Details for: JAG2

Gene ID: 3714

Symbol: JAG2

Ensembl ID: ENSG00000184916

Description: jagged canonical Notch ligand 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.7121
    Cell Significance Index: -10.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.3412
    Cell Significance Index: -8.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.0286
    Cell Significance Index: -8.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3864
    Cell Significance Index: -9.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8860
    Cell Significance Index: -10.4100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.2273
    Cell Significance Index: 10.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1683
    Cell Significance Index: 32.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8073
    Cell Significance Index: 79.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6500
    Cell Significance Index: 45.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6489
    Cell Significance Index: 585.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5762
    Cell Significance Index: 254.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5567
    Cell Significance Index: 12.1900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5451
    Cell Significance Index: 7.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5374
    Cell Significance Index: 27.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4289
    Cell Significance Index: 86.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4146
    Cell Significance Index: 4.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4131
    Cell Significance Index: 67.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3915
    Cell Significance Index: 42.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2922
    Cell Significance Index: 17.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2898
    Cell Significance Index: 103.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2400
    Cell Significance Index: 43.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2199
    Cell Significance Index: 41.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2084
    Cell Significance Index: 25.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2017
    Cell Significance Index: 13.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1708
    Cell Significance Index: 4.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1514
    Cell Significance Index: 82.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1363
    Cell Significance Index: 6.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1249
    Cell Significance Index: 3.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1118
    Cell Significance Index: 3.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1047
    Cell Significance Index: 12.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0596
    Cell Significance Index: 0.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0378
    Cell Significance Index: 0.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0193
    Cell Significance Index: 1.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0131
    Cell Significance Index: 0.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0117
    Cell Significance Index: 0.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0009
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0027
    Cell Significance Index: -0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0058
    Cell Significance Index: -0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0074
    Cell Significance Index: -10.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0081
    Cell Significance Index: -5.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0103
    Cell Significance Index: -7.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0158
    Cell Significance Index: -3.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0166
    Cell Significance Index: -9.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0169
    Cell Significance Index: -10.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0193
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0228
    Cell Significance Index: -10.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0258
    Cell Significance Index: -0.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0287
    Cell Significance Index: -8.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0349
    Cell Significance Index: -5.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0375
    Cell Significance Index: -1.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0395
    Cell Significance Index: -3.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0453
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0537
    Cell Significance Index: -11.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0571
    Cell Significance Index: -7.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0593
    Cell Significance Index: -7.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0608
    Cell Significance Index: -6.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0620
    Cell Significance Index: -1.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0643
    Cell Significance Index: -8.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0656
    Cell Significance Index: -6.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0726
    Cell Significance Index: -0.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0726
    Cell Significance Index: -1.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0880
    Cell Significance Index: -10.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0935
    Cell Significance Index: -1.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0941
    Cell Significance Index: -4.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0996
    Cell Significance Index: -10.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1105
    Cell Significance Index: -1.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1194
    Cell Significance Index: -3.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1212
    Cell Significance Index: -9.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1244
    Cell Significance Index: -6.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1280
    Cell Significance Index: -7.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1289
    Cell Significance Index: -9.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1297
    Cell Significance Index: -4.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1520
    Cell Significance Index: -8.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1564
    Cell Significance Index: -10.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1698
    Cell Significance Index: -5.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1734
    Cell Significance Index: -10.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1915
    Cell Significance Index: -6.7100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1990
    Cell Significance Index: -4.3000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2077
    Cell Significance Index: -2.7700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2212
    Cell Significance Index: -2.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2238
    Cell Significance Index: -4.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2301
    Cell Significance Index: -4.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2316
    Cell Significance Index: -3.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2341
    Cell Significance Index: -5.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2452
    Cell Significance Index: -8.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2453
    Cell Significance Index: -4.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2532
    Cell Significance Index: -4.4800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.2635
    Cell Significance Index: -1.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2715
    Cell Significance Index: -7.2500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2715
    Cell Significance Index: -2.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2740
    Cell Significance Index: -10.0600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2915
    Cell Significance Index: -3.7800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2941
    Cell Significance Index: -2.5000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3049
    Cell Significance Index: -4.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3050
    Cell Significance Index: -7.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** JAG2 is a protein-coding gene that encodes a transmembrane protein, Jagged-2. It is a member of the Notch ligand family and is expressed in various cell types, including neural progenitor cells, cortical thymic epithelial cells, cardiac endothelial cells, and granulocyte-monocyte progenitor cells. JAG2 is characterized by its ability to bind to Notch receptors, triggering a signaling cascade that regulates cell fate decisions. **Pathways and Functions** JAG2 is involved in several signaling pathways, including the Notch signaling pathway, which is a key regulator of cell fate decisions during development and tissue homeostasis. The Notch signaling pathway involves the interaction between JAG2 and Notch receptors, leading to the activation of downstream transcription factors that regulate gene expression. JAG2 is also involved in other signaling pathways, including the Wnt/β-catenin pathway, which regulates cell proliferation and differentiation. The functions of JAG2 include: * Cell differentiation: JAG2 plays a crucial role in regulating cell fate decisions during development and tissue homeostasis. * Cell proliferation: JAG2 regulates cell proliferation by modulating the Notch signaling pathway. * Cell death: JAG2 can induce cell death in certain contexts, such as during embryonic development. * Tissue development: JAG2 is involved in the development of various tissues, including the nervous system, the thymus, and the heart. **Clinical Significance** Mutations in the JAG2 gene have been implicated in several diseases, including: * Cancer: JAG2 mutations have been found in various types of cancer, including lung, breast, and colon cancer. * Developmental disorders: JAG2 mutations have been associated with developmental disorders, such as Down syndrome and congenital heart defects. * Neurological disorders: JAG2 mutations have been implicated in neurological disorders, such as autism and schizophrenia. The clinical significance of JAG2 mutations highlights the importance of this gene in regulating cellular processes and tissue development. Further research is needed to fully understand the mechanisms by which JAG2 mutations contribute to disease. **Regulation and Expression** JAG2 is regulated by various transcription factors, including the Notch signaling pathway. The expression of JAG2 is tissue-specific and is regulated by various factors, including epigenetic modifications and transcriptional regulators. **Evolutionary Conservation** JAG2 is evolutionarily conserved across species, suggesting that it plays a crucial role in regulating cellular processes and tissue development. **Conclusion** In conclusion, the JAG2 gene plays a crucial role in regulating cellular processes, including cell differentiation, proliferation, and death. Its involvement in various signaling pathways, including the Notch signaling pathway, highlights its importance in tissue development and homeostasis. Mutations in the JAG2 gene have been implicated in several diseases, including cancer and developmental disorders, underscoring the need for further research into the mechanisms by which JAG2 mutations contribute to disease.

