Details for: ITGA3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 143.8810
Cell Significance Index: -22.3800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 88.2144
Cell Significance Index: -22.3800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 19.7383
Cell Significance Index: -18.8500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.1515
Cell Significance Index: -22.3800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.5260
Cell Significance Index: -22.8400 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 4.7597
Cell Significance Index: 42.2500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 3.6590
Cell Significance Index: 190.0800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.1845
Cell Significance Index: 86.6800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.2877
Cell Significance Index: 281.3000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.9995
Cell Significance Index: 55.8800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.9574
Cell Significance Index: 352.8600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5019
Cell Significance Index: 148.5700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2229
Cell Significance Index: 245.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1545
Cell Significance Index: 52.3300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.0529
Cell Significance Index: 17.3500 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.0300
Cell Significance Index: 6.3600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9457
Cell Significance Index: 56.7800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9377
Cell Significance Index: 102.0000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9158
Cell Significance Index: 19.8400 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.8938
Cell Significance Index: 7.6800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7979
Cell Significance Index: 22.9900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.7440
Cell Significance Index: 19.9400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.6559
Cell Significance Index: 6.0400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5911
Cell Significance Index: 322.8200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5854
Cell Significance Index: 209.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5643
Cell Significance Index: 43.3000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4608
Cell Significance Index: 34.3400 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.4005
Cell Significance Index: 2.4700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3902
Cell Significance Index: 27.6000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3846
Cell Significance Index: 170.0300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.3791
Cell Significance Index: 8.3000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3622
Cell Significance Index: 25.0500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.2661
Cell Significance Index: 30.4900 - Cell Name: peg cell (CL4033014)
Fold Change: 0.2446
Cell Significance Index: 5.6500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2396
Cell Significance Index: 10.6000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2302
Cell Significance Index: 207.8300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2292
Cell Significance Index: 8.6800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1907
Cell Significance Index: 131.9200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1790
Cell Significance Index: 34.0700 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.1557
Cell Significance Index: 1.0200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1124
Cell Significance Index: 173.0600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1113
Cell Significance Index: 3.9100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1072
Cell Significance Index: 197.7100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0961
Cell Significance Index: 6.4600 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0717
Cell Significance Index: 9.2600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0493
Cell Significance Index: 1.0500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0489
Cell Significance Index: 8.3500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0477
Cell Significance Index: 21.6700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0475
Cell Significance Index: 64.6000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0455
Cell Significance Index: 85.6700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.0310
Cell Significance Index: 0.3900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0268
Cell Significance Index: 1.2600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0259
Cell Significance Index: 16.4400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0197
Cell Significance Index: 14.9400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0056
Cell Significance Index: -0.8200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0079
Cell Significance Index: -4.9600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0100
Cell Significance Index: -7.3200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0116
Cell Significance Index: -8.5900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0185
Cell Significance Index: -3.6700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0185
Cell Significance Index: -10.4100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0243
Cell Significance Index: -3.9500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0378
Cell Significance Index: -0.7900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0484
Cell Significance Index: -0.6600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0487
Cell Significance Index: -2.2700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0521
Cell Significance Index: -6.0700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0535
Cell Significance Index: -15.4000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0573
Cell Significance Index: -5.8500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0609
Cell Significance Index: -12.8300 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0738
Cell Significance Index: -1.0500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0860
Cell Significance Index: -11.8100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1025
Cell Significance Index: -6.4600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1026
Cell Significance Index: -0.6200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1036
Cell Significance Index: -2.5900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1045
Cell Significance Index: -13.4000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1210
Cell Significance Index: -7.4400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1315
Cell Significance Index: -3.5100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1331
Cell Significance Index: -15.1900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1460
Cell Significance Index: -15.2000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1480
Cell Significance Index: -2.2900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1608
Cell Significance Index: -4.5900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1880
Cell Significance Index: -22.1700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1907
Cell Significance Index: -10.0100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2082
Cell Significance Index: -2.1600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2334
Cell Significance Index: -12.1600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2355
Cell Significance Index: -14.4400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2376
Cell Significance Index: -4.7700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2395
Cell Significance Index: -7.6700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2398
Cell Significance Index: -4.1100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2687
Cell Significance Index: -21.2800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2820
Cell Significance Index: -7.2500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3156
Cell Significance Index: -4.6600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3353
Cell Significance Index: -10.6800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3491
Cell Significance Index: -22.5200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.3500
Cell Significance Index: -2.9400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3503
Cell Significance Index: -11.4700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3574
Cell Significance Index: -12.4200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3583
Cell Significance Index: -7.6100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3663
Cell Significance Index: -20.5600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4081
Cell Significance Index: -5.8500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4108
Cell Significance Index: -12.1000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3799473898
Symbol: ITA3_HUMAN
Name: Integrin alpha-3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1655803
Title: Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.
PubMed ID: 1655803
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1714443
Title: Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3.
PubMed ID: 1714443
PubMed ID: 8187758
Title: Molecular and biological characterization of fusion regulatory proteins (FRPs): anti-FRP mAbs induced HIV-mediated cell fusion via an integrin system.
PubMed ID: 8187758
PubMed ID: 3033641
Title: The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.
PubMed ID: 3033641
PubMed ID: 10455171
Title: A novel protease-docking function of integrin at invadopodia.
PubMed ID: 10455171
PubMed ID: 9111516
Title: The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization.
PubMed ID: 9111516
PubMed ID: 14596610
Title: Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains.
PubMed ID: 14596610
DOI: 10.1021/bi034726u
PubMed ID: 15611341
Title: Palmitoylation supports assembly and function of integrin-tetraspanin complexes.
PubMed ID: 15611341
PubMed ID: 15181153
Title: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.
PubMed ID: 15181153
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 32487760
Title: GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.
PubMed ID: 32487760
PubMed ID: 22512483
Title: Integrin alpha3 mutations with kidney, lung, and skin disease.
PubMed ID: 22512483
PubMed ID: 27717396
Title: Viable phenotype of ILNEB syndrome without nephrotic impairment in siblings heterozygous for unreported integrin alpha3 mutations.
PubMed ID: 27717396
Sequence Information:
- Length: 1051
- Mass: 116612
- Checksum: EEAFA7778EF17B21
- Sequence:
MGPGPSRAPR APRLMLCALA LMVAAGGCVV SAFNLDTRFL VVKEAGNPGS LFGYSVALHR QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT RTSERSGEDA HEALLTLVVP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET VLTCATGRAH CVWLECPIPD APVVTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCGFFK RARTRALYEA KRQKAEMKSQ PSETERLTDD Y
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.