Details for: KLRC1

Gene ID: 3821

Symbol: KLRC1

Ensembl ID: ENSG00000134545

Description: killer cell lectin like receptor C1

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Adaptive immune response
    (GO:0002250)
  • Carbohydrate binding
    (GO:0030246)
  • Cd8-positive, gamma-delta intraepithelial t cell differentiation
    (GO:0002305)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • External side of plasma membrane
    (GO:0009897)
  • Hla-e specific inhibitory mhc class ib receptor activity
    (GO:0062082)
  • Inhibitory mhc class ib receptor activity
    (GO:0062080)
  • Innate immune response
    (GO:0045087)
  • Mhc class i protein complex binding
    (GO:0023024)
  • Natural killer cell inhibitory signaling pathway
    (GO:0002769)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of t cell mediated cytotoxicity
    (GO:0001915)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Protein antigen binding
    (GO:1990405)
  • Protein binding
    (GO:0005515)
  • Receptor complex
    (GO:0043235)
  • Regulation of natural killer cell activation
    (GO:0032814)
  • Stimulatory c-type lectin receptor signaling pathway
    (GO:0002223)
  • Transmembrane signaling receptor activity
    (GO:0004888)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.21
    Marker Score: 11641
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.58
    Marker Score: 850
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.34
    Marker Score: 9053
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.07
    Marker Score: 6524
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.73
    Marker Score: 439
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.48
    Marker Score: 1480
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.34
    Marker Score: 3923
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.2
    Marker Score: 867
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 485
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.95
    Marker Score: 407
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.94
    Marker Score: 404
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5327
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.85
    Marker Score: 1101
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 487
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.79
    Marker Score: 178
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.77
    Marker Score: 278
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.77
    Marker Score: 852
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.75
    Marker Score: 611
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.72
    Marker Score: 1368
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.65
    Marker Score: 333
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.62
    Marker Score: 312
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.59
    Marker Score: 400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 366.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.54
    Marker Score: 418
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.5
    Marker Score: 155
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.5
    Marker Score: 289
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.49
    Marker Score: 136
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.41
    Marker Score: 227
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.37
    Marker Score: 3702
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.34
    Marker Score: 5362
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.33
    Marker Score: 483
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.32
    Marker Score: 528
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.32
    Marker Score: 145
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.32
    Marker Score: 282
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.31
    Marker Score: 257
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 301
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.29
    Marker Score: 213
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.29
    Marker Score: 698
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.28
    Marker Score: 129
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.26
    Marker Score: 232
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.25
    Marker Score: 200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.25
    Marker Score: 216
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 108
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.22
    Marker Score: 51
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.21
    Marker Score: 2419
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 118
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.2
    Marker Score: 130
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.18
    Marker Score: 260
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.18
    Marker Score: 307.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.17
    Marker Score: 105
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 333
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.15
    Marker Score: 182
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.14
    Marker Score: 932
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.12
    Marker Score: 91
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 224
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 115
  • Cell Name: group 2 innate lymphoid cell, human (CL0001081)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.1
    Marker Score: 25

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Other Information

## Summary KLRC1 is a killer cell lectin-like receptor that plays a crucial role in regulating the adaptive immune response. It is expressed on various immune cells, including natural killer (NK) cells, dendritic cells, and epithelial cells. ## Key characteristics * KLRC1 is a cell surface receptor that is expressed on NK cells, dendritic cells, and epithelial cells. * It is a member of the killer cell lectin-like receptor (KLRC) family of immune receptors. * KLRC1 is a type II integral membrane protein that is expressed on the cell surface. * It is a negative regulator of NK cell-mediated cytotoxicity. * It is also involved in the regulation of innate immune responses. ## Pathways and functions * KLRC1 is involved in the regulation of adaptive immune responses. * It binds to the NKG2A receptor on NK cells, which is a positive regulator of NK cell cytotoxicity. * When KLRC1 binds to NKG2A, it blocks the activation of NK cells and inhibits their cytotoxicity. * This helps to maintain immune homeostasis and prevent excessive immune responses. * In addition, KLRC1 is also involved in the regulation of innate immune responses. * It binds to proteins expressed on dendritic cells and epithelial cells, which are immune-stimulatory molecules. * This binding triggers the activation of dendritic cells and the presentation of antigens to NK cells, which then become activated and kill infected cells. ## Clinical significance * Mutations in KLRC1 have been linked to several human diseases, including cancer and autoimmune disorders. * In cancer, mutations in KLRC1 can lead to the development of tumors that are resistant to NK cell-mediated destruction. * Targeting KLRC1 has been investigated as a potential therapeutic strategy for cancer and autoimmune disorders.

