Details for: INHBB

Gene ID: 3625

Symbol: INHBB

Ensembl ID: ENSG00000163083

Description: inhibin subunit beta B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.87
    Marker Score: 11102
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.37
    Marker Score: 2598
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4802
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17847
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1
    Marker Score: 637
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1
    Marker Score: 3445
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 1985
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.96
    Marker Score: 8317
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.93
    Marker Score: 698
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.81
    Marker Score: 470
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.72
    Marker Score: 173
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.63
    Marker Score: 1551
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 378
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.63
    Marker Score: 21666
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.62
    Marker Score: 197
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.61
    Marker Score: 238
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 397.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.59
    Marker Score: 2294
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.59
    Marker Score: 1174
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 274
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.57
    Marker Score: 1299
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.57
    Marker Score: 121
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.55
    Marker Score: 1050.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.55
    Marker Score: 256
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.53
    Marker Score: 939
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.53
    Marker Score: 193
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.52
    Marker Score: 755
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.51
    Marker Score: 868
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.51
    Marker Score: 6858
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.48
    Marker Score: 220
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.46
    Marker Score: 624
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.46
    Marker Score: 1788
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.46
    Marker Score: 133
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.46
    Marker Score: 411
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.44
    Marker Score: 163
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 431
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4
    Marker Score: 428
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 211
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.37
    Marker Score: 84
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.36
    Marker Score: 549
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.36
    Marker Score: 7580
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 153
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.34
    Marker Score: 123
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.34
    Marker Score: 406
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 311
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.31
    Marker Score: 209
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.3
    Marker Score: 350
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.3
    Marker Score: 106
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.29
    Marker Score: 260
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.27
    Marker Score: 269
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 156
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 232
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.27
    Marker Score: 1406
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.27
    Marker Score: 268
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.26
    Marker Score: 161
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.26
    Marker Score: 233
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.25
    Marker Score: 217
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.25
    Marker Score: 100.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.25
    Marker Score: 286
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.23
    Marker Score: 227
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.22
    Marker Score: 53
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.21
    Marker Score: 79
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 125
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.21
    Marker Score: 892

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Other Information

**Key characteristics:** - INHBB is a glycoprotein with a molecular weight of approximately 150 kDa. - It is produced in response to starvation and is also induced by cytokines such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). - INHBB binds to the activin receptor, which is expressed on the surface of Sertoli cells and granulosa cells. - Upon binding to activin, INHBB inhibits the activation of the receptor, leading to the inhibition of follicle development and growth. **Pathways and functions:** - INHBB negatively regulates the expression of genes involved in follicle development, such as those encoding for growth factors, receptors, and cytokines. - It also inhibits the production of growth factors and cytokines, including FSH and LH. - By blocking the action of activin, INHBB helps to maintain the developmental status of ovarian follicles and prevents the growth of new follicles. - In addition, INHBB plays a role in the regulation of uterine growth and development. **Clinical significance:** - Mutations in the INHBB gene have been linked to polycystic ovary syndrome (PCOS), a genetic disorder characterized by the formation of numerous and small follicles in the ovaries. - INHBB inhibitors are being investigated as potential treatments for PCOS, as they could be used to block the effects of activin and promote the development of healthy follicles. **Other important points:** - INHBB is a key regulator of female fertility. - It is also involved in the regulation of male fertility by inhibiting the growth of male reproductive cells. - The development of INHBB inhibitors is a promising area of research for the treatment of female infertility.

Genular Protein ID: 1633030493

Symbol: INHBB_HUMAN

Name: Inhibin beta B chain

UniProtKB Accession Codes:

P09529 Q53T31 Q8N1D3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2575216

Title: Activin B: precursor sequences, genomic structure and in vitro activities.

PubMed ID: 2575216

DOI: 10.1210/mend-3-9-1352

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2739657

Title: Characterization and regulation of testicular inhibin beta-subunit mRNA.

PubMed ID: 2739657

DOI: 10.1210/mend-3-6-939

PubMed ID: 3754442

Title: Structure of two human ovarian inhibins.

PubMed ID: 3754442

DOI: 10.1016/0006-291x(86)91021-1

PubMed ID: 2364091

Title: Purification and characterization of recombinant human activin B.

PubMed ID: 2364091

DOI: 10.1016/0167-4838(90)90178-i

PubMed ID: 12697670

Title: Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG).

PubMed ID: 12697670

DOI: 10.1210/en.2002-0203

Sequence Information:

  • Length: 407
  • Mass: 45122
  • Checksum: 90316C83597BA6B4
  • Sequence:
    • MDGLPGRALG AACLLLLAAG WLGPEAWGSP TPPPTPAAPP PPPPPGSPGG SQDTCTSCGG 
FRRPEELGRV DGDFLEAVKR HILSRLQMRG RPNITHAVPK AAMVTALRKL HAGKVREDGR 
VEIPHLDGHA SPGADGQERV SEIISFAETD GLASSRVRLY FFISNEGNQN LFVVQASLWL 
YLKLLPYVLE KGSRRKVRVK VYFQEQGHGD RWNMVEKRVD LKRSGWHTFP LTEAIQALFE 
RGERRLNLDV QCDSCQELAV VPVFVDPGEE SHRPFVVVQA RLGDSRHRIR KRGLECDGRT 
NLCCRQQFFI DFRLIGWNDW IIAPTGYYGN YCEGSCPAYL AGVPGSASSF HTAVVNQYRM 
RGLNPGTVNS CCIPTKLSTM SMLYFDDEYN IVKRDVPNMI VEECGCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.