Details for: LAIR1

Gene ID: 3903

Symbol: LAIR1

Ensembl ID: ENSG00000167613

Description: leukocyte associated immunoglobulin like receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.7
    Marker Score: 1904
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.55
    Marker Score: 2915
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.24
    Marker Score: 57258
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.12
    Marker Score: 883
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.98
    Marker Score: 1992
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.97
    Marker Score: 8169
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.89
    Marker Score: 7752
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.68
    Marker Score: 10205.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.65
    Marker Score: 910.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.59
    Marker Score: 1663.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1143
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.51
    Marker Score: 2950.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.37
    Marker Score: 992
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.27
    Marker Score: 1274
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.26
    Marker Score: 70579
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.25
    Marker Score: 3243
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.23
    Marker Score: 832
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2
    Marker Score: 12210
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.2
    Marker Score: 1417.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.16
    Marker Score: 791
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4774.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.13
    Marker Score: 13165
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.11
    Marker Score: 3236
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.07
    Marker Score: 388
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.06
    Marker Score: 431
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251757
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.02
    Marker Score: 356
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71775
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47999
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.99
    Marker Score: 487
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.99
    Marker Score: 6594
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.98
    Marker Score: 245
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.97
    Marker Score: 3053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 392
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.94
    Marker Score: 216
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.92
    Marker Score: 456
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.9
    Marker Score: 569
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.89
    Marker Score: 470
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5078
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.87
    Marker Score: 1517
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5270
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.83
    Marker Score: 1998
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.83
    Marker Score: 738
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.83
    Marker Score: 285
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.8
    Marker Score: 891
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.79
    Marker Score: 598
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.78
    Marker Score: 944
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.78
    Marker Score: 378
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.77
    Marker Score: 2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.77
    Marker Score: 1921.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 678
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.73
    Marker Score: 484
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1152
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.72
    Marker Score: 230
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.72
    Marker Score: 4575
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.71
    Marker Score: 1726
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.7
    Marker Score: 986
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.68
    Marker Score: 448.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 216
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.67
    Marker Score: 985
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.64
    Marker Score: 565
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.64
    Marker Score: 311
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.63
    Marker Score: 519
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.63
    Marker Score: 337
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.62
    Marker Score: 311
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.61
    Marker Score: 441
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.6
    Marker Score: 577
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 378.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.58
    Marker Score: 252
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.58
    Marker Score: 146
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.57
    Marker Score: 560
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.56
    Marker Score: 5543
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.55
    Marker Score: 1084
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.55
    Marker Score: 181
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.55
    Marker Score: 466
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.53
    Marker Score: 237
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.52
    Marker Score: 258
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.51
    Marker Score: 1076
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.51
    Marker Score: 176.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.51
    Marker Score: 565
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.51
    Marker Score: 297
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 485
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5
    Marker Score: 155
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.5
    Marker Score: 256

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * LAIR1 is a cell surface protein that is expressed on monocytes, macrophages, and dendritic cells. * It is a member of the immunoglobulin superfamily, which are expressed on immune cells. * LAIR1 is a ligand for CD80 and CD86, which are cell surface markers for T cells. * It is involved in the regulation of T cell activation and the development of immune tolerance. * LAIR1 is also involved in the regulation of the innate immune response. **Pathways and functions:** * LAIR1 is expressed on monocytes and macrophages, which are the first line of defense against infection. * It binds to CD80 and CD86 on activated T cells, which leads to the inhibition of T cell activation and the suppression of inflammation. * It also binds to the protein CD40, which is expressed on activated B cells and dendritic cells. * This interaction between LAIR1 and CD40 is important for the regulation of immune responses. **Clinical significance:** * Mutations in the LAIR1 gene have been linked to several human diseases, including rheumatoid arthritis, lupus, and cancer. * In rheumatoid arthritis, LAIR1 is expressed on macrophages and dendritic cells in the joints. * This expression of LAIR1 allows macrophages and dendritic cells to regulate the inflammatory response in the joints, and mutations in the gene can lead to the development of rheumatoid arthritis. **Additional notes:** * LAIR1 is a relatively new protein, and there is still much that is unknown about its function. * It is a promising target for the treatment of inflammatory diseases.

Genular Protein ID: 1157721331

Symbol: LAIR1_HUMAN

Name: Leukocyte-associated immunoglobulin-like receptor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9285412

Title: LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.

PubMed ID: 9285412

DOI: 10.1016/s1074-7613(00)80530-0

PubMed ID: 10229813

Title: Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.

