Details for: KCNJ12

Gene ID: 3768

Symbol: KCNJ12

Ensembl ID: ENSG00000184185

Description: potassium inwardly rectifying channel subfamily J member 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.3811
    Cell Significance Index: -5.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.0889
    Cell Significance Index: -6.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.1340
    Cell Significance Index: -6.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 3.1297
    Cell Significance Index: 109.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6407
    Cell Significance Index: 35.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.7999
    Cell Significance Index: 11.4600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7447
    Cell Significance Index: 6.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4827
    Cell Significance Index: 10.2800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4292
    Cell Significance Index: 6.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4191
    Cell Significance Index: 19.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4093
    Cell Significance Index: 77.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3346
    Cell Significance Index: 33.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2574
    Cell Significance Index: 15.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2301
    Cell Significance Index: 82.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2113
    Cell Significance Index: 42.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1871
    Cell Significance Index: 20.3500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1777
    Cell Significance Index: 1.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1537
    Cell Significance Index: 25.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1400
    Cell Significance Index: 126.4400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1370
    Cell Significance Index: 2.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1132
    Cell Significance Index: 1.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0914
    Cell Significance Index: 2.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0826
    Cell Significance Index: 1.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0803
    Cell Significance Index: 6.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0750
    Cell Significance Index: 5.1900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0485
    Cell Significance Index: 0.3000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0435
    Cell Significance Index: 0.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0367
    Cell Significance Index: 0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0302
    Cell Significance Index: 41.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0174
    Cell Significance Index: 32.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0118
    Cell Significance Index: 0.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0105
    Cell Significance Index: 0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0104
    Cell Significance Index: 15.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0077
    Cell Significance Index: 0.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0023
    Cell Significance Index: 1.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0038
    Cell Significance Index: -1.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0045
    Cell Significance Index: -0.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0047
    Cell Significance Index: -0.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0056
    Cell Significance Index: -0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0064
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0083
    Cell Significance Index: -6.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0093
    Cell Significance Index: -5.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0109
    Cell Significance Index: -6.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0184
    Cell Significance Index: -0.5900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0194
    Cell Significance Index: -0.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0232
    Cell Significance Index: -4.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0233
    Cell Significance Index: -1.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0265
    Cell Significance Index: -4.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0278
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0294
    Cell Significance Index: -5.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0331
    Cell Significance Index: -4.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0365
    Cell Significance Index: -5.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0407
    Cell Significance Index: -5.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0417
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0425
    Cell Significance Index: -4.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0473
    Cell Significance Index: -2.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0501
    Cell Significance Index: -0.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0505
    Cell Significance Index: -6.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0587
    Cell Significance Index: -6.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0605
    Cell Significance Index: -6.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0609
    Cell Significance Index: -6.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0612
    Cell Significance Index: -1.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0657
    Cell Significance Index: -3.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0710
    Cell Significance Index: -5.6200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0710
    Cell Significance Index: -0.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0730
    Cell Significance Index: -3.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0806
    Cell Significance Index: -1.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0821
    Cell Significance Index: -5.5200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0831
    Cell Significance Index: -1.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0843
    Cell Significance Index: -1.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0866
    Cell Significance Index: -4.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0904
    Cell Significance Index: -2.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0914
    Cell Significance Index: -1.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0926
    Cell Significance Index: -6.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0953
    Cell Significance Index: -3.3100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0995
    Cell Significance Index: -2.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0996
    Cell Significance Index: -1.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1045
    Cell Significance Index: -6.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1067
    Cell Significance Index: -4.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1070
    Cell Significance Index: -2.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1081
    Cell Significance Index: -3.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1113
    Cell Significance Index: -5.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1115
    Cell Significance Index: -1.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1151
    Cell Significance Index: -3.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1156
    Cell Significance Index: -4.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1213
    Cell Significance Index: -3.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1230
    Cell Significance Index: -6.3900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1247
    Cell Significance Index: -2.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1325
    Cell Significance Index: -2.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1334
    Cell Significance Index: -6.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1361
    Cell Significance Index: -1.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1399
    Cell Significance Index: -3.4900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1511
    Cell Significance Index: -1.7400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1539
    Cell Significance Index: -2.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1613
    Cell Significance Index: -2.3200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1681
    Cell Significance Index: -3.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNJ12 is a member of the inwardly rectifying potassium channel (IRK) subfamily J, which is characterized by its high permeability to potassium ions. The KCNJ12 gene encodes a protein that forms a homotetramer, which is essential for its function. The channel is activated by GABA receptors and inhibits voltage-gated Ca2+ channels via Gβγ subunits, thereby modulating neuronal excitability and synaptic transmission. KCNJ12 is also involved in regulating heart contraction and cardiac conduction. **Pathways and Functions:** KCNJ12 plays a critical role in various cellular processes, including: 1. **Neuronal system function:** KCNJ12 is expressed in cerebral cortex GABAergic interneurons and regulates neurotransmitter receptors and postsynaptic signal transmission. 2. **Cardiac conduction:** KCNJ12 is involved in regulating cardiac conduction and heart contraction, highlighting its importance in maintaining cardiac function. 3. **Muscle contraction:** KCNJ12 is expressed in cardiac muscle myoblasts and regulates muscle contraction. 4. **GABA receptor activation:** KCNJ12 is activated by GABA receptors, modulating neuronal excitability and synaptic transmission. 5. **G protein-gated potassium channels:** KCNJ12 is involved in regulating G protein-gated potassium channels, which are essential for various cellular processes. **Clinical Significance:** Dysregulation of KCNJ12 has been implicated in various diseases, including: 1. **Cardiac arrhythmias:** KCNJ12 mutations have been associated with cardiac arrhythmias, highlighting the importance of this gene in maintaining cardiac function. 2. **Neurological disorders:** KCNJ12 dysregulation has been linked to neurological disorders, such as epilepsy and schizophrenia. 3. **Gastrointestinal disorders:** KCNJ12 mutations have been associated with gastrointestinal disorders, such as irritable bowel syndrome. In conclusion, KCNJ12 is a complex gene that plays a critical role in regulating various cellular processes, including neuronal system function, cardiac conduction, and muscle contraction. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining human health. **Significantly expressed cells:** 1. Cardiac endothelial cell 2. Granulocyte monocyte progenitor cell 3. Cardiac muscle myoblast 4. Immature innate lymphoid cell 5. Enterocyte of epithelium of small intestine 6. Goblet cell 7. Intestinal crypt stem cell of small intestine 8. Cerebral cortex GABAergic interneuron 9. Forebrain radial glial cell 10. Tuft cell of colon **Proteins:** KCNJ12_HUMAN (ATP-sensitive inward rectifier potassium channel 12) **References:** [Insert references to relevant scientific articles and studies] Note: This article is a summary of the gene KCNJ12 and its functions, and is not intended to be a comprehensive review of the literature.

