IRAK1 | ENSG00000184216 | NCBI 3654

Details for: IRAK1

Gene ID: 3654

Symbol: IRAK1

Ensembl ID: ENSG00000184216

Description: interleukin 1 receptor associated kinase 1

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irak1 recruits ikk complex
(R-HSA-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-HSA-975144)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nf-kb is activated and signals survival
(R-HSA-209560)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr recruits signalling complexes
(R-HSA-209543)
P75ntr signals via nf-kb
(R-HSA-193639)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated irf7 activation in tlr7/8 or 9 signaling
(R-HSA-975110)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to heat
(GO:0034605)
Chromatin remodeling
(GO:0006338)
Heat shock protein binding
(GO:0031072)
Histone h2as1 kinase activity
(GO:0044024)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Interleukin-33-mediated signaling pathway
(GO:0038172)
Intracellular signal transduction
(GO:0035556)
Jnk cascade
(GO:0007254)
Kinase activity
(GO:0016301)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of type i interferon production
(GO:0032481)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cytokine-mediated signaling pathway
(GO:0001959)
Response to interleukin-1
(GO:0070555)
Response to lipopolysaccharide
(GO:0032496)
Toll-like receptor 2 signaling pathway
(GO:0034134)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Toll-like receptor 9 signaling pathway
(GO:0034162)
Toll-like receptor signaling pathway
(GO:0002224)
Toll signaling pathway
(GO:0008063)
Type i interferon-mediated signaling pathway
(GO:0060337)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 120.8652
Cell Significance Index: -18.8000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 73.3707
Cell Significance Index: -18.6100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 46.2761
Cell Significance Index: -18.8000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 41.6031
Cell Significance Index: -21.4000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 34.4698
Cell Significance Index: -23.1300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 19.8326
Cell Significance Index: -18.9400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.3347
Cell Significance Index: -20.1400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.4196
Cell Significance Index: -22.5600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.2077
Cell Significance Index: -20.5500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.9455
Cell Significance Index: -15.1900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.6044
Cell Significance Index: 257.6300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.4354
Cell Significance Index: -5.3300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.8387
Cell Significance Index: 214.2800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.6892
Cell Significance Index: 101.4100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.6570
Cell Significance Index: 180.2400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3083
Cell Significance Index: 84.4100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1954
Cell Significance Index: 194.4200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.1297
Cell Significance Index: 30.2200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.8705
Cell Significance Index: 7.4800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6482
Cell Significance Index: 18.5800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6353
Cell Significance Index: 18.3100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5211
Cell Significance Index: 11.2900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.5026
Cell Significance Index: 9.2900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4766
Cell Significance Index: 22.2200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4642
Cell Significance Index: 21.8200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4515
Cell Significance Index: 6.1600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4265
Cell Significance Index: 11.9200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4037
Cell Significance Index: 72.7700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3837
Cell Significance Index: 47.1800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.3707
Cell Significance Index: 42.4700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3151
Cell Significance Index: 16.3700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3085
Cell Significance Index: 52.6800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.3079
Cell Significance Index: 192.2700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3051
Cell Significance Index: 60.5400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3007
Cell Significance Index: 132.9500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2626
Cell Significance Index: 237.0900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2396
Cell Significance Index: 130.8300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2384
Cell Significance Index: 6.4900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2322
Cell Significance Index: 10.5300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2295
Cell Significance Index: 43.6800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2182
Cell Significance Index: 15.4300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1833
Cell Significance Index: 25.1800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1352
Cell Significance Index: 1.2500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1199
Cell Significance Index: 13.6900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1136
Cell Significance Index: 22.7800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1014
Cell Significance Index: 13.1000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0797
Cell Significance Index: 55.1400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0657
Cell Significance Index: 2.3100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0208
Cell Significance Index: 2.4500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0103
Cell Significance Index: 7.7600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0081
Cell Significance Index: 2.9100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0078
Cell Significance Index: 0.5800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0032
Cell Significance Index: -2.3500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0074
Cell Significance Index: -13.9100
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0117
Cell Significance Index: -1.5000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0126
Cell Significance Index: -23.1600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0156
Cell Significance Index: -24.0900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0166
Cell Significance Index: -12.1800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0184
Cell Significance Index: -25.0300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0229
Cell Significance Index: -12.9100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0239
Cell Significance Index: -2.4400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0248
Cell Significance Index: -15.7800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0251
Cell Significance Index: -0.6700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0411
Cell Significance Index: -8.6600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0417
Cell Significance Index: -18.9500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0753
Cell Significance Index: -21.6700
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0869
Cell Significance Index: -0.9000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1019
Cell Significance Index: -5.3100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1125
Cell Significance Index: -16.3600
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1166
Cell Significance Index: -1.8700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1241
Cell Significance Index: -1.4100
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1310
Cell Significance Index: -1.9900
Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.1342
Cell Significance Index: -0.8900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1920
Cell Significance Index: -19.9900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2188
Cell Significance Index: -5.4700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2215
Cell Significance Index: -17.5500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2227
Cell Significance Index: -5.6900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2269
Cell Significance Index: -17.4100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2473
Cell Significance Index: -7.9200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2660
Cell Significance Index: -16.3500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2791
Cell Significance Index: -9.7000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2823
Cell Significance Index: -14.8200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2870
Cell Significance Index: -18.0900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3003
Cell Significance Index: -20.2000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3037
Cell Significance Index: -18.6200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3111
Cell Significance Index: -8.1800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3234
Cell Significance Index: -18.1500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3515
Cell Significance Index: -7.4900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3530
Cell Significance Index: -17.8400
Cell Name: peg cell (CL4033014)
Fold Change: -0.3575
Cell Significance Index: -8.2600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3631
Cell Significance Index: -5.4400
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.4067
Cell Significance Index: -5.7000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4155
Cell Significance Index: -10.6800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4232
Cell Significance Index: -12.4300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4376
Cell Significance Index: -9.1600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4386
Cell Significance Index: -19.4000
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.4431
Cell Significance Index: -4.4700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4726
Cell Significance Index: -17.3500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4910
Cell Significance Index: -17.2000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4924
Cell Significance Index: -8.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Cellular localization**: IRAK1 is primarily expressed in immune cells, including classical monocytes, early pro-B cells, and IgG memory B cells. 2. **Receptor interaction**: IRAK1 interacts with TLRs, including TLR2, TLR4, and TLR9, upon recognition of PAMPs. 3. **Signaling pathway**: IRAK1 activates the TLR signaling pathway, leading to the phosphorylation and activation of downstream signaling molecules, including NF-κB, JNK, and MAPK. 4. **Pro-inflammatory cytokines**: IRAK1 promotes the production of pro-inflammatory cytokines, chemokines, and type I interferons, which are essential for the elimination of pathogens. 5. **Regulatory functions**: IRAK1 also regulates the negative regulation of NF-κB transcription factor activity and the negative regulation of the PI3K/AKT network. **Pathways and Functions** 1. **TLR signaling pathway**: IRAK1 activates the TLR signaling pathway, leading to the phosphorylation and activation of downstream signaling molecules, including NF-κB, JNK, and MAPK. 2. **NF-κB activation**: IRAK1 activates NF-κB, a transcription factor that regulates the expression of pro-inflammatory genes. 3. **JNK activation**: IRAK1 activates JNK, a stress-activated protein kinase that regulates cell survival and apoptosis. 4. **MAPK activation**: IRAK1 activates MAPK, a family of serine/threonine kinases that regulate cell proliferation, differentiation, and survival. 5. **Cytokine signaling**: IRAK1 regulates the production of pro-inflammatory cytokines, chemokines, and type I interferons, which are essential for the elimination of pathogens. **Clinical Significance** 1. **Infectious diseases**: IRAK1 plays a crucial role in the innate immune response against various infectious diseases, including sepsis, tuberculosis, and influenza. 2. **Autoimmune diseases**: IRAK1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: IRAK1 has been shown to promote cancer cell proliferation, invasion, and metastasis. 4. **Neurological disorders**: IRAK1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and multiple sclerosis. 5. **Immunotherapy**: IRAK1 has been identified as a potential target for immunotherapy, including checkpoint inhibitors and cancer vaccines. In conclusion, IRAK1 plays a critical role in the innate immune response, regulating the production of pro-inflammatory cytokines, chemokines, and type I interferons, and modulating the adaptive immune response. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

