Details for: KRT18

Gene ID: 3875

Symbol: KRT18

Ensembl ID: ENSG00000111057

Description: keratin 18

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.29
    Marker Score: 5173
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.25
    Marker Score: 3330
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.18
    Marker Score: 26643
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 4.03
    Marker Score: 12659
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.92
    Marker Score: 3753
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.9
    Marker Score: 1246
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.8
    Marker Score: 28286.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.8
    Marker Score: 9269.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.7
    Marker Score: 19458
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.62
    Marker Score: 8240
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.61
    Marker Score: 1158
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.56
    Marker Score: 17086
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.5
    Marker Score: 5567
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.48
    Marker Score: 13407
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.4
    Marker Score: 7713
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.37
    Marker Score: 8507
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.32
    Marker Score: 2614
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.23
    Marker Score: 111833
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.15
    Marker Score: 2807
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.12
    Marker Score: 1540
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.03
    Marker Score: 26358
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.91
    Marker Score: 1160
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.9
    Marker Score: 5292
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.86
    Marker Score: 1668
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.86
    Marker Score: 4747
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.84
    Marker Score: 1326
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.78
    Marker Score: 4468
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.76
    Marker Score: 4899
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.74
    Marker Score: 6501
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.72
    Marker Score: 7406
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.68
    Marker Score: 17466
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.66
    Marker Score: 4100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.64
    Marker Score: 838
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.63
    Marker Score: 3069
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.62
    Marker Score: 9310
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.62
    Marker Score: 929.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.61
    Marker Score: 971
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6
    Marker Score: 2740
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.59
    Marker Score: 3669
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.59
    Marker Score: 1084
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.58
    Marker Score: 3794
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.56
    Marker Score: 1712
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.53
    Marker Score: 25439
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.51
    Marker Score: 867
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.34
    Marker Score: 9208
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.34
    Marker Score: 674.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.32
    Marker Score: 19997
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.28
    Marker Score: 1023
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.22
    Marker Score: 1921
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.2
    Marker Score: 1242
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.17
    Marker Score: 2253
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.16
    Marker Score: 1192
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.16
    Marker Score: 3546
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.14
    Marker Score: 4063
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.14
    Marker Score: 617
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.11
    Marker Score: 2230
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.1
    Marker Score: 791.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.06
    Marker Score: 4339
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.05
    Marker Score: 676
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.02
    Marker Score: 2011
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.01
    Marker Score: 1036
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2
    Marker Score: 1336.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2
    Marker Score: 15597
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2
    Marker Score: 482
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.99
    Marker Score: 1356
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.99
    Marker Score: 5325
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.98
    Marker Score: 1057
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.95
    Marker Score: 6704
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.94
    Marker Score: 7191
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.92
    Marker Score: 376
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.92
    Marker Score: 1573
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.82
    Marker Score: 451
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.79
    Marker Score: 654.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.79
    Marker Score: 2312
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.79
    Marker Score: 28723
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.73
    Marker Score: 405
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.69
    Marker Score: 1189
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.69
    Marker Score: 429
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.68
    Marker Score: 338.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.68
    Marker Score: 923
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.61
    Marker Score: 647
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.59
    Marker Score: 1104
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.58
    Marker Score: 1318
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.56
    Marker Score: 352
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.51
    Marker Score: 929
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.49
    Marker Score: 1582
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.48
    Marker Score: 3082
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.46
    Marker Score: 757
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.4
    Marker Score: 1425
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.4
    Marker Score: 666.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.4
    Marker Score: 1321
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.33
    Marker Score: 1418
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.33
    Marker Score: 363.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.32
    Marker Score: 533
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.32
    Marker Score: 5486
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.31
    Marker Score: 375
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.31
    Marker Score: 317
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.28
    Marker Score: 556
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.27
    Marker Score: 336
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.26
    Marker Score: 16597

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Other Information

**Key characteristics:** - Keratin 18 is a transmembrane protein with a molecular weight of approximately 350 kDa. - It is a key component of the intermediate filament cytoskeleton, which provides structural support and elasticity to various tissues. - Keratin 18 is also involved in cell adhesion, cell cycle regulation, apoptosis, and tissue morphogenesis. **Pathways and functions:** - **Anatomical structure and morphogenesis:** Keratin 18 is essential for the structural integrity of epithelial tissues, where it helps to maintain the integrity of cell-cell junctions and the overall integrity of the tissue. - **Cell-cell adhesion:** It plays a crucial role in cell adhesion, facilitating cell-cell interactions and tissue morphogenesis. - **Cell cycle regulation:** Keratin 18 is involved in cell cycle regulation by interacting with cyclin-dependent kinase inhibitors (CDKIs), thereby regulating the progression of cells through the cell cycle. - **Apoptosis:** Keratin 18 is a key regulator of apoptosis, where it acts as a pro-apoptotic protein. It can directly activate caspases and promote apoptosis in various cell types. - **Formation of the cornified envelope:** Keratin 18 is a component of the cornified envelope, a specialized layer that surrounds and protects epithelial cells in stratified squamous epithelia. - **Golgi to plasma membrane protein transport:** It is involved in the transport of proteins between the Golgi apparatus and the plasma membrane. - **Hepatocyte apoptotic process:** Keratin 18 is expressed in hepatocytes and plays a role in the regulation of hepatocyte apoptosis. - **Intermediate filament cytoskeleton organization:** It is a key component of the intermediate filament cytoskeleton, which provides structural support and elasticity to epithelial tissues. - **Keratinization:** Keratin 18 is involved in keratinization, a process that involves the formation of a protective barrier on the surface of epithelial cells. - **Negative regulation of apoptotic process:** Keratin 18 can act as a negative regulator of apoptosis by binding to and inhibiting the pro-apoptotic protein Bax. - **Nucleolus:** It is expressed in the nucleus and is involved in the regulation of gene expression. - **Protein binding:** Keratin 18 can bind to various proteins, including cadherins, integrins, and other cytoskeletal proteins. **Clinical significance:** - Mutations in the KRT18 gene have been linked to several human diseases, including epithelial cancers, skin disorders, and developmental abnormalities. - Targeting KRT18 has emerged as a potential therapeutic strategy for these diseases.

