Details for: KCNMB1

Gene ID: 3779

Symbol: KCNMB1

Ensembl ID: ENSG00000145936

Description: potassium calcium-activated channel subfamily M regulatory beta subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 51.0462
    Cell Significance Index: -7.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.0960
    Cell Significance Index: -7.3800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 16.4341
    Cell Significance Index: -6.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 13.4335
    Cell Significance Index: -6.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 13.1110
    Cell Significance Index: -6.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 10.0891
    Cell Significance Index: -6.7700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 6.8671
    Cell Significance Index: 36.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.4479
    Cell Significance Index: -7.9500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.1846
    Cell Significance Index: 35.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3623
    Cell Significance Index: -5.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4126
    Cell Significance Index: 78.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.3926
    Cell Significance Index: 2.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2185
    Cell Significance Index: 13.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1699
    Cell Significance Index: 4.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1656
    Cell Significance Index: 3.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1487
    Cell Significance Index: 14.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1479
    Cell Significance Index: 16.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1375
    Cell Significance Index: 124.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0894
    Cell Significance Index: 14.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0883
    Cell Significance Index: 1.5600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0777
    Cell Significance Index: 1.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0702
    Cell Significance Index: 25.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0617
    Cell Significance Index: 4.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0566
    Cell Significance Index: 3.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0487
    Cell Significance Index: 22.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0464
    Cell Significance Index: 1.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0277
    Cell Significance Index: 3.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0234
    Cell Significance Index: 1.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0149
    Cell Significance Index: 0.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0125
    Cell Significance Index: 0.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0114
    Cell Significance Index: 1.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0104
    Cell Significance Index: 0.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0049
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0092
    Cell Significance Index: -0.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0098
    Cell Significance Index: -7.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0098
    Cell Significance Index: -4.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0124
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0144
    Cell Significance Index: -4.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0145
    Cell Significance Index: -7.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0156
    Cell Significance Index: -8.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0176
    Cell Significance Index: -3.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0188
    Cell Significance Index: -3.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0191
    Cell Significance Index: -2.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0215
    Cell Significance Index: -1.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0257
    Cell Significance Index: -0.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0308
    Cell Significance Index: -6.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0337
    Cell Significance Index: -4.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0347
    Cell Significance Index: -4.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0362
    Cell Significance Index: -1.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0380
    Cell Significance Index: -2.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0432
    Cell Significance Index: -5.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0443
    Cell Significance Index: -9.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0464
    Cell Significance Index: -7.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0467
    Cell Significance Index: -1.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0557
    Cell Significance Index: -5.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0585
    Cell Significance Index: -6.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0660
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0692
    Cell Significance Index: -7.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0699
    Cell Significance Index: -5.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0752
    Cell Significance Index: -5.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0968
    Cell Significance Index: -5.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1005
    Cell Significance Index: -6.1800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1099
    Cell Significance Index: -1.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1132
    Cell Significance Index: -7.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1177
    Cell Significance Index: -5.4900
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1216
    Cell Significance Index: -0.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1258
    Cell Significance Index: -5.1600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1444
    Cell Significance Index: -1.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1459
    Cell Significance Index: -7.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1509
    Cell Significance Index: -8.4700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1541
    Cell Significance Index: -2.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1560
    Cell Significance Index: -4.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1677
    Cell Significance Index: -3.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1700
    Cell Significance Index: -4.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1770
    Cell Significance Index: -6.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1835
    Cell Significance Index: -5.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1845
    Cell Significance Index: -2.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1875
    Cell Significance Index: -3.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1910
    Cell Significance Index: -8.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1946
    Cell Significance Index: -5.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1960
    Cell Significance Index: -4.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2018
    Cell Significance Index: -7.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2202
    Cell Significance Index: -5.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2205
    Cell Significance Index: -8.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2208
    Cell Significance Index: -7.2300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2212
    Cell Significance Index: -2.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2258
    Cell Significance Index: -6.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2258
    Cell Significance Index: -9.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2310
    Cell Significance Index: -3.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2339
    Cell Significance Index: -7.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2376
    Cell Significance Index: -3.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNMB1 is a member of the potassium calcium-activated channel subunit M regulatory beta subunit family. It is characterized by its ability to regulate the activity of calcium-activated potassium channels (KCa channels), which are crucial for maintaining cellular homeostasis and regulating various physiological processes. The KCNMB1 protein is specifically expressed in neurons, particularly in the cochlea, where it plays a key role in sensory processing and sound perception. **Pathways and Functions:** KCNMB1 is involved in various cellular pathways, including: 1. **Acetylcholine inhibits contraction of outer hair cells**: KCNMB1 regulates the activity of KCa channels in outer hair cells, which are responsible for sound processing in the cochlea. The interaction between acetylcholine and KCNMB1 helps to inhibit the contraction of these cells, thereby fine-tuning sound perception. 2. **Ca2+ activated K+ channels**: KCNMB1 regulates the activity of KCa channels, which are essential for maintaining cellular homeostasis and regulating various physiological processes. 3. **Cellular response to toxins**: KCNMB1 plays a role in regulating the cellular response to toxins, such as ethanol and bile acids, by modulating the activity of KCa channels. 4. **Cellular response to hypoxia**: KCNMB1 is involved in regulating the cellular response to hypoxia, a condition characterized by reduced oxygen levels. 5. **Sensory perception**: KCNMB1 is specifically expressed in neurons, particularly in the cochlea, where it plays a key role in sensory processing and sound perception. **Clinical Significance:** Dysregulation of KCNMB1 has been implicated in various diseases, including: 1. **Hearing loss**: Mutations in the KCNMB1 gene have been associated with hearing loss, particularly in cases of autosomal dominant non-syndromic hearing loss. 2. **Neurodegenerative diseases**: KCNMB1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where dysregulation of KCa channels and KCNMB1 has been observed. 3. **Cancer**: KCNMB1 has been identified as a potential biomarker for cancer, particularly in cases of glioblastoma and breast cancer, where its expression is altered. In conclusion, KCNMB1 plays a crucial role in regulating various cellular processes, including sensory perception, cellular homeostasis, and response to toxins. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of KCNMB1 and its potential therapeutic applications.

