Details for: LLGL2

Gene ID: 3993

Symbol: LLGL2

Ensembl ID: ENSG00000073350

Description: LLGL scribble cell polarity complex component 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.43
    Marker Score: 7641
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.36
    Marker Score: 1816
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.29
    Marker Score: 2105.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.23
    Marker Score: 1152
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.99
    Marker Score: 1331
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.92
    Marker Score: 5156
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.91
    Marker Score: 1937
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.86
    Marker Score: 1609
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.85
    Marker Score: 11781
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.84
    Marker Score: 2219
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.82
    Marker Score: 1813
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.79
    Marker Score: 1220
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.77
    Marker Score: 1881
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.77
    Marker Score: 4342
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.75
    Marker Score: 924
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.71
    Marker Score: 8193
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.69
    Marker Score: 628
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.64
    Marker Score: 4136
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.63
    Marker Score: 469
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.62
    Marker Score: 403
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.6
    Marker Score: 3802
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.59
    Marker Score: 2342
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.51
    Marker Score: 2503
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.5
    Marker Score: 3409.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.45
    Marker Score: 1502
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.45
    Marker Score: 686
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.41
    Marker Score: 3313
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4
    Marker Score: 22482
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.39
    Marker Score: 4784
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.39
    Marker Score: 1332
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.38
    Marker Score: 806
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.36
    Marker Score: 1930
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.34
    Marker Score: 4767
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.34
    Marker Score: 661
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.33
    Marker Score: 384
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.33
    Marker Score: 11535
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.31
    Marker Score: 45371
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.29
    Marker Score: 1567
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.27
    Marker Score: 569
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.25
    Marker Score: 522
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.24
    Marker Score: 2171
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.22
    Marker Score: 1348
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.22
    Marker Score: 246
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.22
    Marker Score: 568
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.21
    Marker Score: 457
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.21
    Marker Score: 1302
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.19
    Marker Score: 412
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.16
    Marker Score: 1217
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.14
    Marker Score: 1816
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.13
    Marker Score: 892
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.13
    Marker Score: 2569
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.12
    Marker Score: 2362
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.1
    Marker Score: 259
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.08
    Marker Score: 434
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.07
    Marker Score: 2033
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.05
    Marker Score: 5523
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.05
    Marker Score: 530
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.04
    Marker Score: 722
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251731
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71750
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47975
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.99
    Marker Score: 515
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.99
    Marker Score: 8522.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.97
    Marker Score: 1719
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.96
    Marker Score: 6288
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.96
    Marker Score: 1122
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.96
    Marker Score: 359
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.95
    Marker Score: 283
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.94
    Marker Score: 229
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1511
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.93
    Marker Score: 246
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5289
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.92
    Marker Score: 766
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.92
    Marker Score: 3821.5
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.91
    Marker Score: 263
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.91
    Marker Score: 6810
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.91
    Marker Score: 5851.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2715
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.9
    Marker Score: 629
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9
    Marker Score: 3895
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.89
    Marker Score: 1151
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.89
    Marker Score: 1626
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.88
    Marker Score: 451
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.86
    Marker Score: 530.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.86
    Marker Score: 271
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.83
    Marker Score: 1122
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.82
    Marker Score: 924.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 489
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.81
    Marker Score: 183
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.8
    Marker Score: 566
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.8
    Marker Score: 344
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.79
    Marker Score: 6199

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Other Information

**Key characteristics:** * The LLGL2 gene is located on chromosome 17p13.1. * It is a large gene with a size of approximately 2.7 kb. * The protein encoded by LLGL2 is a transmembrane protein with a molecular weight of approximately 180 kDa. * LLGL2 is a member of the cadherin family of cell adhesion molecules. * It is expressed in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. **Pathways and functions:** * LLGL2 is involved in the establishment and maintenance of epithelial cell polarity. * It is essential for the proper organization of the cell membrane, which is responsible for the cell's polarity. * LLGL2 is also involved in cell migration and cell adhesion. * It is a key regulator of epithelial cell behavior, including cell migration, cell adhesion, and cell signaling. **Clinical significance:** * Mutations in the LLGL2 gene have been linked to a number of human diseases, including cancer and developmental disorders. * These diseases are often associated with abnormal cell polarity, which can lead to cell migration and tumor formation. * Therefore, LLGL2 is a promising target for the treatment of cancer and other diseases that are characterized by abnormal cell polarity. **Additional information:** * LLGL2 is a recently identified gene, and there is still much that is unknown about its function. * However, it is clear that LLGL2 is a critical component of epithelial cell polarity and that it plays an important role in cell migration and cell signaling.

