Details for: INPP1

Gene ID: 3628

Symbol: INPP1

Ensembl ID: ENSG00000151689

Description: inositol polyphosphate-1-phosphatase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 178.0190
    Cell Significance Index: -27.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.8376
    Cell Significance Index: -26.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 69.1350
    Cell Significance Index: -28.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.4021
    Cell Significance Index: -23.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.6693
    Cell Significance Index: -27.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.4464
    Cell Significance Index: -23.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.4582
    Cell Significance Index: -27.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7765
    Cell Significance Index: -26.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0520
    Cell Significance Index: -27.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2218
    Cell Significance Index: -19.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.1134
    Cell Significance Index: 49.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6394
    Cell Significance Index: 137.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2304
    Cell Significance Index: 60.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7825
    Cell Significance Index: 24.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4450
    Cell Significance Index: 25.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2031
    Cell Significance Index: 1086.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2028
    Cell Significance Index: 34.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1890
    Cell Significance Index: 71.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1498
    Cell Significance Index: 32.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0060
    Cell Significance Index: 26.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9841
    Cell Significance Index: 107.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9120
    Cell Significance Index: 41.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8501
    Cell Significance Index: 104.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7623
    Cell Significance Index: 152.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7432
    Cell Significance Index: 20.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7399
    Cell Significance Index: 16.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7383
    Cell Significance Index: 120.0900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6821
    Cell Significance Index: 9.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6633
    Cell Significance Index: 119.5800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6358
    Cell Significance Index: 9.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6221
    Cell Significance Index: 223.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5986
    Cell Significance Index: 8.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3048
    Cell Significance Index: 58.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2897
    Cell Significance Index: 158.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2429
    Cell Significance Index: 2.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2355
    Cell Significance Index: 32.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2210
    Cell Significance Index: 97.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2184
    Cell Significance Index: 151.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2090
    Cell Significance Index: 27.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1387
    Cell Significance Index: 23.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1357
    Cell Significance Index: 4.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1205
    Cell Significance Index: 11.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0884
    Cell Significance Index: 11.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0840
    Cell Significance Index: 38.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0784
    Cell Significance Index: 147.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0721
    Cell Significance Index: 14.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0674
    Cell Significance Index: 3.1700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.0541
    Cell Significance Index: 0.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0458
    Cell Significance Index: 3.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0219
    Cell Significance Index: 1.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0215
    Cell Significance Index: 0.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0103
    Cell Significance Index: 0.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0076
    Cell Significance Index: 0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0068
    Cell Significance Index: 10.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0058
    Cell Significance Index: 7.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0056
    Cell Significance Index: 3.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0052
    Cell Significance Index: 9.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0074
    Cell Significance Index: -0.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0098
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0172
    Cell Significance Index: -10.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0173
    Cell Significance Index: -9.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0249
    Cell Significance Index: -18.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0275
    Cell Significance Index: -20.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0360
    Cell Significance Index: -7.5900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0362
    Cell Significance Index: -0.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0427
    Cell Significance Index: -4.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0781
    Cell Significance Index: -11.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0794
    Cell Significance Index: -22.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0843
    Cell Significance Index: -9.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0935
    Cell Significance Index: -6.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1005
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1027
    Cell Significance Index: -11.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1088
    Cell Significance Index: -12.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1158
    Cell Significance Index: -4.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1171
    Cell Significance Index: -5.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1271
    Cell Significance Index: -14.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1366
    Cell Significance Index: -6.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1439
    Cell Significance Index: -9.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1796
    Cell Significance Index: -3.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1985
    Cell Significance Index: -11.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2149
    Cell Significance Index: -22.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2328
    Cell Significance Index: -3.9900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2339
    Cell Significance Index: -3.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2671
    Cell Significance Index: -17.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2680
    Cell Significance Index: -5.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2743
    Cell Significance Index: -2.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2858
    Cell Significance Index: -8.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3006
    Cell Significance Index: -23.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3345
    Cell Significance Index: -7.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4240
    Cell Significance Index: -10.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4388
    Cell Significance Index: -22.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4489
    Cell Significance Index: -27.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4615
    Cell Significance Index: -14.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4685
    Cell Significance Index: -15.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4720
    Cell Significance Index: -11.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4740
    Cell Significance Index: -10.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4741
    Cell Significance Index: -12.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4813
    Cell Significance Index: -15.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4898
    Cell Significance Index: -4.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** INPP1 is a metal-dependent phosphatase that specifically hydrolyzes inositol polyphosphates, including inositol-1,3,4-trisphosphate (IP3) and inositol-1,4-bisphosphate (IP2), to produce inositol monophosphates. 2. **Cellular Expression:** INPP1 is widely expressed in various cell types, including endothelial cells, epithelial cells, oligodendrocytes, and fibroblasts. 3. **Protein Interactions:** INPP1 interacts with multiple proteins, including SH2-containing inositol phosphatase (SHIP), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt). 4. **Regulatory Mechanisms:** INPP1 is regulated by various mechanisms, including phosphorylation, ubiquitination, and protein-protein interactions. **Pathways and Functions:** 1. **Inositol Phosphate Metabolism:** INPP1 is central to the regulation of inositol phosphate metabolism, influencing the levels of IP3 and IP2, which in turn modulate various cellular processes, including cell signaling, growth, and differentiation. 2. **Signal Transduction:** INPP1 modulates signaling pathways, including the PI3K/Akt pathway, which is involved in cell survival, proliferation, and metabolism. 3. **Cell Growth and Differentiation:** INPP1 regulates cell growth and differentiation by modulating the levels of IP3 and IP2, which in turn influence the activity of various transcription factors. 4. **Metabolic Regulation:** INPP1 plays a role in metabolic regulation, influencing the levels of inositol phosphates, which are involved in energy metabolism and glucose homeostasis. **Clinical Significance:** 1. **Cancer:** INPP1 has been implicated in various cancers, including breast, lung, and colon cancer, where it is often overexpressed or mutated, leading to enhanced cell growth and survival. 2. **Neurological Disorders:** INPP1 has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it is thought to play a role in the regulation of inositol phosphate metabolism and signaling pathways. 3. **Endothelial Dysfunction:** INPP1 has been shown to be involved in endothelial dysfunction, which is a key component of various cardiovascular diseases, including atherosclerosis and hypertension. 4. **Metabolic Disorders:** INPP1 has been implicated in metabolic disorders, including obesity and diabetes, where it is thought to play a role in the regulation of inositol phosphate metabolism and glucose homeostasis. In conclusion, INPP1 is a critical enzyme involved in the regulation of inositol phosphate metabolism, signaling pathways, and cellular processes. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, endothelial dysfunction, and metabolic disorders. Further research is needed to fully elucidate the role of INPP1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2334294613

Symbol: INPP_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49441

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8390685

Title: Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase.

PubMed ID: 8390685

DOI: 10.1073/pnas.90.12.5833

PubMed ID: 10780272

Title: Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1).

PubMed ID: 10780272

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9682271

Title: The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness.

PubMed ID: 9682271

Sequence Information:

  • Length: 399
  • Mass: 43998
  • Checksum: AEFD592199A40C6C
  • Sequence:
    • MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV 
IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE EETAELLSKV LNGNKVASEA 
LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ 
CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR 
NGSETHTGNT GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG 
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA 
AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.