Details for: KRT86

Gene ID: 3892

Symbol: KRT86

Ensembl ID: ENSG00000170442

Description: keratin 86

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.7
    Marker Score: 7459
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.8
    Marker Score: 407
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.76
    Marker Score: 1957
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.41
    Marker Score: 1403
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4816.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.05
    Marker Score: 1985
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251811
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 380
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 392
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.83
    Marker Score: 182
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 603.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10959
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 390
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.58
    Marker Score: 305
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 357
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 261
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 298
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.47
    Marker Score: 1115
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 122
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 194
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.41
    Marker Score: 112
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.39
    Marker Score: 225
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.38
    Marker Score: 159
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 167
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 111
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 299
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.28
    Marker Score: 87
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.28
    Marker Score: 359
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.25
    Marker Score: 207
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.24
    Marker Score: 2052
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.21
    Marker Score: 438
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.2
    Marker Score: 1316
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 111
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.18
    Marker Score: 709
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.18
    Marker Score: 534
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.18
    Marker Score: 228
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.18
    Marker Score: 449
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.17
    Marker Score: 394
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.16
    Marker Score: 193
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 56
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.15
    Marker Score: 109
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.15
    Marker Score: 219
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.15
    Marker Score: 1459
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.14
    Marker Score: 281
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.13
    Marker Score: 117
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.12
    Marker Score: 413
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 204
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.12
    Marker Score: 100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.11
    Marker Score: 149
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 120
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 70
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.11
    Marker Score: 559
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.11
    Marker Score: 174
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 114
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.09
    Marker Score: 459.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.09
    Marker Score: 1487
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.09
    Marker Score: 176
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.09
    Marker Score: 119

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Other Information

**Key characteristics:** - Keratin 86 is a type II keratin, which is a family of keratin proteins that are expressed in the skin, hair, and nails. - It is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in the skin, hair, and nails of humans and other primates. **Pathways and functions:** - KRT86 is involved in the formation of the cornified envelope, which is a protective barrier that covers the surface of cells. - It also plays a role in the intermediate filament organization, which is a network of intermediate filaments that helps to maintain the structural integrity of the skin. - KRT86 is involved in the keratin filament, which is a protein that is responsible for the strength and elasticity of skin. **Clinical significance:** Mutations in the KRT86 gene have been linked to several skin conditions, including ichthyosis vulgaris, psoriasis, and eczema. These conditions are characterized by dry, flaky skin that is red, cracked, and itchy. Treatment with topical corticosteroids can help to relieve symptoms, but there is no cure for these disorders. **Additional information:** - KRT86 is a highly conserved protein, with a similar sequence found in mammals, birds, and reptiles. - It is a transmembrane protein that is expressed in the nucleus, cytoplasm, and cell membrane. - It is a key protein in the assembly of the cornified envelope and the intermediate filament network in the skin.

Genular Protein ID: 4042339349

Symbol: KRT86_HUMAN

Name: Keratin, type II cuticular Hb6

UniProtKB Accession Codes:

O43790 P78387

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9457912

Title: Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.

PubMed ID: 9457912

DOI: 10.1046/j.1523-1747.1998.00097.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9084137

Title: Sequences and differential expression of three novel human type-II hair keratins.

PubMed ID: 9084137

DOI: 10.1046/j.1432-0436.1997.6130187.x

PubMed ID: 9402962

Title: A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.

PubMed ID: 9402962

DOI: 10.1007/s004390050607

PubMed ID: 10469314

Title: Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6.

PubMed ID: 10469314

DOI: 10.1046/j.1523-1747.1999.00685.x

PubMed ID: 10504448

Title: Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype.

PubMed ID: 10504448

DOI: 10.1046/j.1523-1747.1999.00722.x

PubMed ID: 10594761

Title: Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix.

PubMed ID: 10594761

DOI: 10.1046/j.1523-1747.1999.00777.x

PubMed ID: 25557232

Title: Novel KRT83 and KRT86 mutations associated with monilethrix.

PubMed ID: 25557232

DOI: 10.1111/exd.12624

Sequence Information:

  • Length: 486
  • Mass: 53501
  • Checksum: 5ED86FB4CCA62688
  • Sequence:
    • MTCGSYCGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG 
RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF 
IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL 
NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR 
RLYEEEIRVL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK 
CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA 
LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG 
VGSVNVCVSS SRGGVVCGDL CASTTAPVVS TRVSSVPSNS NVVVGTTNAC APSARVGVCG 
GSCKRC

Genular Protein ID: 1372622416

Symbol: A8K872_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K872

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 3 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 486
  • Mass: 53473
  • Checksum: 72FAAD982D5B0A68
  • Sequence:
    • MTCGSYCGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG 
RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF 
IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL 
NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR 
RLYEEEIRVL QSHISDTSVV VKLDNSQDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK 
CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA 
LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG 
VGSVNVCVSS SRGGVVCGDL CASTTAPVVS TRVSSVPSNS NVVVGTTNAC APSARVGVCG 
GSCKRC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.