Details for: ITGA3

Gene ID: 3675

Symbol: ITGA3

Ensembl ID: ENSG00000005884

Description: integrin subunit alpha 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.63
    Marker Score: 3173
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.16
    Marker Score: 1915
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.09
    Marker Score: 3026
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.94
    Marker Score: 9529
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.88
    Marker Score: 2776
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.67
    Marker Score: 26875
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.59
    Marker Score: 1676
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.59
    Marker Score: 1518
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.58
    Marker Score: 508
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.52
    Marker Score: 1837
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.51
    Marker Score: 2028
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168268.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.46
    Marker Score: 1653.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.4
    Marker Score: 629
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.39
    Marker Score: 7287
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 854
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.34
    Marker Score: 778
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.34
    Marker Score: 13786
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.33
    Marker Score: 1051
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.33
    Marker Score: 12660
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.31
    Marker Score: 5332
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.29
    Marker Score: 48890
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.28
    Marker Score: 10964
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.27
    Marker Score: 11984
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.27
    Marker Score: 256
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.23
    Marker Score: 75852.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.23
    Marker Score: 1355.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.22
    Marker Score: 1884
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.22
    Marker Score: 847
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.22
    Marker Score: 5066
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.2
    Marker Score: 700
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.2
    Marker Score: 434
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.16
    Marker Score: 2840
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17863.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.14
    Marker Score: 4389
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1463
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.13
    Marker Score: 2485.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.12
    Marker Score: 397
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.1
    Marker Score: 5267
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.07
    Marker Score: 1894
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.04
    Marker Score: 6811
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.04
    Marker Score: 1054
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.04
    Marker Score: 7945
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.03
    Marker Score: 382
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 781
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.01
    Marker Score: 8755
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1
    Marker Score: 289
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48004
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1
    Marker Score: 1916
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.99
    Marker Score: 538
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.98
    Marker Score: 36269
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.98
    Marker Score: 19550
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.97
    Marker Score: 1554
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.96
    Marker Score: 3020
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.96
    Marker Score: 244
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.95
    Marker Score: 32983
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.95
    Marker Score: 14206
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.95
    Marker Score: 7037.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.94
    Marker Score: 1013.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.91
    Marker Score: 5830.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.91
    Marker Score: 3780
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1460
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.89
    Marker Score: 2375.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.89
    Marker Score: 420
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5034
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.88
    Marker Score: 1396
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5270
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.86
    Marker Score: 2349
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.84
    Marker Score: 875
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.84
    Marker Score: 2981
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.83
    Marker Score: 3219
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.83
    Marker Score: 830
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.8
    Marker Score: 1137
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.8
    Marker Score: 1465
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.78
    Marker Score: 327
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.78
    Marker Score: 1911
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.77
    Marker Score: 2723
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.75
    Marker Score: 2591
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.75
    Marker Score: 533
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.74
    Marker Score: 235
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.74
    Marker Score: 1414
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.74
    Marker Score: 787
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3068.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.72
    Marker Score: 835
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.71
    Marker Score: 615
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.69
    Marker Score: 15499
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.68
    Marker Score: 229
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.67
    Marker Score: 1714
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.67
    Marker Score: 2819

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Other Information

**Key characteristics:** * ITGA3 is a large transmembrane protein with a molecular weight of approximately 140 kDa. * It is a key player in cell adhesion, cell migration, and signaling. * It is a ligand for various extracellular matrix proteins, including collagen, laminin, and proteoglycans. * It is involved in cell migration, cell adhesion, and angiogenesis. **Pathways and functions:** * ITGA3 plays a crucial role in cell adhesion by interacting with the extracellular matrix proteins collagen, laminin, and proteoglycans. * It is involved in cell migration by facilitating cell adhesion to extracellular matrix proteins and guiding cell movement. * It is also involved in cell adhesion to the vascular wall and the formation of blood vessels. * ITGA3 is a key regulator of cell migration and adhesion, and its dysfunction can lead to various diseases, including cancer and vascular diseases. **Clinical significance:** * ITGA3 is a potential therapeutic target for various diseases, including cancer, cardiovascular diseases, and rheumatoid arthritis. * Inhibition of ITGA3 has been shown to inhibit cell migration and adhesion, suggesting that it could be a potential treatment for cancer and other diseases characterized by abnormal cell adhesion. * However, the clinical potential of ITGA3 inhibitors is still being investigated, and further research is needed to develop safe and effective therapeutics.

Genular Protein ID: 3799473898

Symbol: ITA3_HUMAN

Name: Integrin alpha-3

UniProtKB Accession Codes:

P26006 A7E246 B7ZM80 B9EGQ1 D3DTX4 D3DTX5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 57 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1655803

Title: Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.

PubMed ID: 1655803

DOI: 10.1083/jcb.115.1.257

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1714443

Title: Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3.

PubMed ID: 1714443

DOI: 10.1093/oxfordjournals.jbchem.a123436

PubMed ID: 8187758

Title: Molecular and biological characterization of fusion regulatory proteins (FRPs): anti-FRP mAbs induced HIV-mediated cell fusion via an integrin system.

PubMed ID: 8187758

DOI: 10.1002/j.1460-2075.1994.tb06479.x

PubMed ID: 3033641

Title: The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

PubMed ID: 3033641

DOI: 10.1073/pnas.84.10.3239

PubMed ID: 10455171

Title: A novel protease-docking function of integrin at invadopodia.

PubMed ID: 10455171

DOI: 10.1074/jbc.274.35.24947

PubMed ID: 9111516

Title: The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization.

PubMed ID: 9111516

PubMed ID: 14596610

Title: Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains.

PubMed ID: 14596610

DOI: 10.1021/bi034726u

PubMed ID: 15611341

Title: Palmitoylation supports assembly and function of integrin-tetraspanin complexes.

PubMed ID: 15611341

DOI: 10.1083/jcb.200404100

PubMed ID: 15181153

Title: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.

PubMed ID: 15181153

DOI: 10.1091/mbc.e04-03-0236

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32487760

Title: GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.

PubMed ID: 32487760

DOI: 10.1128/mbio.01087-20

PubMed ID: 22512483

Title: Integrin alpha3 mutations with kidney, lung, and skin disease.

PubMed ID: 22512483

DOI: 10.1056/nejmoa1110813

PubMed ID: 27717396

Title: Viable phenotype of ILNEB syndrome without nephrotic impairment in siblings heterozygous for unreported integrin alpha3 mutations.

PubMed ID: 27717396

DOI: 10.1186/s13023-016-0514-z

Sequence Information:

  • Length: 1051
  • Mass: 116612
  • Checksum: EEAFA7778EF17B21
  • Sequence:
    • MGPGPSRAPR APRLMLCALA LMVAAGGCVV SAFNLDTRFL VVKEAGNPGS LFGYSVALHR 
QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 
DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 
HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 
DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 
SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 
LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 
KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 
DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 
GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 
QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 
RTSERSGEDA HEALLTLVVP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 
EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 
GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 
NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 
VLTCATGRAH CVWLECPIPD APVVTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 
SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCGFFK 
RARTRALYEA KRQKAEMKSQ PSETERLTDD Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.