Gene IRAK2 - ENSG00000134070 | NCBI Gene ID: 3656

Details for: IRAK2

Gene ID: 3656

Symbol: IRAK2

Ensembl ID: ENSG00000134070

Description: interleukin 1 receptor associated kinase 2

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Irak2 mediated activation of tak1 complex
(R-HSA-937042)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-HSA-975163)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-HSA-937072)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endosome membrane
(GO:0010008)
Inflammatory response
(GO:0006954)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Intracellular signal transduction
(GO:0035556)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Molecular adaptor activity
(GO:0060090)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Regulation of cytokine-mediated signaling pathway
(GO:0001959)
Response to interleukin-1
(GO:0070555)
Signaling adaptor activity
(GO:0035591)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Toll signaling pathway
(GO:0008063)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.1
Marker Score: 6014
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.31
Marker Score: 423
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.17
Marker Score: 1293
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.06
Marker Score: 2160
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.03
Marker Score: 2568.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.02
Marker Score: 15900
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1
Marker Score: 390
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1
Marker Score: 600
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71786
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48011
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.95
Marker Score: 643
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.92
Marker Score: 289
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5253
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.92
Marker Score: 380
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2731
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.9
Marker Score: 2110
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.89
Marker Score: 1313
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.83
Marker Score: 484
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.81
Marker Score: 1177
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 604
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.78
Marker Score: 6661
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.77
Marker Score: 7314
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1246
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.75
Marker Score: 238
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.75
Marker Score: 1839
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.75
Marker Score: 785
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 385
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 296.5
Cell Name: interneuron (CL0000099)
Fold Change: 0.74
Marker Score: 337
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 665
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.72
Marker Score: 502
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2967
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.66
Marker Score: 6229
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.65
Marker Score: 936
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.64
Marker Score: 129
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.63
Marker Score: 3811
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.62
Marker Score: 552
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.61
Marker Score: 6341
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.61
Marker Score: 221
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.61
Marker Score: 248
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.6
Marker Score: 21986
Cell Name: fat cell (CL0000136)
Fold Change: 0.58
Marker Score: 326
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.57
Marker Score: 451
Cell Name: neuron (CL0000540)
Fold Change: 0.57
Marker Score: 2320
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.56
Marker Score: 3632
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.56
Marker Score: 358
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.55
Marker Score: 2372
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.54
Marker Score: 366
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.53
Marker Score: 169
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.53
Marker Score: 32326
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.51
Marker Score: 1229
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5
Marker Score: 570
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.5
Marker Score: 606
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.5
Marker Score: 243
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.49
Marker Score: 246
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.49
Marker Score: 223
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.48
Marker Score: 1171.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.47
Marker Score: 16075
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.47
Marker Score: 9980
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.47
Marker Score: 207
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.47
Marker Score: 1954
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.46
Marker Score: 119
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.45
Marker Score: 3474
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.45
Marker Score: 223
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.45
Marker Score: 437
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.44
Marker Score: 117
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.44
Marker Score: 321
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.43
Marker Score: 16394
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.43
Marker Score: 8544
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.43
Marker Score: 1780
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.43
Marker Score: 103
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.41
Marker Score: 6131
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.41
Marker Score: 194
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.41
Marker Score: 402
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.4
Marker Score: 231
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.39
Marker Score: 103
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.39
Marker Score: 146
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.39
Marker Score: 416
Cell Name: microglial cell (CL0000129)
Fold Change: 0.38
Marker Score: 698
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.38
Marker Score: 368
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.38
Marker Score: 153
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.37
Marker Score: 1448
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.37
Marker Score: 453
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.36
Marker Score: 132
Cell Name: astrocyte (CL0000127)
Fold Change: 0.36
Marker Score: 312
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.36
Marker Score: 1922
Cell Name: plasmablast (CL0000980)
Fold Change: 0.36
Marker Score: 475
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.35
Marker Score: 127
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.35
Marker Score: 594
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.35
Marker Score: 121
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.35
Marker Score: 897
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.35
Marker Score: 310

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## Summary The IRAK2 gene encodes a protein that is a key regulator of the innate immune system. It is expressed in a variety of cells, including retinal cone cells, mononuclear cells, corneal epithelial cells, and immune cells. The protein is involved in the regulation of inflammation and immune responses. ## Key characteristics * The IRAK2 gene is located on chromosome 15q21.1. * It is a member of the IRAK family of kinases, which are involved in the regulation of innate immune responses. * IRAK2 is a key regulator of the production of inflammatory cytokines, including interleukin-1 (IL-1). * It is also involved in the regulation of cell migration and survival. ## Pathways and functions The IRAK2 gene is involved in a variety of cellular processes, including: * **Inflammatory responses:** IRAK2 is essential for the production of IL-1, which is a key cytokine in the inflammatory response. * **Cell migration:** IRAK2 is involved in the migration of immune cells to sites of inflammation. * **Cell survival:** IRAK2 is involved in the survival of immune cells. * **Cell proliferation:** IRAK2 is involved in the proliferation of immune cells. ## Clinical significance Mutations in the IRAK2 gene have been linked to a number of human diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. These diseases are characterized by inflammation and tissue damage. IRAK2 is a potential target for the treatment of these diseases. ## Other important points * IRAK2 is a highly conserved protein. It is found in cells in humans, mice, and rats. * It is a ubiquitin-dependent kinase. * It is a member of the cullin-1/Cullin-2 (C1/C2) family of kinases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-1 receptor-associated kinase-like 2

Genular Protein ID: 4083627663

Symbol: IRAK2_HUMAN

Name: Interleukin-1 receptor-associated kinase-like 2

UniProtKB Accession Codes:

O43187 B4DQZ6 Q08AG6 Q5K546

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9374458

Title: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

PubMed ID: 9374458

DOI: 10.1126/science.278.5343.1612

PubMed ID: 10383454

Title: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.

PubMed ID: 10383454

DOI: 10.1074/jbc.274.27.19403

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20485341

Title: Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.

PubMed ID: 20485341

DOI: 10.1038/nature09121

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 625
Mass: 69433
Checksum: 715C954BC9452710
Sequence:

MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER VQGVSITREL 
LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR CPIPAFPDSV KPEKPLAASV 
RKAEDEQEEG QPVRMATFPG PGSSPARAHQ PAFLQPPEED APHSLRSDLP TSSDSKDFST 
SIPKQEKLLS LAGDSLFWSE ADVVQATDDF NQNRKISQGT FADVYRGHRH GKPFVFKKLR 
ETACSSPGSI ERFFQAELQI CLRCCHPNVL PVLGFCAARQ FHSFIYPYMA NGSLQDRLQG 
QGGSDPLPWP QRVSICSGLL CAVEYLHGLE IIHSNVKSSN VLLDQNLTPK LAHPMAHLCP 
VNKRSKYTMM KTHLLRTSAA YLPEDFIRVG QLTKRVDIFS CGIVLAEVLT GIPAMDNNRS 
PVYLKDLLLS DIPSSTASLC SRKTGVENVM AKEICQKYLE KGAGRLPEDC AEALATAACL 
CLRRRNTSLQ EVCGSVAAVE ERLRGRETLL PWSGLSEGTG SSSNTPEETD DVDNSSLDAS 
SSMSVAPWAG AATPLLPTEN GEGRLRVIVG READSSSEAC VGLEPPQDVT ETSWQIEINE 
AKRKLMENIL LYKEEKVDSI ELFGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IRAK2

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. PubMed ID: 9374458

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. PubMed ID: 10383454

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. PubMed ID: 20485341

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846