Details for: KRT32

Gene ID: 3882

Symbol: KRT32

Ensembl ID: ENSG00000108759

Description: keratin 32

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 3.9003
    Cell Significance Index: 4.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.7579
    Cell Significance Index: 19.3100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2734
    Cell Significance Index: 1.8200
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.2318
    Cell Significance Index: 2.0400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1761
    Cell Significance Index: 3.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1757
    Cell Significance Index: 2.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1309
    Cell Significance Index: 57.8900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1112
    Cell Significance Index: 1.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0642
    Cell Significance Index: 0.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0216
    Cell Significance Index: 2.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0162
    Cell Significance Index: 0.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0125
    Cell Significance Index: 0.1700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0116
    Cell Significance Index: 0.1500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0029
    Cell Significance Index: 0.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0009
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0019
    Cell Significance Index: -0.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0025
    Cell Significance Index: -0.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0036
    Cell Significance Index: -0.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0039
    Cell Significance Index: -0.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0039
    Cell Significance Index: -0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0043
    Cell Significance Index: -2.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0066
    Cell Significance Index: -3.7200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0072
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0075
    Cell Significance Index: -1.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0081
    Cell Significance Index: -3.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0088
    Cell Significance Index: -2.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0115
    Cell Significance Index: -2.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0148
    Cell Significance Index: -2.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0165
    Cell Significance Index: -2.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0172
    Cell Significance Index: -2.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0187
    Cell Significance Index: -1.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0187
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0216
    Cell Significance Index: -3.6900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0311
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0320
    Cell Significance Index: -3.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0338
    Cell Significance Index: -0.8400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0375
    Cell Significance Index: -0.4900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0411
    Cell Significance Index: -0.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0426
    Cell Significance Index: -1.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0433
    Cell Significance Index: -2.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0433
    Cell Significance Index: -3.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0436
    Cell Significance Index: -2.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0442
    Cell Significance Index: -1.1800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0472
    Cell Significance Index: -0.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0473
    Cell Significance Index: -0.4900
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0577
    Cell Significance Index: -0.6000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0590
    Cell Significance Index: -0.6300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0603
    Cell Significance Index: -0.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0633
    Cell Significance Index: -2.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0661
    Cell Significance Index: -2.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0683
    Cell Significance Index: -2.4000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0683
    Cell Significance Index: -0.6100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0711
    Cell Significance Index: -0.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0719
    Cell Significance Index: -1.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0731
    Cell Significance Index: -2.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0736
    Cell Significance Index: -2.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0744
    Cell Significance Index: -2.3700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0747
    Cell Significance Index: -1.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0773
    Cell Significance Index: -2.0700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0827
    Cell Significance Index: -0.9400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0832
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0862
    Cell Significance Index: -2.4600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0875
    Cell Significance Index: -1.1800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0906
    Cell Significance Index: -1.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0920
    Cell Significance Index: -2.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0927
    Cell Significance Index: -1.2000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0937
    Cell Significance Index: -1.0200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0994
    Cell Significance Index: -2.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1001
    Cell Significance Index: -2.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1028
    Cell Significance Index: -2.2500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1059
    Cell Significance Index: -1.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1102
    Cell Significance Index: -1.2200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1109
    Cell Significance Index: -1.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1139
    Cell Significance Index: -2.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1167
    Cell Significance Index: -1.2100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1167
    Cell Significance Index: -1.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1192
    Cell Significance Index: -2.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1270
    Cell Significance Index: -2.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1284
    Cell Significance Index: -3.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1292
    Cell Significance Index: -2.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1348
    Cell Significance Index: -3.2900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1375
    Cell Significance Index: -1.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1377
    Cell Significance Index: -2.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1377
    Cell Significance Index: -2.7100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1378
    Cell Significance Index: -1.8600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1405
    Cell Significance Index: -1.6600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1418
    Cell Significance Index: -2.2800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1419
    Cell Significance Index: -1.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1423
    Cell Significance Index: -1.1600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1434
    Cell Significance Index: -1.8200
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1443
    Cell Significance Index: -0.9000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1453
    Cell Significance Index: -2.8400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1458
    Cell Significance Index: -3.0400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1486
    Cell Significance Index: -2.5700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1501
    Cell Significance Index: -1.8000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1507
    Cell Significance Index: -1.5900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1544
    Cell Significance Index: -2.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT32 is a type I keratin, which is distinct from type II keratins like KRT5 and KRT14. Type I keratins are typically associated with the cytoskeleton and are involved in maintaining the structural integrity of cells. In contrast, type II keratins are often linked to cell adhesion and signaling processes. The unique characteristics of KRT32, including its ability to form dimers with other keratins, contribute to its specific functions in epithelial cells. **Pathways and Functions:** KRT32 is involved in several key pathways and processes, including: 1. **Cytoskeleton organization:** KRT32 interacts with other intermediate filaments, such as keratin 14, to form a cytoskeletal network that provides mechanical support and stability to epithelial cells. 2. **Epithelial cell differentiation:** KRT32 plays a critical role in the development and differentiation of epithelial cells, particularly in the formation of the cornified envelope, a complex structure composed of multiple layers of dead cells that provides mechanical strength to the skin. 3. **Extracellular matrix interactions:** KRT32 can interact with extracellular matrix proteins, such as laminin and collagen, to regulate cell adhesion and migration. 4. **Protein binding:** KRT32 can bind to various proteins, including other keratins, intermediate filaments, and signaling molecules, to modulate cellular processes. **Clinical Significance:** Dysregulation or mutations in the KRT32 gene have been associated with various epithelial disorders, including: 1. **Epidermolysis bullosa simplex (EBS):** A genetic disorder characterized by skin blistering and fragility, caused by mutations in the KRT5 and KRT14 genes, which are closely related to KRT32. 2. **Cancer:** Aberrant expression of KRT32 has been observed in various types of cancer, including squamous cell carcinoma and basal cell carcinoma, suggesting its potential as a biomarker or therapeutic target. 3. **Neurological disorders:** KRT32 has been implicated in the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where abnormal keratin expression can contribute to neuronal dysfunction and death. In conclusion, KRT32 is a critical component of the intermediate filament family, essential for maintaining epithelial integrity and function. Its dysregulation can lead to various epithelial disorders, highlighting the importance of further research into the mechanisms of KRT32 and its potential applications in disease diagnosis and therapy.

Genular Protein ID: 1314273283

Symbol: K1H2_HUMAN

Name: Keratin, type I cuticular Ha2

UniProtKB Accession Codes:

Q14532

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8823373

Title: Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5.

PubMed ID: 8823373

DOI: 10.1111/1523-1747.ep12584243

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 7556444

Title: Sequence data and chromosomal localization of human type I and type II hair keratin genes.

PubMed ID: 7556444

DOI: 10.1006/excr.1995.1326

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 448
  • Mass: 50343
  • Checksum: F223A4F828B7EACB
  • Sequence:
    • MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV CLPTTFRPAS 
CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM QFLNDRLASY LTRVRQLEQE 
NAELESRIQE ASHSQVLTMT PDYQSHFRTI EELQQKILCT KAENARMVVN IDNAKLAADD 
FRAKYEAELA MRQLVEADIN GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS 
LRCQLGDRLN IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT 
SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ LAQMQCMITN 
VEAQLAEIRA DLERQNQEYQ VLLDVRARLE GEINTYRSLL ENEDCKLPCN PCSTPSCTTC 
VPSPCVPRTV CVPRTVGMPC SPCPQGRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.