Details for: KCNG1

Gene ID: 3755

Symbol: KCNG1

Ensembl ID: ENSG00000026559

Description: potassium voltage-gated channel modifier subfamily G member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.2818
    Cell Significance Index: -7.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.2393
    Cell Significance Index: -7.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 17.9028
    Cell Significance Index: -7.3800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.1846
    Cell Significance Index: 30.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5140
    Cell Significance Index: 78.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1587
    Cell Significance Index: 30.9400
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.9994
    Cell Significance Index: 11.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7526
    Cell Significance Index: 20.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7314
    Cell Significance Index: 6.7400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.6180
    Cell Significance Index: 5.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5578
    Cell Significance Index: 7.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5311
    Cell Significance Index: 190.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4256
    Cell Significance Index: 10.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4094
    Cell Significance Index: 52.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2244
    Cell Significance Index: 3.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1752
    Cell Significance Index: 33.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1647
    Cell Significance Index: 33.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1469
    Cell Significance Index: 8.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1432
    Cell Significance Index: 8.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1052
    Cell Significance Index: 12.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1049
    Cell Significance Index: 3.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1008
    Cell Significance Index: 18.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0628
    Cell Significance Index: 1.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0459
    Cell Significance Index: 1.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0428
    Cell Significance Index: 23.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0407
    Cell Significance Index: 17.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0357
    Cell Significance Index: 3.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0311
    Cell Significance Index: 0.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0301
    Cell Significance Index: 3.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0225
    Cell Significance Index: 1.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0096
    Cell Significance Index: 5.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0095
    Cell Significance Index: 6.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0073
    Cell Significance Index: 0.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0035
    Cell Significance Index: 0.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0001
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0044
    Cell Significance Index: -0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0078
    Cell Significance Index: -1.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0106
    Cell Significance Index: -8.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0126
    Cell Significance Index: -1.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0126
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0149
    Cell Significance Index: -1.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0163
    Cell Significance Index: -2.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0166
    Cell Significance Index: -7.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0167
    Cell Significance Index: -4.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0167
    Cell Significance Index: -2.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0202
    Cell Significance Index: -4.0000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0207
    Cell Significance Index: -0.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0210
    Cell Significance Index: -0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0211
    Cell Significance Index: -0.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0219
    Cell Significance Index: -2.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0222
    Cell Significance Index: -0.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0302
    Cell Significance Index: -1.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0325
    Cell Significance Index: -0.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0348
    Cell Significance Index: -0.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0352
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0385
    Cell Significance Index: -4.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0403
    Cell Significance Index: -2.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0473
    Cell Significance Index: -1.5500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0573
    Cell Significance Index: -0.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0600
    Cell Significance Index: -7.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0613
    Cell Significance Index: -3.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0686
    Cell Significance Index: -1.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0717
    Cell Significance Index: -1.7200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0745
    Cell Significance Index: -1.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0812
    Cell Significance Index: -5.1200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0824
    Cell Significance Index: -0.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0868
    Cell Significance Index: -3.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0903
    Cell Significance Index: -3.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0933
    Cell Significance Index: -6.9500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0936
    Cell Significance Index: -1.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0938
    Cell Significance Index: -6.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0999
    Cell Significance Index: -3.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1041
    Cell Significance Index: -7.9900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1046
    Cell Significance Index: -1.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1096
    Cell Significance Index: -5.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1101
    Cell Significance Index: -1.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1104
    Cell Significance Index: -5.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1146
    Cell Significance Index: -2.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1217
    Cell Significance Index: -6.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1225
    Cell Significance Index: -3.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1227
    Cell Significance Index: -5.7200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1318
    Cell Significance Index: -0.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1350
    Cell Significance Index: -2.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1370
    Cell Significance Index: -2.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1391
    Cell Significance Index: -1.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1465
    Cell Significance Index: -8.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1493
    Cell Significance Index: -2.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1509
    Cell Significance Index: -4.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1626
    Cell Significance Index: -5.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1771
    Cell Significance Index: -1.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1780
    Cell Significance Index: -6.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Potassium Channel Modulation:** KCNG1 is a potassium voltage-gated channel modifier subfamily G member 1, which interacts with voltage-gated potassium channels to regulate their activity. 2. **Tissue Expression:** KCNG1 is expressed in a wide range of tissues, including the brain, gastrointestinal tract, and immune cells. 3. **Cell Type Specificity:** The gene is specifically expressed in GABAergic cortical interneurons, goblet cells, and other cell types that require precise potassium channel regulation. 4. **Protein Structure:** KCNG1 is a transmembrane protein that forms homooligomers with other KCNG family members to regulate potassium channel activity. **Pathways and Functions:** 1. **Voltage-Gated Potassium Channels:** KCNG1 interacts with voltage-gated potassium channels to regulate their activity, influencing neuronal excitability and synaptic transmission. 2. **Delayed Rectifier Potassium Channels:** KCNG1 modulates the activity of delayed rectifier potassium channels, which are essential for maintaining proper potassium balance and neuronal function. 3. **Protein Homooligomerization:** KCNG1 forms homooligomers with other KCNG family members to regulate potassium channel activity and protein-protein interactions. 4. **Regulation of Delayed Rectifier Potassium Channel Activity:** KCNG1 plays a crucial role in regulating the activity of delayed rectifier potassium channels, which is essential for maintaining proper potassium balance and neuronal function. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in KCNG1 expression have been linked to several neurological disorders, including epilepsy, anxiety disorders, and autism spectrum disorder. 2. **Gastrointestinal Disorders:** KCNG1 is also expressed in gastrointestinal cells, and alterations in its expression have been linked to gastrointestinal disorders, such as inflammatory bowel disease and colon cancer. 3. **Cancer:** KCNG1 has been identified as a potential oncogene in certain types of cancer, including colon cancer and glioblastoma. 4. **Therapeutic Target:** KCNG1 is a promising therapeutic target for the treatment of neurological and gastrointestinal disorders, as well as cancer. In conclusion, KCNG1 is a critical gene that plays a key role in regulating potassium channels and maintaining proper ion balance and neuronal function. Its dysregulation has been linked to several neurological and gastrointestinal disorders, highlighting its importance as a therapeutic target. Further research is needed to fully elucidate the mechanisms of KCNG1 and its potential therapeutic applications.

