Details for: KIF3C

Gene ID: 3797

Symbol: KIF3C

Ensembl ID: ENSG00000084731

Description: kinesin family member 3C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.1878
    Cell Significance Index: -21.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.7647
    Cell Significance Index: -21.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 47.9309
    Cell Significance Index: -19.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.4516
    Cell Significance Index: -16.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.5675
    Cell Significance Index: -21.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5258
    Cell Significance Index: -21.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0196
    Cell Significance Index: 405.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6843
    Cell Significance Index: 36.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5674
    Cell Significance Index: 37.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5513
    Cell Significance Index: 44.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3598
    Cell Significance Index: 487.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1839
    Cell Significance Index: 72.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0783
    Cell Significance Index: 13.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8676
    Cell Significance Index: 58.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5930
    Cell Significance Index: 26.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5865
    Cell Significance Index: 22.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5591
    Cell Significance Index: 55.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5188
    Cell Significance Index: 8.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5188
    Cell Significance Index: 468.4700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3706
    Cell Significance Index: 3.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3379
    Cell Significance Index: 18.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3045
    Cell Significance Index: 49.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2596
    Cell Significance Index: 28.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2529
    Cell Significance Index: 174.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1653
    Cell Significance Index: 8.6800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1387
    Cell Significance Index: 1.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1271
    Cell Significance Index: 7.6300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1241
    Cell Significance Index: 1.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1207
    Cell Significance Index: 7.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1096
    Cell Significance Index: 3.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1062
    Cell Significance Index: 21.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1003
    Cell Significance Index: 2.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0989
    Cell Significance Index: 6.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0704
    Cell Significance Index: 1.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0291
    Cell Significance Index: 5.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0262
    Cell Significance Index: 4.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0008
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0055
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0142
    Cell Significance Index: -6.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0195
    Cell Significance Index: -12.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0211
    Cell Significance Index: -2.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0252
    Cell Significance Index: -18.4600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0304
    Cell Significance Index: -23.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0327
    Cell Significance Index: -1.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0344
    Cell Significance Index: -15.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0346
    Cell Significance Index: -4.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0389
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0456
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0588
    Cell Significance Index: -12.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0598
    Cell Significance Index: -17.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0839
    Cell Significance Index: -9.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0857
    Cell Significance Index: -11.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0900
    Cell Significance Index: -1.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0953
    Cell Significance Index: -3.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0968
    Cell Significance Index: -5.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1045
    Cell Significance Index: -15.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1180
    Cell Significance Index: -3.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1208
    Cell Significance Index: -5.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1231
    Cell Significance Index: -3.9200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1235
    Cell Significance Index: -2.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1278
    Cell Significance Index: -1.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1288
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1330
    Cell Significance Index: -15.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1389
    Cell Significance Index: -17.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1460
    Cell Significance Index: -18.8600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1548
    Cell Significance Index: -2.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1706
    Cell Significance Index: -17.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1736
    Cell Significance Index: -20.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1993
    Cell Significance Index: -14.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2042
    Cell Significance Index: -10.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2098
    Cell Significance Index: -21.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2126
    Cell Significance Index: -4.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2347
    Cell Significance Index: -18.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2372
    Cell Significance Index: -15.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2375
    Cell Significance Index: -18.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2501
    Cell Significance Index: -2.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2517
    Cell Significance Index: -6.7500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2722
    Cell Significance Index: -2.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2926
    Cell Significance Index: -7.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2958
    Cell Significance Index: -20.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3027
    Cell Significance Index: -6.5400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3146
    Cell Significance Index: -3.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3185
    Cell Significance Index: -8.3800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3398
    Cell Significance Index: -2.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3494
    Cell Significance Index: -16.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3528
    Cell Significance Index: -12.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3588
    Cell Significance Index: -8.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3790
    Cell Significance Index: -9.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3837
    Cell Significance Index: -13.4400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4258
    Cell Significance Index: -2.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4322
    Cell Significance Index: -9.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KIF3C is a kinesin-like protein with a conserved motor domain, which enables it to interact with microtubules and facilitate their movement. Its expression is predominantly found in cells of the kidney, brain, and immune system, indicating a specialized role in these tissues. Notably, KIF3C is highly expressed in cells involved in adaptive immunity, suggesting its involvement in the regulation of immune responses. **Pathways and Functions:** KIF3C is implicated in multiple cellular pathways, including: 1. **Adaptive Immune System:** KIF3C is involved in the regulation of immune responses, particularly in the presentation of MHC class II antigens and the trafficking of immune cells. 2. **Ciliary Tip and Intraflagellar Transport:** KIF3C contributes to the maintenance of cilia structure and function, which is essential for sensing environmental cues and regulating cell migration. 3. **Golgi-to-ER Retrograde Transport:** KIF3C is involved in the retrograde transport of proteins and lipids within the Golgi apparatus, regulating protein secretion and cell signaling. 4. **Cytoskeletal Motor Activity:** KIF3C interacts with microtubules, facilitating their movement and contributing to cell migration, shape changes, and intracellular transport. **Clinical Significance:** Dysregulation of KIF3C has been implicated in various diseases, including: 1. **Immune System Disorders:** Altered KIF3C expression has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological Disorders:** Abnormalities in KIF3C function have been associated with neurodegenerative diseases, including Alzheimer's and Parkinson's. 3. **Hemostasis and Blood Disorders:** KIF3C plays a crucial role in the development and function of megakaryocytes, which are essential for platelet production and blood clotting. In conclusion, KIF3C is a multifunctional protein with significant implications in various cellular processes, including adaptive immunity, cell migration, and protein trafficking. Further research is necessary to fully elucidate the mechanisms underlying KIF3C function and its clinical significance in human diseases.

Genular Protein ID: 2985997399

Symbol: KIF3C_HUMAN

Name: Kinesin-like protein KIF3C

UniProtKB Accession Codes:

O14782 O43544 Q4ZG18 Q53SX5 Q562F7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9480755

Title: KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23.

PubMed ID: 9480755

DOI: 10.1006/geno.1997.5123

PubMed ID: 9446808

Title: cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C.

PubMed ID: 9446808

DOI: 10.1006/bbrc.1997.7977

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26138355

Title: Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome.

PubMed ID: 26138355

DOI: 10.1111/cge.12636

Sequence Information:

  • Length: 793
  • Mass: 89454
  • Checksum: 04CB96C5F6BED45E
  • Sequence:
    • MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA PGELPKTFTF 
DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG TGKTYTMQGT WVEPELRGVI 
PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ EEIRDLLSKE PGKRLELKEN PETGVYIKDL 
SSFVTKNVKE IEHVMNLGNQ TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG 
KLNLVDLAGS ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL 
GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD ESLSTLRFAN 
RAKNIKNKPR VNEDPKDTLL REFQEEIARL KAQLEKRGML GKRPRRKSSR RKKAVSAPPG 
YPEGPVIEAW VAEEEDDNNN NHRPPQPILE SALEKNMENY LQEQKERLEE EKAAIQDDRS 
LVSEEKQKLL EEKEKMLEDL RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE 
LKRQEIAEQK RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA 
EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL FLDCEEEQWK 
FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS HPRYRAENIM FLELDVSPPA 
VFEMEFSHDQ EQDPRALHME RLMRLDSFLE RPSTSKVRKS RSWCQSPQRP PPSTTHASLA 
SASLRPATVA DHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.