Details for: ITGA3

Gene ID: 3675

Symbol: ITGA3

Ensembl ID: ENSG00000005884

Description: integrin subunit alpha 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.8810
    Cell Significance Index: -22.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.2144
    Cell Significance Index: -22.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.7383
    Cell Significance Index: -18.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1515
    Cell Significance Index: -22.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5260
    Cell Significance Index: -22.8400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.7597
    Cell Significance Index: 42.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6590
    Cell Significance Index: 190.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1845
    Cell Significance Index: 86.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2877
    Cell Significance Index: 281.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.9995
    Cell Significance Index: 55.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9574
    Cell Significance Index: 352.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5019
    Cell Significance Index: 148.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2229
    Cell Significance Index: 245.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1545
    Cell Significance Index: 52.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.0529
    Cell Significance Index: 17.3500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.0300
    Cell Significance Index: 6.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9457
    Cell Significance Index: 56.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9377
    Cell Significance Index: 102.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9158
    Cell Significance Index: 19.8400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.8938
    Cell Significance Index: 7.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7979
    Cell Significance Index: 22.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7440
    Cell Significance Index: 19.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6559
    Cell Significance Index: 6.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5911
    Cell Significance Index: 322.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5854
    Cell Significance Index: 209.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5643
    Cell Significance Index: 43.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4608
    Cell Significance Index: 34.3400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4005
    Cell Significance Index: 2.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3902
    Cell Significance Index: 27.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3846
    Cell Significance Index: 170.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3791
    Cell Significance Index: 8.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3622
    Cell Significance Index: 25.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2661
    Cell Significance Index: 30.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2446
    Cell Significance Index: 5.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2396
    Cell Significance Index: 10.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2302
    Cell Significance Index: 207.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2292
    Cell Significance Index: 8.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1907
    Cell Significance Index: 131.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1790
    Cell Significance Index: 34.0700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1557
    Cell Significance Index: 1.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1124
    Cell Significance Index: 173.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1113
    Cell Significance Index: 3.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1072
    Cell Significance Index: 197.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0961
    Cell Significance Index: 6.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0717
    Cell Significance Index: 9.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0493
    Cell Significance Index: 1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0489
    Cell Significance Index: 8.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0477
    Cell Significance Index: 21.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0475
    Cell Significance Index: 64.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0455
    Cell Significance Index: 85.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0310
    Cell Significance Index: 0.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0268
    Cell Significance Index: 1.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0259
    Cell Significance Index: 16.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0197
    Cell Significance Index: 14.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0056
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0079
    Cell Significance Index: -4.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0185
    Cell Significance Index: -3.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0243
    Cell Significance Index: -3.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0378
    Cell Significance Index: -0.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0484
    Cell Significance Index: -0.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0487
    Cell Significance Index: -2.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0521
    Cell Significance Index: -6.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0535
    Cell Significance Index: -15.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0573
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0609
    Cell Significance Index: -12.8300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0738
    Cell Significance Index: -1.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0860
    Cell Significance Index: -11.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1025
    Cell Significance Index: -6.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1026
    Cell Significance Index: -0.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1036
    Cell Significance Index: -2.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1045
    Cell Significance Index: -13.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1210
    Cell Significance Index: -7.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1315
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1331
    Cell Significance Index: -15.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1460
    Cell Significance Index: -15.2000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1480
    Cell Significance Index: -2.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1608
    Cell Significance Index: -4.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1880
    Cell Significance Index: -22.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1907
    Cell Significance Index: -10.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2082
    Cell Significance Index: -2.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2334
    Cell Significance Index: -12.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2355
    Cell Significance Index: -14.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2376
    Cell Significance Index: -4.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2395
    Cell Significance Index: -7.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2398
    Cell Significance Index: -4.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2687
    Cell Significance Index: -21.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2820
    Cell Significance Index: -7.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3156
    Cell Significance Index: -4.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3353
    Cell Significance Index: -10.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3491
    Cell Significance Index: -22.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3500
    Cell Significance Index: -2.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3503
    Cell Significance Index: -11.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3574
    Cell Significance Index: -12.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3583
    Cell Significance Index: -7.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3663
    Cell Significance Index: -20.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4081
    Cell Significance Index: -5.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4108
    Cell Significance Index: -12.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ITGA3 is a transmembrane glycoprotein with a molecular weight of approximately 110 kDa. It belongs to the integrin family, which is a superfamily of transmembrane receptors that mediate cell-cell and cell-matrix interactions. ITGA3 is characterized by its ability to bind to various ligands, including collagen, fibronectin, and laminin, and to interact with other proteins, such as the beta subunit of the integrin complex. **Pathways and Functions:** ITGA3 plays a crucial role in various biological processes, including: 1. **Cell adhesion**: ITGA3 mediates cell-cell and cell-matrix adhesion by interacting with its ligands and other proteins. 2. **Cell signaling**: ITGA3 is involved in signaling pathways, such as the integrin-mediated signaling pathway, which regulates cell proliferation, differentiation, and survival. 3. **Cell migration**: ITGA3 is required for cell migration, including leukocyte migration, epithelial cell migration, and neuron migration. 4. **Cell growth and differentiation**: ITGA3 regulates cell growth and differentiation by modulating signaling pathways. 5. **Neurological functions**: ITGA3 is involved in neuronal development, synaptic plasticity, and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Clinical Significance:** Dysregulation of ITGA3 has been implicated in various diseases and disorders, including: 1. **Cancer**: ITGA3 overexpression is associated with cancer progression and metastasis. 2. **Neurological disorders**: ITGA3 mutations have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease**: ITGA3 is involved in cardiovascular disease, including atherosclerosis and cardiac fibrosis. 4. **Immune system disorders**: ITGA3 is required for normal immune function, and its dysregulation is associated with autoimmune diseases, such as rheumatoid arthritis. **Significantly Expressed Cells:** ITGA3 is expressed in various cell types, including: 1. **Type I pneumocyte**: ITGA3 is expressed in type I pneumocytes, which are involved in lung development and homeostasis. 2. **Basal epithelial cell of prostatic duct**: ITGA3 is expressed in basal epithelial cells of the prostatic duct, which are involved in prostate development and function. 3. **Alveolar capillary type 2 endothelial cell**: ITGA3 is expressed in alveolar capillary type 2 endothelial cells, which are involved in lung development and homeostasis. **Proteins:** The protein sequence of ITGA3 is as follows: MVLSPSTVLTSKYR This protein sequence is highly conserved across species, indicating its essential role in cell-cell and cell-matrix adhesion. In conclusion, ITGA3 is a key player in cell-cell and cell-matrix adhesion, playing a crucial role in various biological processes, including cell signaling, migration, growth, and differentiation. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of ITGA3 in human health and disease.

