Details for: INPP5A

Gene ID: 3632

Symbol: INPP5A

Ensembl ID: ENSG00000068383

Description: inositol polyphosphate-5-phosphatase A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 182.3907
    Cell Significance Index: -28.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.1009
    Cell Significance Index: -28.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.0871
    Cell Significance Index: -26.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.0606
    Cell Significance Index: -22.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.0665
    Cell Significance Index: -28.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7952
    Cell Significance Index: -26.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2427
    Cell Significance Index: -28.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1507
    Cell Significance Index: -15.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.3434
    Cell Significance Index: 236.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.7938
    Cell Significance Index: 181.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5466
    Cell Significance Index: 310.2400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5417
    Cell Significance Index: 12.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3721
    Cell Significance Index: 105.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1274
    Cell Significance Index: 223.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9889
    Cell Significance Index: 25.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9742
    Cell Significance Index: 349.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9380
    Cell Significance Index: 25.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8712
    Cell Significance Index: 12.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8674
    Cell Significance Index: 101.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7714
    Cell Significance Index: 76.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7674
    Cell Significance Index: 124.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7007
    Cell Significance Index: 20.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6628
    Cell Significance Index: 598.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6538
    Cell Significance Index: 13.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6340
    Cell Significance Index: 287.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5680
    Cell Significance Index: 34.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5045
    Cell Significance Index: 12.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4872
    Cell Significance Index: 52.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.4549
    Cell Significance Index: 47.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4259
    Cell Significance Index: 801.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3804
    Cell Significance Index: 19.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3330
    Cell Significance Index: 9.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3240
    Cell Significance Index: 7.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2993
    Cell Significance Index: 53.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2296
    Cell Significance Index: 15.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2267
    Cell Significance Index: 12.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2068
    Cell Significance Index: 25.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1990
    Cell Significance Index: 13.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1697
    Cell Significance Index: 7.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1496
    Cell Significance Index: 94.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1416
    Cell Significance Index: 2.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0994
    Cell Significance Index: 6.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0876
    Cell Significance Index: 4.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0825
    Cell Significance Index: 45.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0756
    Cell Significance Index: 10.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0700
    Cell Significance Index: 30.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0592
    Cell Significance Index: 91.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0310
    Cell Significance Index: 42.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0301
    Cell Significance Index: 55.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0235
    Cell Significance Index: 0.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0244
    Cell Significance Index: -17.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0311
    Cell Significance Index: -23.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0363
    Cell Significance Index: -26.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0478
    Cell Significance Index: -26.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0488
    Cell Significance Index: -30.4600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0496
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0509
    Cell Significance Index: -8.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0672
    Cell Significance Index: -4.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0715
    Cell Significance Index: -10.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0798
    Cell Significance Index: -2.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0831
    Cell Significance Index: -1.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0833
    Cell Significance Index: -23.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0907
    Cell Significance Index: -0.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0990
    Cell Significance Index: -3.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1019
    Cell Significance Index: -2.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1226
    Cell Significance Index: -7.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1251
    Cell Significance Index: -16.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1446
    Cell Significance Index: -30.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1564
    Cell Significance Index: -17.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1634
    Cell Significance Index: -21.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1676
    Cell Significance Index: -4.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1788
    Cell Significance Index: -2.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1850
    Cell Significance Index: -3.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1961
    Cell Significance Index: -23.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2026
    Cell Significance Index: -4.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2039
    Cell Significance Index: -20.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2190
    Cell Significance Index: -10.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2362
    Cell Significance Index: -4.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2382
    Cell Significance Index: -15.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2619
    Cell Significance Index: -18.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2809
    Cell Significance Index: -6.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2880
    Cell Significance Index: -15.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2909
    Cell Significance Index: -23.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2916
    Cell Significance Index: -21.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3045
    Cell Significance Index: -1.8400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3672
    Cell Significance Index: -4.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3947
    Cell Significance Index: -20.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4198
    Cell Significance Index: -13.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4227
    Cell Significance Index: -21.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4291
    Cell Significance Index: -14.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4504
    Cell Significance Index: -10.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4758
    Cell Significance Index: -15.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4875
    Cell Significance Index: -9.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4914
    Cell Significance Index: -9.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4945
    Cell Significance Index: -8.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5010
    Cell Significance Index: -7.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5703
    Cell Significance Index: -11.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5709
    Cell Significance Index: -20.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5763
    Cell Significance Index: -16.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** INPP5A is a mitochondrial enzyme that catalyzes the dephosphorylation of inositol polyphosphates, including InsP5, InsP4, and InsP3, thereby regulating their levels and activity. This enzyme is characterized by its high affinity for phosphatidylinositol (PI) and its ability to modulate phospholipase C (PLC) activity. INPP5A has been implicated in various cellular processes, including cell proliferation, differentiation, and survival. **Pathways and Functions:** INPP5A is involved in several signaling pathways that regulate immune responses, including: 1. **Negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway:** INPP5A regulates the activity of PLC, which is a crucial enzyme in the production of second messengers involved in immune responses. 2. **Inositol phosphate metabolic process:** INPP5A is involved in the regulation of inositol phosphate levels, which are essential for signaling pathways involved in immune responses. 3. **Synthesis of InsP2, InsP, and Ins:** INPP5A regulates the dephosphorylation of InsP2, InsP, and Ins, which are key inositol phosphates involved in immune responses. **Clinical Significance:** Dysregulation of INPP5A has been implicated in various diseases, including: 1. **Autoimmune disorders:** Alterations in INPP5A expression and activity have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** INPP5A has been shown to play a role in cancer development and progression, particularly in the regulation of cell proliferation and survival. 3. **Neurological disorders:** INPP5A has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, INPP5A is a critical enzyme that regulates immune responses, cellular growth, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of INPP5A in maintaining immune homeostasis and overall cellular health. **Implications for Research and Therapy:** 1. **Immunotherapy:** Targeting INPP5A may provide a new therapeutic strategy for autoimmune disorders and cancer. 2. **Cancer treatment:** INPP5A inhibitors may be used to regulate cell proliferation and survival in cancer cells. 3. **Neurological disorders:** INPP5A modulators may be used to regulate immune responses and inflammation in neurological disorders. In summary, INPP5A is a crucial enzyme that plays a pivotal role in regulating immune responses, cellular growth, and differentiation. Further research on INPP5A is necessary to fully understand its role in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 1613262063

Symbol: I5P1_HUMAN

Name: Inositol polyphosphate-5-phosphatase A

UniProtKB Accession Codes:

Q14642 D3DXI3 Q14640 Q5JSF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 4 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8013665

Title: Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells.

PubMed ID: 8013665

DOI: 10.1016/0014-5793(94)00509-5

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8006039

Title: Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase.

PubMed ID: 8006039

DOI: 10.1016/s0021-9258(17)32555-3

PubMed ID: 8769125

Title: Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.

PubMed ID: 8769125

DOI: 10.1006/bbrc.1996.1161

PubMed ID: 8626616

Title: Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation.

PubMed ID: 8626616

DOI: 10.1074/jbc.271.17.10419

Sequence Information:

  • Length: 412
  • Mass: 47820
  • Checksum: F55C0DFDDA01A850
  • Sequence:
    • MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN 
YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH FTALGSFYFL HESLKNIYQF 
DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFIRTR WCIADCAFDL 
VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK 
SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT 
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR ILMSPSAKEL 
VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK PHAHVHKCCV VQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.