Details for: ING1

Gene ID: 3621

Symbol: ING1

Ensembl ID: ENSG00000153487

Description: inhibitor of growth family member 1

Associated with

  • Cell cycle
    (GO:0007049)
  • Metal ion binding
    (GO:0046872)
  • Methylated histone binding
    (GO:0035064)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of stem cell population maintenance
    (GO:1902455)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of stem cell population maintenance
    (GO:1902459)
  • Protein binding
    (GO:0005515)
  • Protein import into nucleus
    (GO:0006606)
  • Regulation of programmed cell death
    (GO:0043067)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.64
    Marker Score: 4021
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.49
    Marker Score: 3024
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.47
    Marker Score: 2785.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.46
    Marker Score: 458
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.33
    Marker Score: 3135
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.31
    Marker Score: 422
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.27
    Marker Score: 761
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18712
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.16
    Marker Score: 39579.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.14
    Marker Score: 4922
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.13
    Marker Score: 1967
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.1
    Marker Score: 417
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.08
    Marker Score: 3987
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71714
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47937.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.99
    Marker Score: 1461
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2697
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.87
    Marker Score: 431
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5233
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.86
    Marker Score: 9718
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.86
    Marker Score: 29872
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.86
    Marker Score: 2344
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.84
    Marker Score: 842
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4800
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.81
    Marker Score: 8197
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8
    Marker Score: 856
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.8
    Marker Score: 846
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.76
    Marker Score: 7703
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.76
    Marker Score: 1243
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.75
    Marker Score: 217
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.74
    Marker Score: 192
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.74
    Marker Score: 4791
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.73
    Marker Score: 414
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.71
    Marker Score: 704.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.71
    Marker Score: 1334
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.71
    Marker Score: 1251
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.68
    Marker Score: 1552
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.68
    Marker Score: 349
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.68
    Marker Score: 168
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.68
    Marker Score: 711
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.66
    Marker Score: 398
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 602
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.66
    Marker Score: 5716
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.66
    Marker Score: 470
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.64
    Marker Score: 148
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2690
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.64
    Marker Score: 265
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.64
    Marker Score: 125
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.64
    Marker Score: 423
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.64
    Marker Score: 191
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.63
    Marker Score: 281
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.63
    Marker Score: 832
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.62
    Marker Score: 1245
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.62
    Marker Score: 1314.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.62
    Marker Score: 152
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.62
    Marker Score: 549
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.61
    Marker Score: 217
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.61
    Marker Score: 295
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.61
    Marker Score: 575
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 404
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.61
    Marker Score: 211
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.61
    Marker Score: 175
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6
    Marker Score: 382
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.6
    Marker Score: 273
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.59
    Marker Score: 1860
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.59
    Marker Score: 1230
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.59
    Marker Score: 398.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.59
    Marker Score: 392
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.58
    Marker Score: 628
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.57
    Marker Score: 606
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.57
    Marker Score: 607
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.57
    Marker Score: 663
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.56
    Marker Score: 383
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.56
    Marker Score: 319
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.55
    Marker Score: 254
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.55
    Marker Score: 935
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.54
    Marker Score: 834
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.54
    Marker Score: 315
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.54
    Marker Score: 219
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.54
    Marker Score: 402
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.54
    Marker Score: 108
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.53
    Marker Score: 185
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.53
    Marker Score: 391
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.53
    Marker Score: 153
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.53
    Marker Score: 514
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.53
    Marker Score: 243