Genular Protein ID: 3289946187

Symbol: JAG2_HUMAN

Name: Protein jagged-2

UniProtKB Accession Codes:

Q9Y219 Q9UE17 Q9UE99 Q9UNK8 Q9Y6P9 Q9Y6Q0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 2 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9315665

Title: Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.

PubMed ID: 9315665

DOI: 10.1128/mcb.17.10.6057

PubMed ID: 10079256

Title: Human ligands of the Notch receptor.

PubMed ID: 10079256

DOI: 10.1016/s0002-9440(10)65325-4

PubMed ID: 10662552

Title: Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene.

PubMed ID: 10662552

DOI: 10.1006/geno.1999.6045

PubMed ID: 9486542

Title: JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions.

PubMed ID: 9486542

DOI: 10.1016/s0925-4773(97)00146-9

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33861953

Title: A form of muscular dystrophy associated with pathogenic variants in JAG2.

PubMed ID: 33861953

DOI: 10.1016/j.ajhg.2021.03.020

PubMed ID: 34087166

Title:

PubMed ID: 34087166

DOI: 10.1016/j.ajhg.2021.04.018

Sequence Information:

  • Length: 1238
  • Mass: 133367
  • Checksum: 23B4FCD7D2891EF7
  • Sequence:
    • MRAQGRGRLP RRLLLLLALW VQAARPMGYF ELQLSALRNV NGELLSGACC DGDGRTTRAG 
GCGHDECDTY VRVCLKEYQA KVTPTGPCSY GHGATPVLGG NSFYLPPAGA AGDRARARAR 
AGGDQDPGLV VIPFQFAWPR SFTLIVEAWD WDNDTTPNEE LLIERVSHAG MINPEDRWKS 
LHFSGHVAHL ELQIRVRCDE NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC 
KEAVCKQGCN LLHGGCTVPG ECRCSYGWQG RFCDECVPYP GCVHGSCVEP WQCNCETNWG 
GLLCDKDLNY CGSHHPCTNG GTCINAEPDQ YRCTCPDGYS GRNCEKAEHA CTSNPCANGG 
SCHEVPSGFE CHCPSGWSGP TCALDIDECA SNPCAAGGTC VDQVDGFECI CPEQWVGATC 
QLDANECEGK PCLNAFSCKN LIGGYYCDCI PGWKGINCHI NVNDCRGQCQ HGGTCKDLVN 
GYQCVCPRGF GGRHCELERD ECASSPCHSG GLCEDLADGF HCHCPQGFSG PLCEVDVDLC 
EPSPCRNGAR CYNLEGDYYC ACPDDFGGKN CSVPREPCPG GACRVIDGCG SDAGPGMPGT 
AASGVCGPHG RCVSQPGGNF SCICDSGFTG TYCHENIDDC LGQPCRNGGT CIDEVDAFRC 
FCPSGWEGEL CDTNPNDCLP DPCHSRGRCY DLVNDFYCAC DDGWKGKTCH SREFQCDAYT 
CSNGGTCYDS GDTFRCACPP GWKGSTCAVA KNSSCLPNPC VNGGTCVGSG ASFSCICRDG 
WEGRTCTHNT NDCNPLPCYN GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA 
TCVDEINGYR CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD 
CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG AEEPPSTPCL 
PRSGHLDNNC ARLTLHFNRD HVPQGTTVGA ICSGIRSLPA TRAVARDRLL VLLCDRASSG 
ASAVEVAVSF SPARDLPDSS LIQGAAHAIV AAITQRGNSS LLLAVTEVKV ETVVTGGSST 
GLLVPVLCGA FSVLWLACVV LCVWWTRKRR KERERSRLPR EESANNQWAP LNPIRNPIER 
PGGHKDVLYQ CKNFTPPPRR ADEALPGPAG HAAVREDEED EDLGRGEEDS LEAEKFLSHK 
FTKDPGRSPG RPAHWASGPK VDNRAVRSIN EARYAGKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.