Gene IRAK1 - ENSG00000184216 | NCBI Gene ID: 3654

Details for: IRAK1

Gene ID: 3654

Symbol: IRAK1

Ensembl ID: ENSG00000184216

Description: interleukin 1 receptor associated kinase 1

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irak1 recruits ikk complex
(R-HSA-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-HSA-975144)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nf-kb is activated and signals survival
(R-HSA-209560)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr recruits signalling complexes
(R-HSA-209543)
P75ntr signals via nf-kb
(R-HSA-193639)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated irf7 activation in tlr7/8 or 9 signaling
(R-HSA-975110)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to heat
(GO:0034605)
Cellular response to hypoxia
(GO:0071456)
Cellular response to lipopolysaccharide
(GO:0071222)
Heat shock protein binding
(GO:0031072)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Interleukin-33-mediated signaling pathway
(GO:0038172)
Intracellular signal transduction
(GO:0035556)
Jnk cascade
(GO:0007254)
Kinase activity
(GO:0016301)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Nucleus
(GO:0005634)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of leukocyte adhesion to vascular endothelial cell
(GO:1904996)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of type i interferon production
(GO:0032481)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cytokine-mediated signaling pathway
(GO:0001959)
Response to interleukin-1
(GO:0070555)
Response to lipopolysaccharide
(GO:0032496)
Toll-like receptor 2 signaling pathway
(GO:0034134)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Toll-like receptor 9 signaling pathway
(GO:0034162)
Toll-like receptor signaling pathway
(GO:0002224)
Toll signaling pathway
(GO:0008063)
Type i interferon-mediated signaling pathway
(GO:0060337)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: classical monocyte (CL0000860)
Fold Change: 1.37
Marker Score: 5682
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.35
Marker Score: 13688
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.3
Marker Score: 2969
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.3
Marker Score: 1156
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.14
Marker Score: 684
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.09
Marker Score: 1242
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.05
Marker Score: 702
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.04
Marker Score: 35524
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.01
Marker Score: 278
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71717
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47941
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.99
Marker Score: 350
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.98
Marker Score: 968
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30394
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.97
Marker Score: 810
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.97
Marker Score: 343
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.96
Marker Score: 4736.5
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.96
Marker Score: 6134
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2397
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.94
Marker Score: 1166
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 475
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.92
Marker Score: 525
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 432
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.91
Marker Score: 50747
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2701
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.89
Marker Score: 22848
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.88
Marker Score: 918
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.88
Marker Score: 232
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.88
Marker Score: 1861
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.87
Marker Score: 301
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.87
Marker Score: 5275.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5230
Cell Name: enterocyte (CL0000584)
Fold Change: 0.85
Marker Score: 4082
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4844
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 304
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.84
Marker Score: 460
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.83
Marker Score: 1228
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.83
Marker Score: 808
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.83
Marker Score: 285
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.82
Marker Score: 582
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.81
Marker Score: 203
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.81
Marker Score: 548
Cell Name: osteoclast (CL0000092)
Fold Change: 0.78
Marker Score: 389
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.77
Marker Score: 514
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.76
Marker Score: 1223
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.76
Marker Score: 1204
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.76
Marker Score: 329
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 575.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 299
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.74
Marker Score: 310
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.74
Marker Score: 363
Cell Name: plasmablast (CL0000980)
Fold Change: 0.74
Marker Score: 986
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.74
Marker Score: 365
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.74
Marker Score: 1501.5
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.74
Marker Score: 468
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.73
Marker Score: 273
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.72
Marker Score: 454
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.71
Marker Score: 369
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.71
Marker Score: 601
Cell Name: paneth cell (CL0000510)
Fold Change: 0.69
Marker Score: 482.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 627
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.68
Marker Score: 727
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2839
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.66
Marker Score: 1064
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.66
Marker Score: 451
Cell Name: germ cell (CL0000586)
Fold Change: 0.66
Marker Score: 1156
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.65
Marker Score: 2420
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.65
Marker Score: 4256
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.65
Marker Score: 1594
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.65
Marker Score: 1471
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.63
Marker Score: 182
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.63
Marker Score: 428
Cell Name: precursor cell (CL0011115)
Fold Change: 0.63
Marker Score: 152
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.62
Marker Score: 4839
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.61
Marker Score: 646
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.61
Marker Score: 586
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.61
Marker Score: 3207
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.61
Marker Score: 2164
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.61
Marker Score: 193
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.6
Marker Score: 566
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.6
Marker Score: 1067
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.6
Marker Score: 396
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.6
Marker Score: 504
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.59
Marker Score: 276
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.58
Marker Score: 630
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.57
Marker Score: 1115
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.57
Marker Score: 366
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.57
Marker Score: 8942
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.57
Marker Score: 4915
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.57
Marker Score: 127
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.57
Marker Score: 341
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.55
Marker Score: 554
Cell Name: plasma cell (CL0000786)
Fold Change: 0.55
Marker Score: 616
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.54
Marker Score: 1350
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.54
Marker Score: 119
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.54
Marker Score: 226
Cell Name: stem cell (CL0000034)
Fold Change: 0.54
Marker Score: 1282
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.54
Marker Score: 366

