Details for: IRAK2

Gene ID: 3656

Symbol: IRAK2

Ensembl ID: ENSG00000134070

Description: interleukin 1 receptor associated kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.0627
    Cell Significance Index: -12.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.7405
    Cell Significance Index: -12.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.7072
    Cell Significance Index: -10.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.6157
    Cell Significance Index: -11.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4789
    Cell Significance Index: -12.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9704
    Cell Significance Index: -13.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7924
    Cell Significance Index: -8.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2818
    Cell Significance Index: -12.9500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7642
    Cell Significance Index: 12.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.4853
    Cell Significance Index: 91.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3337
    Cell Significance Index: 69.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.7344
    Cell Significance Index: 17.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7343
    Cell Significance Index: 18.8800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7156
    Cell Significance Index: 4.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6189
    Cell Significance Index: 122.8300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.5971
    Cell Significance Index: 5.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5121
    Cell Significance Index: 13.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4998
    Cell Significance Index: 95.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4623
    Cell Significance Index: 12.9200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.4480
    Cell Significance Index: 5.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4001
    Cell Significance Index: 72.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2950
    Cell Significance Index: 59.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2373
    Cell Significance Index: 27.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2360
    Cell Significance Index: 163.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2291
    Cell Significance Index: 3.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2269
    Cell Significance Index: 27.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2136
    Cell Significance Index: 192.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1843
    Cell Significance Index: 18.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1812
    Cell Significance Index: 13.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1429
    Cell Significance Index: 4.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1401
    Cell Significance Index: 50.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1186
    Cell Significance Index: 5.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0994
    Cell Significance Index: 16.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0932
    Cell Significance Index: 10.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0908
    Cell Significance Index: 9.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0791
    Cell Significance Index: 4.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0705
    Cell Significance Index: 2.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0577
    Cell Significance Index: 31.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0481
    Cell Significance Index: 1.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0348
    Cell Significance Index: 65.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0339
    Cell Significance Index: 46.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0306
    Cell Significance Index: 3.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0295
    Cell Significance Index: 45.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0237
    Cell Significance Index: 0.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0188
    Cell Significance Index: 1.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0183
    Cell Significance Index: 11.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0166
    Cell Significance Index: 0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0147
    Cell Significance Index: 27.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0135
    Cell Significance Index: 0.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0122
    Cell Significance Index: 0.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0117
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0061
    Cell Significance Index: 1.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0090
    Cell Significance Index: -4.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0103
    Cell Significance Index: -5.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0208
    Cell Significance Index: -0.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0214
    Cell Significance Index: -0.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0234
    Cell Significance Index: -10.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0236
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0299
    Cell Significance Index: -6.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0368
    Cell Significance Index: -10.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0412
    Cell Significance Index: -1.8700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0446
    Cell Significance Index: -0.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0454
    Cell Significance Index: -0.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0509
    Cell Significance Index: -6.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0569
    Cell Significance Index: -0.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0680
    Cell Significance Index: -9.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0738
    Cell Significance Index: -9.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0764
    Cell Significance Index: -1.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0897
    Cell Significance Index: -4.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0907
    Cell Significance Index: -2.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0908
    Cell Significance Index: -9.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0912
    Cell Significance Index: -4.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0963
    Cell Significance Index: -7.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1039
    Cell Significance Index: -2.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1114
    Cell Significance Index: -7.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1125
    Cell Significance Index: -11.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1225
    Cell Significance Index: -8.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1393
    Cell Significance Index: -8.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1531
    Cell Significance Index: -1.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1533
    Cell Significance Index: -10.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1561
    Cell Significance Index: -12.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1564
    Cell Significance Index: -2.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1667
    Cell Significance Index: -2.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1817
    Cell Significance Index: -5.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1821
    Cell Significance Index: -5.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2177
    Cell Significance Index: -4.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2188
    Cell Significance Index: -9.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2228
    Cell Significance Index: -12.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2301
    Cell Significance Index: -7.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2356
    Cell Significance Index: -12.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2596
    Cell Significance Index: -11.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2662
    Cell Significance Index: -10.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2726
    Cell Significance Index: -5.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2746
    Cell Significance Index: -5.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2756
    Cell Significance Index: -5.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** IRAK2 is a cytoplasmic protein that belongs to the IRAK family. It contains a kinase domain and a substrate-binding domain, which are essential for its function. 2. **Expression:** IRAK2 is widely expressed in various cell types, including immune cells, such as mononuclear cells, dendritic cells, and macrophages. 3. **Function:** IRAK2 is involved in the recognition of pathogens and the activation of the immune response through the TLR and MyD88-dependent pathways. 4. **Signaling pathways:** IRAK2 is involved in the regulation of multiple signaling pathways, including the NF-κB pathway, MAPK pathway, and JNK pathway. **Pathways and Functions:** 1. **TLR signaling pathway:** IRAK2 is involved in the recognition of TLR ligands, such as LPS and viral RNA, and the activation of downstream signaling pathways. 2. **MyD88-dependent pathway:** IRAK2 is involved in the activation of the MyD88-dependent pathway, which is essential for the production of inflammatory cytokines. 3. **NF-κB pathway:** IRAK2 is involved in the regulation of NF-κB activity, which is essential for the production of inflammatory cytokines and the regulation of immune responses. 4. **MAPK pathway:** IRAK2 is involved in the regulation of MAPK activity, which is essential for the production of inflammatory cytokines and the regulation of immune responses. 5. **JNK pathway:** IRAK2 is involved in the regulation of JNK activity, which is essential for the production of inflammatory cytokines and the regulation of immune responses. **Clinical Significance:** 1. **Autoimmune diseases:** IRAK2 dysfunction has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** IRAK2 has been implicated in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. 3. **Viral infections:** IRAK2 is involved in the recognition of viral infections and the activation of the immune response. 4. **Inflammatory disorders:** IRAK2 is involved in the regulation of inflammatory responses, which is essential for the development of inflammatory disorders, such as atherosclerosis and inflammatory bowel disease. In conclusion, IRAK2 is a crucial protein that plays a pivotal role in the recognition of pathogens and the activation of the immune response. Its dysfunction has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and inflammatory disorders. Further research is necessary to fully understand the role of IRAK2 in the immune response and to develop therapeutic strategies to target this protein in the treatment of immune-related disorders.

