Gene KIF3C - ENSG00000084731 | NCBI Gene ID: 3797

Details for: KIF3C

Gene ID: 3797

Symbol: KIF3C

Ensembl ID: ENSG00000084731

Description: kinesin family member 3C

Associated with

Adaptive immune system
(R-HSA-1280218)
Cilium assembly
(R-HSA-5617833)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intraflagellar transport
(R-HSA-5620924)
Kinesins
(R-HSA-983189)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Vesicle-mediated transport
(R-HSA-5653656)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Ciliary tip
(GO:0097542)
Cilium
(GO:0005929)
Cytoskeletal motor activity
(GO:0003774)
Cytosol
(GO:0005829)
Kinesin complex
(GO:0005871)
Microtubule
(GO:0005874)
Microtubule-based movement
(GO:0007018)
Microtubule binding
(GO:0008017)
Microtubule motor activity
(GO:0003777)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 2.29
Marker Score: 4741.5
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.91
Marker Score: 7912
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.87
Marker Score: 115186
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.87
Marker Score: 14328
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.87
Marker Score: 782
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.87
Marker Score: 68842.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.86
Marker Score: 17540
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.86
Marker Score: 27783
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.84
Marker Score: 36647
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.83
Marker Score: 7094
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.82
Marker Score: 69086
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.79
Marker Score: 18512
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.74
Marker Score: 14955
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.74
Marker Score: 16501
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.67
Marker Score: 7734
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.6
Marker Score: 54138
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.52
Marker Score: 2346
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.51
Marker Score: 3065
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.48
Marker Score: 1662
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.48
Marker Score: 404
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169466
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.46
Marker Score: 1457
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.37
Marker Score: 7164
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.23
Marker Score: 1729
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.21
Marker Score: 2298.5
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.18
Marker Score: 6352
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.18
Marker Score: 3945
Cell Name: neuron (CL0000540)
Fold Change: 1.16
Marker Score: 4732
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.15
Marker Score: 838
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4804
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.09
Marker Score: 17040
Cell Name: granule cell (CL0000120)
Fold Change: 1.08
Marker Score: 8159
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.04
Marker Score: 603
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.04
Marker Score: 465
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.02
Marker Score: 1709
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1
Marker Score: 386
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71814
Cell Name: mesangial cell (CL0000650)
Fold Change: 1
Marker Score: 1205
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48039
Cell Name: macroglial cell (CL0000126)
Fold Change: 1
Marker Score: 2290
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 368
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5235
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5284
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.85
Marker Score: 286
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.82
Marker Score: 1672
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.82
Marker Score: 17401
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.81
Marker Score: 453
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.81
Marker Score: 2305
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1257
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.77
Marker Score: 372
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 693
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 565
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.72
Marker Score: 230
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.68
Marker Score: 214
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.68
Marker Score: 409
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.65
Marker Score: 337
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.63
Marker Score: 782.5
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.61
Marker Score: 3690
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.56
Marker Score: 692
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.55
Marker Score: 175
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.51
Marker Score: 241
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.5
Marker Score: 153
Cell Name: germ cell (CL0000586)
Fold Change: 0.5
Marker Score: 878
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.49
Marker Score: 233
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.49
Marker Score: 1148
Cell Name: motor neuron (CL0000100)
Fold Change: 0.47
Marker Score: 277
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.45
Marker Score: 224
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.44
Marker Score: 218
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.44
Marker Score: 1044
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.42
Marker Score: 451
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.41
Marker Score: 272.5
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.41
Marker Score: 183
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.41
Marker Score: 1708
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.41
Marker Score: 237
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.4
Marker Score: 146
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4
Marker Score: 166
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.4
Marker Score: 128
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.39
Marker Score: 474
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.39
Marker Score: 6860
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.37
Marker Score: 300
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.37
Marker Score: 352
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.37
Marker Score: 425
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.37
Marker Score: 347
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.37
Marker Score: 208
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.36
Marker Score: 147
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.36
Marker Score: 241
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.36
Marker Score: 155
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.35
Marker Score: 112
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.35
Marker Score: 350
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.35
Marker Score: 3542
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.35
Marker Score: 2056

Hover over a box to see details here...

**Key characteristics:** - KIF3C is a large protein with a molecular weight of approximately 130 kDa. - It is expressed in a variety of cell types, including epithelial cells, neurons, and immune cells. - It is a key regulator of the adaptive immune response and is involved in the regulation of dendritic cell activation. **Pathways and functions:** - KIF3C is involved in the assembly of the cilium, a hair-like structure that extends from the base of the kidney. - It is also involved in the retrograde transport of vesicles between the endoplasmic reticulum (ER) and the Golgi apparatus. - KIF3C is a key regulator of the activation of dendritic cells, which are important for the initiation of adaptive immune responses. - It is also involved in the regulation of platelet production and the maintenance of epithelial cell function. **Clinical significance:** - Mutations in KIF3C have been linked to several human diseases, including nephritis, autoimmune disorders, and cancer. - Understanding the role of KIF3C in the adaptive immune system has implications for the development of new therapies for these diseases. **Additional notes:** - KIF3C is a highly conserved protein with significant expression in vertebrates. - It is a member of the kinesin family of motor proteins, which are involved in the transport of vesicles between the ER and the Golgi apparatus. - KIF3C is also involved in the regulation of cell migration and differentiation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Kinesin-like protein KIF3C

Genular Protein ID: 2985997399

Symbol: KIF3C_HUMAN

Name: Kinesin-like protein KIF3C

UniProtKB Accession Codes:

O14782 O43544 Q4ZG18 Q53SX5 Q562F7

Database IDs:

Citations:

PubMed ID: 9480755

Title: KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23.

PubMed ID: 9480755

DOI: 10.1006/geno.1997.5123

PubMed ID: 9446808

Title: cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C.

PubMed ID: 9446808

DOI: 10.1006/bbrc.1997.7977

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26138355

Title: Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome.

PubMed ID: 26138355

DOI: 10.1111/cge.12636

Sequence Information:

Length: 793
Mass: 89454
Checksum: 04CB96C5F6BED45E
Sequence:

MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA PGELPKTFTF 
DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG TGKTYTMQGT WVEPELRGVI 
PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ EEIRDLLSKE PGKRLELKEN PETGVYIKDL 
SSFVTKNVKE IEHVMNLGNQ TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG 
KLNLVDLAGS ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL 
GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD ESLSTLRFAN 
RAKNIKNKPR VNEDPKDTLL REFQEEIARL KAQLEKRGML GKRPRRKSSR RKKAVSAPPG 
YPEGPVIEAW VAEEEDDNNN NHRPPQPILE SALEKNMENY LQEQKERLEE EKAAIQDDRS 
LVSEEKQKLL EEKEKMLEDL RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE 
LKRQEIAEQK RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA 
EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL FLDCEEEQWK 
FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS HPRYRAENIM FLELDVSPPA 
VFEMEFSHDQ EQDPRALHME RLMRLDSFLE RPSTSKVRKS RSWCQSPQRP PPSTTHASLA 
SASLRPATVA DHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KIF3C

Associated with

Cells (max top 100)

Other Information

KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. PubMed ID: 9480755

cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C. PubMed ID: 9446808

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621