Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 322.9286
Cell Significance Index: -50.2300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 166.0205
Cell Significance Index: -42.1100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 122.2728
Cell Significance Index: -50.3700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 108.5766
Cell Significance Index: -44.1100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 79.7589
Cell Significance Index: -53.5200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 46.0438
Cell Significance Index: -43.9600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.8044
Cell Significance Index: -50.3100 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 23.2890
Cell Significance Index: 143.3300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.9965
Cell Significance Index: -48.2100 - Cell Name: salivary gland glandular cell (CL1001596)
Fold Change: 15.5622
Cell Significance Index: 86.6200 - Cell Name: peg cell (CL4033014)
Fold Change: 13.2357
Cell Significance Index: 305.7900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 11.8046
Cell Significance Index: 108.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 10.1444
Cell Significance Index: 756.0500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 10.0717
Cell Significance Index: 469.5900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 9.7975
Cell Significance Index: 266.6800 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 8.9431
Cell Significance Index: 43.5000 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 7.0515
Cell Significance Index: 27.0000 - Cell Name: lactocyte (CL0002325)
Fold Change: 6.6182
Cell Significance Index: 855.0300 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 5.7361
Cell Significance Index: 119.6300 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 5.5502
Cell Significance Index: 55.9900 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 5.3770
Cell Significance Index: 33.4100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 5.1556
Cell Significance Index: 267.8200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 5.0195
Cell Significance Index: 2741.2700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 4.7437
Cell Significance Index: 71.0800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.4066
Cell Significance Index: 794.3700 - Cell Name: kidney cell (CL1000497)
Fold Change: 4.2277
Cell Significance Index: 33.7600 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 4.1510
Cell Significance Index: 25.6900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.9017
Cell Significance Index: 479.7500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.8335
Cell Significance Index: 102.3600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 3.7107
Cell Significance Index: 367.0700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.1724
Cell Significance Index: 149.1000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.6899
Cell Significance Index: 70.7300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.5243
Cell Significance Index: 72.7300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.3956
Cell Significance Index: 108.5900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.9876
Cell Significance Index: 323.2700 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 1.8493
Cell Significance Index: 6.9700 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.6537
Cell Significance Index: 14.2100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5716
Cell Significance Index: 311.8900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.4959
Cell Significance Index: 255.4400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.3373
Cell Significance Index: 20.6900 - Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1.2873
Cell Significance Index: 0.9200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1452
Cell Significance Index: 68.7500 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.8977
Cell Significance Index: 9.2900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8623
Cell Significance Index: 164.1000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7275
Cell Significance Index: 79.1400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.7016
Cell Significance Index: 7.9700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.6892
Cell Significance Index: 22.0800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.6288
Cell Significance Index: 475.9700 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.2139
Cell Significance Index: 1.8500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1790
Cell Significance Index: 20.4300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1310
Cell Significance Index: 3.6600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.1214
Cell Significance Index: 0.9900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1175
Cell Significance Index: 0.7100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1036
Cell Significance Index: 75.9400 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.0536
Cell Significance Index: 0.6900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0327
Cell Significance Index: 4.1900 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.0232
Cell Significance Index: 0.2200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0192
Cell Significance Index: 8.5100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0024
Cell Significance Index: -1.8100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0254
Cell Significance Index: -47.8000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0257
Cell Significance Index: -1.3000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0302
Cell Significance Index: -55.7300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0358
Cell Significance Index: -1.4700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0362
Cell Significance Index: -10.4200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0362
Cell Significance Index: -55.8000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0414
Cell Significance Index: -25.8800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0418
Cell Significance Index: -4.2700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0443
Cell Significance Index: -5.0700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0446
Cell Significance Index: -28.3000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0523
Cell Significance Index: -29.4900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0704
Cell Significance Index: -1.7600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0737
Cell Significance Index: -15.5300 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: -0.0893
Cell Significance Index: -0.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0962
Cell Significance Index: -13.9800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1092
Cell Significance Index: -15.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1133
Cell Significance Index: -51.4400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1239
Cell Significance Index: -1.6900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1397
Cell Significance Index: -50.0900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1431
Cell Significance Index: -3.1000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1682
Cell Significance Index: -11.6400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1692
Cell Significance Index: -2.9900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2033
Cell Significance Index: -3.4300 - Cell Name: secretory cell (CL0000151)
Fold Change: -0.2250
Cell Significance Index: -1.5600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2326
Cell Significance Index: -27.1100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2549
Cell Significance Index: -51.1400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2763
Cell Significance Index: -19.5400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2973
Cell Significance Index: -23.5500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3505
Cell Significance Index: -12.1800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3781
Cell Significance Index: -19.7000 - Cell Name: tracheal goblet cell (CL1000329)
Fold Change: -0.4041
Cell Significance Index: -3.3400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4120
Cell Significance Index: -6.9000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.4584
Cell Significance Index: -4.7500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4601
Cell Significance Index: -54.2600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4878
Cell Significance Index: -50.7900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5359
Cell Significance Index: -7.9100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5510
Cell Significance Index: -16.2300 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.5565
Cell Significance Index: -5.8700 - Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
Fold Change: -0.5751
Cell Significance Index: -3.8400 - Cell Name: colon endothelial cell (CL1001572)
Fold Change: -0.6027
Cell Significance Index: -0.4600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.6075
Cell Significance Index: -21.3500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1301449574
Symbol: K1C18_HUMAN
Name: Keratin, type I cytoskeletal 18
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2434380
Title: Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation.