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Other Information

**Key characteristics:** * Ing1 is a secreted protein that is highly expressed in epithelial cells, particularly in the developing and regenerating tissues. * It is a transmembrane protein with a molecular weight of approximately 130 kDa. * Ing1 binds to the EGFR receptor, which is expressed on the surface of various cell types. * Binding to EGFR inhibits the activation of the receptor and blocks the downstream signaling pathways that promote cell growth and proliferation. * Ing1 also interacts with other proteins, including p53 and p21, which are key regulators of cell cycle progression and apoptosis (programmed cell death). **Pathways and functions:** * Ing1 inhibits cell cycle progression by binding to the EGFR receptor and blocking its signaling pathways. * It also inhibits the expression of cyclin D1 and other cell cycle regulators, thereby preventing the progression of cells through the G1 and S phases of the cell cycle. * Ing1 plays a crucial role in maintaining stem cell populations by preventing the proliferation of self-renewing cells. * It also inhibits the differentiation of pluripotent stem cells into various cell types, thereby maintaining the self-renewing capacity of these cells. * Ing1 has been shown to be a potential therapeutic target for various cancers, as its inhibition leads to cell cycle arrest and tumor regression. **Clinical significance:** * Mutations in the ING1 gene have been linked to several human cancers, including breast cancer, lung cancer, and colorectal cancer. * Targeting ING1 signaling has shown promise in preclinical models of cancer, resulting in tumor regression and improved patient outcomes. * Clinical trials are currently exploring the use of antibodies and small molecule inhibitors to block ING1 and overcome cancer resistance.

Genular Protein ID: 1079695373

Symbol: ING1_HUMAN

Name: Inhibitor of growth protein 1

UniProtKB Accession Codes:

Q9UK53 O00532 O43658 Q53ZR3 Q5T9G8 Q5T9G9 Q5T9H0 Q5T9H1 Q9H007 Q9HD98 Q9HD99 Q9NS83 Q9P0U6 Q9UBC6 Q9UIJ1 Q9UIJ2 Q9UIJ3 Q9UIJ4 Q9UK52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 3 DIP 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 32 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 5 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8944021

Title: Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation.

PubMed ID: 8944021

DOI: 10.1038/ng1296-415

PubMed ID: 10626813

Title: Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene.

PubMed ID: 10626813

PubMed ID: 10779953

Title: Genomic organization of the suppressor gene for tumor growth ING1.

PubMed ID: 10779953

PubMed ID: 10866301

Title: Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.

PubMed ID: 10866301

PubMed ID: 10807544

Title: p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.

PubMed ID: 10807544

DOI: 10.1007/s100380050206

PubMed ID: 11481424

Title: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.

PubMed ID: 11481424

DOI: 10.1073/pnas.161151798

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9440695

Title: The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control.

PubMed ID: 9440695

DOI: 10.1038/34675

PubMed ID: 16728974

Title: ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

PubMed ID: 16728974

DOI: 10.1038/nature04835

PubMed ID: 22419112

Title: Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis.

PubMed ID: 22419112

DOI: 10.1038/cddis.2012.22

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18533182

Title: Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.

PubMed ID: 18533182

DOI: 10.1016/j.jmb.2008.04.061

Sequence Information:

  • Length: 422
  • Mass: 46738
  • Checksum: 03D6AEEAA6E39090
  • Sequence:
    • MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG RVDLNVFGSL 
GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG GSRGAGRVSR WPPPHWLEAW 
RVSPLPLSPL SPATFGRGFI AVAVIPGLWA RGRGCSSDRL PRPAGPARRQ FQAASLLTRG 
WGRAWPWKQI LKELDECYER FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE 
LVENRTRQVD SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE 
NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ 
VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA LEKSKKERAY 
NR

Genular Protein ID: 2879243553

Symbol: A0A0C4DFW2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFW2

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 8 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 422
  • Mass: 46781
  • Checksum: 606EC90D3EF324C1
  • Sequence:
    • MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG RVDLNVFGSL 
GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG GSRGAGRVSR WPPPHWLEAW 
RVSPRPLSPL SPATFGRGFI AVAVIPGLWA RGRGCSSDRL PRPAGPARRQ FQAASLLTRG 
WGRAWPWKQI LKELDECYER FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE 
LVENRTRQVD SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE 
NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ 
VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA LEKSKKERAY 
NR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.