Details for: KPNA1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 291.5551
Cell Significance Index: -45.3500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 189.0055
Cell Significance Index: -47.9400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 106.5401
Cell Significance Index: -50.3000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 98.5090
Cell Significance Index: -40.0200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 90.1853
Cell Significance Index: -46.3900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 42.2522
Cell Significance Index: -40.3400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 38.4442
Cell Significance Index: -47.4000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.0632
Cell Significance Index: -45.7100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.1631
Cell Significance Index: -40.4300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.5442
Cell Significance Index: -49.5000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.1709
Cell Significance Index: -22.2600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.8923
Cell Significance Index: 70.5700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.5346
Cell Significance Index: 65.1500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2529
Cell Significance Index: 451.9300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.7829
Cell Significance Index: 123.3000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6087
Cell Significance Index: 319.2500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.4968
Cell Significance Index: 83.9900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2534
Cell Significance Index: 96.1900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2174
Cell Significance Index: 16.6100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0941
Cell Significance Index: 392.4400 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.9117
Cell Significance Index: 14.7100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8940
Cell Significance Index: 97.2400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8673
Cell Significance Index: 141.0500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7982
Cell Significance Index: 552.0400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.7885
Cell Significance Index: 19.7100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6752
Cell Significance Index: 25.5700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.6436
Cell Significance Index: 28.4700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6123
Cell Significance Index: 75.2900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6078
Cell Significance Index: 109.5700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.6025
Cell Significance Index: 40.5100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5654
Cell Significance Index: 15.8000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4835
Cell Significance Index: 29.7200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4773
Cell Significance Index: 12.7900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4253
Cell Significance Index: 12.2600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.4125
Cell Significance Index: 8.0500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3754
Cell Significance Index: 37.1400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.3494
Cell Significance Index: 4.1700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2937
Cell Significance Index: 160.3900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2897
Cell Significance Index: 18.2600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2810
Cell Significance Index: 8.0200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2542
Cell Significance Index: 5.5700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.2409
Cell Significance Index: 4.0600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1911
Cell Significance Index: 294.1700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1831
Cell Significance Index: 9.5400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1765
Cell Significance Index: 112.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1719
Cell Significance Index: 323.6900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1620
Cell Significance Index: 220.2700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1555
Cell Significance Index: 68.7700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1491
Cell Significance Index: 274.9600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1444
Cell Significance Index: 6.7900 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.1404
Cell Significance Index: 2.0200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1392
Cell Significance Index: 19.1100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0950
Cell Significance Index: 18.0700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0822
Cell Significance Index: 37.3000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0579
Cell Significance Index: 9.8800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0342
Cell Significance Index: 1.2000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0255
Cell Significance Index: 3.0100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0016
Cell Significance Index: 0.1200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0026
Cell Significance Index: -0.0700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0182
Cell Significance Index: -13.5000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0182
Cell Significance Index: -11.4000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0246
Cell Significance Index: -0.6700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0269
Cell Significance Index: -3.9200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0290
Cell Significance Index: -1.3500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0429
Cell Significance Index: -31.4500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0470
Cell Significance Index: -6.0300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0484
Cell Significance Index: -1.1600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0503
Cell Significance Index: -38.0400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0553
Cell Significance Index: -7.1400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0582
Cell Significance Index: -32.8100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0719
Cell Significance Index: -2.0600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0812
Cell Significance Index: -4.2200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0895
Cell Significance Index: -1.9400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0916
Cell Significance Index: -1.5700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1026
Cell Significance Index: -0.6200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1324
Cell Significance Index: -27.8900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1440
Cell Significance Index: -41.4200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1547
Cell Significance Index: -15.8100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1840
Cell Significance Index: -8.3400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1873
Cell Significance Index: -21.3800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2072
Cell Significance Index: -13.3700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2426
Cell Significance Index: -5.1900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2457
Cell Significance Index: -28.1500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2617
Cell Significance Index: -30.5000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2719
Cell Significance Index: -19.2300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2888
Cell Significance Index: -30.0700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3770
Cell Significance Index: -8.0300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4746
Cell Significance Index: -4.3700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4782
Cell Significance Index: -7.0600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5172
Cell Significance Index: -40.9600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5264
Cell Significance Index: -7.7700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5472
Cell Significance Index: -33.5500 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5989
Cell Significance Index: -8.6000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6226
Cell Significance Index: -32.6900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.7587
Cell Significance Index: -9.4100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7617
Cell Significance Index: -24.2600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7770
Cell Significance Index: -25.4400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7858
Cell Significance Index: -27.3100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.8601
Cell Significance Index: -22.6200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.8870
Cell Significance Index: -18.8300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2908025333
Symbol: IMA5_HUMAN
Name: Importin subunit alpha-5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7831767
Title: NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein.
