Details for: KLRC1

Gene ID: 3821

Symbol: KLRC1

Ensembl ID: ENSG00000134545

Description: killer cell lectin like receptor C1

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Adaptive immune response
    (GO:0002250)
  • Carbohydrate binding
    (GO:0030246)
  • Cd8-positive, gamma-delta intraepithelial t cell differentiation
    (GO:0002305)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • External side of plasma membrane
    (GO:0009897)
  • Hla-e specific inhibitory mhc class ib receptor activity
    (GO:0062082)
  • Inhibitory mhc class ib receptor activity
    (GO:0062080)
  • Innate immune response
    (GO:0045087)
  • Mhc class i protein complex binding
    (GO:0023024)
  • Natural killer cell inhibitory signaling pathway
    (GO:0002769)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of t cell mediated cytotoxicity
    (GO:0001915)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Protein antigen binding
    (GO:1990405)
  • Protein binding
    (GO:0005515)
  • Receptor complex
    (GO:0043235)
  • Regulation of natural killer cell activation
    (GO:0032814)
  • Stimulatory c-type lectin receptor signaling pathway
    (GO:0002223)
  • Transmembrane signaling receptor activity
    (GO:0004888)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 16.3688
    Cell Significance Index: 43.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.3760
    Cell Significance Index: 145.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1233
    Cell Significance Index: 32.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5978
    Cell Significance Index: 34.6200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.0339
    Cell Significance Index: 11.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7489
    Cell Significance Index: 142.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4953
    Cell Significance Index: 49.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4404
    Cell Significance Index: 397.6700
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.3711
    Cell Significance Index: 0.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2609
    Cell Significance Index: 42.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2234
    Cell Significance Index: 24.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2209
    Cell Significance Index: 4.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1060
    Cell Significance Index: 7.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0986
    Cell Significance Index: 5.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0041
    Cell Significance Index: -7.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0056
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0095
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0107
    Cell Significance Index: -7.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0130
    Cell Significance Index: -2.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0135
    Cell Significance Index: -7.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0140
    Cell Significance Index: -2.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0160
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0173
    Cell Significance Index: -7.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0179
    Cell Significance Index: -6.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0183
    Cell Significance Index: -3.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0219
    Cell Significance Index: -2.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0248
    Cell Significance Index: -7.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0355
    Cell Significance Index: -7.0400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0417
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0421
    Cell Significance Index: -7.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0438
    Cell Significance Index: -0.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0468
    Cell Significance Index: -1.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0491
    Cell Significance Index: -6.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0511
    Cell Significance Index: -7.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0522
    Cell Significance Index: -2.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0534
    Cell Significance Index: -7.3400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0537
    Cell Significance Index: -0.7300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0545
    Cell Significance Index: -0.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0575
    Cell Significance Index: -2.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0610
    Cell Significance Index: -7.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0649
    Cell Significance Index: -6.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0649
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0655
    Cell Significance Index: -7.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0662
    Cell Significance Index: -2.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0662
    Cell Significance Index: -7.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0716
    Cell Significance Index: -4.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0783
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0839
    Cell Significance Index: -1.7400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0889
    Cell Significance Index: -0.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0952
    Cell Significance Index: -2.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1008
    Cell Significance Index: -6.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1071
    Cell Significance Index: -8.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1075
    Cell Significance Index: -8.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1093
    Cell Significance Index: -6.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1154
    Cell Significance Index: -5.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1155
    Cell Significance Index: -3.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1167
    Cell Significance Index: -3.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1218
    Cell Significance Index: -7.8600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1228
    Cell Significance Index: -1.3600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1550
    Cell Significance Index: -1.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1554
    Cell Significance Index: -8.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1613
    Cell Significance Index: -9.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1616
    Cell Significance Index: -5.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1706
    Cell Significance Index: -3.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1757
    Cell Significance Index: -7.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1825
    Cell Significance Index: -4.5500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1848
    Cell Significance Index: -5.8500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1870
    Cell Significance Index: -1.8500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1899
    Cell Significance Index: -1.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1899
    Cell Significance Index: -6.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2068
    Cell Significance Index: -6.0900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2078
    Cell Significance Index: -3.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2083
    Cell Significance Index: -6.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2101
    Cell Significance Index: -3.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2105
    Cell Significance Index: -7.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2129
    Cell Significance Index: -6.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2190
    Cell Significance Index: -8.0400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2325
    Cell Significance Index: -2.6200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2372
    Cell Significance Index: -2.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2513
    Cell Significance Index: -6.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2578
    Cell Significance Index: -7.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2583
    Cell Significance Index: -7.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2618
    Cell Significance Index: -7.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2653
    Cell Significance Index: -7.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2674
    Cell Significance Index: -5.8600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2710
    Cell Significance Index: -6.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2770
    Cell Significance Index: -7.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2825
    Cell Significance Index: -7.5700
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2844
    Cell Significance Index: -3.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2871
    Cell Significance Index: -7.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2878
    Cell Significance Index: -3.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2906
    Cell Significance Index: -7.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2959
    Cell Significance Index: -7.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLRC1, also known as NKG2A, is a type II integral membrane protein that belongs to the C-type lectin receptor family. It is primarily expressed on the surface of NK cells, T cells, and other immune cells, including decidual NK cells, ILC1 cells, and granulocyte-monocyte progenitor cells. KLRC1's molecular weight is approximately 55 kDa, and it contains two Ig-like domains that are essential for its binding properties. **Pathways and Functions:** KLRC1's primary function is to regulate the activity of immune cells, particularly NK cells and T cells. Its binding to HLA-E and MHC class I molecules triggers a cascade of signaling events that ultimately modulate the cytotoxic activity of these cells. KLRC1's inhibitory effects on NK cells and T cells are mediated through the inhibition of the activation of the immune cells. Additionally, KLRC1's binding to MHC class I molecules can also activate the stimulatory signaling pathway, leading to the activation of immune cells. KLRC1's involvement in immune regulation extends beyond its effects on NK cells and T cells. It also plays a role in the differentiation of gamma-delta T cells and the regulation of innate lymphoid cells (ILCs). Furthermore, KLRC1's expression on the surface of enterocytes and intestinal stem cells suggests its involvement in the maintenance of intestinal homeostasis and tolerance. **Clinical Significance:** KLRC1's dysregulation has been implicated in various immune-related disorders, including cancer, autoimmune diseases, and infectious diseases. For instance, alterations in KLRC1 expression have been observed in patients with acute myeloid leukemia, chronic lymphocytic leukemia, and multiple sclerosis. Additionally, KLRC1's involvement in tumor surveillance has been demonstrated, with studies showing that its expression is downregulated in tumor cells. In the context of cancer, KLRC1's inhibitory effects on NK cells and T cells can contribute to tumor immune evasion. Conversely, the activation of KLRC1 can enhance the cytotoxic activity of immune cells against tumor cells. Therefore, targeting KLRC1 or its ligands may provide a novel therapeutic strategy for cancer treatment. In conclusion, KLRC1 is a multifunctional receptor that plays a critical role in regulating the activity of immune cells and maintaining immune homeostasis. Its dysregulation has been implicated in various immune-related disorders, and its targeting may offer new therapeutic opportunities for the treatment of cancer and other immune-related diseases. Further research is needed to fully elucidate the mechanisms of KLRC1's immune regulatory functions and to explore its potential as a therapeutic target.

