Details for: KRT9

Gene ID: 3857

Symbol: KRT9

Ensembl ID: ENSG00000171403

Description: keratin 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.52
    Marker Score: 4340
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2207.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1211
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7686.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1461
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 496
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1197
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 696
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 533
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 381
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 231
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3
    Marker Score: 566
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.25
    Marker Score: 500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.19
    Marker Score: 169
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.19
    Marker Score: 2957
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.13
    Marker Score: 218
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.13
    Marker Score: 140.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 796
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.12
    Marker Score: 241
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.09
    Marker Score: 130
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 27.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 61
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 60
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.03
    Marker Score: 218.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 86.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.03
    Marker Score: 152
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.03
    Marker Score: 116
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.03
    Marker Score: 46.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 24.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 46
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 132
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.01
    Marker Score: 60
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 40
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 35
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.01
    Marker Score: 72
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.01
    Marker Score: 44

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Other Information

**Key characteristics:** * Gene name: KRT9 * Ensembl ID: ENSG00000171403 * Protein: K1C9_HUMAN (Keratin, type I cytoskeletal 9) * Function: Provides structural support and elasticity to the skin, hair, and nails. * Expression: Highly expressed in skin, hair, and nails * Pathway/Ontology: Cytoskeleton, cytosol, developmental biology, epidermis development, epithelial cell differentiation, extracellular exosome, extracellular space, formation of the cornified envelope, intermediate filament organization, keratin filament, keratinization, membrane, nucleus, skin development, spermatogenesis **Pathways and functions:** * The KRT9 gene is involved in various cellular processes, including cell adhesion, migration, and differentiation. * It is a key component of the intermediate filament network, which is responsible for providing structural support and elasticity to the skin. * The intermediate filament network is a complex network of protein filaments that connects the cytoskeleton to the extracellular matrix. * Keratin 9 is a major component of the intermediate filament network, and its mutations can lead to a variety of skin disorders, such as psoriasis and eczema. **Clinical significance:** * Mutations in the KRT9 gene have been linked to a number of skin conditions, including psoriasis, eczema, and acne. * These mutations can also lead to other health problems, such as cancer and heart disease. * Targeting the KRT9 gene is a promising new therapy for a variety of skin disorders.

Genular Protein ID: 242928717

Symbol: K1C9_HUMAN

Name: Keratin, type I cytoskeletal 9

UniProtKB Accession Codes:

P35527 O00109 Q0IJ47 Q14665

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 5 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7507869

Title: Molecular characterization of the body site-specific human epidermal cytokeratin 9: cDNA cloning, amino acid sequence, and tissue specificity of gene expression.

PubMed ID: 7507869

DOI: 10.1111/j.1432-0436.1993.tb00033.x

PubMed ID: 7512862

Title: Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK).

PubMed ID: 7512862

DOI: 10.1038/ng0294-174

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 8647270

Title: Keratin 9 point mutation in the pedigree of epidermolytic hereditary palmoplantar keratoderma perturbs keratin intermediate filament network formation.

PubMed ID: 8647270

DOI: 10.1016/0014-5793(96)00393-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2140676

Title: Human placenta contains an epithelial scatter protein.

PubMed ID: 2140676

DOI: 10.1016/0006-291x(90)91140-n

PubMed ID: 10218578

Title: Demonstration of the pathogenic effect of point mutated keratin 9 in vivo.

PubMed ID: 10218578

DOI: 10.1016/s0014-5793(99)00233-1

PubMed ID: 10201533

Title: Regulation of keratin 9 in nonpalmoplantar keratinocytes by palmoplantar fibroblasts through epithelial-mesenchymal interactions.

PubMed ID: 10201533

DOI: 10.1046/j.1523-1747.1999.00544.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 7516304

Title: Keratin 9 gene mutational heterogeneity in patients with epidermolytic palmoplantar keratoderma.

PubMed ID: 7516304

DOI: 10.1007/bf00201564

PubMed ID: 7523529

Title: Mutations of keratin 9 in two families with palmoplantar epidermolytic hyperkeratosis.

PubMed ID: 7523529

DOI: 10.1111/1523-1747.ep12395570

PubMed ID: 7511021

Title: Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancer.

PubMed ID: 7511021

DOI: 10.1038/ng0194-106

PubMed ID: 7532199

Title: Mutations in the 1A domain of keratin 9 in patients with epidermolytic palmoplantar keratoderma.

PubMed ID: 7532199

DOI: 10.1111/1523-1747.ep12666018

PubMed ID: 9204965

Title: A novel mutation of a leucine residue in coil 1A of keratin 9 in epidermolytic palmoplantar keratoderma.

PubMed ID: 9204965

DOI: 10.1111/1523-1747.ep12276751

PubMed ID: 9856842

Title: Mutations in keratin K9 in kindreds with epidermolytic palmoplantar keratoderma and epidemiology in Northern Ireland.

PubMed ID: 9856842

DOI: 10.1046/j.1523-1747.1998.00445.x

PubMed ID: 10632938

Title: Keratin 9 mutations in the coil 1A region in epidermolytic palmoplantar keratoderma.

