Details for: INPP5A

Gene ID: 3632

Symbol: INPP5A

Ensembl ID: ENSG00000068383

Description: inositol polyphosphate-5-phosphatase A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.61
    Marker Score: 5725
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.58
    Marker Score: 814
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.32
    Marker Score: 9707.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.08
    Marker Score: 1987
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.85
    Marker Score: 1029
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.79
    Marker Score: 3631.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.74
    Marker Score: 7203
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.72
    Marker Score: 538
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.71
    Marker Score: 63094
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.63
    Marker Score: 100328.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.58
    Marker Score: 14864
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.54
    Marker Score: 13231
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.54
    Marker Score: 645
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.52
    Marker Score: 5870.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.47
    Marker Score: 13957
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.46
    Marker Score: 29020
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.44
    Marker Score: 465
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.4
    Marker Score: 10741
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.39
    Marker Score: 14386
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.39
    Marker Score: 1602
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.38
    Marker Score: 5605
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.37
    Marker Score: 2626.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.36
    Marker Score: 813
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21283
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.36
    Marker Score: 3203
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.35
    Marker Score: 809
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.33
    Marker Score: 700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.31
    Marker Score: 19564
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.3
    Marker Score: 49508
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.3
    Marker Score: 27680
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.29
    Marker Score: 1426
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.28
    Marker Score: 374
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.26
    Marker Score: 1946
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.1
    Marker Score: 301
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.08
    Marker Score: 831
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.07
    Marker Score: 6405
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.06
    Marker Score: 620
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.06
    Marker Score: 23628
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.04
    Marker Score: 494
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71772
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47996
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.96
    Marker Score: 1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.95
    Marker Score: 274
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.95
    Marker Score: 1146
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.92
    Marker Score: 987
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.89
    Marker Score: 521
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1430
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5008
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.86
    Marker Score: 1447
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.83
    Marker Score: 409
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.82
    Marker Score: 447
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.82
    Marker Score: 1194
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.8
    Marker Score: 353.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.77
    Marker Score: 4980
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.77
    Marker Score: 2753
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.75
    Marker Score: 536
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.74
    Marker Score: 2103.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.74
    Marker Score: 3208
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.74
    Marker Score: 13125
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.73
    Marker Score: 266
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3070
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.72
    Marker Score: 774
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 638
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.7
    Marker Score: 181
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.69
    Marker Score: 470
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 455
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.67
    Marker Score: 988
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.67
    Marker Score: 947
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.66
    Marker Score: 250
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.66
    Marker Score: 883
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.63
    Marker Score: 225
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.62
    Marker Score: 3342
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 531
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.61
    Marker Score: 525
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.61
    Marker Score: 344
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.61
    Marker Score: 154
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.6
    Marker Score: 155
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.6
    Marker Score: 189
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.59
    Marker Score: 9542
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.59
    Marker Score: 163
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.59
    Marker Score: 374
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.59
    Marker Score: 222
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.58
    Marker Score: 1380
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.57
    Marker Score: 116
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.57
    Marker Score: 197
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.57
    Marker Score: 320
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.57
    Marker Score: 213
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.56
    Marker Score: 583.5

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Other Information

**Key characteristics:** * INPP5A is a protein with a molecular weight of approximately 150 kDa. * It is a phosphatases enzyme, which means it breaks down phosphate groups from molecules. * It is expressed in a variety of cell types, including ciliary muscle cells, smooth muscle cells of the sphincter of pupil, pigmented epithelial cells, renal interstitial pericytes, alveolar type 2 fibroblasts, immature innate lymphoid cells, chandelier pvalb GABAergic cortical interneurons, kidney capillary endothelial cells, and pvalb GABAergic cortical interneurons. * It is a highly conserved protein, with the sequence of its catalytic domain being found in mammals, birds, and fish. **Pathways and functions:** * INPP5A is involved in the regulation of the PI3K/Akt pathway, a major signaling pathway that is involved in cell growth, proliferation, and survival. * It is also involved in the regulation of the MAPK pathway, which is involved in cell migration, differentiation, and survival. * It is involved in the regulation of the G protein-coupled receptor signaling pathway, which is involved in cell proliferation and differentiation. * It is also involved in the regulation of the insulin/IGF-1 signaling pathway, which is involved in growth and development. **Clinical significance:** INPP5A gene mutations have been linked to a number of human diseases, including: * Inherited retinal dystrophia, a genetic disorder that affects the light-sensitive cells in the eyes. * Renal cell carcinoma, a type of cancer that affects the kidneys. * Breast cancer, lung cancer, and other types of cancer. INPP5A is a promising target for the treatment of cancer and other diseases that are characterized by abnormal cell growth.

Genular Protein ID: 1613262063

Symbol: I5P1_HUMAN

Name: Inositol polyphosphate-5-phosphatase A

UniProtKB Accession Codes:

Q14642 D3DXI3 Q14640 Q5JSF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 4 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8013665

Title: Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells.

PubMed ID: 8013665

DOI: 10.1016/0014-5793(94)00509-5

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8006039

Title: Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase.

PubMed ID: 8006039

DOI: 10.1016/s0021-9258(17)32555-3

PubMed ID: 8769125

Title: Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.

PubMed ID: 8769125

DOI: 10.1006/bbrc.1996.1161

PubMed ID: 8626616

Title: Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation.

PubMed ID: 8626616

DOI: 10.1074/jbc.271.17.10419

Sequence Information:

  • Length: 412
  • Mass: 47820
  • Checksum: F55C0DFDDA01A850
  • Sequence:
    • MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN 
YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH FTALGSFYFL HESLKNIYQF 
DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFIRTR WCIADCAFDL 
VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK 
SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT 
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR ILMSPSAKEL 
VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK PHAHVHKCCV VQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.