Details for: KCNJ12

Gene ID: 3768

Symbol: KCNJ12

Ensembl ID: ENSG00000184185

Description: potassium inwardly rectifying channel subfamily J member 12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.53
    Marker Score: 2898.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19526
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6949
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 681
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 390
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.84
    Marker Score: 490
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1348
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 630
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.8
    Marker Score: 482
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.74
    Marker Score: 1144
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.69
    Marker Score: 1430
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 324
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.62
    Marker Score: 2288
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 373.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.57
    Marker Score: 2343
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.55
    Marker Score: 242
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.52
    Marker Score: 2017
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 154
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.46
    Marker Score: 6924
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.43
    Marker Score: 16268
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.43
    Marker Score: 614
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.42
    Marker Score: 5550
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.39
    Marker Score: 3702
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.39
    Marker Score: 1795
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.38
    Marker Score: 585
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.37
    Marker Score: 22641
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 210
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.35
    Marker Score: 435
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.35
    Marker Score: 12747
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.34
    Marker Score: 463
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.33
    Marker Score: 568
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.32
    Marker Score: 911
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.31
    Marker Score: 101
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.31
    Marker Score: 625
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.28
    Marker Score: 2394
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.28
    Marker Score: 2606
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.27
    Marker Score: 2095
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.27
    Marker Score: 257
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.26
    Marker Score: 1042
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 151
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.23
    Marker Score: 279
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.22
    Marker Score: 276
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.21
    Marker Score: 560
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 460
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.19
    Marker Score: 3835
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.19
    Marker Score: 55
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.19
    Marker Score: 94
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.17
    Marker Score: 123
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.17
    Marker Score: 449
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.17
    Marker Score: 590
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.16
    Marker Score: 680
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.16
    Marker Score: 221
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.16
    Marker Score: 30.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.15
    Marker Score: 56
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.15
    Marker Score: 165
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.15
    Marker Score: 90
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.15
    Marker Score: 287
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.15
    Marker Score: 137
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.14
    Marker Score: 56
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.14
    Marker Score: 300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.14
    Marker Score: 56
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 755
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.12
    Marker Score: 172
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.12
    Marker Score: 346
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.11
    Marker Score: 137
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.11
    Marker Score: 38

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Other Information

**Key characteristics:** * The protein is a member of the KCNJ family of potassium channels. * It is an inwardly rectifying channel, which means that it opens when the membrane potential is negative. * The protein is expressed in high levels in cardiac muscle, where it is thought to play a role in maintaining the resting membrane potential of cardiac cells. * It is also expressed in other cell types, where it is thought to regulate potassium homeostasis and cardiac function. **Pathways and functions:** * Activation of Gaba receptors: The protein is a Gaba receptor-gated potassium channel, which means that it opens when Gaba receptors are activated. * Activation of g protein-gated potassium channels: The protein is also a G protein-gated potassium channel, which means that it opens when G protein-coupled receptors are activated. * Cardiac conduction: The protein is expressed in cardiac endothelial cells, which are the cells that line the heart. It is thought to play a role in cardiac conduction by regulating the flow of potassium ions across the heart's plasma membrane. * Classical Kir channels: The protein is also expressed in classical Kir channels, which are a family of potassium channels that are found in the brain and other tissues. It is thought to play a role in regulating potassium homeostasis and neuronal excitability. * Gaba b receptor activation: The protein is also a Gaba b receptor-gated potassium channel. It is expressed in a variety of cell types, including enterocytes and neurons. It is thought to play a role in regulating potassium homeostasis and neuronal excitability. * G protein-gated potassium channels: The protein is also a G protein-gated potassium channel. It is expressed in a variety of cell types, including cardiac endothelial cells, neurons, and skeletal muscle cells. It is thought to play a role in regulating potassium homeostasis and neuronal excitability. **Clinical significance:** Mutations in the KCNJ12 gene have been linked to a number of human diseases, including cardiac arrhythmias, heart failure, and stroke. These mutations can lead to a decrease in the expression of the protein, which can result in abnormal potassium channel function. This can lead to a variety of symptoms, including cardiac conduction defects, seizures, and neurological symptoms.

Genular Protein ID: 2921695614

Symbol: KCJ12_HUMAN

Name: ATP-sensitive inward rectifier potassium channel 12

UniProtKB Accession Codes:

Q14500 O43401 Q15756 Q8NG63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 6 Ensembl 2 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7859381

Title: Cloning and functional expression of an inwardly rectifying K+ channel from human atrium.

PubMed ID: 7859381

DOI: 10.1161/01.res.76.3.343

PubMed ID: 8647284

Title: Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2.

PubMed ID: 8647284

DOI: 10.1016/0014-5793(96)00445-0

PubMed ID: 12417321

Title: Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes.

PubMed ID: 12417321

DOI: 10.1016/s0014-5793(02)03512-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430667

Title: An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene.

PubMed ID: 9430667

DOI: 10.1074/jbc.273.3.1339

PubMed ID: 12032359

Title: Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

PubMed ID: 12032359

DOI: 10.1073/pnas.102609499

PubMed ID: 20921230

Title: Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate.

PubMed ID: 20921230

DOI: 10.1074/jbc.c110.186692

Sequence Information:

  • Length: 433
  • Mass: 49001
  • Checksum: 082027A1765B6F4E
  • Sequence:
    • MTAASRANPY SIVSSEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN GQCNIEFANM 
DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGI IFWVIAVAHG DLEPAEGRGR 
TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECPVAVF MVVAQSIVGC IIDSFMIGAI 
MAKMARPKKR AQTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE 
GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE 
GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE VPSTPRCSAK 
DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS RDGLSPQARH DFDRLQAGGG 
VLEQRPYRRE SEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.