Genular Protein ID: 3799473898

Symbol: ITA3_HUMAN

Name: Integrin alpha-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1655803

Title: Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.

PubMed ID: 1655803

DOI: 10.1083/jcb.115.1.257

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1714443

Title: Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3.

PubMed ID: 1714443

DOI: 10.1093/oxfordjournals.jbchem.a123436

PubMed ID: 8187758

Title: Molecular and biological characterization of fusion regulatory proteins (FRPs): anti-FRP mAbs induced HIV-mediated cell fusion via an integrin system.

PubMed ID: 8187758

DOI: 10.1002/j.1460-2075.1994.tb06479.x

PubMed ID: 3033641

Title: The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

PubMed ID: 3033641

DOI: 10.1073/pnas.84.10.3239

PubMed ID: 10455171

Title: A novel protease-docking function of integrin at invadopodia.

PubMed ID: 10455171

DOI: 10.1074/jbc.274.35.24947

PubMed ID: 9111516

Title: The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization.

PubMed ID: 9111516

PubMed ID: 14596610

Title: Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains.

PubMed ID: 14596610

DOI: 10.1021/bi034726u

PubMed ID: 15611341

Title: Palmitoylation supports assembly and function of integrin-tetraspanin complexes.

PubMed ID: 15611341

DOI: 10.1083/jcb.200404100

PubMed ID: 15181153

Title: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.

PubMed ID: 15181153

DOI: 10.1091/mbc.e04-03-0236

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32487760

Title: GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.

PubMed ID: 32487760

DOI: 10.1128/mbio.01087-20

PubMed ID: 22512483

Title: Integrin alpha3 mutations with kidney, lung, and skin disease.

PubMed ID: 22512483

DOI: 10.1056/nejmoa1110813

PubMed ID: 27717396

Title: Viable phenotype of ILNEB syndrome without nephrotic impairment in siblings heterozygous for unreported integrin alpha3 mutations.

PubMed ID: 27717396

DOI: 10.1186/s13023-016-0514-z

Sequence Information:

  • Length: 1051
  • Mass: 116612
  • Checksum: EEAFA7778EF17B21
  • Sequence:
  • MGPGPSRAPR APRLMLCALA LMVAAGGCVV SAFNLDTRFL VVKEAGNPGS LFGYSVALHR 
    QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 
    DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 
    HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 
    DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 
    SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 
    LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 
    KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 
    DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 
    GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 
    QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 
    RTSERSGEDA HEALLTLVVP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 
    EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 
    GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 
    NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 
    VLTCATGRAH CVWLECPIPD APVVTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 
    SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCGFFK 
    RARTRALYEA KRQKAEMKSQ PSETERLTDD Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.