fibroblast (CL0000057)
Fold Change: 0.19
Marker Score: 181
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.18
Marker Score: 107
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.18
Marker Score: 184
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.18
Marker Score: 290
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.17
Marker Score: 2724
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.16
Marker Score: 71
Cell Name: male germ cell (CL0000015)
Fold Change: 0.15
Marker Score: 44
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.14
Marker Score: 292.5
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.14
Marker Score: 197
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.13
Marker Score: 77
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.13
Marker Score: 158
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.12
Marker Score: 477
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.12
Marker Score: 84
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.12
Marker Score: 166
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.12
Marker Score: 50
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.12
Marker Score: 112.5
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.11
Marker Score: 215
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.11
Marker Score: 53
Cell Name: macrophage (CL0000235)
Fold Change: 0.11
Marker Score: 121
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.11
Marker Score: 154
Cell Name: plasma cell (CL0000786)
Fold Change: 0.11
Marker Score: 118
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1
Marker Score: 213
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.1
Marker Score: 123
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.1
Marker Score: 19.5
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.1
Marker Score: 83
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.1
Marker Score: 47
Cell Name: interneuron (CL0000099)
Fold Change: 0.09
Marker Score: 42
Cell Name: neuron (CL0000540)
Fold Change: 0.09
Marker Score: 374
Cell Name: goblet cell (CL0000160)
Fold Change: 0.09
Marker Score: 600
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.09
Marker Score: 17.5
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.09
Marker Score: 332
Cell Name: keratocyte (CL0002363)
Fold Change: 0.08
Marker Score: 18.5
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.08
Marker Score: 71
Cell Name: tendon cell (CL0000388)
Fold Change: 0.08
Marker Score: 19.5
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.08
Marker Score: 36
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.08
Marker Score: 20
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.08
Marker Score: 27
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.08
Marker Score: 51
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.07
Marker Score: 52
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.07
Marker Score: 32
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.07
Marker Score: 29
Cell Name: B cell (CL0000236)
Fold Change: 0.07
Marker Score: 68
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.07
Marker Score: 174
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.07
Marker Score: 22
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.07
Marker Score: 85
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.07
Marker Score: 18
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.07
Marker Score: 31
Cell Name: muscle cell (CL0000187)
Fold Change: 0.07
Marker Score: 19
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.07
Marker Score: 92
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.07
Marker Score: 327

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**Key characteristics:** * IL-11 is a cytokine belonging to the interleukin 11 family. * It is produced by various cell types in the gut, including epithelial cells, immune cells, and stromal cells. * IL-11 has both pro- and anti-inflammatory effects on immune cells. * It plays a role in promoting the differentiation of megakaryocytes from hematopoietic stem cells. * It also regulates the proliferation and survival of intestinal epithelial cells, immune cells, and stem cells. **Pathways and functions:** * IL-11 signaling pathway is activated by binding to its receptor, IL-11R on various cell types. * This binding triggers a cascade of intracellular events that lead to the activation of the MAPK signaling pathway. * IL-11 also modulates the activity of other cytokines, such as IL-6 and IL-23. * It plays a role in regulating cell proliferation, differentiation, and survival in various tissues, including the gut, skin, and immune system. **Clinical significance:** * Dysregulation of IL-11 signaling has been implicated in various diseases, including inflammatory bowel disease (IBD), cancer, and autoimmune disorders. * IL-11 is a potential therapeutic target for treating these diseases. * Inhibition of IL-11 signaling has been shown to ameliorate disease activity in animal models. **Conclusion:** IL-11 is a key cytokine that plays a critical role in regulating cell proliferation, differentiation, and survival in the gut and immune system. Dysregulation of IL-11 signaling has significant implications for human health and may contribute to various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

IL11_HUMAN

Genular Protein ID: 3347798559

Symbol: IL11_HUMAN

Name: N/A

UniProtKB Accession Codes:

P20809 B4DQV5 Q96EB4

Database IDs:

Citations:

PubMed ID: 2145578

Title: Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

PubMed ID: 2145578

DOI: 10.1073/pnas.87.19.7512

PubMed ID: 1828438

Title: Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11.

PubMed ID: 1828438

DOI: 10.1016/0014-5793(91)80587-s

PubMed ID: 1386338

Title: Genomic sequence and chromosomal location of human interleukin-11 gene (IL11).

PubMed ID: 1386338

DOI: 10.1016/0888-7543(92)90158-o

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12919066

Title: Characterization of a potent human interleukin-11 agonist.

PubMed ID: 12919066

DOI: 10.1042/bj20030459

PubMed ID: 30279168

Title: Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.

PubMed ID: 30279168

DOI: 10.1126/scisignal.aar7388

PubMed ID: 25195742

Title: The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.

PubMed ID: 25195742

DOI: 10.1107/s1399004714012267

Sequence Information:

Length: 199
Mass: 21429
Checksum: F292BF8B34F4096D
Sequence:

MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL 
RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK 
TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG 
LHLTLDWAVR GLLLLKTRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL11

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. PubMed ID: 2145578

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. PubMed ID: 1828438

Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). PubMed ID: 1386338

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of a potent human interleukin-11 agonist. PubMed ID: 12919066

Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses. PubMed ID: 30279168

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6. PubMed ID: 25195742