Details for: KCNC1

Gene ID: 3746

Symbol: KCNC1

Ensembl ID: ENSG00000129159

Description: potassium voltage-gated channel subfamily C member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 127.5513
    Cell Significance Index: -19.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.5893
    Cell Significance Index: -19.6800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 5.1878
    Cell Significance Index: 64.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.2613
    Cell Significance Index: 55.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9199
    Cell Significance Index: 100.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7326
    Cell Significance Index: 347.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5831
    Cell Significance Index: 567.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9465
    Cell Significance Index: 22.7000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.9238
    Cell Significance Index: 11.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8599
    Cell Significance Index: 57.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8463
    Cell Significance Index: 52.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8019
    Cell Significance Index: 35.4700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7526
    Cell Significance Index: 10.0400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.7233
    Cell Significance Index: 5.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7178
    Cell Significance Index: 27.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6768
    Cell Significance Index: 14.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4548
    Cell Significance Index: 27.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3957
    Cell Significance Index: 273.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3160
    Cell Significance Index: 62.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2309
    Cell Significance Index: 43.9500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2175
    Cell Significance Index: 1.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1724
    Cell Significance Index: 25.0700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1347
    Cell Significance Index: 1.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1093
    Cell Significance Index: 168.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1051
    Cell Significance Index: 3.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0673
    Cell Significance Index: 124.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0623
    Cell Significance Index: 4.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0556
    Cell Significance Index: 50.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0476
    Cell Significance Index: 1.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0358
    Cell Significance Index: 67.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0263
    Cell Significance Index: 35.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0093
    Cell Significance Index: 5.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0054
    Cell Significance Index: -0.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0108
    Cell Significance Index: -4.7700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0119
    Cell Significance Index: -0.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0143
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0178
    Cell Significance Index: -8.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0203
    Cell Significance Index: -1.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0232
    Cell Significance Index: -2.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0245
    Cell Significance Index: -17.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0247
    Cell Significance Index: -0.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0258
    Cell Significance Index: -0.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0266
    Cell Significance Index: -14.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0296
    Cell Significance Index: -5.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0299
    Cell Significance Index: -1.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0333
    Cell Significance Index: -0.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0362
    Cell Significance Index: -19.7900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0420
    Cell Significance Index: -0.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0439
    Cell Significance Index: -0.9500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0467
    Cell Significance Index: -0.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0496
    Cell Significance Index: -0.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0501
    Cell Significance Index: -4.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0543
    Cell Significance Index: -15.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0766
    Cell Significance Index: -1.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0795
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0833
    Cell Significance Index: -17.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0902
    Cell Significance Index: -11.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1035
    Cell Significance Index: -17.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1044
    Cell Significance Index: -6.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1058
    Cell Significance Index: -7.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1081
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1122
    Cell Significance Index: -12.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1218
    Cell Significance Index: -5.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1229
    Cell Significance Index: -16.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1262
    Cell Significance Index: -7.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1263
    Cell Significance Index: -3.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1316
    Cell Significance Index: -17.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1349
    Cell Significance Index: -15.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1380
    Cell Significance Index: -4.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1442
    Cell Significance Index: -4.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1606
    Cell Significance Index: -18.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1623
    Cell Significance Index: -5.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1676
    Cell Significance Index: -17.4500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1713
    Cell Significance Index: -1.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1726
    Cell Significance Index: -3.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1733
    Cell Significance Index: -12.2600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1744
    Cell Significance Index: -1.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1837
    Cell Significance Index: -18.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1897
    Cell Significance Index: -9.8600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1990
    Cell Significance Index: -2.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2101
    Cell Significance Index: -15.6600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2416
    Cell Significance Index: -2.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2477
    Cell Significance Index: -2.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2543
    Cell Significance Index: -16.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2646
    Cell Significance Index: -6.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2689
    Cell Significance Index: -9.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2715
    Cell Significance Index: -12.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2873
    Cell Significance Index: -4.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2961
    Cell Significance Index: -7.6100
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.3065
    Cell Significance Index: -3.3000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3202
    Cell Significance Index: -4.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3265
    Cell Significance Index: -17.0100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3312
    Cell Significance Index: -3.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3526
    Cell Significance Index: -7.5100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3968
    Cell Significance Index: -7.8100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4533
    Cell Significance Index: -9.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4570
    Cell Significance Index: -8.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Voltage-Gated Potassium Channel:** KCNC1 is a member of the voltage-gated potassium channel family, which is characterized by its ability to regulate the flow of potassium ions across the neuronal membrane. 2. **GABAergic Interneurons:** KCNC1 is highly expressed in GABAergic interneurons, a subset of neurons that play a critical role in regulating the activity of other neurons in the brain. 3. **Developmental Expression:** KCNC1 is also expressed in other neuronal populations, including the caudal ganglionic eminence-derived GABAergic cortical interneurons, highlighting its importance in neural development. 4. **Cellular Localization:** KCNC1 is primarily localized to the neuronal cell body membrane, postsynaptic membrane, and presynaptic membrane, suggesting its involvement in regulating the excitability of neurons. **Pathways and Functions:** 1. **Regulation of Neuronal Excitability:** KCNC1 plays a crucial role in regulating the excitability of neurons by modulating the flow of potassium ions across the neuronal membrane. 2. **GABAergic Signaling:** As a GABAergic interneuron-specific channel, KCNC1 is involved in regulating the activity of GABAergic neurons, which are essential for maintaining the balance of neuronal activity in the brain. 3. **Neuronal Development:** KCNC1 is expressed in various neuronal populations during development, suggesting its involvement in regulating the maturation and differentiation of neurons. 4. **Response to Xenobiotics:** KCNC1 is also involved in responding to toxic substances, highlighting its role in protecting neurons from oxidative stress and other forms of damage. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in KCNC1 have been associated with neurological disorders, including epilepsy, and suggest its importance in maintaining proper neuronal function. 2. **GABAergic Dysregulation:** Alterations in KCNC1 expression or function may contribute to GABAergic dysregulation, leading to various neurological and psychiatric disorders. 3. **Neurodevelopmental Disorders:** KCNC1's role in regulating neuronal development and maturation makes it a potential contributor to neurodevelopmental disorders, such as autism spectrum disorder. 4. **Cancer:** KCNC1's expression in kidney proximal convoluted tubule epithelial cells suggests its potential involvement in cancer development and progression. In conclusion, KCNC1 is a critical gene that plays a pivotal role in maintaining neuronal function and development. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 3682779263

