Details for: INSIG1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 288.0834
Cell Significance Index: -44.8100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 174.6941
Cell Significance Index: -44.3100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 118.0004
Cell Significance Index: -48.6100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 89.7382
Cell Significance Index: -46.1600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 38.7524
Cell Significance Index: -47.7800 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 16.4552
Cell Significance Index: 21.2900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.8836
Cell Significance Index: -42.5500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.1767
Cell Significance Index: -48.0500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.5743
Cell Significance Index: -35.5500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.3877
Cell Significance Index: -13.9800 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 5.5988
Cell Significance Index: 40.2100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 5.0721
Cell Significance Index: 89.6300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.9629
Cell Significance Index: 66.7600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.2459
Cell Significance Index: 86.9800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.5717
Cell Significance Index: 75.5300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.2977
Cell Significance Index: 120.6400 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.4217
Cell Significance Index: 183.6700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0227
Cell Significance Index: 47.6900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.0070
Cell Significance Index: 47.3300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9550
Cell Significance Index: 862.2500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.7346
Cell Significance Index: 6.7700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6863
Cell Significance Index: 19.7800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.6337
Cell Significance Index: 108.2100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.5996
Cell Significance Index: 8.8500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5986
Cell Significance Index: 97.3600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5777
Cell Significance Index: 16.5600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5656
Cell Significance Index: 29.3800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5453
Cell Significance Index: 14.5600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5438
Cell Significance Index: 59.1500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4730
Cell Significance Index: 58.1600 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.4702
Cell Significance Index: 60.2800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4605
Cell Significance Index: 251.5000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4515
Cell Significance Index: 81.3900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4297
Cell Significance Index: 19.4800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3202
Cell Significance Index: 19.2300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3093
Cell Significance Index: 23.0500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3066
Cell Significance Index: 109.9800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2927
Cell Significance Index: 58.7300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2909
Cell Significance Index: 57.7400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2903
Cell Significance Index: 6.2900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2342
Cell Significance Index: 440.9000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2138
Cell Significance Index: 290.7000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1928
Cell Significance Index: 22.7400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1867
Cell Significance Index: 18.4700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1519
Cell Significance Index: 10.5100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1167
Cell Significance Index: 7.5300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0999
Cell Significance Index: 3.5100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0871
Cell Significance Index: 65.8900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0831
Cell Significance Index: 15.8100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0710
Cell Significance Index: 109.2500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0614
Cell Significance Index: 27.1400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0179
Cell Significance Index: 11.3900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0143
Cell Significance Index: 26.3500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0063
Cell Significance Index: -4.6800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0136
Cell Significance Index: -8.5000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0240
Cell Significance Index: -3.3000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0249
Cell Significance Index: -17.2500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0465
Cell Significance Index: -4.7500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0489
Cell Significance Index: -35.8400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0526
Cell Significance Index: -29.6700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0672
Cell Significance Index: -7.6700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0699
Cell Significance Index: -3.9200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0866
Cell Significance Index: -39.3000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1110
Cell Significance Index: -23.3900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1140
Cell Significance Index: -32.8000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1829
Cell Significance Index: -2.8300 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2110
Cell Significance Index: -2.9600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2250
Cell Significance Index: -26.2300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2264
Cell Significance Index: -25.9400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2628
Cell Significance Index: -38.2000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3102
Cell Significance Index: -10.7800 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.3108
Cell Significance Index: -5.3400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3149
Cell Significance Index: -8.8000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3200
Cell Significance Index: -22.6300 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3288
Cell Significance Index: -5.5300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3746
Cell Significance Index: -9.8500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3818
Cell Significance Index: -12.2300 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -0.4074
Cell Significance Index: -1.5600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4187
Cell Significance Index: -43.6000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4623
Cell Significance Index: -8.5500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5349
Cell Significance Index: -35.9700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5484
Cell Significance Index: -43.4300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6370
Cell Significance Index: -48.8900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6714
Cell Significance Index: -41.2700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6800
Cell Significance Index: -18.5100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.6821
Cell Significance Index: -8.4600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7167
Cell Significance Index: -45.1700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.7362
Cell Significance Index: -15.4100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7430
Cell Significance Index: -12.4400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.7454
Cell Significance Index: -19.9400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.7512
Cell Significance Index: -19.1900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7836
Cell Significance Index: -48.0500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8423
Cell Significance Index: -21.0600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.8996
Cell Significance Index: -10.2200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.9169
Cell Significance Index: -33.6600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.9631
Cell Significance Index: -13.1400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9960
Cell Significance Index: -44.0600 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -1.0115
Cell Significance Index: -6.2900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.0410
Cell Significance Index: -22.1700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.1326
Cell Significance Index: -32.3200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 749189692
Symbol: INSI1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9268630
Title: Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.
