Details for: FADS1

Gene ID: 3992

Symbol: FADS1

Ensembl ID: ENSG00000149485

Description: fatty acid desaturase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.7986
    Cell Significance Index: -30.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.5633
    Cell Significance Index: -27.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.7822
    Cell Significance Index: -33.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.1958
    Cell Significance Index: -26.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.1039
    Cell Significance Index: -32.1900
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 19.0908
    Cell Significance Index: 24.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2969
    Cell Significance Index: -32.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 5.1952
    Cell Significance Index: 166.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1573
    Cell Significance Index: -6.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7612
    Cell Significance Index: 61.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5135
    Cell Significance Index: 84.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4061
    Cell Significance Index: 279.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0466
    Cell Significance Index: 28.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7305
    Cell Significance Index: 15.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.7214
    Cell Significance Index: 18.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6117
    Cell Significance Index: 60.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6103
    Cell Significance Index: 83.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5483
    Cell Significance Index: 34.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4954
    Cell Significance Index: 99.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4807
    Cell Significance Index: 262.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3068
    Cell Significance Index: 212.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2805
    Cell Significance Index: 178.1400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2789
    Cell Significance Index: 2.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2720
    Cell Significance Index: 14.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2632
    Cell Significance Index: 237.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2398
    Cell Significance Index: 45.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2255
    Cell Significance Index: 80.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2179
    Cell Significance Index: 5.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2153
    Cell Significance Index: 35.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2045
    Cell Significance Index: 26.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1609
    Cell Significance Index: 17.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1141
    Cell Significance Index: 1.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1118
    Cell Significance Index: 7.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1066
    Cell Significance Index: 80.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0836
    Cell Significance Index: 128.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0744
    Cell Significance Index: 140.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0553
    Cell Significance Index: 102.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0541
    Cell Significance Index: 1.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0259
    Cell Significance Index: 35.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0102
    Cell Significance Index: 1.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0056
    Cell Significance Index: -2.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0073
    Cell Significance Index: -0.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0120
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0174
    Cell Significance Index: -7.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0175
    Cell Significance Index: -3.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0328
    Cell Significance Index: -24.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0345
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0375
    Cell Significance Index: -4.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0384
    Cell Significance Index: -21.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0516
    Cell Significance Index: -2.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0536
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0632
    Cell Significance Index: -6.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0654
    Cell Significance Index: -9.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0659
    Cell Significance Index: -13.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0739
    Cell Significance Index: -1.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0863
    Cell Significance Index: -3.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0937
    Cell Significance Index: -26.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0980
    Cell Significance Index: -1.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1036
    Cell Significance Index: -7.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1041
    Cell Significance Index: -6.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1262
    Cell Significance Index: -15.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1299
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1440
    Cell Significance Index: -16.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1702
    Cell Significance Index: -19.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1849
    Cell Significance Index: -4.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1987
    Cell Significance Index: -15.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2010
    Cell Significance Index: -25.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2101
    Cell Significance Index: -3.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2125
    Cell Significance Index: -25.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2222
    Cell Significance Index: -6.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2414
    Cell Significance Index: -7.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2813
    Cell Significance Index: -29.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2867
    Cell Significance Index: -20.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3028
    Cell Significance Index: -20.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3272
    Cell Significance Index: -3.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3719
    Cell Significance Index: -29.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3966
    Cell Significance Index: -29.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4451
    Cell Significance Index: -20.9200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4930
    Cell Significance Index: -6.9100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4971
    Cell Significance Index: -2.9500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5261
    Cell Significance Index: -6.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5275
    Cell Significance Index: -9.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5313
    Cell Significance Index: -27.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5497
    Cell Significance Index: -25.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5696
    Cell Significance Index: -13.6600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.5791
    Cell Significance Index: -4.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5842
    Cell Significance Index: -25.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5996
    Cell Significance Index: -16.0100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6505
    Cell Significance Index: -8.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6635
    Cell Significance Index: -11.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6694
    Cell Significance Index: -18.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6838
    Cell Significance Index: -20.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6974
    Cell Significance Index: -26.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7181
    Cell Significance Index: -23.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7182
    Cell Significance Index: -25.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7193
    Cell Significance Index: -22.9100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.7315
    Cell Significance Index: -7.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7421
    Cell Significance Index: -16.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FADS1 is a member of the desaturase family of enzymes, which are responsible for the introduction of double bonds into fatty acid chains. The enzyme specifically catalyzes the conversion of 18:2n-6 (LA) and 18:3n-3 (ALA) into 18:3n-6 and 18:4n-6, respectively. This process is essential for the synthesis of various eicosanoids, which are signaling molecules involved in inflammation, immune response, and cell growth. FADS1 is also involved in the regulation of lipid metabolism by influencing the expression of genes involved in fatty acid synthesis and degradation. **Pathways and Functions:** FADS1 is involved in several key pathways, including: 1. **Fatty acid metabolism**: FADS1 plays a critical role in the metabolism of essential fatty acids, including ALA and LA. The enzyme's activity influences the production of eicosanoids, which are involved in various physiological processes. 2. **Cell signaling**: FADS1-generated eicosanoids, such as prostaglandins and leukotrienes, regulate cell signaling pathways involved in inflammation, immune response, and cell growth. 3. **Lipid metabolism**: FADS1 influences the expression of genes involved in fatty acid synthesis and degradation, thereby regulating lipid metabolism. 4. **Regulation of cell differentiation**: FADS1-generated eicosanoids have been shown to regulate cell differentiation, particularly in the context of immune cell development. **Clinical Significance:** Dysregulation of FADS1 expression and function has been linked to various diseases, including: 1. **Atherosclerosis**: Abnormalities in FADS1 expression have been associated with an increased risk of atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. 2. **Inflammatory disorders**: FADS1-generated eicosanoids play a critical role in regulating inflammation, and dysregulation of this enzyme has been linked to various inflammatory disorders, including rheumatoid arthritis and asthma. 3. **Cancer**: FADS1 has been implicated in the regulation of cell growth and differentiation, and its dysregulation has been associated with an increased risk of certain types of cancer. 4. **Neurological disorders**: FADS1-generated eicosanoids have been shown to regulate neuronal function, and dysregulation of this enzyme has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FADS1 is a critical enzyme involved in fatty acid metabolism and cell signaling. Its dysregulation has been linked to various diseases, highlighting the importance of this gene in maintaining human health. Further research is needed to fully understand the mechanisms by which FADS1 regulates fatty acid metabolism and cell signaling, and to develop therapeutic strategies for the treatment of diseases associated with FADS1 dysfunction.

