Details for: INSIG1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.14
Marker Score: 2,580 - Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.06
Marker Score: 1,293 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.99
Marker Score: 1,881 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.93
Marker Score: 751 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.92
Marker Score: 10,316 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.91
Marker Score: 12,450 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.88
Marker Score: 12,005 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.87
Marker Score: 3,799 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.86
Marker Score: 1,087 - Cell Name: pneumocyte (CL0000322)
Fold Change: 1.84
Marker Score: 2,951 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.83
Marker Score: 1,563 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.82
Marker Score: 32,322 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.76
Marker Score: 2,971 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.73
Marker Score: 7,464 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.71
Marker Score: 710 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.69
Marker Score: 3,569 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.64
Marker Score: 1,878 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.63
Marker Score: 3,096 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.58
Marker Score: 4,103 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.55
Marker Score: 387 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.55
Marker Score: 905 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.54
Marker Score: 387 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.51
Marker Score: 522 - Cell Name: Mueller cell (CL0000636)
Fold Change: 1.51
Marker Score: 2,098 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.51
Marker Score: 9,707 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.49
Marker Score: 5,529 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.49
Marker Score: 3,596 - Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166,660 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.38
Marker Score: 47,121 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.38
Marker Score: 671 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.34
Marker Score: 1,929 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.32
Marker Score: 1,407 - Cell Name: reticular cell (CL0000432)
Fold Change: 1.31
Marker Score: 479 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.31
Marker Score: 1,642 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.31
Marker Score: 2,974 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.3
Marker Score: 5,428 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.29
Marker Score: 4,058 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.25
Marker Score: 1,847 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.23
Marker Score: 778 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.22
Marker Score: 2,429 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.19
Marker Score: 2,919 - Cell Name: peptic cell (CL0000155)
Fold Change: 1.18
Marker Score: 495 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.18
Marker Score: 340 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.17
Marker Score: 797 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.17
Marker Score: 2,646 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.16
Marker Score: 501 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.16
Marker Score: 1,037 - Cell Name: granulocyte (CL0000094)
Fold Change: 1.16
Marker Score: 520 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.16
Marker Score: 7,373 - Cell Name: oocyte (CL0000023)
Fold Change: 1.15
Marker Score: 284 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.15
Marker Score: 1,881 - Cell Name: keratinocyte (CL0000312)
Fold Change: 1.15
Marker Score: 957 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.13
Marker Score: 2,715 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.13
Marker Score: 601 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.11
Marker Score: 743 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.11
Marker Score: 224 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.09
Marker Score: 1,908 - Cell Name: macrophage (CL0000235)
Fold Change: 1.09
Marker Score: 1,216 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.09
Marker Score: 1,207 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.09
Marker Score: 656 - Cell Name: secretory cell (CL0000151)
Fold Change: 1.09
Marker Score: 1,993 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.08
Marker Score: 1,308 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.08
Marker Score: 1,489 - Cell Name: club cell (CL0000158)
Fold Change: 1.07
Marker Score: 1,255 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.07
Marker Score: 2,087 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.07
Marker Score: 256 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.06
Marker Score: 340 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.05
Marker Score: 1,133 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.05
Marker Score: 303 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.04
Marker Score: 640 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.04
Marker Score: 2,834 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.04
Marker Score: 352 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 1.04
Marker Score: 312 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,586 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.04
Marker Score: 16,206 - Cell Name: leukocyte (CL0000738)
Fold Change: 1.04
Marker Score: 594 - Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.03
Marker Score: 298 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.03
Marker Score: 808 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.02
Marker Score: 385 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.01
Marker Score: 1,064 - Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.01
Marker Score: 459 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.01
Marker Score: 377 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.01
Marker Score: 587 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.01
Marker Score: 318 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1
Marker Score: 1,017 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,607 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.99
Marker Score: 953 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.99
Marker Score: 1,581 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,832 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.99
Marker Score: 685 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Marker Score: 3,880 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.99
Marker Score: 982 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.98
Marker Score: 4,718 - Cell Name: Unknown (CL0000548)
Fold Change: 0.98
Marker Score: 714 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,368 - Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.98
Marker Score: 1,172 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.97
Marker Score: 232 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.97
Marker Score: 479 - Cell Name: PP cell (CL0000696)
Fold Change: 0.97
Marker Score: 218 - Cell Name: serous secreting cell (CL0000313)
Fold Change: 0.97
Marker Score: 386
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 749189692
Symbol: INSI1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9268630
Title: Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.