PubMed ID: 9268630
PubMed ID: 12202038
Title: Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
PubMed ID: 12202038
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12535518
Title: Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.
PubMed ID: 12535518
PubMed ID: 14660594
Title: Membrane topology of human insig-1, a protein regulator of lipid synthesis.
PubMed ID: 14660594
PubMed ID: 15899885
Title: Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.
PubMed ID: 15899885
PubMed ID: 16168377
Title: Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
PubMed ID: 16168377
PubMed ID: 16399501
Title: Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
PubMed ID: 16399501
PubMed ID: 17043353
Title: Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.
PubMed ID: 17043353
PubMed ID: 16606821
Title: Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.
PubMed ID: 16606821
PubMed ID: 20068067
Title: The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
PubMed ID: 20068067
PubMed ID: 22143767
Title: Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
PubMed ID: 22143767
PubMed ID: 28604676
Title: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.
PubMed ID: 28604676
DOI: 10.1038/ncb3551
PubMed ID: 29184177
Title: Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.
PubMed ID: 29184177
DOI: 10.1038/ncb3651
PubMed ID: 28849786
Title: SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.
PubMed ID: 28849786
PubMed ID: 29374057
Title: Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.
PubMed ID: 29374057
PubMed ID: 32322062
Title: The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
PubMed ID: 32322062
PubMed ID: 23481256
Title: Rules for the recognition of dilysine retrieval motifs by coatomer.
PubMed ID: 23481256
Sequence Information:
- Length: 277
- Mass: 29987
- Checksum: 198068D53C658A58
- Sequence:
MPRLHDHFWS CSCAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA HGAPDADPAP RGRSAAMSGP EPGSPYPNTW HHRLLQRSLV LFSVGVVLAL VLNLLQIQRN VTLFPEEVIA TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH LGEPHKFKRE WASVMRCIAV FVGINHASAK LDFANNVQLS LTLAALSLGL WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD FLYIRSWLPC IFFSGGVTVG NIGRQLAMGV PEKPHSD
Genular Protein ID: 2342973333
Symbol: F5H6P3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 12853948
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 178
- Mass: 20370
- Checksum: 8FD0FAD53542FE0F
- Sequence:
MPRLHDHFWS CSCAHSARRR GPPRASAKLD FANNVQLSLT LAALSLGLWW TFDRSRSGLG LGITIAFLAT LITQFLVYNG VYQYTSPDFL YIRSWLPCIF FSGGVTVGNI GRQLAMLIPF CEELNLKTTW LFHKTRSNYR VFLKSPIVIE SSKPPILRAR KILEENLTVD YDKDYLFS
Genular Protein ID: 136794793
Symbol: A4D2M9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
Sequence Information:
- Length: 330
- Mass: 36452
- Checksum: 26F51232C0875C9D
- Sequence:
MPRLHDHFWS CSCAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA HGAPDADPAP RGRSAAMSGP EPGSPYPNTW HHRLLQRSLV LFSVGVVLAL VLNLLQIQRN VTLFPEEVIA TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH LGEPHKFKRE WASVMRCIAV FVGINHASAK LDFANNVQLS LTLAALSLGL WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD FLYIRSWLPC IFFSGGVTVG NIGRQLAMLI PFCEELNLKT TWLFHKTRSN YRVFLKSPIV IESSKPPILR ARKILEENLT VDYDKDYLFS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.