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**Key characteristics:** * IRAK1 is a member of the IRAK family of kinases. * It is expressed in high levels in the immune system. * It is involved in the regulation of inflammation, cell growth, and differentiation. **Pathways and functions:** * IRAK1 is a key regulator of the innate immune response. * It is involved in the activation of the NF-kappaB and MAPK signaling pathways. * It also regulates the expression of other cytokines and chemokines. * IRAK1 is a key regulator of the inflammatory response to viral infection. **Clinical significance:** * Mutations in the IRAK1 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and psoriasis. * IRAK1 inhibitors are being investigated as a treatment for these diseases. **Additional information:** * IRAK1 is a protein that is expressed in high levels in the immune system. * It is a key regulator of inflammation and cell growth. * It is involved in the regulation of the innate immune response to viral infection.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

IRAK1_HUMAN

Genular Protein ID: 2914672404

Symbol: IRAK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P51617 D3DWW3 D3DWW4 Q7Z5V4 Q96C06 Q96RL2

Database IDs:

Citations:

PubMed ID: 8599092

Title: IRAK: a kinase associated with the interleukin-1 receptor.

PubMed ID: 8599092

DOI: 10.1126/science.271.5252.1128

PubMed ID: 10723722

Title: Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.

PubMed ID: 10723722

DOI: 10.1007/s003350010035

PubMed ID: 11397809

Title: IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.

PubMed ID: 11397809

DOI: 10.1074/jbc.m103815200

PubMed ID: 16024789

Title: A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.

PubMed ID: 16024789

DOI: 10.1128/mcb.25.15.6521-6532.2005

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430229

Title: MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

PubMed ID: 9430229

DOI: 10.1016/s1074-7613(00)80402-1

PubMed ID: 10854325

Title: Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor.

PubMed ID: 10854325

DOI: 10.1038/35014038

PubMed ID: 11960013

Title: IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase.

PubMed ID: 11960013

DOI: 10.1073/pnas.082100399

PubMed ID: 12496252

Title: Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.

PubMed ID: 12496252

DOI: 10.1074/jbc.m212112200

PubMed ID: 12860405

Title: Characterization of Pellino2, a substrate of IRAK1 and IRAK4.

PubMed ID: 12860405

DOI: 10.1016/s0014-5793(03)00697-5

PubMed ID: 12538665

Title: Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.

PubMed ID: 12538665

DOI: 10.1084/jem.20021790

PubMed ID: 12874243

Title: Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.

PubMed ID: 12874243

DOI: 10.4049/jimmunol.171.3.1500

PubMed ID: 14684752

Title: Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C.

PubMed ID: 14684752

DOI: 10.1074/jbc.c300431200

PubMed ID: 14625308

Title: Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.

PubMed ID: 14625308

DOI: 10.1074/jbc.m309251200

PubMed ID: 15084582

Title: IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness.

PubMed ID: 15084582

DOI: 10.1074/jbc.m400785200

PubMed ID: 15465816

Title: IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.

PubMed ID: 15465816

DOI: 10.1074/jbc.m410369200

PubMed ID: 16286016

Title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines.

