Details for: INHBB

Gene ID: 3625

Symbol: INHBB

Ensembl ID: ENSG00000163083

Description: inhibin subunit beta B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.0202
    Cell Significance Index: -12.1800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.2346
    Cell Significance Index: 45.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0436
    Cell Significance Index: -12.0100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.8950
    Cell Significance Index: 40.6600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.7362
    Cell Significance Index: 10.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5465
    Cell Significance Index: 11.8400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4460
    Cell Significance Index: 6.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4287
    Cell Significance Index: 234.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3956
    Cell Significance Index: 6.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3518
    Cell Significance Index: 66.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2688
    Cell Significance Index: 20.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2591
    Cell Significance Index: 8.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2210
    Cell Significance Index: 5.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2187
    Cell Significance Index: 21.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2175
    Cell Significance Index: 96.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2049
    Cell Significance Index: 14.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2016
    Cell Significance Index: 182.0300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1359
    Cell Significance Index: 2.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1321
    Cell Significance Index: 6.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1293
    Cell Significance Index: 6.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1081
    Cell Significance Index: 17.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0999
    Cell Significance Index: 1.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0366
    Cell Significance Index: 3.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0295
    Cell Significance Index: 5.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0221
    Cell Significance Index: 40.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0204
    Cell Significance Index: 1.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0133
    Cell Significance Index: 20.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0063
    Cell Significance Index: 0.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0057
    Cell Significance Index: 0.3500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0038
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0057
    Cell Significance Index: -3.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0087
    Cell Significance Index: -4.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0088
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0149
    Cell Significance Index: -11.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0167
    Cell Significance Index: -0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0172
    Cell Significance Index: -12.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0198
    Cell Significance Index: -12.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0237
    Cell Significance Index: -6.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0238
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0261
    Cell Significance Index: -5.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0265
    Cell Significance Index: -1.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0268
    Cell Significance Index: -1.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0272
    Cell Significance Index: -12.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0331
    Cell Significance Index: -5.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0361
    Cell Significance Index: -4.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0369
    Cell Significance Index: -4.7300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0397
    Cell Significance Index: -0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0515
    Cell Significance Index: -10.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0578
    Cell Significance Index: -7.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0781
    Cell Significance Index: -8.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0788
    Cell Significance Index: -10.8200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0827
    Cell Significance Index: -0.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0833
    Cell Significance Index: -5.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0859
    Cell Significance Index: -12.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0920
    Cell Significance Index: -10.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0959
    Cell Significance Index: -10.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1039
    Cell Significance Index: -10.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1160
    Cell Significance Index: -13.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1183
    Cell Significance Index: -12.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1212
    Cell Significance Index: -7.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1753
    Cell Significance Index: -13.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1841
    Cell Significance Index: -3.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1863
    Cell Significance Index: -12.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1879
    Cell Significance Index: -11.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2064
    Cell Significance Index: -4.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2115
    Cell Significance Index: -11.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2151
    Cell Significance Index: -6.0100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2207
    Cell Significance Index: -1.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2223
    Cell Significance Index: -11.6700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2350
    Cell Significance Index: -3.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2384
    Cell Significance Index: -4.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2424
    Cell Significance Index: -6.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2534
    Cell Significance Index: -7.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2812
    Cell Significance Index: -4.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2822
    Cell Significance Index: -10.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2920
    Cell Significance Index: -14.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2968
    Cell Significance Index: -13.1300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2980
    Cell Significance Index: -5.0200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3025
    Cell Significance Index: -3.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3110
    Cell Significance Index: -6.0700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3168
    Cell Significance Index: -1.8800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3190
    Cell Significance Index: -3.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3290
    Cell Significance Index: -9.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3331
    Cell Significance Index: -11.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3577
    Cell Significance Index: -9.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3602
    Cell Significance Index: -13.6400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3661
    Cell Significance Index: -6.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3824
    Cell Significance Index: -10.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3859
    Cell Significance Index: -12.6400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3930
    Cell Significance Index: -5.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3975
    Cell Significance Index: -12.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3987
    Cell Significance Index: -5.7100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4105
    Cell Significance Index: -17.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4175
    Cell Significance Index: -11.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4183
    Cell Significance Index: -17.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** INHBB is a single-copy gene that encodes for a 115-amino acid protein, which is a subunit of the inhibin complex. 2. **Expression:** INHBB is widely expressed in various tissues, including the reproductive system, pancreas, and gastrointestinal tract. 3. **Function:** INHBB acts as a negative regulator of the follicle-stimulating hormone (FSH) secretion, which is essential for ovulation and spermatogenesis. **Pathways and Functions:** 1. **Activin Receptor Signaling Pathway:** INHBB interacts with the activin receptor complex, modulating the signaling pathways involved in cell differentiation, apoptosis, and growth. 2. **Apoptotic Signaling Pathway:** INHBB regulates the apoptotic signaling pathway, influencing cell death and survival in various tissues. 3. **Cell Differentiation:** INHBB plays a role in regulating cell differentiation, particularly in the development of the reproductive system and the pancreas. 4. **Metabolic Processes:** INHBB is involved in regulating metabolic processes, including glucose and lipid metabolism, in the pancreas and other tissues. 5. **Cytokine Activity:** INHBB modulates cytokine activity, influencing the immune response and inflammation. **Clinical Significance:** 1. **Reproductive Disorders:** Alterations in INHBB expression have been linked to reproductive disorders, including polycystic ovary syndrome (PCOS) and infertility. 2. **Metabolic Disorders:** INHBB dysregulation has been associated with metabolic disorders, such as type 2 diabetes and obesity. 3. **Cancer:** INHBB expression has been found to be altered in various types of cancer, including ovarian and breast cancer. 4. **Immune System:** INHBB plays a role in modulating the immune response, and its dysregulation may contribute to autoimmune diseases, such as rheumatoid arthritis. In conclusion, the INHBB gene is a critical regulator of reproductive and metabolic processes, and its dysregulation has been implicated in various human diseases. Further research is necessary to fully understand the mechanisms by which INHBB influences these processes and to explore its potential as a therapeutic target for the treatment of these disorders.

