Details for: FADS1

Gene ID: 3992

Symbol: FADS1

Ensembl ID: ENSG00000149485

Description: fatty acid desaturase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.23
    Marker Score: 7301
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.9
    Marker Score: 3053
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.75
    Marker Score: 1825
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.62
    Marker Score: 1819
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.52
    Marker Score: 510
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.5
    Marker Score: 9795
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.5
    Marker Score: 1015.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.48
    Marker Score: 1586
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.47
    Marker Score: 1385
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168438
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.42
    Marker Score: 2969
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.42
    Marker Score: 1532
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.37
    Marker Score: 815
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.37
    Marker Score: 660.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.33
    Marker Score: 2267
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.32
    Marker Score: 5103
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.27
    Marker Score: 1352
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.27
    Marker Score: 1534
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.23
    Marker Score: 775
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.23
    Marker Score: 3355
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.19
    Marker Score: 563
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.17
    Marker Score: 2224.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.17
    Marker Score: 343
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.17
    Marker Score: 4861
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.16
    Marker Score: 840.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.15
    Marker Score: 370
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.14
    Marker Score: 667
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.12
    Marker Score: 1569
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.09
    Marker Score: 19397
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.09
    Marker Score: 639
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.09
    Marker Score: 2571
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.06
    Marker Score: 6305
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.03
    Marker Score: 21965
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16090.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.02
    Marker Score: 1372
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.01
    Marker Score: 10149
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.01
    Marker Score: 1757
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71749
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1
    Marker Score: 321
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47972.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.97
    Marker Score: 1340
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.96
    Marker Score: 698
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.96
    Marker Score: 4022.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.96
    Marker Score: 3913
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444.5
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.94
    Marker Score: 211
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.93
    Marker Score: 295
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.93
    Marker Score: 520
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.92
    Marker Score: 506
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.91
    Marker Score: 683
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.91
    Marker Score: 33548
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.91
    Marker Score: 18052
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 358
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1795
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.88
    Marker Score: 249
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.88
    Marker Score: 2098
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.87
    Marker Score: 366
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.87
    Marker Score: 959
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4975
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.86
    Marker Score: 32835
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.85
    Marker Score: 352.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.85
    Marker Score: 9572
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.84
    Marker Score: 791
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.84
    Marker Score: 530
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.84
    Marker Score: 3618
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.84
    Marker Score: 417
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.84
    Marker Score: 51424
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.82
    Marker Score: 3350
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.81
    Marker Score: 437.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.81
    Marker Score: 5278
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.79
    Marker Score: 8181
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.79
    Marker Score: 215
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.79
    Marker Score: 905
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.78
    Marker Score: 11712.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.78
    Marker Score: 273
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.78
    Marker Score: 26974
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.77
    Marker Score: 3210
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.77
    Marker Score: 312
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.77
    Marker Score: 7244
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.77
    Marker Score: 1444
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1244
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.76
    Marker Score: 866
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3161
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.74
    Marker Score: 493
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 672
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1133
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.73
    Marker Score: 629
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.72
    Marker Score: 350
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.72
    Marker Score: 382.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.71
    Marker Score: 989
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.71
    Marker Score: 390

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Other Information

**Key characteristics:** * FADS1 is a transmembrane protein that is located on the cell surface. * It is a member of the fatty acid desaturase family of proteins. * FADS1 is a multi-functional protein that can be activated by a variety of stimuli, including growth factors, hormones, and cytokines. **Pathways and functions:** * FADS1 is involved in the desaturation of fatty acids, which is the conversion of alpha-linolenic (omega3) and linoleic (omega6) acids into their corresponding fatty acid derivatives. * It is also involved in the regulation of cell-cell signaling and the development of the gut. * FADS1 is a key regulator of the metabolism of alpha-linolenic and linoleic acids, and it is involved in the production of eicosanoids, which are a class of lipid mediators that have a variety of effects on cell function. * FADS1 is also involved in the regulation of inflammation and fibrosis. **Clinical significance:** * Mutations in FADS1 have been linked to a number of human diseases, including cardiovascular disease, cancer, and obesity. * FADS1 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 2465164299

Symbol: FADS1_HUMAN

Name: Delta(5) fatty acid desaturase

UniProtKB Accession Codes:

O60427 A8K0I7 B2RAI0 Q53GM5 Q8N3A6 Q8NCC7 Q8NCG0 Q96I39 Q96SV3 Q96T10 Q9NRP8 Q9NYX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 16 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10601301

Title: Cloning, expression, and fatty acid regulation of the human Delta-5 desaturase.

PubMed ID: 10601301

DOI: 10.1074/jbc.274.52.37335

PubMed ID: 10769175

Title: cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid.

PubMed ID: 10769175

DOI: 10.1042/bj3470719

PubMed ID: 10860662

Title: cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.

PubMed ID: 10860662

DOI: 10.1006/geno.2000.6196

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22619218

Title: A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.

PubMed ID: 22619218

DOI: 10.1194/jlr.m025312

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

Sequence Information:

  • Length: 444
  • Mass: 51964
  • Checksum: CC3C28D82AA49BF2
  • Sequence:
    • MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR RHPGGSRVIS 
HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF EPTKNKELTD EFRELRATVE 
RMGLMKANHV FFLLYLLHIL LLDGAAWLTL WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD 
FGHLSVFSTS KWNHLLHHFV IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA 
LGKILSVELG KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI 
TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD RNMDWVSTQL 
QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA PLVQSLCAKH GIEYQSKPLL 
SAFADIIHSL KESGQLWLDA YLHQ

Genular Protein ID: 1958973775

Symbol: A0A0A0MR51_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR51

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 501
  • Mass: 57886
  • Checksum: DB59ACB64C59B329
  • Sequence:
    • MGTRAARPAG LPCGAENPAR RRLALGARQQ IHSWSPRTPS TRLTAPAGPA RGVARPAMAP 
DPVAAETAAQ GPTPRYFTWD EVAQRSGCEE RWLVIDRKVY NISEFTRRHP GGSRVISHYA 
GQDATDPFVA FHINKGLVKK YMNSLLIGEL SPEQPSFEPT KNKELTDEFR ELRATVERMG 
LMKANHVFFL LYLLHILLLD GAAWLTLWVF GTSFLPFLLC AVLLSAVQAQ AGWLQHDFGH 
LSVFSTSKWN HLLHHFVIGH LKGAPASWWN HMHFQHHAKP NCFRKDPDIN MHPFFFALGK 
ILSVELGKQK KKYMPYNHQH KYFFLIGPPA LLPLYFQWYI FYFVIQRKKW VDLAWMITFY 
VRFFLTYVPL LGLKAFLGLF FIVRFLESNW FVWVTQMNHI PMHIDHDRNM DWVSTQLQAT 
CNVHKSAFND WFSGHLNFQI EHHLFPTMPR HNYHKVAPLV QSLCAKHGIE YQSKPLLSAF 
ADIIHSLKES GQLWLDAYLH Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.