Details for: LAIR1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 2.7
Marker Score: 1904 - Cell Name: lung macrophage (CL1001603)
Fold Change: 2.55
Marker Score: 2915 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.24
Marker Score: 57258 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.12
Marker Score: 883 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.98
Marker Score: 1992 - Cell Name: classical monocyte (CL0000860)
Fold Change: 1.97
Marker Score: 8169 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.89
Marker Score: 7752 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.68
Marker Score: 10205.5 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.65
Marker Score: 910.5 - Cell Name: thymocyte (CL0000893)
Fold Change: 1.59
Marker Score: 1663.5 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.57
Marker Score: 1143 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.51
Marker Score: 2950.5 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168704 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.37
Marker Score: 992 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.27
Marker Score: 1274 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.26
Marker Score: 70579 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.25
Marker Score: 3243 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.23
Marker Score: 832 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2
Marker Score: 12210 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.2
Marker Score: 1417.5 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.16
Marker Score: 791 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4774.5 - Cell Name: blood cell (CL0000081)
Fold Change: 1.13
Marker Score: 13165 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 1.11
Marker Score: 3236 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.07
Marker Score: 388 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.06
Marker Score: 431 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251757 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.02
Marker Score: 356 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71775 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47999 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.99
Marker Score: 487 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.99
Marker Score: 6594 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.98
Marker Score: 245 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.97
Marker Score: 3053 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.95
Marker Score: 392 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.94
Marker Score: 216 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.92
Marker Score: 456 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2728 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 361 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.9
Marker Score: 569 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.89
Marker Score: 470 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5078 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.87
Marker Score: 400.5 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.87
Marker Score: 1517 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5270 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.83
Marker Score: 1998 - Cell Name: naive B cell (CL0000788)
Fold Change: 0.83
Marker Score: 738 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.83
Marker Score: 285 - Cell Name: macrophage (CL0000235)
Fold Change: 0.8
Marker Score: 891 - Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.79
Marker Score: 598 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.78
Marker Score: 944 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.78
Marker Score: 378 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1260 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.77
Marker Score: 2100 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.77
Marker Score: 1921.5 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 568 - Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 678 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 384 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.73
Marker Score: 484 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.72
Marker Score: 1152 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.72
Marker Score: 230 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.72
Marker Score: 4575 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.71
Marker Score: 1726 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.7
Marker Score: 986 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174 - Cell Name: immature B cell (CL0000816)
Fold Change: 0.68
Marker Score: 448.5 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.67
Marker Score: 216 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.67
Marker Score: 985 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.64
Marker Score: 565 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.64
Marker Score: 311 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.63
Marker Score: 519 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.63
Marker Score: 337 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.62
Marker Score: 311 - Cell Name: Unknown (CL0000548)
Fold Change: 0.61
Marker Score: 441 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.6
Marker Score: 577 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.59
Marker Score: 378.5 - Cell Name: myelocyte (CL0002193)
Fold Change: 0.58
Marker Score: 252 - Cell Name: ILC1, human (CL0001077)
Fold Change: 0.58
Marker Score: 146 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.57
Marker Score: 560 - Cell Name: mature T cell (CL0002419)
Fold Change: 0.56
Marker Score: 5543 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.55
Marker Score: 1084 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.55
Marker Score: 181 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.55
Marker Score: 466 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.53
Marker Score: 169 - Cell Name: granulocyte (CL0000094)
Fold Change: 0.53
Marker Score: 237 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.52
Marker Score: 258 - Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.51
Marker Score: 135 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.51
Marker Score: 1076 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.51
Marker Score: 176.5 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 0.51
Marker Score: 565 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.51
Marker Score: 297 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.5
Marker Score: 485 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.5
Marker Score: 155 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.5
Marker Score: 256
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Other Information
Genular Protein ID: 1157721331
Symbol: LAIR1_HUMAN
Name: Leukocyte-associated immunoglobulin-like receptor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9285412
Title: LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.