PubMed ID: 9268630
PubMed ID: 12202038
Title: Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
PubMed ID: 12202038
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12535518
Title: Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.
PubMed ID: 12535518
PubMed ID: 14660594
Title: Membrane topology of human insig-1, a protein regulator of lipid synthesis.
PubMed ID: 14660594
PubMed ID: 15899885
Title: Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.
PubMed ID: 15899885
PubMed ID: 16168377
Title: Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
PubMed ID: 16168377
PubMed ID: 16399501
Title: Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
PubMed ID: 16399501
PubMed ID: 17043353
Title: Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.
PubMed ID: 17043353
PubMed ID: 16606821
Title: Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.
PubMed ID: 16606821
PubMed ID: 20068067
Title: The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
PubMed ID: 20068067
PubMed ID: 22143767
Title: Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
PubMed ID: 22143767
PubMed ID: 28604676
Title: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.
PubMed ID: 28604676
DOI: 10.1038/ncb3551
PubMed ID: 29184177
Title: Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.
PubMed ID: 29184177
DOI: 10.1038/ncb3651
PubMed ID: 28849786
Title: SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.
PubMed ID: 28849786
PubMed ID: 29374057
Title: Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.
PubMed ID: 29374057
PubMed ID: 32322062
Title: The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
PubMed ID: 32322062
PubMed ID: 23481256
Title: Rules for the recognition of dilysine retrieval motifs by coatomer.
PubMed ID: 23481256
Sequence Information:
- Length: 277
- Mass: 29987
- Checksum: 198068D53C658A58
- Sequence:
MPRLHDHFWS CSCAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA HGAPDADPAP RGRSAAMSGP EPGSPYPNTW HHRLLQRSLV LFSVGVVLAL VLNLLQIQRN VTLFPEEVIA TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH LGEPHKFKRE WASVMRCIAV FVGINHASAK LDFANNVQLS LTLAALSLGL WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD FLYIRSWLPC IFFSGGVTVG NIGRQLAMGV PEKPHSD
Genular Protein ID: 2342973333
Symbol: F5H6P3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12853948
Sequence Information:
- Length: 178
- Mass: 20370
- Checksum: 8FD0FAD53542FE0F
- Sequence:
MPRLHDHFWS CSCAHSARRR GPPRASAKLD FANNVQLSLT LAALSLGLWW TFDRSRSGLG LGITIAFLAT LITQFLVYNG VYQYTSPDFL YIRSWLPCIF FSGGVTVGNI GRQLAMLIPF CEELNLKTTW LFHKTRSNYR VFLKSPIVIE SSKPPILRAR KILEENLTVD YDKDYLFS
Genular Protein ID: 136794793
Symbol: A4D2M9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
Sequence Information:
- Length: 330
- Mass: 36452
- Checksum: 26F51232C0875C9D
- Sequence:
MPRLHDHFWS CSCAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA HGAPDADPAP RGRSAAMSGP EPGSPYPNTW HHRLLQRSLV LFSVGVVLAL VLNLLQIQRN VTLFPEEVIA TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH LGEPHKFKRE WASVMRCIAV FVGINHASAK LDFANNVQLS LTLAALSLGL WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD FLYIRSWLPC IFFSGGVTVG NIGRQLAMLI PFCEELNLKT TWLFHKTRSN YRVFLKSPIV IESSKPPILR ARKILEENLT VDYDKDYLFS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.