Details for: IL11

Gene ID: 3589

Symbol: IL11

Ensembl ID: ENSG00000095752

Description: interleukin 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.9960
    Cell Significance Index: -3.5500
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 3.2736
    Cell Significance Index: 15.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6940
    Cell Significance Index: 103.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5015
    Cell Significance Index: 32.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9665
    Cell Significance Index: 30.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7683
    Cell Significance Index: 12.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5446
    Cell Significance Index: 103.6500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.4581
    Cell Significance Index: 5.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3484
    Cell Significance Index: 7.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3451
    Cell Significance Index: 34.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2751
    Cell Significance Index: 248.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2073
    Cell Significance Index: 22.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1978
    Cell Significance Index: 11.8800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1835
    Cell Significance Index: 1.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1797
    Cell Significance Index: 29.2200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1528
    Cell Significance Index: 1.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1087
    Cell Significance Index: 7.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1052
    Cell Significance Index: 3.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0984
    Cell Significance Index: 61.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0984
    Cell Significance Index: 5.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0957
    Cell Significance Index: 2.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0662
    Cell Significance Index: 3.0000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0598
    Cell Significance Index: 0.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0586
    Cell Significance Index: 1.2200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0366
    Cell Significance Index: 0.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0317
    Cell Significance Index: 3.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0287
    Cell Significance Index: 12.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0283
    Cell Significance Index: 10.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0198
    Cell Significance Index: 2.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0179
    Cell Significance Index: 3.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0176
    Cell Significance Index: 0.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0110
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0073
    Cell Significance Index: 0.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0063
    Cell Significance Index: 1.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0040
    Cell Significance Index: 0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0039
    Cell Significance Index: 2.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0024
    Cell Significance Index: 0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0004
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0059
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0062
    Cell Significance Index: -1.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0065
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0072
    Cell Significance Index: -3.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0072
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0129
    Cell Significance Index: -0.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0139
    Cell Significance Index: -2.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0139
    Cell Significance Index: -0.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0230
    Cell Significance Index: -2.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0235
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0239
    Cell Significance Index: -0.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0321
    Cell Significance Index: -0.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0328
    Cell Significance Index: -3.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0336
    Cell Significance Index: -3.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0358
    Cell Significance Index: -2.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0380
    Cell Significance Index: -2.4000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0381
    Cell Significance Index: -0.5900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0390
    Cell Significance Index: -0.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0396
    Cell Significance Index: -2.6600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0447
    Cell Significance Index: -0.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0451
    Cell Significance Index: -2.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0457
    Cell Significance Index: -1.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0484
    Cell Significance Index: -2.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0495
    Cell Significance Index: -3.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0504
    Cell Significance Index: -0.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0512
    Cell Significance Index: -3.9300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0524
    Cell Significance Index: -0.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0554
    Cell Significance Index: -1.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0599
    Cell Significance Index: -3.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0601
    Cell Significance Index: -1.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0610
    Cell Significance Index: -3.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0614
    Cell Significance Index: -2.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0652
    Cell Significance Index: -1.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0682
    Cell Significance Index: -2.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0688
    Cell Significance Index: -3.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0704
    Cell Significance Index: -2.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0712
    Cell Significance Index: -2.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0790
    Cell Significance Index: -2.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0798
    Cell Significance Index: -1.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0810
    Cell Significance Index: -2.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0827
    Cell Significance Index: -3.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0837
    Cell Significance Index: -1.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0847
    Cell Significance Index: -3.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0876
    Cell Significance Index: -3.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0921
    Cell Significance Index: -2.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0959
    Cell Significance Index: -3.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1012
    Cell Significance Index: -3.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1016
    Cell Significance Index: -2.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1023
    Cell Significance Index: -1.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1074
    Cell Significance Index: -2.6800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1089
    Cell Significance Index: -0.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL-11 is a 206-amino acid protein that belongs to the IL-6 family of cytokines. It is primarily produced by immune cells, such as T cells, B cells, and macrophages, as well as by epithelial cells and stem cells. IL-11 exhibits a unique structure, with a hydrophobic region and a hydrophilic region, which allows it to interact with its receptor and other proteins. The protein has a molecular weight of approximately 22 kDa and is secreted in a soluble form. **Pathways and Functions** IL-11 is involved in various signaling pathways that regulate immune responses, cell proliferation, and differentiation. Some of the key pathways and functions of IL-11 include: 1. **B cell differentiation**: IL-11 promotes the differentiation of B cells into plasma cells, which produce antibodies. 2. **Cell population proliferation**: IL-11 stimulates the proliferation of immune cells, such as T cells and B cells, and epithelial cells. 3. **Cytokine activity**: IL-11 modulates the activity of other cytokines, such as IL-6, TNF-α, and IL-10. 4. **Cytokine signaling in immune system**: IL-11 triggers signaling pathways that regulate immune responses, including the activation of immune cells and the production of cytokines. 5. **Megakaryocyte differentiation**: IL-11 promotes the differentiation of megakaryocytes, which produce platelets. 6. **Fat cell differentiation**: IL-11 inhibits the differentiation of fat cells, which reduces the accumulation of lipids. 7. **Growth factor activity**: IL-11 acts as a growth factor for various cell types, including epithelial cells and immune cells. **Clinical Significance** IL-11 has been implicated in various diseases and disorders, including: 1. **Autoimmune diseases**: IL-11 has been shown to contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: IL-11 has been linked to cancer development and progression, particularly in hematological malignancies. 3. **Inflammatory diseases**: IL-11 has been implicated in inflammatory diseases, such as asthma and inflammatory bowel disease. 4. **Cardiovascular disease**: IL-11 has been shown to contribute to the development of cardiovascular disease, particularly in relation to atherosclerosis. 5. **Neurological disorders**: IL-11 has been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, IL-11 is a multifunctional cytokine that plays a crucial role in various physiological and pathological processes within the immune system and beyond. Its dysregulation has been implicated in various diseases and disorders, highlighting the need for further research into the mechanisms of IL-11 and its potential therapeutic applications.

Genular Protein ID: 3347798559

Symbol: IL11_HUMAN

Name: N/A

UniProtKB Accession Codes:

P20809 B4DQV5 Q96EB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2145578

Title: Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

PubMed ID: 2145578

DOI: 10.1073/pnas.87.19.7512

PubMed ID: 1828438

Title: Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11.

PubMed ID: 1828438

DOI: 10.1016/0014-5793(91)80587-s

PubMed ID: 1386338

Title: Genomic sequence and chromosomal location of human interleukin-11 gene (IL11).

PubMed ID: 1386338

DOI: 10.1016/0888-7543(92)90158-o

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12919066

Title: Characterization of a potent human interleukin-11 agonist.

PubMed ID: 12919066

DOI: 10.1042/bj20030459

PubMed ID: 30279168

Title: Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.

PubMed ID: 30279168

DOI: 10.1126/scisignal.aar7388

PubMed ID: 25195742

Title: The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.

PubMed ID: 25195742

DOI: 10.1107/s1399004714012267

Sequence Information:

  • Length: 199
  • Mass: 21429
  • Checksum: F292BF8B34F4096D
  • Sequence:
    • MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL 
RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK 
TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG 
LHLTLDWAVR GLLLLKTRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.