Details for: KISS1

Gene ID: 3814

Symbol: KISS1

Ensembl ID: ENSG00000170498

Description: KiSS-1 metastasis suppressor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 32.5095
    Cell Significance Index: 234.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7083
    Cell Significance Index: 88.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.5624
    Cell Significance Index: 9.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3147
    Cell Significance Index: 250.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2745
    Cell Significance Index: 34.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6934
    Cell Significance Index: 626.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5505
    Cell Significance Index: 15.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4771
    Cell Significance Index: 51.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4636
    Cell Significance Index: 27.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4324
    Cell Significance Index: 11.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4187
    Cell Significance Index: 68.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4075
    Cell Significance Index: 47.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3654
    Cell Significance Index: 2.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3395
    Cell Significance Index: 7.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2824
    Cell Significance Index: 19.5300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2676
    Cell Significance Index: 4.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2566
    Cell Significance Index: 11.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2456
    Cell Significance Index: 5.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2356
    Cell Significance Index: 23.3100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2298
    Cell Significance Index: 2.3700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.1556
    Cell Significance Index: 1.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0940
    Cell Significance Index: 1.9500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0684
    Cell Significance Index: 0.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0683
    Cell Significance Index: 2.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0242
    Cell Significance Index: 4.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0184
    Cell Significance Index: 0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0167
    Cell Significance Index: 2.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0162
    Cell Significance Index: 3.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0155
    Cell Significance Index: 0.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0044
    Cell Significance Index: 0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0036
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0064
    Cell Significance Index: -11.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0087
    Cell Significance Index: -11.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0091
    Cell Significance Index: -5.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0092
    Cell Significance Index: -5.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0109
    Cell Significance Index: -3.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0117
    Cell Significance Index: -4.2100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0126
    Cell Significance Index: -0.1600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0146
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0152
    Cell Significance Index: -6.9100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0155
    Cell Significance Index: -0.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0163
    Cell Significance Index: -0.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0175
    Cell Significance Index: -0.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0203
    Cell Significance Index: -0.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0215
    Cell Significance Index: -4.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0217
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0224
    Cell Significance Index: -3.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0312
    Cell Significance Index: -3.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0320
    Cell Significance Index: -14.1300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0386
    Cell Significance Index: -0.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0394
    Cell Significance Index: -5.7200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0401
    Cell Significance Index: -0.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0468
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0468
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0479
    Cell Significance Index: -5.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0486
    Cell Significance Index: -6.6700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0540
    Cell Significance Index: -0.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0587
    Cell Significance Index: -6.1100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0662
    Cell Significance Index: -0.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0697
    Cell Significance Index: -9.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0744
    Cell Significance Index: -5.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0806
    Cell Significance Index: -5.2000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0806
    Cell Significance Index: -1.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0896
    Cell Significance Index: -6.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0928
    Cell Significance Index: -4.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0956
    Cell Significance Index: -5.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1033
    Cell Significance Index: -5.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1124
    Cell Significance Index: -6.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1255
    Cell Significance Index: -7.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1314
    Cell Significance Index: -5.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1335
    Cell Significance Index: -6.2800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.1359
    Cell Significance Index: -0.8400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1399
    Cell Significance Index: -1.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1436
    Cell Significance Index: -5.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1501
    Cell Significance Index: -2.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1555
    Cell Significance Index: -4.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1635
    Cell Significance Index: -2.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1664
    Cell Significance Index: -6.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1672
    Cell Significance Index: -3.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1696
    Cell Significance Index: -4.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1707
    Cell Significance Index: -5.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1708
    Cell Significance Index: -4.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1758
    Cell Significance Index: -6.1100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1807
    Cell Significance Index: -1.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1849
    Cell Significance Index: -5.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1857
    Cell Significance Index: -5.4700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1878
    Cell Significance Index: -2.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1884
    Cell Significance Index: -2.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1907
    Cell Significance Index: -5.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1941
    Cell Significance Index: -5.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1943
    Cell Significance Index: -2.8000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2061
    Cell Significance Index: -3.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2163
    Cell Significance Index: -5.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2182
    Cell Significance Index: -8.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The KiSS1 gene is a non-coding gene that is significantly expressed in various cell types, including respiratory basal cells, trophoblast giant cells, and GABAergic interneurons. It is also highly expressed in the placenta and the brain. The KiSS1 protein is a metastasis suppressor that has been shown to inhibit the growth and metastasis of various cancer cells. Additionally, KiSS1 has been implicated in the regulation of cell proliferation, differentiation, and survival in various cell types. **Pathways and Functions:** KiSS1 is involved in several signaling pathways that regulate immune responses, including: 1. **G protein-coupled receptor signaling pathway:** KiSS1 interacts with G protein-coupled receptors, such as the kisspeptin receptor, to regulate cell signaling and immune responses. 2. **Cytoskeleton organization:** KiSS1 regulates the organization of the cytoskeleton, which is essential for cell migration, differentiation, and survival. 3. **Signaling by GPCR:** KiSS1 interacts with G protein-coupled receptors to regulate signaling pathways that control cell proliferation, differentiation, and survival. 4. **Generation of ovulation cycle rhythm:** KiSS1 is involved in the regulation of the ovulation cycle rhythm, which is essential for reproductive function. 5. **Negative regulation of cell population proliferation:** KiSS1 inhibits the growth and proliferation of cancer cells by regulating cell cycle progression and apoptosis. **Clinical Significance:** The KiSS1 gene has been implicated in various diseases, including: 1. **Cancer:** KiSS1 has been shown to inhibit the growth and metastasis of various cancer cells, including breast, lung, and colon cancer. 2. **Autoimmune diseases:** KiSS1 has been implicated in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Reproductive disorders:** KiSS1 is involved in the regulation of the ovulation cycle rhythm, which is essential for reproductive function. 4. **Neurological disorders:** KiSS1 has been implicated in the regulation of synaptic transmission and neuronal cell body morphology, which is essential for neurological function. In conclusion, the KiSS1 gene is a critical component of the immune system that plays a pivotal role in regulating various physiological and pathological processes. Further research is needed to fully understand the mechanisms by which KiSS1 regulates immune responses and to explore its therapeutic potential in various diseases. **Recommendations:** 1. **Further research:** Conduct further research to elucidate the mechanisms by which KiSS1 regulates immune responses and to explore its therapeutic potential in various diseases. 2. **Clinical trials:** Conduct clinical trials to evaluate the efficacy and safety of KiSS1-based therapies in various diseases. 3. **Immunotherapy:** Develop immunotherapies that target KiSS1 and its signaling pathways to treat various cancers and autoimmune diseases. 4. **Gene therapy:** Develop gene therapies that restore or enhance KiSS1 expression in patients with genetic disorders or cancer.

