Details for: KRT86

Gene ID: 3892

Symbol: KRT86

Ensembl ID: ENSG00000170442

Description: keratin 86

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.5086
    Cell Significance Index: 276.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.5553
    Cell Significance Index: 32.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6633
    Cell Significance Index: 75.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1750
    Cell Significance Index: 223.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9236
    Cell Significance Index: 91.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7455
    Cell Significance Index: 673.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5721
    Cell Significance Index: 29.7200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.4721
    Cell Significance Index: 6.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4617
    Cell Significance Index: 75.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4024
    Cell Significance Index: 43.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3308
    Cell Significance Index: 8.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2223
    Cell Significance Index: 4.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2135
    Cell Significance Index: 14.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.1829
    Cell Significance Index: -0.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1329
    Cell Significance Index: 7.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0631
    Cell Significance Index: 2.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0549
    Cell Significance Index: 2.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0343
    Cell Significance Index: 0.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0300
    Cell Significance Index: 0.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0205
    Cell Significance Index: 4.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0134
    Cell Significance Index: 3.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0121
    Cell Significance Index: 2.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0112
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0109
    Cell Significance Index: 1.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0079
    Cell Significance Index: 1.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0062
    Cell Significance Index: 0.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0033
    Cell Significance Index: 1.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0025
    Cell Significance Index: 0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0023
    Cell Significance Index: 0.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0011
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -4.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0036
    Cell Significance Index: -1.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0072
    Cell Significance Index: -5.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0102
    Cell Significance Index: -1.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0112
    Cell Significance Index: -5.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0143
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0259
    Cell Significance Index: -5.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0263
    Cell Significance Index: -1.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0306
    Cell Significance Index: -4.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0331
    Cell Significance Index: -4.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0337
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0349
    Cell Significance Index: -0.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0362
    Cell Significance Index: -3.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0410
    Cell Significance Index: -0.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0445
    Cell Significance Index: -0.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0446
    Cell Significance Index: -3.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0462
    Cell Significance Index: -4.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0488
    Cell Significance Index: -5.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0535
    Cell Significance Index: -3.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0551
    Cell Significance Index: -1.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0587
    Cell Significance Index: -3.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0607
    Cell Significance Index: -2.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0616
    Cell Significance Index: -3.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0652
    Cell Significance Index: -1.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0658
    Cell Significance Index: -5.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0739
    Cell Significance Index: -1.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0870
    Cell Significance Index: -5.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0892
    Cell Significance Index: -2.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0905
    Cell Significance Index: -5.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0933
    Cell Significance Index: -4.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1045
    Cell Significance Index: -3.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1055
    Cell Significance Index: -3.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1108
    Cell Significance Index: -2.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1132
    Cell Significance Index: -1.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1176
    Cell Significance Index: -5.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1320
    Cell Significance Index: -5.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1373
    Cell Significance Index: -5.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1413
    Cell Significance Index: -2.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1430
    Cell Significance Index: -4.0800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1434
    Cell Significance Index: -1.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1500
    Cell Significance Index: -4.0200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1509
    Cell Significance Index: -0.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1523
    Cell Significance Index: -3.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1558
    Cell Significance Index: -5.4200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1566
    Cell Significance Index: -1.8200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1578
    Cell Significance Index: -4.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1611
    Cell Significance Index: -2.7100
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: -0.1634
    Cell Significance Index: -1.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1692
    Cell Significance Index: -4.4500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1700
    Cell Significance Index: -2.0000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1708
    Cell Significance Index: -2.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1722
    Cell Significance Index: -4.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1727
    Cell Significance Index: -1.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1745
    Cell Significance Index: -5.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1774
    Cell Significance Index: -3.8900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1775
    Cell Significance Index: -1.9300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1802
    Cell Significance Index: -2.5600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1864
    Cell Significance Index: -2.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1883
    Cell Significance Index: -4.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT86 is a type II keratin, which distinguishes it from type I keratins that are more abundant in the skin. Type II keratins, such as KRT86, are characterized by their ability to form dimers and interact with other keratin subunits to form a robust filament network. This network provides mechanical strength and resilience to skin cells, particularly during processes like keratinization. KRT86 is also notable for its expression in various cell types, including immune cells, which suggests a broader role in immune regulation. **Pathways and Functions:** KRT86 is involved in several critical pathways, including: 1. **Formation of the Cornified Envelope:** KRT86 plays a crucial role in the formation of the cornified envelope, a specialized structure that provides mechanical strength to the skin. 2. **Intermediate Filament Organization:** KRT86 interacts with other keratin subunits to form a robust filament network, which is essential for maintaining the structural integrity of skin cells. 3. **Keratin Filament:** KRT86 is a component of the keratin filament network, which provides mechanical strength and resilience to skin cells. 4. **Protein Binding:** KRT86 interacts with various proteins, including other keratin subunits, to form dimers and interact with the cytoskeleton. 5. **Developmental Biology:** KRT86 is involved in the development of skin and other tissues, where it plays a crucial role in establishing the proper tissue architecture. **Clinical Significance:** The dysregulation of KRT86 has been implicated in various immune-mediated disorders, including: 1. **Psoriasis:** Abnormal expression of KRT86 has been observed in psoriatic skin, suggesting a role in the development of this chronic skin condition. 2. **Atopic Dermatitis:** KRT86 expression has been found to be altered in atopic dermatitis, a condition characterized by skin inflammation and barrier dysfunction. 3. **Autoimmune Disorders:** KRT86 has been implicated in autoimmune disorders, such as systemic lupus erythematosus (SLE), where it may contribute to the development of skin lesions. In conclusion, KRT86 is a multifunctional protein that plays a critical role in maintaining skin homeostasis and regulating immune responses. Further studies are needed to fully elucidate the mechanisms by which KRT86 contributes to immune-mediated disorders and to explore potential therapeutic strategies for the treatment of these conditions.

