Details for: KISS1

Gene ID: 3814

Symbol: KISS1

Ensembl ID: ENSG00000170498

Description: KiSS-1 metastasis suppressor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 4.18
    Marker Score: 6004
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 2.38
    Marker Score: 772
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 647
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5333
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.91
    Marker Score: 1017
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 797.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.7
    Marker Score: 1446
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.65
    Marker Score: 376
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2702
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 366
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.51
    Marker Score: 816
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.42
    Marker Score: 205
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6186
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.38
    Marker Score: 375
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.29
    Marker Score: 375
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 584
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 542.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.28
    Marker Score: 419
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.28
    Marker Score: 347
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.27
    Marker Score: 187
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.25
    Marker Score: 209
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.25
    Marker Score: 386
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.25
    Marker Score: 137
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 101
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.24
    Marker Score: 226.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.24
    Marker Score: 103
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.24
    Marker Score: 429
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.23
    Marker Score: 439
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 527
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.22
    Marker Score: 1310
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.21
    Marker Score: 512
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.21
    Marker Score: 96
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.2
    Marker Score: 61
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.2
    Marker Score: 968.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2
    Marker Score: 136
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.2
    Marker Score: 111
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 110
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.19
    Marker Score: 78
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.18
    Marker Score: 415
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.18
    Marker Score: 716
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.18
    Marker Score: 189
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.18
    Marker Score: 425
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.17
    Marker Score: 489
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.17
    Marker Score: 140
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 99
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.16
    Marker Score: 1202
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 122
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.15
    Marker Score: 105
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.15
    Marker Score: 399
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.15
    Marker Score: 155
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.14
    Marker Score: 113
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.14
    Marker Score: 222
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.14
    Marker Score: 1388
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.13
    Marker Score: 114
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.13
    Marker Score: 204
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.12
    Marker Score: 812
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 59
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.12
    Marker Score: 768
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 131
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.11
    Marker Score: 1507
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.11
    Marker Score: 103

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Other Information

**Key characteristics:** * KISS1 is a protein that belongs to the Kiss1 family of cell surface receptors. * It is a Rhodopsin-like receptor that is involved in multiple cellular processes, including cell migration, proliferation, and survival. * It has been shown to play a role in the regulation of oocyte development and fertility. **Pathways and functions:** * Kiss1 signaling is involved in the regulation of cell proliferation and survival through the MAPK signaling pathway. * It promotes cell cycle progression and inhibits apoptosis. * It also regulates the expression of other genes involved in cell growth and differentiation. * Kiss1 signaling is important for the development and maintenance of reproductive tissues, including the uterus, cervix, and oviduct. **Clinical significance:** * Mutations in the KISS1 gene have been linked to the development of several human cancers, including breast cancer, ovarian cancer, and colon cancer. * Targeting the KISS1 receptor has emerged as a promising therapeutic strategy for cancer treatment. * Kissimumab (Herceptin), a monoclonal antibody that blocks the KISS1 receptor, is currently used in clinical trials for the treatment of cancer. **Additional points:** * Kiss1 is a highly conserved protein with homologs in other species. * It is a promising target for cancer immunotherapy due to its expression in cancer cells and its role in cell growth and survival. * Further research is needed to understand the full role of Kiss1 in cancer and to develop more effective therapeutic strategies.

Genular Protein ID: 196505099

Symbol: KISS1_HUMAN

Name: Metastasis-suppressor KiSS-1

UniProtKB Accession Codes:

Q15726 A8K6N0 Q9HBP1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 15 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8944003

Title: KiSS-1, a novel human malignant melanoma metastasis-suppressor gene.

PubMed ID: 8944003

DOI: 10.1093/jnci/88.23.1731

PubMed ID: 9806840

Title: Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1).

PubMed ID: 9806840

DOI: 10.1006/geno.1998.5566

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11385580

Title: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.

PubMed ID: 11385580

DOI: 10.1038/35079135

PubMed ID: 9192814

Title: Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1.

PubMed ID: 9192814

PubMed ID: 9185708

Title: Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display.

PubMed ID: 9185708

DOI: 10.1002/(sici)1097-0215(19970611)71:6<1035::aid-ijc20>3.0.co;2-b

PubMed ID: 11457843

Title: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.

PubMed ID: 11457843

DOI: 10.1074/jbc.m104847200

PubMed ID: 11527393

Title: Metastin suppresses the motility and growth of CHO cells transfected with its receptor.

PubMed ID: 11527393

DOI: 10.1006/bbrc.2001.5470

PubMed ID: 11060311

Title: KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation.

PubMed ID: 11060311

DOI: 10.1074/jbc.m008681200

PubMed ID: 11606374

Title: Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23.

PubMed ID: 11606374

PubMed ID: 12414911

Title: Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.

PubMed ID: 12414911

DOI: 10.1210/jc.2002-021093

PubMed ID: 11994395

Title: Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells.

PubMed ID: 11994395

DOI: 10.1210/jcem.87.5.8626

PubMed ID: 12547718

Title: Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome.

PubMed ID: 12547718

DOI: 10.1016/s0002-9440(10)63854-0

PubMed ID: 12574233

Title: Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans.

PubMed ID: 12574233

DOI: 10.1210/jc.2002-021235

PubMed ID: 12879005

Title: Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.

PubMed ID: 12879005

DOI: 10.1038/sj.onc.1206542

PubMed ID: 12898236

Title: Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma.

PubMed ID: 12898236

DOI: 10.1007/s00432-003-0469-z

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 14977840

Title: Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma.

PubMed ID: 14977840

DOI: 10.1158/1078-0432.ccr-1519-02

PubMed ID: 15020672

Title: Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts.

PubMed ID: 15020672

DOI: 10.1242/jcs.00971

PubMed ID: 15300798

Title: Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma.

PubMed ID: 15300798

DOI: 10.1002/ijc.20357

PubMed ID: 15219839

Title: Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat.

PubMed ID: 15219839

DOI: 10.1016/j.bbrc.2004.05.185

PubMed ID: 15500545

Title: Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

PubMed ID: 15500545

DOI: 10.1111/j.1365-2826.2004.01240.x

PubMed ID: 15596153

Title: Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors.

PubMed ID: 15596153

DOI: 10.1016/j.bbrc.2004.11.094

PubMed ID: 15598687

Title: Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.

PubMed ID: 15598687

DOI: 10.1210/jc.2004-1418

PubMed ID: 22335740

Title: Inactivating KISS1 mutation and hypogonadotropic hypogonadism.

PubMed ID: 22335740

DOI: 10.1056/nejmoa1111184

Sequence Information:

  • Length: 138
  • Mass: 14705
  • Checksum: 0F0A1E1D66EDC22A
  • Sequence:
    • MNSLVSWQLL LFLCATHFGE PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA 
TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR 
FGKREAAPGN HGRSAGRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.