Details for: KPNA1

Gene ID: 3836

Symbol: KPNA1

Ensembl ID: ENSG00000114030

Description: karyopherin subunit alpha 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.32
    Marker Score: 8980
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.16
    Marker Score: 2609
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.15
    Marker Score: 1258
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.01
    Marker Score: 8375
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.96
    Marker Score: 2633
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.91
    Marker Score: 4771
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.81
    Marker Score: 1994
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.77
    Marker Score: 516
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.74
    Marker Score: 106869
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.71
    Marker Score: 2984
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.71
    Marker Score: 17614
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.68
    Marker Score: 63986
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.68
    Marker Score: 7036
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.64
    Marker Score: 60557
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.63
    Marker Score: 24432
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.63
    Marker Score: 14024
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.63
    Marker Score: 15493
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.62
    Marker Score: 1865
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.59
    Marker Score: 3481.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.57
    Marker Score: 6077
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.57
    Marker Score: 14744.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.54
    Marker Score: 32797.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.54
    Marker Score: 30537.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.51
    Marker Score: 6148
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.51
    Marker Score: 901
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.51
    Marker Score: 6244
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.49
    Marker Score: 11439
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.48
    Marker Score: 863
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.47
    Marker Score: 49731
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.46
    Marker Score: 2258
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.46
    Marker Score: 460
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.42
    Marker Score: 595
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4
    Marker Score: 24864
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.35
    Marker Score: 426
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.31
    Marker Score: 29232
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3
    Marker Score: 1367
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.29
    Marker Score: 625
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.26
    Marker Score: 4462
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.25
    Marker Score: 2412
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.25
    Marker Score: 1343
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.24
    Marker Score: 615
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.21
    Marker Score: 639
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.2
    Marker Score: 5160
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.18
    Marker Score: 5473
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.17
    Marker Score: 7541
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.15
    Marker Score: 641
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.13
    Marker Score: 38529
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.13
    Marker Score: 870
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.12
    Marker Score: 1401
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.12
    Marker Score: 380
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.12
    Marker Score: 2672
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.08
    Marker Score: 295
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.08
    Marker Score: 1029
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.07
    Marker Score: 3506
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.07
    Marker Score: 1140
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.06
    Marker Score: 5719
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.06
    Marker Score: 1772
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.05
    Marker Score: 1266
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.05
    Marker Score: 16811
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.04
    Marker Score: 393
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.04
    Marker Score: 1508
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.04
    Marker Score: 383
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.03
    Marker Score: 510
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.01
    Marker Score: 377
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.01
    Marker Score: 873
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1
    Marker Score: 3441
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1
    Marker Score: 1236
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1
    Marker Score: 2850
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71625
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47850
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.98
    Marker Score: 1387.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30377
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.98
    Marker Score: 896.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.96
    Marker Score: 387
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.96
    Marker Score: 304
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.95
    Marker Score: 650
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.95
    Marker Score: 643
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14801.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.95
    Marker Score: 383
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.94
    Marker Score: 341
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.94
    Marker Score: 589
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2388
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.93
    Marker Score: 322
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.92
    Marker Score: 1191.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 432.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.91
    Marker Score: 1035
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.91
    Marker Score: 683
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.9
    Marker Score: 238
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.9
    Marker Score: 956
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.9
    Marker Score: 1128
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2684
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.9
    Marker Score: 468
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.9
    Marker Score: 959
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.89
    Marker Score: 497
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.89
    Marker Score: 212
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.87
    Marker Score: 221
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.87
    Marker Score: 935

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Other Information

**Key characteristics:** * KPNA1 is a large protein with a molecular weight of approximately 200 kDa. * It is a cytoskeletal protein that is expressed in high levels in cells that are actively dividing or replicating DNA. * It is a member of the immunoglobulin superfamily, which are involved in cell adhesion, signaling, and migration. * It is a key component of the pre-replicative complex, which is responsible for initiating DNA replication in eukaryotic cells. **Pathways and functions:** * KPNA1 is a key component of the pre-replicative complex, which is responsible for initiating DNA replication in eukaryotic cells. * The pre-replicative complex is a large protein complex that is responsible for recognizing and binding to DNA templates. * Once the pre-replicative complex is assembled, it begins to unwind DNA and form a replication bubble. * KPNA1 is a key component of this process, and its mutation can lead to the formation of DNA double-strand breaks, which can lead to cell death. **Clinical significance:** * Mutations in KPNA1 have been linked to a number of eye conditions, including glaucoma, cataracts, and macular degeneration. * These mutations can also lead to developmental abnormalities in the eyes, such as microcephaly and facial malformations. * KPNA1 is a promising target for the treatment of eye diseases.