Genular Protein ID: 4042339349

Symbol: KRT86_HUMAN

Name: Keratin, type II cuticular Hb6

UniProtKB Accession Codes:

O43790 P78387

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9457912

Title: Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.

PubMed ID: 9457912

DOI: 10.1046/j.1523-1747.1998.00097.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9084137

Title: Sequences and differential expression of three novel human type-II hair keratins.

PubMed ID: 9084137

DOI: 10.1046/j.1432-0436.1997.6130187.x

PubMed ID: 9402962

Title: A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.

PubMed ID: 9402962

DOI: 10.1007/s004390050607

PubMed ID: 10469314

Title: Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6.

PubMed ID: 10469314

DOI: 10.1046/j.1523-1747.1999.00685.x

PubMed ID: 10504448

Title: Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype.

PubMed ID: 10504448

DOI: 10.1046/j.1523-1747.1999.00722.x

PubMed ID: 10594761

Title: Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix.

PubMed ID: 10594761

DOI: 10.1046/j.1523-1747.1999.00777.x

PubMed ID: 25557232

Title: Novel KRT83 and KRT86 mutations associated with monilethrix.

PubMed ID: 25557232

DOI: 10.1111/exd.12624

Sequence Information:

  • Length: 486
  • Mass: 53501
  • Checksum: 5ED86FB4CCA62688
  • Sequence:
    • MTCGSYCGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG 
RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF 
IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL 
NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR 
RLYEEEIRVL QSHISDTSVV VKLDNSRDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK 
CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA 
LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG 
VGSVNVCVSS SRGGVVCGDL CASTTAPVVS TRVSSVPSNS NVVVGTTNAC APSARVGVCG 
GSCKRC

Genular Protein ID: 1372622416

Symbol: A8K872_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K872

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 3 InterPro 4 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 486
  • Mass: 53473
  • Checksum: 72FAAD982D5B0A68
  • Sequence:
    • MTCGSYCGGR AFSCISACGP RPGRCCITAA PYRGISCYRG LTGGFGSHSV CGGFRAGSCG 
RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF 
IDKVRFLEQQ NKLLETKLQF YQNRECCQSN LEPLFEGYIE TLRREAECVE ADSGRLASEL 
NHVQEVLEGY KKKYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANVE ALIQEIDFLR 
RLYEEEIRVL QSHISDTSVV VKLDNSQDLN MDCIIAEIKA QYDDIVTRSR AEAESWYRSK 
CEEMKATVIR HGETLRRTKE EINELNRMIQ RLTAEVENAK CQNSKLEAAV AQSEQQGEAA 
LSDARCKLAE LEGALQKAKQ DMACLIREYQ EVMNSKLGLD IEIATYRRLL EGEEQRLCEG 
VGSVNVCVSS SRGGVVCGDL CASTTAPVVS TRVSSVPSNS NVVVGTTNAC APSARVGVCG 
GSCKRC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.