Details for: KCNMB1

Gene ID: 3779

Symbol: KCNMB1

Ensembl ID: ENSG00000145936

Description: potassium calcium-activated channel subfamily M regulatory beta subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.6
    Marker Score: 3393
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.49
    Marker Score: 942
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.23
    Marker Score: 5246
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.16
    Marker Score: 781
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.1
    Marker Score: 2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.5
    Marker Score: 426
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.45
    Marker Score: 2724
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.05
    Marker Score: 692
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 378
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.91
    Marker Score: 267
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.84
    Marker Score: 418
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.84
    Marker Score: 1839
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.83
    Marker Score: 382
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.78
    Marker Score: 4671.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 569.5
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.73
    Marker Score: 192
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.7
    Marker Score: 2707
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2833
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.67
    Marker Score: 3303
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.65
    Marker Score: 2817
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.63
    Marker Score: 194
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.57
    Marker Score: 404
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1081
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.53
    Marker Score: 5951
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.53
    Marker Score: 502
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.51
    Marker Score: 924
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.5
    Marker Score: 1297
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.47
    Marker Score: 580
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 742.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.42
    Marker Score: 230
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.42
    Marker Score: 814
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.41
    Marker Score: 172
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.41
    Marker Score: 115
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.39
    Marker Score: 398
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.39
    Marker Score: 5149
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.39
    Marker Score: 98
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 249
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.37
    Marker Score: 112
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.37
    Marker Score: 96
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 365
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.36
    Marker Score: 234
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.35
    Marker Score: 99
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.35
    Marker Score: 19498
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.34
    Marker Score: 331
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.34
    Marker Score: 492
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.34
    Marker Score: 388
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.34
    Marker Score: 231
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.34
    Marker Score: 196
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.33
    Marker Score: 335
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.33
    Marker Score: 95
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.33
    Marker Score: 228
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.33
    Marker Score: 380
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 187
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.33
    Marker Score: 113
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.32
    Marker Score: 149
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.31
    Marker Score: 299
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.29
    Marker Score: 4589
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.29
    Marker Score: 351
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.29
    Marker Score: 142
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 165
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.28
    Marker Score: 192
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.28
    Marker Score: 405
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 74
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.28
    Marker Score: 87
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.27
    Marker Score: 157
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.27
    Marker Score: 94
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.26
    Marker Score: 624
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.26
    Marker Score: 1697
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.25
    Marker Score: 313
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 120
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.25
    Marker Score: 102
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.24
    Marker Score: 1002
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.24
    Marker Score: 122
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.24
    Marker Score: 399
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.23
    Marker Score: 235
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.23
    Marker Score: 319
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.23
    Marker Score: 82

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Other Information

**Key characteristics:** - KCNMB1 is a type of potassium channel that is activated by calcium ions. - It is a transmembrane protein with a molecular weight of approximately 145 kDa. - It is expressed in high levels in the heart, skeletal muscle, and smooth muscle. - It is also expressed in low levels in the central nervous system. **Pathways and functions:** - KCNMB1 is a key regulator of smooth muscle contraction. - It is thought to be involved in the regulation of cardiac output, blood pressure, and gastrointestinal motility. - It is also involved in the regulation of inflammation and pain. **Clinical significance:** - Mutations in KCNMB1 have been linked to a number of human diseases, including hypertension, heart failure, and gastrointestinal disorders. - KCNMB1 inhibitors are being investigated as a treatment for these diseases. **Additional information:** - KCNMB1 is a highly conserved protein, with a similar protein found in mammals, birds, and reptiles. - It is a member of the potassium channel superfamily, which is a large family of potassium channels that are involved in a variety of cellular processes, including muscle contraction, neurotransmission, and fluid transport. - KCNMB1 is a promising target for the treatment of a variety of diseases.

Genular Protein ID: 3189585286

Symbol: KCMB1_HUMAN

Name: Calcium-activated potassium channel subunit beta-1

UniProtKB Accession Codes:

Q16558 O00707 O00708 P78475 Q53YR0 Q8TAX3 Q93005

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 14 Ensembl 2 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8612769

Title: A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels.

PubMed ID: 8612769

DOI: 10.1016/0014-5793(96)00151-2

PubMed ID: 8764643

Title: Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation.

PubMed ID: 8764643

DOI: 10.1523/jneurosci.16-15-04543.1996

PubMed ID: 8799178

Title: Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain.

PubMed ID: 8799178

DOI: 10.1073/pnas.93.17.9200

PubMed ID: 12434576

Title: Calcium-activated potassium channel expression in human myometrium: effect of pregnancy.

PubMed ID: 12434576

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10792058

Title: A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.

PubMed ID: 10792058

DOI: 10.1073/pnas.100118597

PubMed ID: 10489376

Title: Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit.

PubMed ID: 10489376

DOI: 10.1126/science.285.5435.1929

PubMed ID: 12136044

Title: New disguises for an old channel: MaxiK channel beta-subunits.

PubMed ID: 12136044

DOI: 10.1152/nips.01387.2002

PubMed ID: 15057310

Title: Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.

PubMed ID: 15057310

DOI: 10.1172/jci20347

Sequence Information:

  • Length: 191
  • Mass: 21797
  • Checksum: 547432FF194E770D
  • Sequence:
    • MVKKLVMAQK RGETRALCLG VTMVVCAVIT YYILVTTVLP LYQKSVWTQE SKCHLIETNI 
RDQEELKGKK VPQYPCLWVN VSAAGRWAVL YHTEDTRDQN QQCSYIPGSV DNYQTARADV 
EKVRAKFQEQ QVFYCFSAPR GNETSVLFQR LYGPQALLFS LFWPTFLLTG GLLIIAMVKS 
NQYLSILAAQ K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.