Details for: KRT32

Gene ID: 3882

Symbol: KRT32

Ensembl ID: ENSG00000108759

Description: keratin 32

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8272
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6838
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.4
    Marker Score: 2412
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2224
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1191
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.92
    Marker Score: 508
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1432
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 496
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1198
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 522
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.59
    Marker Score: 389
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.59
    Marker Score: 9192
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 742
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 382
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.42
    Marker Score: 686
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 236
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.33
    Marker Score: 474.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.32
    Marker Score: 304.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 158
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 474
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.24
    Marker Score: 330
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.23
    Marker Score: 465
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.21
    Marker Score: 113
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2
    Marker Score: 416
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.18
    Marker Score: 326
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.18
    Marker Score: 153
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.17
    Marker Score: 176
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 91
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.14
    Marker Score: 892
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.14
    Marker Score: 813
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.13
    Marker Score: 56
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.13
    Marker Score: 1080
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.12
    Marker Score: 968
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1
    Marker Score: 110
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.09
    Marker Score: 117
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 27.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.04
    Marker Score: 143
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.03
    Marker Score: 60
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 79
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 89.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.03
    Marker Score: 113
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 115
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 43
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.02
    Marker Score: 32

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Other Information

**Key characteristics:** * Keratin 32 is a transmembrane protein that is expressed in various cell types. * It is a key component of the cornified envelope, a protective barrier that surrounds and protects cells. * It is involved in the formation of the cornified envelope by interacting with other keratin proteins. * It is also involved in the maintenance of cell structure and function. **Pathways and functions:** * KRT32 is involved in the cytoskeleton, cytosol, and epithelial cell differentiation. * It is also involved in the formation of the cornified envelope, the intermediate filament, and the intermediate filament organization. * It is involved in the regulation of cell migration and adhesion. * It is also involved in the formation of the blood-brain barrier. **Clinical significance:** * Mutations in the KRT32 gene have been linked to several human diseases, including autism, schizophrenia, and Alzheimer's disease. * Keratin 32 is a potential therapeutic target for these diseases, as it is involved in the formation of the cornified envelope and the maintenance of cell structure and function. **Additional notes:** * The KRT32 gene is highly expressed in oligodendrocyte precursor cells, which are cells that give rise to the myelin sheath of nerve cells. * Keratin 32 is also expressed in microglial cells, which are cells that are found in the brain and spinal cord. * Mutations in the KRT32 gene have been linked to a number of human diseases, including autism, schizophrenia, and Alzheimer's disease.

Genular Protein ID: 1314273283

Symbol: K1H2_HUMAN

Name: Keratin, type I cuticular Ha2

UniProtKB Accession Codes:

Q14532

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8823373

Title: Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5.

PubMed ID: 8823373

DOI: 10.1111/1523-1747.ep12584243

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 7556444

Title: Sequence data and chromosomal localization of human type I and type II hair keratin genes.

PubMed ID: 7556444

DOI: 10.1006/excr.1995.1326

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 448
  • Mass: 50343
  • Checksum: F223A4F828B7EACB
  • Sequence:
    • MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV CLPTTFRPAS 
CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM QFLNDRLASY LTRVRQLEQE 
NAELESRIQE ASHSQVLTMT PDYQSHFRTI EELQQKILCT KAENARMVVN IDNAKLAADD 
FRAKYEAELA MRQLVEADIN GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS 
LRCQLGDRLN IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT 
SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ LAQMQCMITN 
VEAQLAEIRA DLERQNQEYQ VLLDVRARLE GEINTYRSLL ENEDCKLPCN PCSTPSCTTC 
VPSPCVPRTV CVPRTVGMPC SPCPQGRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.