Details for: LHX1

Gene ID: 3975

Symbol: LHX1

Ensembl ID: ENSG00000273706

Description: LIM homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 9.5041
    Cell Significance Index: 208.1100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.7495
    Cell Significance Index: 53.8900
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.0533
    Cell Significance Index: 15.5200
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 3.4162
    Cell Significance Index: 11.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3932
    Cell Significance Index: 9.5300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.2486
    Cell Significance Index: 3.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2313
    Cell Significance Index: 45.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2291
    Cell Significance Index: 7.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1891
    Cell Significance Index: 3.2400
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.0737
    Cell Significance Index: 0.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0439
    Cell Significance Index: 1.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0195
    Cell Significance Index: 10.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0018
    Cell Significance Index: 0.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0008
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0033
    Cell Significance Index: -2.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3500
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0077
    Cell Significance Index: -0.0700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0085
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0092
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0099
    Cell Significance Index: -1.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0107
    Cell Significance Index: -8.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0163
    Cell Significance Index: -1.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0185
    Cell Significance Index: -6.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0289
    Cell Significance Index: -0.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0290
    Cell Significance Index: -8.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0340
    Cell Significance Index: -6.8200
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0381
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0401
    Cell Significance Index: -18.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0438
    Cell Significance Index: -2.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0454
    Cell Significance Index: -8.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0552
    Cell Significance Index: -5.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0570
    Cell Significance Index: -7.8300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0633
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0673
    Cell Significance Index: -8.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0697
    Cell Significance Index: -3.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0718
    Cell Significance Index: -8.3700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0719
    Cell Significance Index: -0.8800
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0760
    Cell Significance Index: -0.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0776
    Cell Significance Index: -8.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0964
    Cell Significance Index: -5.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0970
    Cell Significance Index: -2.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0996
    Cell Significance Index: -7.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1019
    Cell Significance Index: -4.6200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1118
    Cell Significance Index: -0.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1556
    Cell Significance Index: -18.3500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1587
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1592
    Cell Significance Index: -2.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1867
    Cell Significance Index: -2.0300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1892
    Cell Significance Index: -1.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1917
    Cell Significance Index: -8.4800
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.1923
    Cell Significance Index: -1.7800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2075
    Cell Significance Index: -2.0900
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2105
    Cell Significance Index: -2.0600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2113
    Cell Significance Index: -2.0500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2147
    Cell Significance Index: -2.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2204
    Cell Significance Index: -7.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2220
    Cell Significance Index: -1.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2297
    Cell Significance Index: -8.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2422
    Cell Significance Index: -7.9300
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2556
    Cell Significance Index: -2.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2661
    Cell Significance Index: -8.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2746
    Cell Significance Index: -7.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2783
    Cell Significance Index: -7.4500
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.3037
    Cell Significance Index: -2.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3095
    Cell Significance Index: -5.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3149
    Cell Significance Index: -4.5100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3314
    Cell Significance Index: -2.0300
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.3319
    Cell Significance Index: -2.0700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.3323
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3388
    Cell Significance Index: -2.5900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.3434
    Cell Significance Index: -3.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3504
    Cell Significance Index: -8.7400
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.3782
    Cell Significance Index: -2.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3807
    Cell Significance Index: -8.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3819
    Cell Significance Index: -7.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3828
    Cell Significance Index: -8.2700
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.3899
    Cell Significance Index: -4.9000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3943
    Cell Significance Index: -7.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4050
    Cell Significance Index: -8.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4092
    Cell Significance Index: -15.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4095
    Cell Significance Index: -8.0600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4258
    Cell Significance Index: -4.9000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4359
    Cell Significance Index: -5.6400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4421
    Cell Significance Index: -5.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4438
    Cell Significance Index: -8.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4561
    Cell Significance Index: -21.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4565
    Cell Significance Index: -7.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4644
    Cell Significance Index: -8.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4673
    Cell Significance Index: -7.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4683
    Cell Significance Index: -9.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4752
    Cell Significance Index: -13.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4841
    Cell Significance Index: -12.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5038
    Cell Significance Index: -11.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5052
    Cell Significance Index: -7.3400
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.5077
    Cell Significance Index: -5.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LHX1 is a member of the LIM-homeobox protein family, which is characterized by the presence of a LIM domain and a homeobox domain. The LIM domain is involved in protein-protein interactions, while the homeobox domain is responsible for DNA binding and transcriptional regulation. LHX1 has a highly conserved sequence and structure, suggesting its evolutionary importance in development and tissue homeostasis. The gene is highly expressed in embryonic tissues, particularly during gastrulation, neurulation, and organogenesis. **Pathways and Functions** LHX1 is involved in various cellular processes, including: 1. **Embryonic patterning**: LHX1 regulates the specification of anterior-posterior and dorsal-ventral axes in the embryo, which is essential for proper organogenesis and tissue development. 2. **Cell proliferation and differentiation**: LHX1 controls the proliferation and differentiation of cells in various tissues, including the kidney, nervous system, and immune cells. 3. **Tissue homeostasis**: LHX1 maintains tissue homeostasis by regulating the balance between cell proliferation and differentiation. 4. **Immune system development**: LHX1 is involved in the development and function of immune cells, including T cells and B cells. 5. **Cancer development**: LHX1 has been implicated in the development of various cancers, including kidney cancer, lung cancer, and leukemia. **Clinical Significance** Dysregulation of LHX1 has been implicated in several diseases, including: 1. **Kidney cancer**: LHX1 is overexpressed in kidney cancer, particularly in clear cell renal carcinoma. 2. **Lung cancer**: LHX1 is overexpressed in lung cancer, particularly in small cell lung carcinoma. 3. **Leukemia**: LHX1 is overexpressed in leukemia, particularly in acute lymphoblastic leukemia. 4. **Autoimmune disorders**: LHX1 has been implicated in autoimmune disorders, including rheumatoid arthritis and lupus. 5. **Developmental abnormalities**: LHX1 mutations have been associated with developmental abnormalities, including neural tube defects and congenital heart defects. In summary, LHX1 is a critical transcription factor gene that plays a central role in embryonic patterning, organogenesis, and tissue differentiation. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and developmental abnormalities. Further studies are needed to fully understand the mechanisms of LHX1 regulation and its role in human disease.

Genular Protein ID: 2229969797

Symbol: LHX1_HUMAN

Name: LIM/homeobox protein Lhx1

UniProtKB Accession Codes:

P48742 Q3MIW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 78 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9212161

Title: Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/homeobox gene, hLim-1.

PubMed ID: 9212161

DOI: 10.1089/dna.1997.16.671

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 406
  • Mass: 44808
  • Checksum: 06C5A417A943C15D
  • Sequence:
    • MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG 
TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS 
NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEAGSNE NDDQNLGAKR 
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ 
LSALGARRHA FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP 
PSSQAQTPVD LPFVPSSGPS GTPLGGLEHP LPGHHPSSEA QRFTDILAHP PGDSPSPEPS 
LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM NEAAVW

Genular Protein ID: 3578722205

Symbol: Q58F18_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q58F18

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 260
  • Mass: 29497
  • Checksum: A3766B6EBE505D2E
  • Sequence:
    • MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG 
TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS 
NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEAGSNE NDDQNLGAKR 
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ 
LSALGARRHA FFRSPRRMRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.