IRAK1_HUMAN

Genular Protein ID: 2914672404

Symbol: IRAK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P51617 D3DWW3 D3DWW4 Q7Z5V4 Q96C06 Q96RL2

Database IDs:

Citations:

PubMed ID: 8599092

Title: IRAK: a kinase associated with the interleukin-1 receptor.

PubMed ID: 8599092

DOI: 10.1126/science.271.5252.1128

PubMed ID: 10723722

Title: Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.

PubMed ID: 10723722

DOI: 10.1007/s003350010035

PubMed ID: 11397809

Title: IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.

PubMed ID: 11397809

DOI: 10.1074/jbc.m103815200

PubMed ID: 16024789

Title: A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.

PubMed ID: 16024789

DOI: 10.1128/mcb.25.15.6521-6532.2005

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430229

Title: MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

PubMed ID: 9430229

DOI: 10.1016/s1074-7613(00)80402-1

PubMed ID: 10854325

Title: Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor.

PubMed ID: 10854325

DOI: 10.1038/35014038

PubMed ID: 11960013

Title: IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase.

PubMed ID: 11960013

DOI: 10.1073/pnas.082100399

PubMed ID: 12496252

Title: Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.

PubMed ID: 12496252

DOI: 10.1074/jbc.m212112200

PubMed ID: 12860405

Title: Characterization of Pellino2, a substrate of IRAK1 and IRAK4.

PubMed ID: 12860405

DOI: 10.1016/s0014-5793(03)00697-5

PubMed ID: 12538665

Title: Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.