Genular Protein ID: 2843275837

Symbol: NKG2A_HUMAN

Name: NKG2-A/NKG2-B type II integral membrane protein

UniProtKB Accession Codes:

P26715

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2007850

Title: DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.

PubMed ID: 2007850

DOI: 10.1084/jem.173.4.1017

PubMed ID: 8753859

Title: Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene.

PubMed ID: 8753859

DOI: 10.1007/bf02602558

PubMed ID: 9598306

Title: Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.

PubMed ID: 9598306

DOI: 10.1006/geno.1997.5197

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430220

Title: Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.

PubMed ID: 9430220

DOI: 10.1016/s1074-7613(00)80393-3

PubMed ID: 9485206

Title: Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.

PubMed ID: 9485206

DOI: 10.1002/(sici)1521-4141(199801)28:01<264::aid-immu264>3.0.co;2-o

PubMed ID: 9486650

Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

PubMed ID: 9486650

DOI: 10.1038/35869

PubMed ID: 10669413

Title: Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.

PubMed ID: 10669413

DOI: 10.1126/science.287.5455.1031

PubMed ID: 12387742

Title: TCR specificity dictates CD94/NKG2A expression by human CTL.

PubMed ID: 12387742

DOI: 10.1016/s1074-7613(02)00427-2

PubMed ID: 12165520

Title: Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal.

PubMed ID: 12165520

DOI: 10.4049/jimmunol.169.4.1948

PubMed ID: 15751767

Title: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.

PubMed ID: 15751767

DOI: 10.1177/135965350501000107

PubMed ID: 18064301

Title: Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease.

PubMed ID: 18064301

DOI: 10.1172/jci30989

PubMed ID: 20952657

Title: NKG2A inhibits NKG2C effector functions of gammadelta T cells: implications in health and disease.

PubMed ID: 20952657

DOI: 10.1189/jlb.0710413

PubMed ID: 23335510

Title: Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.

PubMed ID: 23335510

DOI: 10.1074/jbc.m112.409672

PubMed ID: 30503213

Title: Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells.

PubMed ID: 30503213

DOI: 10.1016/j.cell.2018.10.014

PubMed ID: 30860984

Title: Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.

PubMed ID: 30860984

DOI: 10.1172/jci123955

PubMed ID: 32203188

Title: Functional exhaustion of antiviral lymphocytes in COVID-19 patients.

PubMed ID: 32203188

DOI: 10.1038/s41423-020-0402-2

PubMed ID: 32859121

Title: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway.

PubMed ID: 32859121

DOI: 10.3390/cells9091975

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 18083576

Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

PubMed ID: 18083576

DOI: 10.1016/j.immuni.2007.10.013

PubMed ID: 18332182

Title: CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.

PubMed ID: 18332182

DOI: 10.1084/jem.20072525

PubMed ID: 18448674

Title: Structural basis for NKG2A/CD94 recognition of HLA-E.

PubMed ID: 18448674

DOI: 10.1073/pnas.0802736105

Sequence Information:

  • Length: 233
  • Mass: 26314
  • Checksum: 93879A5C8D110C62
  • Sequence:
    • MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ DFQGNDKTYH 
CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR HNNSSLNTRT QKARHCGHCP 
EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN 
SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.