Genular Protein ID: 196505099

Symbol: KISS1_HUMAN

Name: Metastasis-suppressor KiSS-1

UniProtKB Accession Codes:

Q15726 A8K6N0 Q9HBP1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 15 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8944003

Title: KiSS-1, a novel human malignant melanoma metastasis-suppressor gene.

PubMed ID: 8944003

DOI: 10.1093/jnci/88.23.1731

PubMed ID: 9806840

Title: Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1).

PubMed ID: 9806840

DOI: 10.1006/geno.1998.5566

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11385580

Title: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.

PubMed ID: 11385580

DOI: 10.1038/35079135

PubMed ID: 9192814

Title: Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1.

PubMed ID: 9192814

PubMed ID: 9185708

Title: Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display.

PubMed ID: 9185708

DOI: 10.1002/(sici)1097-0215(19970611)71:6<1035::aid-ijc20>3.0.co;2-b

PubMed ID: 11457843

Title: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.

PubMed ID: 11457843

DOI: 10.1074/jbc.m104847200

PubMed ID: 11527393

Title: Metastin suppresses the motility and growth of CHO cells transfected with its receptor.

PubMed ID: 11527393

DOI: 10.1006/bbrc.2001.5470

PubMed ID: 11060311

Title: KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation.

PubMed ID: 11060311

DOI: 10.1074/jbc.m008681200

PubMed ID: 11606374

Title: Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23.

PubMed ID: 11606374

PubMed ID: 12414911

Title: Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.

PubMed ID: 12414911

DOI: 10.1210/jc.2002-021093

PubMed ID: 11994395

Title: Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells.

PubMed ID: 11994395

DOI: 10.1210/jcem.87.5.8626

PubMed ID: 12547718

Title: Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome.

PubMed ID: 12547718

DOI: 10.1016/s0002-9440(10)63854-0

PubMed ID: 12574233

Title: Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans.

PubMed ID: 12574233

DOI: 10.1210/jc.2002-021235

PubMed ID: 12879005

Title: Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.

PubMed ID: 12879005

DOI: 10.1038/sj.onc.1206542

PubMed ID: 12898236

Title: Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma.

PubMed ID: 12898236

DOI: 10.1007/s00432-003-0469-z

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 14977840

Title: Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma.

PubMed ID: 14977840

DOI: 10.1158/1078-0432.ccr-1519-02

PubMed ID: 15020672

Title: Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts.

PubMed ID: 15020672

DOI: 10.1242/jcs.00971

PubMed ID: 15300798

Title: Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma.

PubMed ID: 15300798

DOI: 10.1002/ijc.20357

PubMed ID: 15219839

Title: Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat.

PubMed ID: 15219839

DOI: 10.1016/j.bbrc.2004.05.185

PubMed ID: 15500545

Title: Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

PubMed ID: 15500545

DOI: 10.1111/j.1365-2826.2004.01240.x

PubMed ID: 15596153

Title: Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors.

PubMed ID: 15596153

DOI: 10.1016/j.bbrc.2004.11.094

PubMed ID: 15598687

Title: Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.

PubMed ID: 15598687

DOI: 10.1210/jc.2004-1418

PubMed ID: 22335740

Title: Inactivating KISS1 mutation and hypogonadotropic hypogonadism.

PubMed ID: 22335740

DOI: 10.1056/nejmoa1111184

Sequence Information:

  • Length: 138
  • Mass: 14705
  • Checksum: 0F0A1E1D66EDC22A
  • Sequence:
    • MNSLVSWQLL LFLCATHFGE PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA 
TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR 
FGKREAAPGN HGRSAGRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.