PubMed ID: 10229813

PubMed ID: 10764762

Title: Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells.

PubMed ID: 10764762

DOI: 10.1074/jbc.m001313200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9692876

Title: p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor.

PubMed ID: 9692876

DOI: 10.1002/(sici)1521-4141(199807)28:07<2086::aid-immu2086>3.0.co;2-t

PubMed ID: 10540327

Title: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling.

PubMed ID: 10540327

DOI: 10.1002/(sici)1521-4141(199910)29:10<3160::aid-immu3160>3.0.co;2-s

PubMed ID: 11069054

Title: Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias.

PubMed ID: 11069054

DOI: 10.1002/1521-4141(200010)30:10<2751::aid-immu2751>3.0.co;2-l

PubMed ID: 11160222

Title: Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells.

PubMed ID: 11160222

DOI: 10.4049/jimmunol.166.3.1763

PubMed ID: 12072189

Title: Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions.

PubMed ID: 12072189

DOI: 10.1016/s0198-8859(02)00409-3

PubMed ID: 14565933

Title: Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment.

PubMed ID: 14565933

DOI: 10.1093/intimm/dxg134

PubMed ID: 12757266

Title: Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells.

PubMed ID: 12757266

DOI: 10.1023/a:1022580929226

PubMed ID: 14604962

Title: Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection.

PubMed ID: 14604962

DOI: 10.1182/blood-2003-07-2375

PubMed ID: 15939744

Title: Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes.

PubMed ID: 15939744

DOI: 10.1128/cdli.12.6.705-712.2005

PubMed ID: 15950745

Title: The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation.

PubMed ID: 15950745

DOI: 10.1016/j.molimm.2005.01.004

PubMed ID: 16380958

Title: Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase.

PubMed ID: 16380958

DOI: 10.1002/eji.200535226

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20007810

Title: Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI.

PubMed ID: 20007810

DOI: 10.1182/blood-2009-10-246322

Sequence Information:

  • Length: 287
  • Mass: 31469
  • Checksum: E2A921D84F426B35
  • Sequence:
  • MSPHPTALLG LVLCLAQTIH TQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL 
    ERDSRSTYND TEDVSQASPS ESEARFRIDS VREGNAGLYR CIYYKPPKWS EQSDYLELLV 
    KESSGGPDSP DTEPGSSAGP TQRPSDNSHN EHAPASQGLK AEHLYILIGV SVVFLFCLLL 
    LVLFCLHRQN QIKQGPPRSK DEEQKPQQRP DLAVDVLERT ADKATVNGLP EKDRETDTSA 
    LAAGSSQEVT YAQLDHWALT QRTARAVSPQ STKPMAESIT YAAVARH

Genular Protein ID: 1322833300

Symbol: D3YTC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 286
  • Mass: 31340
  • Checksum: 53FCE0F650369F0D
  • Sequence:
  • MSPHPTALLG LVLCLAQTIH TQEDLPRPSI SAEPGTVIPL GSHVTFVCRG PVGVQTFRLE 
    RDSRSTYNDT EDVSQASPSE SEARFRIDSV REGNAGLYRC IYYKPPKWSE QSDYLELLVK 
    ESSGGPDSPD TEPGSSAGPT QRPSDNSHNE HAPASQGLKA EHLYILIGVS VVFLFCLLLL 
    VLFCLHRQNQ IKQGPPRSKD EEQKPQQRPD LAVDVLERTA DKATVNGLPE KDRETDTSAL 
    AAGSSQEVTY AQLDHWALTQ RTARAVSPQS TKPMAESITY AAVARH

Genular Protein ID: 3920772421

Symbol: A8MZ84_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 269
  • Mass: 29690
  • Checksum: A8B327C4E6DA9B1A
  • Sequence:
  • MEREMEDLPR PSISAEPGTV IPLGSHVTFV CRGPVGVQTF RLERDSRSTY NDTEDVSQAS 
    PSESEARFRI DSVREGNAGL YRCIYYKPPK WSEQSDYLEL LVKESSGGPD SPDTEPGSSA 
    GPTQRPSDNS HNEHAPASQG LKAEHLYILI GVSVVFLFCL LLLVLFCLHR QNQIKQGPPR 
    SKDEEQKPQQ RPDLAVDVLE RTADKATVNG LPEKDRETDT SALAAGSSQE VTYAQLDHWA 
    LTQRTARAVS PQSTKPMAES ITYAAVARH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.