Genular Protein ID: 2908025333

Symbol: IMA5_HUMAN

Name: Importin subunit alpha-5

UniProtKB Accession Codes:

P52294 D3DN93 Q6IBQ9 Q9BQ56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7831767

Title: NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein.

PubMed ID: 7831767

DOI: 10.1016/s0042-6822(95)80026-3

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8052633

Title: RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.

PubMed ID: 8052633

DOI: 10.1073/pnas.91.16.7633

PubMed ID: 7892216

Title: Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.

PubMed ID: 7892216

DOI: 10.1073/pnas.92.6.2008

PubMed ID: 8692858

Title: The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence.

PubMed ID: 8692858

DOI: 10.1073/pnas.93.13.6572

PubMed ID: 7604027

Title: Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

PubMed ID: 7604027

DOI: 10.1073/pnas.92.14.6532

PubMed ID: 9463369

Title: Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.

PubMed ID: 9463369

DOI: 10.1093/emboj/17.4.909

PubMed ID: 10612665

Title: Epstein-barr virus nuclear antigen-1 binds to nuclear transporter karyopherin alpha1/NPI-1 in addition to karyopherin alpha2/Rch1.

PubMed ID: 10612665

DOI: 10.1006/viro.1999.0054

PubMed ID: 12610148

Title: A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.

PubMed ID: 12610148

DOI: 10.1128/jvi.77.6.3734-3748.2003

PubMed ID: 15942031

Title: Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

PubMed ID: 15942031

DOI: 10.1093/nar/gki641

PubMed ID: 16698996

Title: Ebola virus VP24 binds karyopherin alpha-1 and blocks STAT1 nuclear accumulation.

PubMed ID: 16698996

DOI: 10.1128/jvi.02349-05

PubMed ID: 17652399

Title: Nuclear import and export of Venezuelan equine encephalitis virus nonstructural protein 2.

PubMed ID: 17652399

DOI: 10.1128/jvi.00371-07

PubMed ID: 17928350

Title: Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

PubMed ID: 17928350

DOI: 10.1128/jvi.01097-07

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19118899

Title: Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.

PubMed ID: 19118899

DOI: 10.1016/j.molimm.2008.11.009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454664

Title: Importin alpha protein acts as a negative regulator for Snail protein nuclear import.

PubMed ID: 21454664

DOI: 10.1074/jbc.m110.213579

PubMed ID: 21385873

Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.

PubMed ID: 21385873

DOI: 10.1074/jbc.m110.208769

PubMed ID: 22500989

Title: Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).

PubMed ID: 22500989

DOI: 10.1016/j.febslet.2012.02.053

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27713473

Title: Identification of the nuclear localisation signal of O-GlcNAc transferase and its nuclear import regulation.

PubMed ID: 27713473

DOI: 10.1038/srep34614

PubMed ID: 28552616

Title: Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.

PubMed ID: 28552616

DOI: 10.1016/j.molcel.2017.04.026

PubMed ID: 29599122

Title: Intersectin goes nuclear: secret life of an endocytic protein.

PubMed ID: 29599122

DOI: 10.1042/bcj20170897

Sequence Information:

  • Length: 538
  • Mass: 60222
  • Checksum: E8407A3352D6051C
  • Sequence:
    • MTTPGKENFR LKSYKNKSLN PDEMRRRREE EGLQLRKQKR EEQLFKRRNV ATAEEETEEE 
VMSDGGFHEA QISNMEMAPG GVITSDMIEM IFSKSPEQQL SATQKFRKLL SKEPNPPIDE 
VISTPGVVAR FVEFLKRKEN CTLQFESAWV LTNIASGNSL QTRIVIQAGA VPIFIELLSS 
EFEDVQEQAV WALGNIAGDS TMCRDYVLDC NILPPLLQLF SKQNRLTMTR NAVWALSNLC 
RGKSPPPEFA KVSPCLNVLS WLLFVSDTDV LADACWALSY LSDGPNDKIQ AVIDAGVCRR 
LVELLMHNDY KVVSPALRAV GNIVTGDDIQ TQVILNCSAL QSLLHLLSSP KESIKKEACW 
TISNITAGNR AQIQTVIDAN IFPALISILQ TAEFRTRKEA AWAITNATSG GSAEQIKYLV 
ELGCIKPLCD LLTVMDSKIV QVALNGLENI LRLGEQEAKR NGTGINPYCA LIEEAYGLDK 
IEFLQSHENQ EIYQKAFDLI EHYFGTEDED SSIAPQVDLN QQQYIFQQCE APMEGFQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.