Details for: KHK

Gene ID: 3795

Symbol: KHK

Ensembl ID: ENSG00000138030

Description: ketohexokinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.7184
    Cell Significance Index: -9.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.3646
    Cell Significance Index: -8.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.8844
    Cell Significance Index: -9.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.9240
    Cell Significance Index: -9.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2700
    Cell Significance Index: -8.7600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.9796
    Cell Significance Index: 7.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.9007
    Cell Significance Index: 83.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3120
    Cell Significance Index: 138.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6989
    Cell Significance Index: 184.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.4895
    Cell Significance Index: -4.5800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.2669
    Cell Significance Index: 12.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1963
    Cell Significance Index: 237.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1239
    Cell Significance Index: 24.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0789
    Cell Significance Index: 175.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0223
    Cell Significance Index: 923.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9779
    Cell Significance Index: 67.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5498
    Cell Significance Index: 54.3900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4634
    Cell Significance Index: 6.6400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4351
    Cell Significance Index: 7.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3737
    Cell Significance Index: 19.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3727
    Cell Significance Index: 70.9200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2812
    Cell Significance Index: 4.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2142
    Cell Significance Index: 1.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1412
    Cell Significance Index: 16.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1366
    Cell Significance Index: 27.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1235
    Cell Significance Index: 5.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1222
    Cell Significance Index: 84.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1118
    Cell Significance Index: 1.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1012
    Cell Significance Index: 0.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0891
    Cell Significance Index: 4.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0859
    Cell Significance Index: 2.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0851
    Cell Significance Index: 37.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0789
    Cell Significance Index: 22.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0751
    Cell Significance Index: 2.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0726
    Cell Significance Index: 5.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0618
    Cell Significance Index: 22.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0313
    Cell Significance Index: 17.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0129
    Cell Significance Index: 1.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0066
    Cell Significance Index: 4.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0025
    Cell Significance Index: 0.3200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0016
    Cell Significance Index: -0.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0019
    Cell Significance Index: -0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0085
    Cell Significance Index: -0.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0088
    Cell Significance Index: -11.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0108
    Cell Significance Index: -7.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0128
    Cell Significance Index: -8.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0129
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0138
    Cell Significance Index: -7.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0144
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0160
    Cell Significance Index: -10.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0210
    Cell Significance Index: -9.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0222
    Cell Significance Index: -3.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0230
    Cell Significance Index: -1.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0277
    Cell Significance Index: -3.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0310
    Cell Significance Index: -0.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0316
    Cell Significance Index: -0.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0332
    Cell Significance Index: -5.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0429
    Cell Significance Index: -4.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0456
    Cell Significance Index: -5.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0470
    Cell Significance Index: -6.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0496
    Cell Significance Index: -10.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0580
    Cell Significance Index: -0.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0607
    Cell Significance Index: -1.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0657
    Cell Significance Index: -4.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0668
    Cell Significance Index: -4.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0684
    Cell Significance Index: -4.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0728
    Cell Significance Index: -1.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0797
    Cell Significance Index: -0.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0825
    Cell Significance Index: -5.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0857
    Cell Significance Index: -3.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0949
    Cell Significance Index: -9.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1199
    Cell Significance Index: -4.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1221
    Cell Significance Index: -5.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1261
    Cell Significance Index: -9.6800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1290
    Cell Significance Index: -1.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1304
    Cell Significance Index: -4.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1326
    Cell Significance Index: -2.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1332
    Cell Significance Index: -6.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1390
    Cell Significance Index: -2.9100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1438
    Cell Significance Index: -1.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1508
    Cell Significance Index: -8.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1544
    Cell Significance Index: -3.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1594
    Cell Significance Index: -4.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1762
    Cell Significance Index: -2.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1849
    Cell Significance Index: -2.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1964
    Cell Significance Index: -6.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2041
    Cell Significance Index: -5.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2051
    Cell Significance Index: -3.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2119
    Cell Significance Index: -4.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2132
    Cell Significance Index: -6.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2181
    Cell Significance Index: -7.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2192
    Cell Significance Index: -5.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2247
    Cell Significance Index: -5.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2300
    Cell Significance Index: -4.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** KHK catalyzes the first step in fructose catabolism, converting fructose-6-phosphate into fructose-1-phosphate, a precursor for glycolysis or gluconeogenesis. 2. **Substrate specificity:** KHK has a high affinity for fructose, making it a crucial enzyme in the fructose metabolic pathway. 3. **Expression profile:** KHK is widely expressed in various tissues, including the colon, kidney, liver, and brain, indicating its role in maintaining metabolic balance. 4. **Regulation:** KHK activity is regulated by various factors, including insulin, glucose, and sucrose, highlighting its importance in glucose metabolism. **Pathways and Functions:** 1. **Fructose catabolism:** KHK is the first enzyme in the fructose catabolic pathway, converting fructose-6-phosphate into fructose-1-phosphate. 2. **Glycolysis:** Fructose-1-phosphate is a precursor for glycolysis, a key pathway for energy production in cells. 3. **Gluconeogenesis:** Fructose-1-phosphate can also be converted into glucose-6-phosphate, a precursor for gluconeogenesis, which is essential for maintaining glucose homeostasis. 4. **Insulin signaling:** KHK activity is regulated by insulin, highlighting its role in glucose metabolism and insulin sensitivity. **Clinical Significance:** 1. **Essential fructosuria:** Mutations in the KHK gene can lead to essential fructosuria, a benign condition characterized by elevated fructose levels in the blood. 2. **Diabetes:** Abnormalities in KHK activity have been linked to diabetes, highlighting the enzyme's role in glucose metabolism and insulin sensitivity. 3. **Metabolic disorders:** KHK dysregulation has been implicated in various metabolic disorders, including obesity, insulin resistance, and metabolic syndrome. 4. **Cancer:** KHK expression has been found in various types of cancer, including colon, breast, and prostate cancer, suggesting its potential role in cancer metabolism. In conclusion, ketohexokinase is a critical enzyme in carbohydrate metabolism, playing a key role in regulating fructose catabolism and glucose homeostasis. Its dysregulation has been implicated in various diseases, including diabetes, metabolic disorders, and cancer. Further research is needed to fully understand the role of KHK in human health and disease.