Genular Protein ID: 2465164299

Symbol: FADS1_HUMAN

Name: Delta(5) fatty acid desaturase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10601301

Title: Cloning, expression, and fatty acid regulation of the human Delta-5 desaturase.

PubMed ID: 10601301

DOI: 10.1074/jbc.274.52.37335

PubMed ID: 10769175

Title: cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid.

PubMed ID: 10769175

DOI: 10.1042/bj3470719

PubMed ID: 10860662

Title: cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.

PubMed ID: 10860662

DOI: 10.1006/geno.2000.6196

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22619218

Title: A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.

PubMed ID: 22619218

DOI: 10.1194/jlr.m025312

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

Sequence Information:

  • Length: 444
  • Mass: 51964
  • Checksum: CC3C28D82AA49BF2
  • Sequence:
  • MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR RHPGGSRVIS 
    HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF EPTKNKELTD EFRELRATVE 
    RMGLMKANHV FFLLYLLHIL LLDGAAWLTL WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD 
    FGHLSVFSTS KWNHLLHHFV IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA 
    LGKILSVELG KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI 
    TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD RNMDWVSTQL 
    QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA PLVQSLCAKH GIEYQSKPLL 
    SAFADIIHSL KESGQLWLDA YLHQ

Genular Protein ID: 1958973775

Symbol: A0A0A0MR51_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 501
  • Mass: 57886
  • Checksum: DB59ACB64C59B329
  • Sequence:
  • MGTRAARPAG LPCGAENPAR RRLALGARQQ IHSWSPRTPS TRLTAPAGPA RGVARPAMAP 
    DPVAAETAAQ GPTPRYFTWD EVAQRSGCEE RWLVIDRKVY NISEFTRRHP GGSRVISHYA 
    GQDATDPFVA FHINKGLVKK YMNSLLIGEL SPEQPSFEPT KNKELTDEFR ELRATVERMG 
    LMKANHVFFL LYLLHILLLD GAAWLTLWVF GTSFLPFLLC AVLLSAVQAQ AGWLQHDFGH 
    LSVFSTSKWN HLLHHFVIGH LKGAPASWWN HMHFQHHAKP NCFRKDPDIN MHPFFFALGK 
    ILSVELGKQK KKYMPYNHQH KYFFLIGPPA LLPLYFQWYI FYFVIQRKKW VDLAWMITFY 
    VRFFLTYVPL LGLKAFLGLF FIVRFLESNW FVWVTQMNHI PMHIDHDRNM DWVSTQLQAT 
    CNVHKSAFND WFSGHLNFQI EHHLFPTMPR HNYHKVAPLV QSLCAKHGIE YQSKPLLSAF 
    ADIIHSLKES GQLWLDAYLH Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.