PubMed ID: 9285412
PubMed ID: 10229813
Title: Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells.
PubMed ID: 10229813
PubMed ID: 10764762
Title: Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells.
PubMed ID: 10764762
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9692876
Title: p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor.
PubMed ID: 9692876
DOI: 10.1002/(sici)1521-4141(199807)28:07<2086::aid-immu2086>3.0.co;2-t
PubMed ID: 10540327
Title: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling.
PubMed ID: 10540327
DOI: 10.1002/(sici)1521-4141(199910)29:10<3160::aid-immu3160>3.0.co;2-s
PubMed ID: 11069054
Title: Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias.
PubMed ID: 11069054
DOI: 10.1002/1521-4141(200010)30:10<2751::aid-immu2751>3.0.co;2-l
PubMed ID: 11160222
Title: Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells.
PubMed ID: 11160222
PubMed ID: 12072189
Title: Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions.
PubMed ID: 12072189
PubMed ID: 14565933
Title: Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment.
PubMed ID: 14565933
PubMed ID: 12757266
Title: Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells.
PubMed ID: 12757266
PubMed ID: 14604962
Title: Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection.
PubMed ID: 14604962
PubMed ID: 15939744
Title: Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes.
PubMed ID: 15939744
PubMed ID: 15950745
Title: The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation.
PubMed ID: 15950745
PubMed ID: 16380958
Title: Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase.
PubMed ID: 16380958
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 20007810
Title: Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI.
PubMed ID: 20007810
Sequence Information:
- Length: 287
- Mass: 31469
- Checksum: E2A921D84F426B35
- Sequence:
MSPHPTALLG LVLCLAQTIH TQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERDSRSTYND TEDVSQASPS ESEARFRIDS VREGNAGLYR CIYYKPPKWS EQSDYLELLV KESSGGPDSP DTEPGSSAGP TQRPSDNSHN EHAPASQGLK AEHLYILIGV SVVFLFCLLL LVLFCLHRQN QIKQGPPRSK DEEQKPQQRP DLAVDVLERT ADKATVNGLP EKDRETDTSA LAAGSSQEVT YAQLDHWALT QRTARAVSPQ STKPMAESIT YAAVARH
Genular Protein ID: 1322833300
Symbol: D3YTC8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 286
- Mass: 31340
- Checksum: 53FCE0F650369F0D
- Sequence:
MSPHPTALLG LVLCLAQTIH TQEDLPRPSI SAEPGTVIPL GSHVTFVCRG PVGVQTFRLE RDSRSTYNDT EDVSQASPSE SEARFRIDSV REGNAGLYRC IYYKPPKWSE QSDYLELLVK ESSGGPDSPD TEPGSSAGPT QRPSDNSHNE HAPASQGLKA EHLYILIGVS VVFLFCLLLL VLFCLHRQNQ IKQGPPRSKD EEQKPQQRPD LAVDVLERTA DKATVNGLPE KDRETDTSAL AAGSSQEVTY AQLDHWALTQ RTARAVSPQS TKPMAESITY AAVARH
Genular Protein ID: 3920772421
Symbol: A8MZ84_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 269
- Mass: 29690
- Checksum: A8B327C4E6DA9B1A
- Sequence:
MEREMEDLPR PSISAEPGTV IPLGSHVTFV CRGPVGVQTF RLERDSRSTY NDTEDVSQAS PSESEARFRI DSVREGNAGL YRCIYYKPPK WSEQSDYLEL LVKESSGGPD SPDTEPGSSA GPTQRPSDNS HNEHAPASQG LKAEHLYILI GVSVVFLFCL LLLVLFCLHR QNQIKQGPPR SKDEEQKPQQ RPDLAVDVLE RTADKATVNG LPEKDRETDT SALAAGSSQE VTYAQLDHWA LTQRTARAVS PQSTKPMAES ITYAAVARH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.