Details for: LAG3

Gene ID: 3902

Symbol: LAG3

Ensembl ID: ENSG00000089692

Description: lymphocyte activating 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.21
    Marker Score: 1271
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.62
    Marker Score: 5103
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.59
    Marker Score: 15746
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 852
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.2
    Marker Score: 3369
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.1
    Marker Score: 922
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.09
    Marker Score: 1213
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.06
    Marker Score: 1560
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.05
    Marker Score: 341
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.04
    Marker Score: 757
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251781
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 779
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48025
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1
    Marker Score: 226
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.96
    Marker Score: 6160
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5287
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1734
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1785
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5277
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.87
    Marker Score: 479
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.85
    Marker Score: 1224
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.83
    Marker Score: 212
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.79
    Marker Score: 407
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.77
    Marker Score: 237
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1247
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3198
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.73
    Marker Score: 315
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.71
    Marker Score: 1248
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10968
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.69
    Marker Score: 213
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.61
    Marker Score: 994
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.59
    Marker Score: 430
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.59
    Marker Score: 815
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.59
    Marker Score: 1219
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.56
    Marker Score: 799
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 143
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.52
    Marker Score: 348
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 329
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.51
    Marker Score: 454
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.51
    Marker Score: 444
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.47
    Marker Score: 416
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.47
    Marker Score: 369
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.46
    Marker Score: 335
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.46
    Marker Score: 126
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.45
    Marker Score: 384
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 215
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.44
    Marker Score: 182
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.43
    Marker Score: 281
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.42
    Marker Score: 214
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.42
    Marker Score: 258
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.42
    Marker Score: 418
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4
    Marker Score: 154
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.39
    Marker Score: 134
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.38
    Marker Score: 1632
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.38
    Marker Score: 208
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 359
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.36
    Marker Score: 393
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.35
    Marker Score: 95
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.33
    Marker Score: 316
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.33
    Marker Score: 226
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.33
    Marker Score: 320
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.3
    Marker Score: 239
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 131
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 190
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.28
    Marker Score: 139
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.28
    Marker Score: 80
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 164
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.27
    Marker Score: 524
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.27
    Marker Score: 52
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 150
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.26
    Marker Score: 76
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.26
    Marker Score: 316
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.26
    Marker Score: 118
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.25
    Marker Score: 182.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 150
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.25
    Marker Score: 116
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 143
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.24
    Marker Score: 91
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.24
    Marker Score: 52
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.24
    Marker Score: 276
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.23
    Marker Score: 232.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.23
    Marker Score: 48

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Other Information

**Key characteristics:** * LAG3 is a type I transmembrane receptor that belongs to the immunoglobulin superfamily. * It is expressed on the surface of activated T cells, NK cells, and plasma cells. * LAG3 is a critical regulator of the activation of T cells and NK cells. * It interacts with the CD28 protein on T cells and the NK cell receptor NKG2A. * It also interacts with the CD94 and CD92 proteins on B cells, promoting the activation of these cells. **Pathways and functions:** * LAG3 signaling pathway: LAG3 binds to CD28 on T cells and NK cells, leading to the activation of the intracellular signaling pathway. * Negative regulation of immune response: LAG3 signaling inhibits the activation of T cells and NK cells by promoting the production of inhibitory cytokines such as IL-10 and TGF-beta. * Activation of natural killer cells: LAG3 signaling also plays a role in the activation of NK cells. * Regulation of T cell activation: LAG3 signaling negatively regulates the activation of T cells by inhibiting the expression of activation markers and promoting the production of inhibitory cytokines. **Clinical significance:** * LAG3 is a potential therapeutic target for autoimmune diseases, such as lupus and rheumatoid arthritis. * Inhibition of LAG3 signaling has been shown to be effective in blocking T cell activation and reducing inflammation. * Therefore, LAG3 is a promising target for the treatment of autoimmune diseases. **Additional notes:** * LAG3 is a highly conserved protein with expression in various tissues, including the immune system, skin, and brain. * It is expressed at high levels in exhausted and memory T cells, suggesting a role in maintaining immune tolerance. * Studies have shown that polymorphisms in the LAG3 gene are associated with an increased risk of autoimmune diseases.

Genular Protein ID: 2323825220

Symbol: LAG3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18627 A8K7T9 Q7Z643

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 2 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1692078

Title: LAG-3, a novel lymphocyte activation gene closely related to CD4.

PubMed ID: 1692078

DOI: 10.1084/jem.171.5.1393

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1380059

Title: Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.

PubMed ID: 1380059

DOI: 10.1084/jem.176.2.327

PubMed ID: 7805750

Title: Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes.

PubMed ID: 7805750

DOI: 10.1002/eji.1830241246

PubMed ID: 7589152

Title: CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins.

PubMed ID: 7589152

DOI: 10.1002/eji.1830250949

PubMed ID: 8647185

Title: T cell major histocompatibility complex class II molecules down-regulate CD4+ T cell clone responses following LAG-3 binding.

PubMed ID: 8647185

DOI: 10.1002/eji.1830260533

PubMed ID: 9159144

Title: Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.

PubMed ID: 9159144

DOI: 10.1073/pnas.94.11.5744

PubMed ID: 9634475

Title: Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II.

PubMed ID: 9634475

DOI: 10.1007/s002510050411

PubMed ID: 20421648

Title: LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites.

PubMed ID: 20421648

DOI: 10.4049/jimmunol.0903879

PubMed ID: 30580966

Title: Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3.

PubMed ID: 30580966

DOI: 10.1016/j.cell.2018.11.010

Sequence Information:

  • Length: 525
  • Mass: 57449
  • Checksum: 5E0BDEF20E9E36D2
  • Sequence:
    • MWEAQFLGLL FLQPLWVAPV KPLQPGAEVP VVWAQEGAPA QLPCSPTIPL QDLSLLRRAG 
VTWQHQPDSG PPAAAPGHPL APGPHPAAPS SWGPRPRRYT VLSVGPGGLR SGRLPLQPRV 
QLDERGRQRG DFSLWLRPAR RADAGEYRAA VHLRDRALSC RLRLRLGQAS MTASPPGSLR 
ASDWVILNCS FSRPDRPASV HWFRNRGQGR VPVRESPHHH LAESFLFLPQ VSPMDSGPWG 
CILTYRDGFN VSIMYNLTVL GLEPPTPLTV YAGAGSRVGL PCRLPAGVGT RSFLTAKWTP 
PGGGPDLLVT GDNGDFTLRL EDVSQAQAGT YTCHIHLQEQ QLNATVTLAI ITVTPKSFGS 
PGSLGKLLCE VTPVSGQERF VWSSLDTPSQ RSFSGPWLEA QEAQLLSQPW QCQLYQGERL 
LGAAVYFTEL SSPGAQRSGR APGALPAGHL LLFLILGVLS LLLLVTGAFG FHLWRRQWRP 
RRFSALEQGI HPPQAQSKIE ELEQEPEPEP EPEPEPEPEP EPEQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.