Genular Protein ID: 3189585286

Symbol: KCMB1_HUMAN

Name: Calcium-activated potassium channel subunit beta-1

UniProtKB Accession Codes:

Q16558 O00707 O00708 P78475 Q53YR0 Q8TAX3 Q93005

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 14 Ensembl 2 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8612769

Title: A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels.

PubMed ID: 8612769

DOI: 10.1016/0014-5793(96)00151-2

PubMed ID: 8764643

Title: Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation.

PubMed ID: 8764643

DOI: 10.1523/jneurosci.16-15-04543.1996

PubMed ID: 8799178

Title: Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain.

PubMed ID: 8799178

DOI: 10.1073/pnas.93.17.9200

PubMed ID: 12434576

Title: Calcium-activated potassium channel expression in human myometrium: effect of pregnancy.

PubMed ID: 12434576

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10792058

Title: A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.

PubMed ID: 10792058

DOI: 10.1073/pnas.100118597

PubMed ID: 10489376

Title: Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit.

PubMed ID: 10489376

DOI: 10.1126/science.285.5435.1929

PubMed ID: 12136044

Title: New disguises for an old channel: MaxiK channel beta-subunits.

PubMed ID: 12136044

DOI: 10.1152/nips.01387.2002

PubMed ID: 15057310

Title: Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.

PubMed ID: 15057310

DOI: 10.1172/jci20347

Sequence Information:

  • Length: 191
  • Mass: 21797
  • Checksum: 547432FF194E770D
  • Sequence:
    • MVKKLVMAQK RGETRALCLG VTMVVCAVIT YYILVTTVLP LYQKSVWTQE SKCHLIETNI 
RDQEELKGKK VPQYPCLWVN VSAAGRWAVL YHTEDTRDQN QQCSYIPGSV DNYQTARADV 
EKVRAKFQEQ QVFYCFSAPR GNETSVLFQR LYGPQALLFS LFWPTFLLTG GLLIIAMVKS 
NQYLSILAAQ K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.