Genular Protein ID: 2843275837

Symbol: NKG2A_HUMAN

Name: NKG2-A/NKG2-B type II integral membrane protein

UniProtKB Accession Codes:

P26715

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2007850

Title: DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.

PubMed ID: 2007850

DOI: 10.1084/jem.173.4.1017

PubMed ID: 8753859

Title: Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene.

PubMed ID: 8753859

DOI: 10.1007/bf02602558

PubMed ID: 9598306

Title: Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.

PubMed ID: 9598306

DOI: 10.1006/geno.1997.5197

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430220

Title: Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.

PubMed ID: 9430220

DOI: 10.1016/s1074-7613(00)80393-3

PubMed ID: 9485206

Title: Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.

PubMed ID: 9485206

DOI: 10.1002/(sici)1521-4141(199801)28:01<264::aid-immu264>3.0.co;2-o

PubMed ID: 9486650

Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

PubMed ID: 9486650

DOI: 10.1038/35869

PubMed ID: 10669413

Title: Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

PubMed ID: 10669413

DOI: 10.1126/science.287.5455.1031

PubMed ID: 12387742

Title: TCR specificity dictates CD94/NKG2A expression by human CTL.

PubMed ID: 12387742

DOI: 10.1016/s1074-7613(02)00427-2

PubMed ID: 12165520

Title: Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal.

PubMed ID: 12165520

DOI: 10.4049/jimmunol.169.4.1948

PubMed ID: 15751767

Title: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.

PubMed ID: 15751767

DOI: 10.1177/135965350501000107

PubMed ID: 18064301

Title: Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease.

PubMed ID: 18064301

DOI: 10.1172/jci30989

PubMed ID: 20952657

Title: NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.

PubMed ID: 20952657

DOI: 10.1189/jlb.0710413

PubMed ID: 23335510

Title: Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.

PubMed ID: 23335510

DOI: 10.1074/jbc.m112.409672

PubMed ID: 30503213

Title: Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells.

PubMed ID: 30503213

DOI: 10.1016/j.cell.2018.10.014

PubMed ID: 30860984

Title: Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.

PubMed ID: 30860984

DOI: 10.1172/jci123955

PubMed ID: 32203188

Title: Functional exhaustion of antiviral lymphocytes in COVID-19 patients.

PubMed ID: 32203188

DOI: 10.1038/s41423-020-0402-2

PubMed ID: 32859121

Title: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway.

PubMed ID: 32859121

DOI: 10.3390/cells9091975

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 18083576

Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

PubMed ID: 18083576

DOI: 10.1016/j.immuni.2007.10.013

PubMed ID: 18332182

Title: CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.

PubMed ID: 18332182

DOI: 10.1084/jem.20072525

PubMed ID: 18448674

Title: Structural basis for NKG2A/CD94 recognition of HLA-E.

PubMed ID: 18448674

DOI: 10.1073/pnas.0802736105

Sequence Information:

  • Length: 233
  • Mass: 26314
  • Checksum: 93879A5C8D110C62
  • Sequence:
    • MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ DFQGNDKTYH 
CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR HNNSSLNTRT QKARHCGHCP 
EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN 
SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.