Details for: KCNG1

Gene ID: 3755

Symbol: KCNG1

Ensembl ID: ENSG00000026559

Description: potassium voltage-gated channel modifier subfamily G member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.28
    Marker Score: 9845
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2
    Marker Score: 869
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4816
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7625
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.13
    Marker Score: 4427
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.01
    Marker Score: 639.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1
    Marker Score: 1440
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.97
    Marker Score: 1491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.92
    Marker Score: 626
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5261
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 380
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.87
    Marker Score: 3358
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.82
    Marker Score: 1062
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1532
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1640
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.79
    Marker Score: 6767
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11746
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.7
    Marker Score: 986
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 364
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 322
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.53
    Marker Score: 236
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5
    Marker Score: 229
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.46
    Marker Score: 394
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 645
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 203
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.41
    Marker Score: 258.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.38
    Marker Score: 926
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.36
    Marker Score: 849
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 155
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.35
    Marker Score: 290
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.35
    Marker Score: 376
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.35
    Marker Score: 110
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 557
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.32
    Marker Score: 671.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.32
    Marker Score: 107
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.29
    Marker Score: 602
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.28
    Marker Score: 1097
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.27
    Marker Score: 244
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.26
    Marker Score: 276.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.25
    Marker Score: 57
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.25
    Marker Score: 197
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.25
    Marker Score: 306
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.24
    Marker Score: 96
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.23
    Marker Score: 225
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.23
    Marker Score: 243
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.23
    Marker Score: 1110
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 233
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.22
    Marker Score: 155
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.21
    Marker Score: 210
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2
    Marker Score: 177
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2
    Marker Score: 12431
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.2
    Marker Score: 814
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.19
    Marker Score: 38
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.19
    Marker Score: 92
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.19
    Marker Score: 213
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.18
    Marker Score: 77
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.18
    Marker Score: 2376
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.18
    Marker Score: 562
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.18
    Marker Score: 40
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.17
    Marker Score: 487
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.17
    Marker Score: 167
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.17
    Marker Score: 38
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 98
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.15
    Marker Score: 1470
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.15
    Marker Score: 83
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.15
    Marker Score: 543
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.15
    Marker Score: 608
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.14
    Marker Score: 97
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.14
    Marker Score: 139
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.14
    Marker Score: 76
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.14
    Marker Score: 40

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Other Information

**Key characteristics** - The KCNG1 gene is located on chromosome 15q21.1. - It is a member of the potassium voltage-gated channel family. - It is a transmembrane protein that is composed of 14 transmembrane domains. - It is a regulator of delayed rectifier potassium channel activity. - It is also involved in the regulation of neuronal excitability. **Pathways and functions** - The KCNG1 gene is involved in the regulation of delayed rectifier potassium channel activity. - The protein is a key regulator of the activity of the delayed rectifier potassium channel, which is a potassium-selective channel that is expressed in the brain and other tissues. - The protein helps to control the resting membrane potential of neurons and other cells. - It also helps to regulate the firing of action potentials. **Clinical significance** - Mutations in the KCNG1 gene have been linked to a number of human diseases, including epilepsy, schizophrenia, and migraine. - The KCNG1 gene is a potential target for the treatment of these diseases. - Studies of the KCNG1 gene have shown that it can be used to treat epilepsy in animal models. **Additional information** - The KCNG1 gene is also known as KvD1. - It is a highly conserved gene, with a similar gene found in other mammals. - The protein is a member of the potassium voltage-gated channel family, which is a large family of ion channels that are involved in a variety of cellular processes, including action potential generation, synaptic transmission, and neuronal excitability.

Genular Protein ID: 1744910564

Symbol: KCNG1_HUMAN

Name: Potassium voltage-gated channel subfamily G member 1

UniProtKB Accession Codes:

Q9UIX4 A8K3S4 O43528 Q5JXL5 Q9BRC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 9 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9434767

Title: Isolation, characterization, and mapping of two human potassium channels.

PubMed ID: 9434767

DOI: 10.1006/bbrc.1997.7830

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19074135

Title: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.

PubMed ID: 19074135

DOI: 10.1074/jbc.m808786200

Sequence Information:

  • Length: 513
  • Mass: 57913
  • Checksum: A002F1C0EF2FBDC5
  • Sequence:
    • MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED 
RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN 
PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV 
EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT 
AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP 
LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS 
LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI 
TMTTVGYGDM VPRSTPGQVV ALSSILSGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR 
RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN

Genular Protein ID: 2370329453

Symbol: Q86Y85_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86Y85

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 513
  • Mass: 57857
  • Checksum: E840CF446CFA02F4
  • Sequence:
    • MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED 
RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFGD ILNVCDDYDV TCNEFFFDRN 
PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV 
EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT 
AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP 
LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS 
LGLQTLGLTA RRCTREFGLL LLFLCMAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI 
TMTTVGYGDM VPRSTPGQVV ALSSILGGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR 
RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.