Genular Protein ID: 1744910564

Symbol: KCNG1_HUMAN

Name: Potassium voltage-gated channel subfamily G member 1

UniProtKB Accession Codes:

Q9UIX4 A8K3S4 O43528 Q5JXL5 Q9BRC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 9 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9434767

Title: Isolation, characterization, and mapping of two human potassium channels.

PubMed ID: 9434767

DOI: 10.1006/bbrc.1997.7830

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19074135

Title: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.

PubMed ID: 19074135

DOI: 10.1074/jbc.m808786200

Sequence Information:

  • Length: 513
  • Mass: 57913
  • Checksum: A002F1C0EF2FBDC5
  • Sequence:
    • MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED 
RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD ILNVCDDYDV TCNEFFFDRN 
PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV 
EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT 
AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP 
LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS 
LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI 
TMTTVGYGDM VPRSTPGQVV ALSSILSGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR 
RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN

Genular Protein ID: 2370329453

Symbol: Q86Y85_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86Y85

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 513
  • Mass: 57857
  • Checksum: E840CF446CFA02F4
  • Sequence:
    • MTLLPGDNSD YDYSALSCTS DASFHPAFLP QRQAIKGAFY RRAQRLRPQD EPRQGCQPED 
RRRRIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFGD ILNVCDDYDV TCNEFFFDRN 
PGAFGTILTF LRAGKLRLLR EMCALSFQEE LLYWGIAEDH LDGCCKRRYL QKIEEFAEMV 
EREEEDDALD SEGRDSEGPA EGEGRLGRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT 
AVNLSVSTLP SLREEEEQGH CSQMCHNVFI VESVCVGWFS LEFLLRLIQA PSKFAFLRSP 
LTLIDLVAIL PYYITLLVDG AAAGRRKPGA GNSYLDKVGL VLRVLRALRI LYVMRLARHS 
LGLQTLGLTA RRCTREFGLL LLFLCMAIAL FAPLLYVIEN EMADSPEFTS IPACYWWAVI 
TMTTVGYGDM VPRSTPGQVV ALSSILGGIL LMAFPVTSIF HTFSRSYLEL KQEQERVMFR 
RAQFLIKTKS QLSVSQDSDI LFGSASSDTR DNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.