Details for: INPP1

Gene ID: 3628

Symbol: INPP1

Ensembl ID: ENSG00000151689

Description: inositol polyphosphate-1-phosphatase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.42
    Marker Score: 3503
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.36
    Marker Score: 1860
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.96
    Marker Score: 4990
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.83
    Marker Score: 4463
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.69
    Marker Score: 2489.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.66
    Marker Score: 12971
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.55
    Marker Score: 3715
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.53
    Marker Score: 13144
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.52
    Marker Score: 2497
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.48
    Marker Score: 50231.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.43
    Marker Score: 3150
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.43
    Marker Score: 1575
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.37
    Marker Score: 6735
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.36
    Marker Score: 14092.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.34
    Marker Score: 4976
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.3
    Marker Score: 2012.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.28
    Marker Score: 1864
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10891.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.22
    Marker Score: 1288
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.22
    Marker Score: 1047
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.2
    Marker Score: 4992
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.2
    Marker Score: 1082
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.17
    Marker Score: 1974.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.16
    Marker Score: 10894.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.15
    Marker Score: 2302.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.11
    Marker Score: 10502.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.1
    Marker Score: 40689
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.1
    Marker Score: 619
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.09
    Marker Score: 4220
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.09
    Marker Score: 5223
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.09
    Marker Score: 4538
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.07
    Marker Score: 1007
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.06
    Marker Score: 1145
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.06
    Marker Score: 65113.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.04
    Marker Score: 39407.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.03
    Marker Score: 4292
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.01
    Marker Score: 242
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71726
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47950
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.98
    Marker Score: 382
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.98
    Marker Score: 3076
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5250
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.92
    Marker Score: 1270
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.91
    Marker Score: 19489
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.91
    Marker Score: 813
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2711
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9
    Marker Score: 1579
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.9
    Marker Score: 3196
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.89
    Marker Score: 301
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.87
    Marker Score: 738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5244
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.86
    Marker Score: 1113
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.86
    Marker Score: 919
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.85
    Marker Score: 6360
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.85
    Marker Score: 734
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.85
    Marker Score: 12653
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.82
    Marker Score: 16243
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.81
    Marker Score: 339
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.79
    Marker Score: 798
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.79
    Marker Score: 978
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.78
    Marker Score: 6016
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.78
    Marker Score: 655
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.78
    Marker Score: 165
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.77
    Marker Score: 820.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.77
    Marker Score: 867
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.76
    Marker Score: 849
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.75
    Marker Score: 3040
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.75
    Marker Score: 3216
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.74
    Marker Score: 310
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.74
    Marker Score: 180
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.72
    Marker Score: 243.5
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.72
    Marker Score: 175
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.72
    Marker Score: 225
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.71
    Marker Score: 194
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.7
    Marker Score: 170
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.7
    Marker Score: 175
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.7
    Marker Score: 175
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.69
    Marker Score: 152
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.69
    Marker Score: 175
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.69
    Marker Score: 10786.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.69
    Marker Score: 411
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.68
    Marker Score: 437
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.68
    Marker Score: 1385
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2854
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.66
    Marker Score: 327.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.66
    Marker Score: 1568.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.66
    Marker Score: 180
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.65
    Marker Score: 231
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.65
    Marker Score: 262

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Other Information

**Key characteristics:** - Inhibits the activity of other phosphatases, such as INPP3 and INPP4 - Regulates the production of second messengers, such as IP3 and IP4 - Is highly expressed in cells of the immune system, particularly in endothelial cells and antigen-presenting cells - Plays a role in the regulation of inflammation, cell migration, and differentiation **Pathways and functions:** - INPP1 is involved in the regulation of inflammation by inhibiting the activity of other phosphatases that are involved in inflammation. - It also plays a role in cell migration and differentiation by regulating the production of IP3 and IP4, which are key second messengers involved in these processes. - INPP1 is also involved in the regulation of cell growth and survival by inhibiting the activity of other phosphatases that are involved in cell cycle progression. **Clinical significance:** - Mutations in INPP1 have been linked to several human diseases, including cancer and autoimmune disorders. - In particular, mutations in INPP1 have been linked to the development of breast cancer, lung cancer, and multiple sclerosis. - InPP1 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 2334294613

Symbol: INPP_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49441

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8390685

Title: Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase.

PubMed ID: 8390685

DOI: 10.1073/pnas.90.12.5833

PubMed ID: 10780272

Title: Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1).

PubMed ID: 10780272

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9682271

Title: The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness.

PubMed ID: 9682271

Sequence Information:

  • Length: 399
  • Mass: 43998
  • Checksum: AEFD592199A40C6C
  • Sequence:
    • MSDILRELLC VSEKAANIAR ACRQQEALFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV 
IKQNMENKFP GLEKNIFGEE SNEFTNDWGE KITLRLCSTE EETAELLSKV LNGNKVASEA 
LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ 
CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR 
NGSETHTGNT GSEAAFSPSF SAVISTSEKE TIKAALSRVC GDRIFGAAGA GYKSLCVVQG 
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA 
AGVDRWANKG GLIAYRSRKR LETFLSLLVQ NLAPAETHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.