Genular Protein ID: 2921695614

Symbol: KCJ12_HUMAN

Name: ATP-sensitive inward rectifier potassium channel 12

UniProtKB Accession Codes:

Q14500 O43401 Q15756 Q8NG63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 6 Ensembl 2 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7859381

Title: Cloning and functional expression of an inwardly rectifying K+ channel from human atrium.

PubMed ID: 7859381

DOI: 10.1161/01.res.76.3.343

PubMed ID: 8647284

Title: Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2.

PubMed ID: 8647284

DOI: 10.1016/0014-5793(96)00445-0

PubMed ID: 12417321

Title: Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes.

PubMed ID: 12417321

DOI: 10.1016/s0014-5793(02)03512-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430667

Title: An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene.

PubMed ID: 9430667

DOI: 10.1074/jbc.273.3.1339

PubMed ID: 12032359

Title: Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

PubMed ID: 12032359

DOI: 10.1073/pnas.102609499

PubMed ID: 20921230

Title: Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate.

PubMed ID: 20921230

DOI: 10.1074/jbc.c110.186692

Sequence Information:

  • Length: 433
  • Mass: 49001
  • Checksum: 082027A1765B6F4E
  • Sequence:
    • MTAASRANPY SIVSSEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN GQCNIEFANM 
DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGI IFWVIAVAHG DLEPAEGRGR 
TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECPVAVF MVVAQSIVGC IIDSFMIGAI 
MAKMARPKKR AQTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE 
GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE 
GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE VPSTPRCSAK 
DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS RDGLSPQARH DFDRLQAGGG 
VLEQRPYRRE SEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.