PubMed ID: 7831767
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8052633
Title: RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.
PubMed ID: 8052633
PubMed ID: 7892216
Title: Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.
PubMed ID: 7892216
PubMed ID: 8692858
Title: The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence.
PubMed ID: 8692858
PubMed ID: 7604027
Title: Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.
PubMed ID: 7604027
PubMed ID: 9463369
Title: Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.
PubMed ID: 9463369
PubMed ID: 10612665
Title: Epstein-barr virus nuclear antigen-1 binds to nuclear transporter karyopherin alpha1/NPI-1 in addition to karyopherin alpha2/Rch1.
PubMed ID: 10612665
PubMed ID: 12610148
Title: A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.
PubMed ID: 12610148
PubMed ID: 15942031
Title: Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).
PubMed ID: 15942031
DOI: 10.1093/nar/gki641
PubMed ID: 16698996
Title: Ebola virus VP24 binds karyopherin alpha-1 and blocks STAT1 nuclear accumulation.
PubMed ID: 16698996
DOI: 10.1128/jvi.02349-05
PubMed ID: 17652399
Title: Nuclear import and export of Venezuelan equine encephalitis virus nonstructural protein 2.
PubMed ID: 17652399
DOI: 10.1128/jvi.00371-07
PubMed ID: 17928350
Title: Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.
PubMed ID: 17928350
DOI: 10.1128/jvi.01097-07
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19118899
Title: Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.
PubMed ID: 19118899
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21454664
Title: Importin alpha protein acts as a negative regulator for Snail protein nuclear import.
PubMed ID: 21454664
PubMed ID: 21385873
Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.
PubMed ID: 21385873
PubMed ID: 22500989
Title: Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).
PubMed ID: 22500989
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27713473
Title: Identification of the nuclear localisation signal of O-GlcNAc transferase and its nuclear import regulation.
PubMed ID: 27713473
DOI: 10.1038/srep34614
PubMed ID: 28552616
Title: Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
PubMed ID: 28552616
PubMed ID: 29599122
Title: Intersectin goes nuclear: secret life of an endocytic protein.
PubMed ID: 29599122
DOI: 10.1042/bcj20170897
PubMed ID: 30576860
Title: Nucleocytoplasmic shuttling of the human parainfluenza virus type 2 phosphoprotein.
PubMed ID: 30576860
PubMed ID: 35446349
Title: Tumor suppressor BAP1 nuclear import is governed by transportin-1.
PubMed ID: 35446349
Sequence Information:
- Length: 538
- Mass: 60222
- Checksum: E8407A3352D6051C
- Sequence:
MTTPGKENFR LKSYKNKSLN PDEMRRRREE EGLQLRKQKR EEQLFKRRNV ATAEEETEEE VMSDGGFHEA QISNMEMAPG GVITSDMIEM IFSKSPEQQL SATQKFRKLL SKEPNPPIDE VISTPGVVAR FVEFLKRKEN CTLQFESAWV LTNIASGNSL QTRIVIQAGA VPIFIELLSS EFEDVQEQAV WALGNIAGDS TMCRDYVLDC NILPPLLQLF SKQNRLTMTR NAVWALSNLC RGKSPPPEFA KVSPCLNVLS WLLFVSDTDV LADACWALSY LSDGPNDKIQ AVIDAGVCRR LVELLMHNDY KVVSPALRAV GNIVTGDDIQ TQVILNCSAL QSLLHLLSSP KESIKKEACW TISNITAGNR AQIQTVIDAN IFPALISILQ TAEFRTRKEA AWAITNATSG GSAEQIKYLV ELGCIKPLCD LLTVMDSKIV QVALNGLENI LRLGEQEAKR NGTGINPYCA LIEEAYGLDK IEFLQSHENQ EIYQKAFDLI EHYFGTEDED SSIAPQVDLN QQQYIFQQCE APMEGFQL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.