Genular Protein ID: 1301449574

Symbol: K1C18_HUMAN

Name: Keratin, type I cytoskeletal 18

UniProtKB Accession Codes:

P05783 Q53G38 Q5U0N8 Q9BW26

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2434380

Title: Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation.

PubMed ID: 2434380

DOI: 10.1111/j.1432-0436.1986.tb00411.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2454392

Title: Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells.

PubMed ID: 2454392

DOI: 10.1128/mcb.8.4.1540-1550.1988

PubMed ID: 2434381

Title: Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ.

PubMed ID: 2434381

DOI: 10.1111/j.1432-0436.1986.tb00412.x

PubMed ID: 2422083

Title: Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone.

PubMed ID: 2422083

DOI: 10.1111/j.1432-0436.1986.tb00787.x

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 1371281

Title: Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18.

PubMed ID: 1371281

DOI: 10.1016/s0021-9258(19)50611-1

PubMed ID: 7523419

Title: Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.

PubMed ID: 7523419

DOI: 10.1083/jcb.127.1.161

PubMed ID: 7538124

Title: Identification and mutational analysis of the glycosylation sites of human keratin 18.

PubMed ID: 7538124

DOI: 10.1074/jbc.270.20.11820

PubMed ID: 8522591

Title: Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant.

PubMed ID: 8522591

DOI: 10.1083/jcb.131.5.1303

PubMed ID: 8609167

Title: 14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor.

PubMed ID: 8609167

DOI: 10.1083/jcb.133.2.345

PubMed ID: 9298992

Title: Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.

PubMed ID: 9298992

DOI: 10.1083/jcb.138.6.1379

PubMed ID: 9524113

Title: Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.

PubMed ID: 9524113

DOI: 10.1093/emboj/17.7.1892

PubMed ID: 10809736

Title: Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.

PubMed ID: 10809736

DOI: 10.1074/jbc.275.20.14910

PubMed ID: 10954706

Title: Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein.

PubMed ID: 10954706

DOI: 10.1074/jbc.m003492200

PubMed ID: 10852826

Title: Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.

PubMed ID: 10852826

DOI: 10.1242/jcs.113.13.2471

PubMed ID: 11684708

Title: Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD.

PubMed ID: 11684708

DOI: 10.1083/jcb.200103078

PubMed ID: 14756564

Title: Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.

PubMed ID: 14756564

DOI: 10.1021/bi035072s

PubMed ID: 15368451

Title: Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.

PubMed ID: 15368451

DOI: 10.1002/hep.20277

PubMed ID: 15529338

Title: Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane.

PubMed ID: 15529338

DOI: 10.1002/pmic.200400850

PubMed ID: 15731013

Title: Identification of trichoplein, a novel keratin filament-binding protein.

PubMed ID: 15731013

DOI: 10.1242/jcs.01667

PubMed ID: 15846844

Title: Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.

PubMed ID: 15846844

DOI: 10.1002/pmic.200401093

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16424149

Title: Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.

PubMed ID: 16424149

DOI: 10.1124/jpet.105.097667

PubMed ID: 17213200

Title: Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations.

PubMed ID: 17213200

DOI: 10.1074/jbc.m604068200

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20729549

Title: O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18.

PubMed ID: 20729549

DOI: 10.1074/jbc.m109.098996

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23902688

Title: A novel mechanism of keratin cytoskeleton organization through casein kinase Ialpha and FAM83H in colorectal cancer.

PubMed ID: 23902688

DOI: 10.1242/jcs.129684

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9011570

Title: Mutation of human keratin 18 in association with cryptogenic cirrhosis.

PubMed ID: 9011570

DOI: 10.1172/jci119127

PubMed ID: 12724528

Title: Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.

PubMed ID: 12724528

DOI: 10.1073/pnas.0936165100

Sequence Information:

  • Length: 430
  • Mass: 48058
  • Checksum: 1E5604C6BCC7A17A
  • Sequence:
    • MSFTTRSTFS TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR STSFRGGMGS 
GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS LETENRRLES KIREHLEKKG 
PQVRDWSHYF KIIEDLRAQI FANTVDNARI VLQIDNARLA ADDFRVKYET ELAMRQSVEN 
DIHGLRKVID DTNITRLQLE TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP 
KSQDLAKIMA DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR 
RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA QTRAEGQRQA 
QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN SMQTIQKTTT RRIVDGKVVS 
ETNDTKVLRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.