Genular Protein ID: 4083627663

Symbol: IRAK2_HUMAN

Name: Interleukin-1 receptor-associated kinase-like 2

UniProtKB Accession Codes:

O43187 B4DQZ6 Q08AG6 Q5K546

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 14 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9374458

Title: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

PubMed ID: 9374458

DOI: 10.1126/science.278.5343.1612

PubMed ID: 10383454

Title: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.

PubMed ID: 10383454

DOI: 10.1074/jbc.274.27.19403

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20485341

Title: Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.

PubMed ID: 20485341

DOI: 10.1038/nature09121

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 625
  • Mass: 69433
  • Checksum: 715C954BC9452710
  • Sequence:
    • MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER VQGVSITREL 
LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR CPIPAFPDSV KPEKPLAASV 
RKAEDEQEEG QPVRMATFPG PGSSPARAHQ PAFLQPPEED APHSLRSDLP TSSDSKDFST 
SIPKQEKLLS LAGDSLFWSE ADVVQATDDF NQNRKISQGT FADVYRGHRH GKPFVFKKLR 
ETACSSPGSI ERFFQAELQI CLRCCHPNVL PVLGFCAARQ FHSFIYPYMA NGSLQDRLQG 
QGGSDPLPWP QRVSICSGLL CAVEYLHGLE IIHSNVKSSN VLLDQNLTPK LAHPMAHLCP 
VNKRSKYTMM KTHLLRTSAA YLPEDFIRVG QLTKRVDIFS CGIVLAEVLT GIPAMDNNRS 
PVYLKDLLLS DIPSSTASLC SRKTGVENVM AKEICQKYLE KGAGRLPEDC AEALATAACL 
CLRRRNTSLQ EVCGSVAAVE ERLRGRETLL PWSGLSEGTG SSSNTPEETD DVDNSSLDAS 
SSMSVAPWAG AATPLLPTEN GEGRLRVIVG READSSSEAC VGLEPPQDVT ETSWQIEINE 
AKRKLMENIL LYKEEKVDSI ELFGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.