PubMed ID: 12538665

DOI: 10.1084/jem.20021790

PubMed ID: 12874243

Title: Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.

PubMed ID: 12874243

DOI: 10.4049/jimmunol.171.3.1500

PubMed ID: 14684752

Title: Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C.

PubMed ID: 14684752

DOI: 10.1074/jbc.c300431200

PubMed ID: 14625308

Title: Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.

PubMed ID: 14625308

DOI: 10.1074/jbc.m309251200

PubMed ID: 15084582

Title: IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness.

PubMed ID: 15084582

DOI: 10.1074/jbc.m400785200

PubMed ID: 15465816

Title: IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.

PubMed ID: 15465816

DOI: 10.1074/jbc.m410369200

PubMed ID: 16286016

Title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines.

PubMed ID: 16286016

DOI: 10.1016/j.immuni.2005.09.015

PubMed ID: 15767370

Title: Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.

PubMed ID: 15767370

DOI: 10.1084/jem.20042372

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 16690127

Title: Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants.

PubMed ID: 16690127

DOI: 10.1016/j.molimm.2006.03.021

PubMed ID: 17997719

Title: The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

PubMed ID: 17997719

DOI: 10.1042/bj20071365

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18347055

Title: Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.

PubMed ID: 18347055

DOI: 10.1128/mcb.02098-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19675569

Title: Direct activation of protein kinases by unanchored polyubiquitin chains.

PubMed ID: 19675569

DOI: 10.1038/nature08247

PubMed ID: 20400509

Title: IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

PubMed ID: 20400509

DOI: 10.1074/jbc.m109.098137

PubMed ID: 17890055

Title: IRAK1: a critical signaling mediator of innate immunity.

PubMed ID: 17890055

DOI: 10.1016/j.cellsig.2007.08.009

PubMed ID: 18691762

Title: The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT.

PubMed ID: 18691762

DOI: 10.1016/j.molimm.2008.06.023

PubMed ID: 19022706

Title: The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling.

PubMed ID: 19022706

DOI: 10.1016/j.it.2008.10.001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28436939

Title: An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.

PubMed ID: 28436939

DOI: 10.1172/jci86282

PubMed ID: 28659487

Title: Mumps virus SH protein inhibits NF-kappaB activation by interacting with tumor necrosis factor receptor 1, interleukin-1 receptor 1, and Toll-like receptor 3 complexes.

PubMed ID: 28659487

DOI: 10.1128/jvi.01037-17

PubMed ID: 29883609

Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.

PubMed ID: 29883609

DOI: 10.1016/j.molcel.2018.05.016

PubMed ID: 33673546

Title: The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling.

PubMed ID: 33673546

DOI: 10.3390/v13030377

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 712
Mass: 76537
Checksum: A7ADED75D3A3981D
Sequence:

MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 
RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPLPS PGTTAPRPSS 
IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS QTHSGPELGL VPSPASLWPP PPSPAPSSTK 
PGPESSVSLL QGARPFPFCW PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR 
LKENADLEWT AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL 
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLTPKLGDFG 
LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVVLETLAG 
QRAVKTHGAR TKYLKDLVEE EAEEAGVALR STQSTLQAGL AADAWAAPIA MQIYKKHLDP 
RPGPCPPELG LGLGQLACCC LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP 
SPQENSYVSS TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR 
SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS ASSSSEPPQI 
IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD RQGPEESDEF QS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IRAK1

Associated with

Cells (max top 100)

Other Information

IRAK: a kinase associated with the interleukin-1 receptor. PubMed ID: 8599092

Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. PubMed ID: 10723722

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. PubMed ID: 11397809

A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. PubMed ID: 16024789

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. PubMed ID: 9430229

Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor. PubMed ID: 10854325

IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase. PubMed ID: 11960013

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. PubMed ID: 12496252

Characterization of Pellino2, a substrate of IRAK1 and IRAK4. PubMed ID: 12860405

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. PubMed ID: 12538665

Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. PubMed ID: 12874243

Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C. PubMed ID: 14684752

Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. PubMed ID: 14625308

IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. PubMed ID: 15084582

IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. PubMed ID: 15465816

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. PubMed ID: 16286016

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. PubMed ID: 15767370

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1. PubMed ID: 16951688

Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants. PubMed ID: 16690127

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. PubMed ID: 17997719

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. PubMed ID: 18347055

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Direct activation of protein kinases by unanchored polyubiquitin chains. PubMed ID: 19675569

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). PubMed ID: 20400509

IRAK1: a critical signaling mediator of innate immunity. PubMed ID: 17890055

The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT. PubMed ID: 18691762

The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. PubMed ID: 19022706

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. PubMed ID: 28436939

Mumps virus SH protein inhibits NF-kappaB activation by interacting with tumor necrosis factor receptor 1, interleukin-1 receptor 1, and Toll-like receptor 3 complexes. PubMed ID: 28659487

PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation. PubMed ID: 29883609

The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling. PubMed ID: 33673546

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846