Details for: LAG3

Gene ID: 3902

Symbol: LAG3

Ensembl ID: ENSG00000089692

Description: lymphocyte activating 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.4390
    Cell Significance Index: -7.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.8738
    Cell Significance Index: -7.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 15.8857
    Cell Significance Index: -7.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.2533
    Cell Significance Index: -7.7100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.5077
    Cell Significance Index: 54.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9919
    Cell Significance Index: -7.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6088
    Cell Significance Index: 47.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2017
    Cell Significance Index: -2.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7799
    Cell Significance Index: 77.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6466
    Cell Significance Index: 583.8500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5854
    Cell Significance Index: 6.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3803
    Cell Significance Index: 48.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3102
    Cell Significance Index: 50.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2824
    Cell Significance Index: 30.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2679
    Cell Significance Index: 5.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1895
    Cell Significance Index: 36.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1410
    Cell Significance Index: 6.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1409
    Cell Significance Index: 8.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1366
    Cell Significance Index: 9.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0993
    Cell Significance Index: 13.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0357
    Cell Significance Index: 1.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0327
    Cell Significance Index: 14.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0293
    Cell Significance Index: 1.5400
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.0215
    Cell Significance Index: 0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0079
    Cell Significance Index: 1.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0033
    Cell Significance Index: 0.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0024
    Cell Significance Index: 0.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0048
    Cell Significance Index: -0.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0139
    Cell Significance Index: -8.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0183
    Cell Significance Index: -6.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0191
    Cell Significance Index: -8.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0197
    Cell Significance Index: -5.6800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0222
    Cell Significance Index: -0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0236
    Cell Significance Index: -4.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0259
    Cell Significance Index: -1.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0275
    Cell Significance Index: -1.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0295
    Cell Significance Index: -5.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0333
    Cell Significance Index: -1.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0345
    Cell Significance Index: -2.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0414
    Cell Significance Index: -8.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0435
    Cell Significance Index: -7.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0439
    Cell Significance Index: -5.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0486
    Cell Significance Index: -4.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0488
    Cell Significance Index: -6.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0525
    Cell Significance Index: -7.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0577
    Cell Significance Index: -7.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0594
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0619
    Cell Significance Index: -7.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0632
    Cell Significance Index: -7.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0678
    Cell Significance Index: -3.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0689
    Cell Significance Index: -0.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0754
    Cell Significance Index: -7.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0882
    Cell Significance Index: -1.8300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0907
    Cell Significance Index: -0.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0983
    Cell Significance Index: -3.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1053
    Cell Significance Index: -7.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1069
    Cell Significance Index: -2.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1072
    Cell Significance Index: -4.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1139
    Cell Significance Index: -6.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1167
    Cell Significance Index: -7.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1213
    Cell Significance Index: -9.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1231
    Cell Significance Index: -2.0600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1268
    Cell Significance Index: -1.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1309
    Cell Significance Index: -2.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1330
    Cell Significance Index: -4.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1369
    Cell Significance Index: -7.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1386
    Cell Significance Index: -8.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1421
    Cell Significance Index: -9.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1462
    Cell Significance Index: -3.9100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1496
    Cell Significance Index: -2.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1514
    Cell Significance Index: -1.5700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1541
    Cell Significance Index: -2.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1582
    Cell Significance Index: -2.6600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1657
    Cell Significance Index: -1.9800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1696
    Cell Significance Index: -2.4300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1812
    Cell Significance Index: -1.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2016
    Cell Significance Index: -2.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2041
    Cell Significance Index: -7.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2082
    Cell Significance Index: -9.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2083
    Cell Significance Index: -3.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2092
    Cell Significance Index: -7.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2128
    Cell Significance Index: -4.6600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2172
    Cell Significance Index: -5.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2180
    Cell Significance Index: -6.4200
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2194
    Cell Significance Index: -2.2100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2219
    Cell Significance Index: -1.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2236
    Cell Significance Index: -5.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2343
    Cell Significance Index: -7.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LAG3 is a member of the immune checkpoint family, characterized by its ability to modulate immune responses by inhibiting T cell activation and proliferation. The protein is expressed on the surface of various immune cells, including exhausted T cells, mature T cells, and granulocyte-monocyte progenitor cells. LAG3 is known to interact with several ligands, including MHC class II molecules, which are essential for antigen presentation and T cell activation. **Pathways and Functions:** The LAG3 protein is involved in several critical pathways that regulate immune responses, including: 1. **Negative regulation of interleukin-2 (IL-2) production**: LAG3 inhibits the production of IL-2, a cytokine that is essential for T cell proliferation and activation. 2. **Negative regulation of regulatory T cell (Treg) differentiation**: LAG3 promotes the differentiation of Treg cells, which are crucial for maintaining immune tolerance and preventing autoimmune diseases. 3. **Plasmacytoid dendritic cell activation**: LAG3 is expressed on the surface of plasmacytoid dendritic cells, which are responsible for initiating immune responses against pathogens. 4. **Natural killer (NK) cell-mediated cytotoxicity**: LAG3 can modulate NK cell activity, influencing their ability to recognize and eliminate tumor cells. **Clinical Significance:** The dysregulation of LAG3 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: LAG3 has been shown to be overexpressed in patients with autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: LAG3 has been found to be overexpressed in several types of cancer, including lung, breast, and colon cancer, where it can promote immune evasion and tumor growth. 3. **Transplant rejection**: LAG3 has been implicated in the rejection of transplanted organs, where it can inhibit the function of Treg cells and promote immune responses against the graft. In conclusion, LAG3 is a critical regulator of immune homeostasis and tolerance, and its dysregulation has been implicated in various immune-related disorders. Further research is needed to fully understand the mechanisms by which LAG3 regulates immune responses and to develop therapeutic strategies to exploit its immunomodulatory properties. **References:** * [Insert relevant references] Note: This is a hypothetical article, and the references should be replaced with actual references from scientific literature.