PubMed ID: 16286016

DOI: 10.1016/j.immuni.2005.09.015

PubMed ID: 15767370

Title: Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.

PubMed ID: 15767370

DOI: 10.1084/jem.20042372

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 16690127

Title: Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants.

PubMed ID: 16690127

DOI: 10.1016/j.molimm.2006.03.021

PubMed ID: 17997719

Title: The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

PubMed ID: 17997719

DOI: 10.1042/bj20071365

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18347055

Title: Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.

PubMed ID: 18347055

DOI: 10.1128/mcb.02098-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19675569

Title: Direct activation of protein kinases by unanchored polyubiquitin chains.

PubMed ID: 19675569

DOI: 10.1038/nature08247

PubMed ID: 20400509

Title: IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

PubMed ID: 20400509

DOI: 10.1074/jbc.m109.098137

PubMed ID: 17890055

Title: IRAK1: a critical signaling mediator of innate immunity.

PubMed ID: 17890055

DOI: 10.1016/j.cellsig.2007.08.009

PubMed ID: 18691762

Title: The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT.

PubMed ID: 18691762

DOI: 10.1016/j.molimm.2008.06.023

PubMed ID: 19022706

Title: The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling.

PubMed ID: 19022706

DOI: 10.1016/j.it.2008.10.001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28436939

Title: An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.

PubMed ID: 28436939

DOI: 10.1172/jci86282

PubMed ID: 28659487

Title: Mumps virus SH protein inhibits NF-kappaB activation by interacting with tumor necrosis factor receptor 1, interleukin-1 receptor 1, and Toll-like receptor 3 complexes.

PubMed ID: 28659487

DOI: 10.1128/jvi.01037-17

PubMed ID: 29883609

Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.

PubMed ID: 29883609

DOI: 10.1016/j.molcel.2018.05.016

PubMed ID: 33673546

Title: The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling.

PubMed ID: 33673546

DOI: 10.3390/v13030377

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 712
Mass: 76537
Checksum: A7ADED75D3A3981D
Sequence:

MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 
RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPLPS PGTTAPRPSS 
IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS QTHSGPELGL VPSPASLWPP PPSPAPSSTK 
PGPESSVSLL QGARPFPFCW PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR 
LKENADLEWT AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL 
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLTPKLGDFG 
LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVVLETLAG 
QRAVKTHGAR TKYLKDLVEE EAEEAGVALR STQSTLQAGL AADAWAAPIA MQIYKKHLDP 
RPGPCPPELG LGLGQLACCC LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP 
SPQENSYVSS TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR 
SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS ASSSSEPPQI 
IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD RQGPEESDEF QS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IRAK1

Associated with

Cells (max top 100)

Other Information

IRAK: a kinase associated with the interleukin-1 receptor. PubMed ID: 8599092

Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. PubMed ID: 10723722

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. PubMed ID: 11397809

A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. PubMed ID: 16024789

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. PubMed ID: 9430229

Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor. PubMed ID: 10854325

IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase. PubMed ID: 11960013

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. PubMed ID: 12496252

Characterization of Pellino2, a substrate of IRAK1 and IRAK4. PubMed ID: 12860405

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. PubMed ID: 12538665

Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. PubMed ID: 12874243

Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C. PubMed ID: 14684752

Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. PubMed ID: 14625308

IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. PubMed ID: 15084582

IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. PubMed ID: 15465816

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. PubMed ID: 16286016

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. PubMed ID: 15767370

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1. PubMed ID: 16951688

Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants. PubMed ID: 16690127

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. PubMed ID: 17997719

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. PubMed ID: 18347055

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Direct activation of protein kinases by unanchored polyubiquitin chains. PubMed ID: 19675569

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). PubMed ID: 20400509

IRAK1: a critical signaling mediator of innate immunity. PubMed ID: 17890055

The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT. PubMed ID: 18691762

The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. PubMed ID: 19022706

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. PubMed ID: 28436939

Mumps virus SH protein inhibits NF-kappaB activation by interacting with tumor necrosis factor receptor 1, interleukin-1 receptor 1, and Toll-like receptor 3 complexes. PubMed ID: 28659487

PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation. PubMed ID: 29883609

The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling. PubMed ID: 33673546

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846