Details for: CD82

Gene ID: 3732

Symbol: CD82

Ensembl ID: ENSG00000085117

Description: CD82 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 101.1924
    Cell Significance Index: -15.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.0303
    Cell Significance Index: -18.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.6104
    Cell Significance Index: -27.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.5498
    Cell Significance Index: -23.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 51.4303
    Cell Significance Index: -26.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.1062
    Cell Significance Index: -23.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.0389
    Cell Significance Index: -25.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4928
    Cell Significance Index: -25.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9567
    Cell Significance Index: -27.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3700
    Cell Significance Index: -16.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9969
    Cell Significance Index: -27.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.5644
    Cell Significance Index: 97.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.4199
    Cell Significance Index: 100.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.9140
    Cell Significance Index: 46.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7611
    Cell Significance Index: 63.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7647
    Cell Significance Index: 91.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7413
    Cell Significance Index: 202.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6893
    Cell Significance Index: 47.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6058
    Cell Significance Index: 189.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3731
    Cell Significance Index: 1239.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2998
    Cell Significance Index: 78.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1571
    Cell Significance Index: 149.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1282
    Cell Significance Index: 52.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0869
    Cell Significance Index: 51.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0847
    Cell Significance Index: 117.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0467
    Cell Significance Index: 67.5300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.9628
    Cell Significance Index: 5.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7517
    Cell Significance Index: 74.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7331
    Cell Significance Index: 38.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6958
    Cell Significance Index: 307.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6141
    Cell Significance Index: 42.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6060
    Cell Significance Index: 16.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5648
    Cell Significance Index: 8.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5458
    Cell Significance Index: 15.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4878
    Cell Significance Index: 34.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4841
    Cell Significance Index: 12.1000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4042
    Cell Significance Index: 4.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3878
    Cell Significance Index: 69.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3865
    Cell Significance Index: 62.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2958
    Cell Significance Index: 37.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2731
    Cell Significance Index: 33.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2496
    Cell Significance Index: 47.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2355
    Cell Significance Index: 17.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1915
    Cell Significance Index: 104.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1735
    Cell Significance Index: 29.6200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1484
    Cell Significance Index: 1.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1229
    Cell Significance Index: 5.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1097
    Cell Significance Index: 21.7700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0405
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0321
    Cell Significance Index: 3.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0292
    Cell Significance Index: 1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0124
    Cell Significance Index: 23.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0079
    Cell Significance Index: -4.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0136
    Cell Significance Index: -25.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0168
    Cell Significance Index: -12.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0169
    Cell Significance Index: -12.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0178
    Cell Significance Index: -27.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0218
    Cell Significance Index: -29.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0267
    Cell Significance Index: -16.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0284
    Cell Significance Index: -2.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0320
    Cell Significance Index: -18.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0368
    Cell Significance Index: -13.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0434
    Cell Significance Index: -2.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0484
    Cell Significance Index: -0.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0495
    Cell Significance Index: -6.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0525
    Cell Significance Index: -23.8500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0563
    Cell Significance Index: -1.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0603
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0694
    Cell Significance Index: -14.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0743
    Cell Significance Index: -21.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1064
    Cell Significance Index: -21.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1177
    Cell Significance Index: -17.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1255
    Cell Significance Index: -2.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1420
    Cell Significance Index: -1.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1563
    Cell Significance Index: -5.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1665
    Cell Significance Index: -19.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1966
    Cell Significance Index: -1.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2287
    Cell Significance Index: -9.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2375
    Cell Significance Index: -18.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2452
    Cell Significance Index: -25.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2686
    Cell Significance Index: -5.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2772
    Cell Significance Index: -4.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2786
    Cell Significance Index: -14.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2870
    Cell Significance Index: -3.1200
  • Cell Name: centroblast (CL0009112)
    Fold Change: -0.2872
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3132
    Cell Significance Index: -24.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3530
    Cell Significance Index: -5.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3948
    Cell Significance Index: -26.5500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.4057
    Cell Significance Index: -2.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4153
    Cell Significance Index: -25.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4160
    Cell Significance Index: -26.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4321
    Cell Significance Index: -26.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4465
    Cell Significance Index: -7.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4872
    Cell Significance Index: -13.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4947
    Cell Significance Index: -27.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5377
    Cell Significance Index: -19.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5945
    Cell Significance Index: -17.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6321
    Cell Significance Index: -16.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6501
    Cell Significance Index: -9.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CD82 is a transmembrane glycoprotein with a molecular weight of approximately 26-30 kDa. It is a member of the integrin family, but unlike other integrins, CD82 does not bind to the extracellular matrix. Instead, it interacts with various ligands, including proteins and lipids, to modulate cell-cell interactions. CD82 expression is often associated with early stages of cell development and differentiation, particularly in hematopoietic cells. Its expression is also elevated in certain types of cancer, suggesting a role in tumor progression and metastasis. **Pathways and Functions** CD82 is involved in several cellular pathways, including: 1. **Cell adhesion and migration**: CD82 interacts with various ligands to regulate cell-cell interactions, facilitating cell migration and adhesion. 2. **Immune regulation**: CD82 modulates immune responses by influencing the activity of immune cells, such as T cells and B cells. 3. **Extracellular signaling**: CD82 transduces signals from the extracellular environment to the cell interior, influencing cellular behavior. 4. **Cell differentiation and survival**: CD82 expression is associated with early stages of cell development and differentiation, and its dysregulation may contribute to cancer progression. **Clinical Significance** CD82 has been implicated in various diseases, including: 1. **Cancer**: Elevated CD82 expression has been observed in several types of cancer, including breast, lung, and colon cancer. CD82 may contribute to tumor progression and metastasis. 2. **Autoimmune diseases**: CD82 may play a role in autoimmune diseases, such as rheumatoid arthritis, where its expression is altered in affected tissues. 3. **Viral infections**: CD82 has been shown to interact with viral proteins, influencing viral entry and replication. 4. **Immune-related disorders**: CD82 expression has been linked to immune-related disorders, such as multiple sclerosis and lupus. In summary, CD82 is a multifunctional protein that plays a crucial role in various cellular processes, including cell adhesion, migration, and immune regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 546798646