Genular Protein ID: 2323825220

Symbol: LAG3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18627 A8K7T9 Q7Z643

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 5 EMDB 2 Ensembl 2 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1692078

Title: LAG-3, a novel lymphocyte activation gene closely related to CD4.

PubMed ID: 1692078

DOI: 10.1084/jem.171.5.1393

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1380059

Title: Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.

PubMed ID: 1380059

DOI: 10.1084/jem.176.2.327

PubMed ID: 7805750

Title: Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes.

PubMed ID: 7805750

DOI: 10.1002/eji.1830241246

PubMed ID: 7589152

Title: CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins.

PubMed ID: 7589152

DOI: 10.1002/eji.1830250949

PubMed ID: 8647185

Title: T cell major histocompatibility complex class II molecules down-regulate CD4+ T cell clone responses following LAG-3 binding.

PubMed ID: 8647185

DOI: 10.1002/eji.1830260533

PubMed ID: 9159144

Title: Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.

PubMed ID: 9159144

DOI: 10.1073/pnas.94.11.5744

PubMed ID: 9634475

Title: Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II.

PubMed ID: 9634475

DOI: 10.1007/s002510050411

PubMed ID: 20421648

Title: LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites.

PubMed ID: 20421648

DOI: 10.4049/jimmunol.0903879

PubMed ID: 30580966

Title: Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3.

PubMed ID: 30580966

DOI: 10.1016/j.cell.2018.11.010

Sequence Information:

  • Length: 525
  • Mass: 57449
  • Checksum: 5E0BDEF20E9E36D2
  • Sequence:
    • MWEAQFLGLL FLQPLWVAPV KPLQPGAEVP VVWAQEGAPA QLPCSPTIPL QDLSLLRRAG 
VTWQHQPDSG PPAAAPGHPL APGPHPAAPS SWGPRPRRYT VLSVGPGGLR SGRLPLQPRV 
QLDERGRQRG DFSLWLRPAR RADAGEYRAA VHLRDRALSC RLRLRLGQAS MTASPPGSLR 
ASDWVILNCS FSRPDRPASV HWFRNRGQGR VPVRESPHHH LAESFLFLPQ VSPMDSGPWG 
CILTYRDGFN VSIMYNLTVL GLEPPTPLTV YAGAGSRVGL PCRLPAGVGT RSFLTAKWTP 
PGGGPDLLVT GDNGDFTLRL EDVSQAQAGT YTCHIHLQEQ QLNATVTLAI ITVTPKSFGS 
PGSLGKLLCE VTPVSGQERF VWSSLDTPSQ RSFSGPWLEA QEAQLLSQPW QCQLYQGERL 
LGAAVYFTEL SSPGAQRSGR APGALPAGHL LLFLILGVLS LLLLVTGAFG FHLWRRQWRP 
RRFSALEQGI HPPQAQSKIE ELEQEPEPEP EPEPEPEPEP EPEQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.