Details for: LHX1

Gene ID: 3975

Symbol: LHX1

Ensembl ID: ENSG00000273706

Description: LIM homeobox 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.23
    Marker Score: 3426
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.5
    Marker Score: 5165
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.36
    Marker Score: 3335
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.84
    Marker Score: 4647
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.72
    Marker Score: 786.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.68
    Marker Score: 1121
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.59
    Marker Score: 374
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.53
    Marker Score: 1707
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.51
    Marker Score: 1166
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.19
    Marker Score: 234
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.03
    Marker Score: 397
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.95
    Marker Score: 1582
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.87
    Marker Score: 827
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.84
    Marker Score: 1981
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.82
    Marker Score: 1704
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.79
    Marker Score: 274
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.74
    Marker Score: 413
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1176
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 475
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 511
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.63
    Marker Score: 690
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.63
    Marker Score: 160
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.62
    Marker Score: 387
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.57
    Marker Score: 542
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.55
    Marker Score: 380.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.46
    Marker Score: 1134
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 239
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.41
    Marker Score: 240
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 363
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.39
    Marker Score: 13276
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 359
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.35
    Marker Score: 202
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.34
    Marker Score: 538
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.34
    Marker Score: 135
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.33
    Marker Score: 1181
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.29
    Marker Score: 289
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.28
    Marker Score: 261
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.26
    Marker Score: 252
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.26
    Marker Score: 260
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.25
    Marker Score: 243
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.25
    Marker Score: 129
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.23
    Marker Score: 238.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 120
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.22
    Marker Score: 101
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.22
    Marker Score: 261
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.21
    Marker Score: 43
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2
    Marker Score: 358
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.2
    Marker Score: 96
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2
    Marker Score: 339
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.19
    Marker Score: 54
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.19
    Marker Score: 68
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.18
    Marker Score: 352
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.17
    Marker Score: 91
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.16
    Marker Score: 39251
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.16
    Marker Score: 154
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.16
    Marker Score: 289
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.16
    Marker Score: 418
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 259.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.14
    Marker Score: 76
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.13
    Marker Score: 380
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.13
    Marker Score: 93
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.13
    Marker Score: 184
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.12
    Marker Score: 130
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.1
    Marker Score: 393
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.07
    Marker Score: 100
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 81.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.06
    Marker Score: 835

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Other Information

**Key characteristics:** * LHX1 is a homeobox family transcription factor. * It is expressed in a gradient along the nephrogenic tube, with higher expression in the distal convoluted tubule epithelial cell. * It is a key regulator of ureteric bud morphogenesis. * It is involved in the regulation of the development of the urogenital system. **Pathways and functions:** * LHX1 is a key regulator of ureteric bud development. * It is involved in the specification of the nephric duct. * It is also involved in the development of the urogenital system, including the formation of the urogenital ridge and the development of the male reproductive tract. **Clinical significance:** * Mutations in LHX1 have been linked to several human genetic disorders, including Wilbrand's disease and aniritism. * These mutations can lead to the formation of malformed urogenital structures, which can result in infertility or kidney failure. * Therefore, LHX1 is a promising target for the treatment of human genetic disorders of the urogenital system. **Additional notes:** * LHX1 is a highly conserved gene, with a similar gene named LHX1_RAT found in rodents. * It is a key transcription factor for the development of the human kidney. * It is also involved in the development of the urogenital system in other animals, including mice and zebrafish.

Genular Protein ID: 2229969797

Symbol: LHX1_HUMAN

Name: LIM/homeobox protein Lhx1

UniProtKB Accession Codes:

P48742 Q3MIW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 78 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9212161

Title: Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/homeobox gene, hLim-1.

PubMed ID: 9212161

DOI: 10.1089/dna.1997.16.671

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 406
  • Mass: 44808
  • Checksum: 06C5A417A943C15D
  • Sequence:
    • MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG 
TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS 
NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEAGSNE NDDQNLGAKR 
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ 
LSALGARRHA FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP 
PSSQAQTPVD LPFVPSSGPS GTPLGGLEHP LPGHHPSSEA QRFTDILAHP PGDSPSPEPS 
LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM NEAAVW

Genular Protein ID: 3578722205

Symbol: Q58F18_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q58F18

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 260
  • Mass: 29497
  • Checksum: A3766B6EBE505D2E
  • Sequence:
    • MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG 
TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS 
NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEAGSNE NDDQNLGAKR 
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ 
LSALGARRHA FFRSPRRMRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.