Details for: IL15

Gene ID: 3600

Symbol: IL15

Ensembl ID: ENSG00000164136

Description: interleukin 15

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.62
    Marker Score: 3467
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.6
    Marker Score: 30444.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.27
    Marker Score: 9780
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168988
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2571
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.15
    Marker Score: 12902
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.05
    Marker Score: 382
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48006
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 629
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.93
    Marker Score: 3872
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 617
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.91
    Marker Score: 547
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5061
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5290
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.87
    Marker Score: 3214
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13168
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.78
    Marker Score: 3023
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 251
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1236
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3088
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1686
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.71
    Marker Score: 697
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 631
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.66
    Marker Score: 2341
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.64
    Marker Score: 933
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 198
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.63
    Marker Score: 4826
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.62
    Marker Score: 1198
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.62
    Marker Score: 705
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.61
    Marker Score: 319
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.6
    Marker Score: 743
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.59
    Marker Score: 1436
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.59
    Marker Score: 641
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.57
    Marker Score: 941
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.55
    Marker Score: 162
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 353
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.55
    Marker Score: 30720
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.55
    Marker Score: 327
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.52
    Marker Score: 1015
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.5
    Marker Score: 121
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.49
    Marker Score: 109
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 231
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.48
    Marker Score: 239
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.48
    Marker Score: 208
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.48
    Marker Score: 4107
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.46
    Marker Score: 7362
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.45
    Marker Score: 10154
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.45
    Marker Score: 484
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.45
    Marker Score: 485
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.44
    Marker Score: 202
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.44
    Marker Score: 159
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.44
    Marker Score: 1896
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.44
    Marker Score: 141
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.44
    Marker Score: 162
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.44
    Marker Score: 4152
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.44
    Marker Score: 307
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 114
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 177
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.42
    Marker Score: 613
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 677
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 376
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.42
    Marker Score: 707
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.41
    Marker Score: 413
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.41
    Marker Score: 3608
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.41
    Marker Score: 152
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.41
    Marker Score: 82
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.4
    Marker Score: 10360
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.39
    Marker Score: 1389
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.39
    Marker Score: 14690
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.38
    Marker Score: 155
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 168
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.38
    Marker Score: 85
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.37
    Marker Score: 108
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.37
    Marker Score: 94
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.36
    Marker Score: 182
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.36
    Marker Score: 76
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.34
    Marker Score: 408
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 107
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.34
    Marker Score: 174
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.34
    Marker Score: 66
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.34
    Marker Score: 230
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.33
    Marker Score: 302
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.33
    Marker Score: 115
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.33
    Marker Score: 657
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.32
    Marker Score: 587.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.32
    Marker Score: 818
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.32
    Marker Score: 605.5

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Other Information

**Key characteristics:** - IL15 is a cytokine of the interleukin-15 family. - It is a pleiotropic cytokine with both pro- and anti-inflammatory effects. - It is expressed in high levels in inflammatory conditions. - It is produced by activated T cells, B cells, dendritic cells, and stromal cells. **Pathways and functions:** - IL15 signaling is initiated by the binding of its receptor, IL15RA, to its receptor complex on immune cells. - This binding triggers the activation of the IL15/IL15RA signaling pathway, which is a key regulator of immune cell proliferation, differentiation, and activation. - IL15 signaling can promote the differentiation of naive T cells into effector T cells, such as Th2 and Th17 cells. - It also promotes the proliferation of dendritic cells, macrophages, and B cells. - IL15 can also regulate the production of inflammatory cytokines, such as TNF-alpha and IL-6, which contribute to inflammation. **Clinical significance:** - Dysregulation of IL15 signaling has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory diseases. - In cancer, IL15 is produced by tumor cells and immune cells and promotes tumor growth, invasion, and metastasis. - Blocking IL15 signaling can inhibit tumor growth and metastasis. - IL15 is also a potential therapeutic target for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and Crohn's disease. **Additional notes:** - IL15 is a highly conserved cytokine with a wide expression pattern. - It is produced in high levels in inflammatory conditions and during immune responses. - It is a key cytokine in regulating immune responses, and its dysregulation can lead to various diseases.

Genular Protein ID: 1416243510

Symbol: IL15_HUMAN

Name: Interleukin-15

UniProtKB Accession Codes:

P40933 D3DNZ2 O00440 O43512 Q495Z8 Q6FGX7 Q93058 Q9UBA3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 21 Ensembl 6 EvolutionaryTrace 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8178155

Title: Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.

PubMed ID: 8178155

DOI: 10.1126/science.8178155

PubMed ID: 8932977

Title: Genomic sequence and chromosomal location of the human interleukin-15 gene (IL15).

PubMed ID: 8932977

DOI: 10.1006/cyto.1996.0089

PubMed ID: 8668345

Title: Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines.

PubMed ID: 8668345

PubMed ID: 9405632

Title: Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides.

PubMed ID: 9405632

DOI: 10.1073/pnas.94.26.14444

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8026467

Title: Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

PubMed ID: 8026467

DOI: 10.1002/j.1460-2075.1994.tb06576.x

PubMed ID: 7568001

Title: Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

PubMed ID: 7568001

DOI: 10.1073/pnas.92.19.8705

PubMed ID: 9326248

Title: Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes.

PubMed ID: 9326248

PubMed ID: 10233906

Title: Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15.

PubMed ID: 10233906

PubMed ID: 15123770

Title: Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.

PubMed ID: 15123770

DOI: 10.1189/jlb.0605298

PubMed ID: 21167836

Title: Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an alpha-helix in VH CDR3 as key component of paratope.

PubMed ID: 21167836

DOI: 10.1016/j.jmb.2010.12.017

PubMed ID: 23104097

Title: Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

PubMed ID: 23104097

DOI: 10.1038/ni.2449

Sequence Information:

  • Length: 162
  • Mass: 18086
  • Checksum: 0CE0520C1D8379E2
  • Sequence:
    • MRISKPHLRS ISIQCYLCLL LNSHFLTEAG IHVFILGCFS AGLPKTEANW VNVISDLKKI 
EDLIQSMHID ATLYTESDVH PSCKVTAMKC FLLELQVISL ESGDASIHDT VENLIILANN 
SLSSNGNVTE SGCKECEELE EKNIKEFLQS FVHIVQMFIN TS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.