Symbol: CD82_HUMAN

Name: CD82 antigen

UniProtKB Accession Codes:

P27701 D3DQN6 E9PC70 Q7Z2D4 Q7Z5N2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1842498

Title: A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23.

PubMed ID: 1842498

DOI: 10.1002/eji.1830210219

PubMed ID: 1401919

Title: C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63.

PubMed ID: 1401919

PubMed ID: 7754374

Title: KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2.

PubMed ID: 7754374

DOI: 10.1126/science.7754374

PubMed ID: 9126478

Title: Genomic organization of the human KAI1 metastasis-suppressor gene.

PubMed ID: 9126478

DOI: 10.1006/geno.1997.4618

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8757325

Title: Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29).

PubMed ID: 8757325

PubMed ID: 10985391

Title: Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1.

PubMed ID: 10985391

DOI: 10.1016/s0960-9822(00)00652-7

PubMed ID: 12750295

Title: EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.

PubMed ID: 12750295

PubMed ID: 15557282

Title: Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion.

PubMed ID: 15557282

DOI: 10.1074/jbc.m406680200

PubMed ID: 15677461

Title: Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.

PubMed ID: 15677461

DOI: 10.1074/jbc.m414189200

PubMed ID: 17560548

Title: Effect of KAI1/CD82 on the beta1 integrin maturation in highly migratory carcinoma cells.

PubMed ID: 17560548

DOI: 10.1016/j.bbrc.2007.05.159

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19497983

Title: CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts.

PubMed ID: 19497983

DOI: 10.1096/fj.08-123414

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 23897813

Title: Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor.

PubMed ID: 23897813

DOI: 10.1074/jbc.m112.439380

PubMed ID: 24623721

Title: The membrane scaffold CD82 regulates cell adhesion by altering alpha4 integrin stability and molecular density.

PubMed ID: 24623721

DOI: 10.1091/mbc.e13-11-0660

PubMed ID: 30463011

Title: A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote alpha-Toxin Cytotoxicity.

PubMed ID: 30463011

DOI: 10.1016/j.celrep.2018.10.088

PubMed ID: 34530889

Title: KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.

PubMed ID: 34530889

DOI: 10.1186/s13045-021-01147-6

PubMed ID: 35538033

Title: CD82 palmitoylation site mutations at Cys5+Cys74 affect EGFR internalization and metabolism through recycling pathway.

PubMed ID: 35538033

DOI: 10.3724/abbs.2022011

PubMed ID: 36945827

Title: Recombinant human KAI1/CD82 attenuates M1 macrophage polarization on LPS-stimulated RAW264.7 cells via blocking TLR4/JNK/NF-kappaB signal pathway.

PubMed ID: 36945827

DOI: 10.5483/bmbrep.2022-0189

Sequence Information:

  • Length: 267
  • Mass: 29626
  • Checksum: FC379855BD1CABDE
  • Sequence:
    • MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS SLRMGAYVFI 
GVGAVTMLMG FLGCIGAVNE VRCLLGLYFA FLLLILIAQV TAGALFYFNM GKLKQEMGGI 
VTELIRDYNS SREDSLQDAW DYVQAQVKCC GWVSFYNWTD NAELMNRPEV TYPCSCEVKG 
EEDNSLSVRK GFCEAPGNRT QSGNHPEDWP VYQEGCMEKV QAWLQENLGI ILGVGVGVAI 
IELLGMVLSI CLCRHVHSED YSKVPKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.