Genular Protein ID: 1633030493

Symbol: INHBB_HUMAN

Name: Inhibin beta B chain

UniProtKB Accession Codes:

P09529 Q53T31 Q8N1D3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2575216

Title: Activin B: precursor sequences, genomic structure and in vitro activities.

PubMed ID: 2575216

DOI: 10.1210/mend-3-9-1352

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2739657

Title: Characterization and regulation of testicular inhibin beta-subunit mRNA.

PubMed ID: 2739657

DOI: 10.1210/mend-3-6-939

PubMed ID: 3754442

Title: Structure of two human ovarian inhibins.

PubMed ID: 3754442

DOI: 10.1016/0006-291x(86)91021-1

PubMed ID: 2364091

Title: Purification and characterization of recombinant human activin B.

PubMed ID: 2364091

DOI: 10.1016/0167-4838(90)90178-i

PubMed ID: 12697670

Title: Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG).

PubMed ID: 12697670

DOI: 10.1210/en.2002-0203

Sequence Information:

  • Length: 407
  • Mass: 45122
  • Checksum: 90316C83597BA6B4
  • Sequence:
    • MDGLPGRALG AACLLLLAAG WLGPEAWGSP TPPPTPAAPP PPPPPGSPGG SQDTCTSCGG 
FRRPEELGRV DGDFLEAVKR HILSRLQMRG RPNITHAVPK AAMVTALRKL HAGKVREDGR 
VEIPHLDGHA SPGADGQERV SEIISFAETD GLASSRVRLY FFISNEGNQN LFVVQASLWL 
YLKLLPYVLE KGSRRKVRVK VYFQEQGHGD RWNMVEKRVD LKRSGWHTFP LTEAIQALFE 
RGERRLNLDV QCDSCQELAV VPVFVDPGEE SHRPFVVVQA RLGDSRHRIR KRGLECDGRT 
NLCCRQQFFI DFRLIGWNDW IIAPTGYYGN YCEGSCPAYL AGVPGSASSF HTAVVNQYRM 
RGLNPGTVNS CCIPTKLSTM SMLYFDDEYN IVKRDVPNMI VEECGCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.