Genular Protein ID: 287416363

Symbol: KHK_HUMAN

Name: Hepatic fructokinase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7833921

Title: Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase).

PubMed ID: 7833921

DOI: 10.1093/hmg/3.9.1627

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9799106

Title: Structure and alternative splicing of the ketohexokinase gene.

PubMed ID: 9799106

DOI: 10.1046/j.1432-1327.1998.2570085.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19237742

Title: Structures of alternatively spliced isoforms of human ketohexokinase.

PubMed ID: 19237742

DOI: 10.1107/s0907444908041115

PubMed ID: 12941785

Title: Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria.

PubMed ID: 12941785

DOI: 10.2337/diabetes.52.9.2426

Sequence Information:

  • Length: 298
  • Mass: 32523
  • Checksum: BE77FC325CAC5721
  • Sequence:
  • MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM 
    GSMAPGHVAD FLVADFRRRG VDVSQVAWQS KGDTPSSCCI INNSNGNRTI VLHDTSLPDV 
    SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF 
    QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL 
    HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV

Genular Protein ID: 4261838461

Symbol: C9JDL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 343
  • Mass: 37622
  • Checksum: A4803569FCA20887
  • Sequence:
  • MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM 
    GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDSFLVAD 
    FRRRGVDVSQ VAWQSKGDTP SSCCIINNSN GNRTIVLHDT SLPDVSATDF EKVDLTQFKW 
    IHIEGRNASE QVKMLQRIDA HNTRQPPEQK IRVSVEVEKP REELFQLFGY GDVVFVSKDV 
    AKHLGFQSAE EALRGLYGRV RKGAVLVCAW AEEGADALGP DGKLLHSDAF PPPRVVDTLG 
    AGDTFNASVI FSLSQGRSVQ EALRFGCQVA GKKCGLQGFD GIV

Genular Protein ID: 2529234734

Symbol: A0A140VJM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 298
  • Mass: 32730
  • Checksum: 1BA47BDC60C1B89F
  • Sequence:
  • MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM 
    GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV 
    SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF 
    QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL 
    HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.