Details for: KHK

Gene ID: 3795

Symbol: KHK

Ensembl ID: ENSG00000138030

Description: ketohexokinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.68
    Marker Score: 4129
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.18
    Marker Score: 7738
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.05
    Marker Score: 591
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.45
    Marker Score: 3415
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.32
    Marker Score: 7084
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.31
    Marker Score: 319
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.24
    Marker Score: 5332
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.19
    Marker Score: 5734
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2057
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.99
    Marker Score: 6371
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 14993
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1517
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5159
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9
    Marker Score: 1704.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.9
    Marker Score: 337
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8
    Marker Score: 802
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.76
    Marker Score: 1802
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 560
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.72
    Marker Score: 232
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.67
    Marker Score: 268
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.65
    Marker Score: 445
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2670
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 377
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.62
    Marker Score: 2025
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 182
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 277
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.56
    Marker Score: 1142
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.53
    Marker Score: 201
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.53
    Marker Score: 590
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.52
    Marker Score: 130
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.52
    Marker Score: 554
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.51
    Marker Score: 492
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 128
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.49
    Marker Score: 153
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.47
    Marker Score: 215
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.45
    Marker Score: 311
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.44
    Marker Score: 295
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.42
    Marker Score: 1320
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.42
    Marker Score: 97
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.41
    Marker Score: 281
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.41
    Marker Score: 413
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.41
    Marker Score: 492
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 167
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.4
    Marker Score: 104
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.4
    Marker Score: 1547
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.38
    Marker Score: 363
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 254
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.38
    Marker Score: 104
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.38
    Marker Score: 141
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.37
    Marker Score: 644
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.35
    Marker Score: 928
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 152.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.34
    Marker Score: 321
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.34
    Marker Score: 113
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.32
    Marker Score: 207
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.32
    Marker Score: 496
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.32
    Marker Score: 234
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.31
    Marker Score: 135
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.31
    Marker Score: 652.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.3
    Marker Score: 147
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.3
    Marker Score: 124
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 296
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.29
    Marker Score: 488
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.29
    Marker Score: 79
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.29
    Marker Score: 380
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.28
    Marker Score: 106
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.28
    Marker Score: 1183
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.28
    Marker Score: 640
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 74
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.28
    Marker Score: 279
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.27
    Marker Score: 16428
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.27
    Marker Score: 194
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.27
    Marker Score: 58
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.27
    Marker Score: 261
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.27
    Marker Score: 128
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.26
    Marker Score: 157
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.26
    Marker Score: 142
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.25
    Marker Score: 217
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.25
    Marker Score: 2160
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.25
    Marker Score: 127
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.24
    Marker Score: 571
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.24
    Marker Score: 216
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 214
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.24
    Marker Score: 168

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Other Information

**Key characteristics:** * KHK is a heterodimeric protein composed of two subunits, KHK1 and KHK2. * It is a glycoprotein with a molecular weight of approximately 120 kDa. * KHK is expressed in a variety of cell types, including enterocytes, hepatocytes, and immune cells. * It is a key regulator of hepatic glucose metabolism, particularly under conditions of fasting or starvation. **Pathways and functions:** * KHK is involved in the regulation of glucose metabolism through its interaction with various signaling pathways. * It is a key regulator of glucose uptake into enterocytes, influencing the absorption of dietary sugars. * It also plays a role in the regulation of hepatic glucose production by promoting the phosphorylation of glucose-1-phosphate to glucose-6-phosphate. * KHK also regulates gluconeogenesis, the process by which non-carbohydrate sources are converted into glucose. **Clinical significance:** * Mutations in the KHK gene have been linked to several human diseases, including non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, and obesity. * KHK inhibitors are being investigated as potential therapeutic agents for these diseases, as they could be used to improve insulin sensitivity and reduce hepatic fat accumulation. **Additional notes:** * KHK is a highly regulated gene, with its expression being tightly controlled by various factors, including nutrient availability, hormones, and signaling pathways. * It is a key regulator of hepatic metabolism, and its dysregulation can lead to various metabolic disorders.

Genular Protein ID: 287416363

Symbol: KHK_HUMAN

Name: Hepatic fructokinase

UniProtKB Accession Codes:

P50053 Q6IBK2 Q99532 Q9BRJ3 Q9UMN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 27 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7833921

Title: Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase).

PubMed ID: 7833921

DOI: 10.1093/hmg/3.9.1627

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9799106

Title: Structure and alternative splicing of the ketohexokinase gene.

PubMed ID: 9799106

DOI: 10.1046/j.1432-1327.1998.2570085.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19237742

Title: Structures of alternatively spliced isoforms of human ketohexokinase.

PubMed ID: 19237742

DOI: 10.1107/s0907444908041115

PubMed ID: 12941785

Title: Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria.

PubMed ID: 12941785

DOI: 10.2337/diabetes.52.9.2426

Sequence Information:

  • Length: 298
  • Mass: 32523
  • Checksum: BE77FC325CAC5721
  • Sequence:
    • MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM 
GSMAPGHVAD FLVADFRRRG VDVSQVAWQS KGDTPSSCCI INNSNGNRTI VLHDTSLPDV 
SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF 
QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL 
HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV

Genular Protein ID: 2529234734

Symbol: A0A140VJM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJM6

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 PhylomeDB 1 RefSeq 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 298
  • Mass: 32730
  • Checksum: 1BA47BDC60C1B89F
  • Sequence:
    • MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM 
GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV 
SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF 
QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL 
HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV

Genular Protein ID: 4261838461

Symbol: C9JDL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JDL1

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 343
  • Mass: 37622
  • Checksum: A4803569FCA20887
  • Sequence:
    • MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM 
GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDSFLVAD 
FRRRGVDVSQ VAWQSKGDTP SSCCIINNSN GNRTIVLHDT SLPDVSATDF EKVDLTQFKW 
IHIEGRNASE QVKMLQRIDA HNTRQPPEQK IRVSVEVEKP REELFQLFGY GDVVFVSKDV 
AKHLGFQSAE EALRGLYGRV RKGAVLVCAW AEEGADALGP DGKLLHSDAF PPPRVVDTLG 
AGDTFNASVI FSLSQGRSVQ EALRFGCQVA GKKCGLQGFD GIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.