Symbol: KCNC1_HUMAN

Name: Potassium voltage-gated channel subfamily C member 1

UniProtKB Accession Codes:

P48547 K4DI87 Q3KNS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 7 EMDB 10 Ensembl 3 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8449507

Title: Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15.

PubMed ID: 8449507

DOI: 10.1006/geno.1993.1075

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1400413

Title: The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells.

PubMed ID: 1400413

DOI: 10.1016/s0021-9258(19)36784-5

PubMed ID: 23734863

Title: Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface.

PubMed ID: 23734863

DOI: 10.1042/bj20130034

PubMed ID: 35840580

Title: Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.

PubMed ID: 35840580

DOI: 10.1038/s41467-022-29594-w

PubMed ID: 25401298

Title: A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.

PubMed ID: 25401298

DOI: 10.1038/ng.3144

Sequence Information:

  • Length: 511
  • Mass: 57942
  • Checksum: 10A93478F7120ABB
  • Sequence:
    • MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP RADEFFFDRH 
PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD VEPCCWMTYR QHRDAEEALD 
SFGGAPLDNS ADDADADGPG DSGDGEDELE MTKRLALSDS PDGRPGGFWR RWQPRIWALF 
EDPYSSRYAR YVAFASLFFI LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE 
TEAFLTYIEG VCVVWFTFEF LMRVIFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS 
KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA 
TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT LGYGDMYPQT WSGMLVGALC 
ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH 
HSTQSDTCPL AQEEILEINR AGRKPLRGMS I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.