PubMed ID: 2434380
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2454392
Title: Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells.
PubMed ID: 2454392
PubMed ID: 2434381
Title: Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ.
PubMed ID: 2434381
PubMed ID: 2422083
Title: Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone.
PubMed ID: 2422083
PubMed ID: 9150948
Title: A two-dimensional gel database of human colon carcinoma proteins.
PubMed ID: 9150948
PubMed ID: 1371281
Title: Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18.
PubMed ID: 1371281
PubMed ID: 7523419
Title: Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.
PubMed ID: 7523419
PubMed ID: 7538124
Title: Identification and mutational analysis of the glycosylation sites of human keratin 18.
PubMed ID: 7538124
PubMed ID: 8522591
Title: Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant.
PubMed ID: 8522591
PubMed ID: 8609167
Title: 14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor.
PubMed ID: 8609167
PubMed ID: 9298992
Title: Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.
PubMed ID: 9298992
PubMed ID: 9524113
Title: Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.
PubMed ID: 9524113
PubMed ID: 10809736
Title: Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.
PubMed ID: 10809736
PubMed ID: 10954706
Title: Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein.
PubMed ID: 10954706
PubMed ID: 10852826
Title: Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.
PubMed ID: 10852826
PubMed ID: 11684708
Title: Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD.
PubMed ID: 11684708
PubMed ID: 14756564
Title: Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.
PubMed ID: 14756564
DOI: 10.1021/bi035072s
PubMed ID: 15368451
Title: Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.
PubMed ID: 15368451
DOI: 10.1002/hep.20277
PubMed ID: 15529338
Title: Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane.
PubMed ID: 15529338
PubMed ID: 15731013
Title: Identification of trichoplein, a novel keratin filament-binding protein.
PubMed ID: 15731013
DOI: 10.1242/jcs.01667
PubMed ID: 15846844
Title: Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.
PubMed ID: 15846844
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16424149
Title: Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.
PubMed ID: 16424149
PubMed ID: 17213200
Title: Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations.
PubMed ID: 17213200
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20729549
Title: O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.
PubMed ID: 20729549
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22002106
Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.
PubMed ID: 22002106
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23902688
Title: A novel mechanism of keratin cytoskeleton organization through casein kinase Ialpha and FAM83H in colorectal cancer.
PubMed ID: 23902688
DOI: 10.1242/jcs.129684
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24940650
Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.
PubMed ID: 24940650
DOI: 10.1038/jid.2014.255
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 9011570
Title: Mutation of human keratin 18 in association with cryptogenic cirrhosis.
PubMed ID: 9011570
DOI: 10.1172/jci119127
PubMed ID: 12724528
Title: Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.
PubMed ID: 12724528
Sequence Information:
- Length: 430
- Mass: 48058
- Checksum: 1E5604C6BCC7A17A
- Sequence:
MSFTTRSTFS TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR STSFRGGMGS GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS LETENRRLES KIREHLEKKG PQVRDWSHYF KIIEDLRAQI FANTVDNARI VLQIDNARLA ADDFRVKYET ELAMRQSVEN DIHGLRKVID DTNITRLQLE TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP KSQDLAKIMA DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA QTRAEGQRQA QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN SMQTIQKTTT RRIVDGKVVS ETNDTKVLRH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.