Genular Protein ID: 1358482829

Symbol: L2GL2_HUMAN

Name: LLGL scribble cell polarity complex component 2

UniProtKB Accession Codes:

Q6P1M3 Q14521 Q9BR62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632202

Title: Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.

PubMed ID: 15632202

DOI: 10.1074/jbc.c400440200

PubMed ID: 12725730

Title: Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.

PubMed ID: 12725730

DOI: 10.1016/s0960-9822(03)00244-6

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20644714

Title: Involvement of Lgl and Mahjong/VprBP in cell competition.

PubMed ID: 20644714

DOI: 10.1371/journal.pbio.1000422

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1020
  • Mass: 113448
  • Checksum: 9C36BFF9F94314B5
  • Sequence:
    • MRRFLRPGHD PVRERLKRDL FQFNKTVEHG FPHQPSALGY SPSLRILAIG TRSGAIKLYG 
APGVEFMGLH QENNAVTQIH LLPGQCQLVT LLDDNSLHLW SLKVKGGASE LQEDESFTLR 
GPPGAAPSAT QITVVLPHSS CELLYLGTES GNVFVVQLPA FRALEDRTIS SDAVLQRLPE 
EARHRRVFEM VEALQEHPRD PNQILIGYSR GLVVIWDLQG SRVLYHFLSS QQLENIWWQR 
DGRLLVSCHS DGSYCQWPVS SEAQQPEPLR SLVPYGPFPC KAITRILWLT TRQGLPFTIF 
QGGMPRASYG DRHCISVIHD GQQTAFDFTS RVIGFTVLTE ADPAATFDDP YALVVLAEEE 
LVVIDLQTAG WPPVQLPYLA SLHCSAITCS HHVSNIPLKL WERIIAAGSR QNAHFSTMEW 
PIDGGTSLTP APPQRDLLLT GHEDGTVRFW DASGVCLRLL YKLSTVRVFL TDTDPNENFS 
AQGEDEWPPL RKVGSFDPYS DDPRLGIQKI FLCKYSGYLA VAGTAGQVLV LELNDEAAEQ 
AVEQVEADLL QDQEGYRWKG HERLAARSGP VRFEPGFQPF VLVQCQPPAV VTSLALHSEW 
RLVAFGTSHG FGLFDHQQRR QVFVKCTLHP SDQLALEGPL SRVKSLKKSL RQSFRRMRRS 
RVSSRKRHPA GPPGEAQEGS AKAERPGLQN MELAPVQRKI EARSAEDSFT GFVRTLYFAD 
TYLKDSSRHC PSLWAGTNGG TIYAFSLRVP PAERRMDEPV RAEQAKEIQL MHRAPVVGIL 
VLDGHSVPLP EPLEVAHDLS KSPDMQGSHQ LLVVSEEQFK VFTLPKVSAK LKLKLTALEG 
SRVRRVSVAH FGSRRAEDYG EHHLAVLTNL GDIQVVSLPL LKPQVRYSCI RREDVSGIAS 
CVFTKYGQGF YLISPSEFER FSLSTKWLVE PRCLVDSAET KNHRPGNGAG PKKAPSRARN 
SGTQSDGEEK QPGLVMERAL LSDERVLKEI QSTLEGDRGS GNWRSHRAAV GCSLSNGGAE

Genular Protein ID: 2775581295

Symbol: A0PJJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0PJJ0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 2 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 271
  • Mass: 29831
  • Checksum: 7E5675D861523139
  • Sequence:
    • VPPAERRMDE PVRAEQAKEI QLMHRAPVVG ILVLDGHSVP LPEPLEVAHD LSKSPDMQGS 
HQLLVVSEEQ FKVFTLPKVS AKLKLKLTAL EGSRVRRVSV AHFGSRRAED YGEHHLAVLT 
NLGDIQVVSL PLLKPQVRYS CIRREDVSGI ASCVFTKYGQ GFYLISPSEF ERFSLSTKWL 
VEPRCLVDSA ETKNHRPGNG AGPKKAPSRA RNSGTQSDGE EKQPGLVMER ALLSDERVLK 
EIQSTLEGDR GSGNWRSHRA AVGCSLSNGG E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.