PubMed ID: 10632938

DOI: 10.1046/j.1525-1470.1999.00111.x

PubMed ID: 10844507

Title: Epidermolytic palmoplantar keratoderma in a Hispanic kindred resulting from a mutation in the keratin 9 gene.

PubMed ID: 10844507

DOI: 10.1046/j.1365-2230.2000.00626.x

PubMed ID: 12192490

Title: Epidermolytic palmoplantar keratoderma of Vorner: re-evaluation of Vorner's original family and identification of a novel keratin 9 mutation.

PubMed ID: 12192490

DOI: 10.1007/s00403-002-0328-9

PubMed ID: 12072061

Title: Diagnosis and confirmation of epidermolytic palmoplantar keratoderma by the identification of mutations in keratin 9 using denaturing high-performance liquid chromatography.

PubMed ID: 12072061

DOI: 10.1046/j.1365-2133.2002.04764.x

PubMed ID: 12926810

Title: Novel N160I mutation of keratin 9 in a large pedigree from Hungary with epidermolytic palmoplantar keratoderma.

PubMed ID: 12926810

DOI: 10.1080/00015550310016652

PubMed ID: 12838553

Title: A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads.

PubMed ID: 12838553

DOI: 10.1002/ajmg.a.20090

PubMed ID: 14675368

Title: Keratin 9 gene mutations in five Korean families with epidermolytic palmoplantar keratoderma.

PubMed ID: 14675368

DOI: 10.1111/j.0906-6705.2003.00012.x

PubMed ID: 15099359

Title: A novel mutation of keratin 9 in a large Chinese family with epidermolytic palmoplantar keratoderma.

PubMed ID: 15099359

DOI: 10.1111/j.0007-0963.2004.05865.x

PubMed ID: 15115518

Title: A novel keratin 9 gene mutation (Asn160His) in a Taiwanese family with epidermolytic palmoplantar keratoderma.

PubMed ID: 15115518

DOI: 10.1111/j.1365-2230.2004.01497.x

PubMed ID: 15605275

Title: A novel mutation of keratin 9 gene (R162P) in a Japanese family with epidermolytic palmoplantar keratoderma.

PubMed ID: 15605275

DOI: 10.1007/s00403-004-0534-8

PubMed ID: 16911293

Title: L457F missense mutation within the 2B rod domain of keratin 9 in a Japanese family with epidermolytic palmoplantar keratoderma.

PubMed ID: 16911293

DOI: 10.1111/j.1365-2133.2006.07358.x

PubMed ID: 16961539

Title: A novel keratin 9 gene mutation (Met156Arg) in a Japanese patient with epidermolytic palmoplantar keratoderma.

PubMed ID: 16961539

DOI: 10.1111/j.1365-4632.2006.02910.x

PubMed ID: 19874353

Title: Mutations in the keratin 9 gene in Pakistani families with epidermolytic palmoplantar keratoderma.

PubMed ID: 19874353

DOI: 10.1111/j.1365-2230.2009.03700.x

PubMed ID: 20964665

Title: A novel mutation of the keratin 9 gene in a Chinese family with epidermolytic palmoplantar keratoderma.

PubMed ID: 20964665

DOI: 10.1111/j.1365-4632.2009.04295.x

PubMed ID: 21715251

Title: A novel mutation within the 2B rod domain of keratin 9 in a Chinese pedigree with epidermolytic palmoplantar keratoderma combined with knuckle pads and camptodactyly.

PubMed ID: 21715251

DOI: 10.1684/ejd.2011.1458

Sequence Information:

  • Length: 623
  • Mass: 62064
  • Checksum: 45C833749B63873D
  • Sequence:
    • MSCRQFSSSY LSRSGGGGGG GLGSGGSIRS SYSRFSSSGG GGGGGRFSSS SGYGGGSSRV 
CGRGGGGSFG YSYGGGSGGG FSASSLGGGF GGGSRGFGGA SGGGYSSSGG FGGGFGGGSG 
GGFGGGYGSG FGGFGGFGGG AGGGDGGILT ANEKSTMQEL NSRLASYLDK VQALEEANND 
LENKIQDWYD KKGPAAIQKN YSPYYNTIDD LKDQIVDLTV GNNKTLLDID NTRMTLDDFR 
IKFEMEQNLR QGVDADINGL RQVLDNLTME KSDLEMQYET LQEELMALKK NHKEEMSQLT 
GQNSGDVNVE INVAPGKDLT KTLNDMRQEY EQLIAKNRKD IENQYETQIT QIEHEVSSSG 
QEVQSSAKEV TQLRHGVQEL EIELQSQLSK KAALEKSLED TKNRYCGQLQ MIQEQISNLE 
AQITDVRQEI ECQNQEYSLL LSIKMRLEKE IETYHNLLEG GQEDFESSGA GKIGLGGRGG 
SGGSYGRGSR GGSGGSYGGG GSGGGYGGGS GSRGGSGGSY GGGSGSGGGS GGGYGGGSGG 
GHSGGSGGGH SGGSGGNYGG GSGSGGGSGG GYGGGSGSRG GSGGSHGGGS GFGGESGGSY 
GGGEEASGSG GGYGGGSGKS SHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.