Details for: LLGL2

Gene ID: 3993

Symbol: LLGL2

Ensembl ID: ENSG00000073350

Description: LLGL scribble cell polarity complex component 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.2071
    Cell Significance Index: -16.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.6918
    Cell Significance Index: -16.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.2701
    Cell Significance Index: -16.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 25.8263
    Cell Significance Index: -17.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.0831
    Cell Significance Index: -16.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.4068
    Cell Significance Index: -16.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0063
    Cell Significance Index: -16.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 5.0915
    Cell Significance Index: 230.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.0313
    Cell Significance Index: 75.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 5.0185
    Cell Significance Index: 347.0600
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 5.0094
    Cell Significance Index: 3.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2124
    Cell Significance Index: -16.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1218
    Cell Significance Index: -12.6600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.9590
    Cell Significance Index: 29.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.8732
    Cell Significance Index: 34.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7278
    Cell Significance Index: -5.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.5899
    Cell Significance Index: 281.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4114
    Cell Significance Index: 32.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0171
    Cell Significance Index: 104.7800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.8699
    Cell Significance Index: 20.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8594
    Cell Significance Index: 302.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8167
    Cell Significance Index: 360.5400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.7609
    Cell Significance Index: 3.9700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2788
    Cell Significance Index: 7.8700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.1291
    Cell Significance Index: 13.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0914
    Cell Significance Index: 30.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0838
    Cell Significance Index: 68.3100
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.0627
    Cell Significance Index: 5.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0276
    Cell Significance Index: 47.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9703
    Cell Significance Index: 8.9400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.8785
    Cell Significance Index: 5.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8748
    Cell Significance Index: 20.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8667
    Cell Significance Index: 30.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8386
    Cell Significance Index: 457.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7831
    Cell Significance Index: 77.4700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.7561
    Cell Significance Index: 10.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7420
    Cell Significance Index: 133.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5867
    Cell Significance Index: 15.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5533
    Cell Significance Index: 68.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5353
    Cell Significance Index: 91.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4938
    Cell Significance Index: 23.2100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.4275
    Cell Significance Index: 1.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3416
    Cell Significance Index: 7.2800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2818
    Cell Significance Index: 2.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2196
    Cell Significance Index: 16.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2065
    Cell Significance Index: 3.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2012
    Cell Significance Index: 6.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1874
    Cell Significance Index: 35.6700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1756
    Cell Significance Index: 2.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1666
    Cell Significance Index: 4.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1513
    Cell Significance Index: 4.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1351
    Cell Significance Index: 2.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1192
    Cell Significance Index: 52.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1162
    Cell Significance Index: 8.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1143
    Cell Significance Index: 103.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0964
    Cell Significance Index: 148.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0760
    Cell Significance Index: 55.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0637
    Cell Significance Index: 86.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0606
    Cell Significance Index: 7.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0603
    Cell Significance Index: 12.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0484
    Cell Significance Index: 89.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0326
    Cell Significance Index: 61.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0278
    Cell Significance Index: 17.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0180
    Cell Significance Index: 13.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0011
    Cell Significance Index: 0.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.0131
    Cell Significance Index: -0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0174
    Cell Significance Index: -2.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0174
    Cell Significance Index: -6.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0195
    Cell Significance Index: -11.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0212
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0245
    Cell Significance Index: -5.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0284
    Cell Significance Index: -12.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0379
    Cell Significance Index: -4.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0409
    Cell Significance Index: -5.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0441
    Cell Significance Index: -12.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0496
    Cell Significance Index: -5.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0532
    Cell Significance Index: -6.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0571
    Cell Significance Index: -7.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0799
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0950
    Cell Significance Index: -11.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1058
    Cell Significance Index: -5.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1058
    Cell Significance Index: -1.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1188
    Cell Significance Index: -9.4100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1220
    Cell Significance Index: -0.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1314
    Cell Significance Index: -13.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1333
    Cell Significance Index: -15.7200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1387
    Cell Significance Index: -1.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1592
    Cell Significance Index: -4.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1782
    Cell Significance Index: -2.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1845
    Cell Significance Index: -14.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1862
    Cell Significance Index: -10.4500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1985
    Cell Significance Index: -4.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2111
    Cell Significance Index: -3.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2222
    Cell Significance Index: -13.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2308
    Cell Significance Index: -5.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2324
    Cell Significance Index: -15.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2496
    Cell Significance Index: -12.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2642
    Cell Significance Index: -5.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LLGL2 is a member of the scribble complex, a multiprotein complex that regulates cellular polarity and is composed of several subunits, including LLGL2, Scribble (Scrib), and Lgl (Legless). The scribble complex is essential for maintaining epithelial cell polarity, which is critical for tissue homeostasis and the prevention of cancer. LLGL2 specifically interacts with various proteins, including PDZ domain-containing proteins, myosin II, and GTPase-activating proteins, to regulate cellular polarity and signaling. The gene is also involved in the regulation of exocytosis, leucine transport, and the Notch signaling pathway. **Pathways and Functions:** LLGL2 is involved in several key cellular pathways, including: 1. **Establishment of Spindle Orientation:** LLGL2 regulates the orientation of the spindle apparatus during cell division, ensuring proper chromosome segregation and maintaining tissue homeostasis. 2. **Establishment or Maintenance of Epithelial Cell Apical/Basal Polarity:** The scribble complex, including LLGL2, is essential for establishing and maintaining epithelial cell polarity, which is critical for the prevention of cancer and tissue homeostasis. 3. **Regulation of Notch Signaling Pathway:** LLGL2 modulates the Notch signaling pathway, which is involved in cell fate determination, differentiation, and proliferation. 4. **Regulation of Protein Secretion:** LLGL2 regulates the secretion of proteins from epithelial cells, which is critical for maintaining tissue homeostasis and preventing disease. **Clinical Significance:** Dysregulation of LLGL2 has been implicated in various human diseases, including: 1. **Cancer:** Loss of LLGL2 function has been observed in several types of cancer, including colon, kidney, and lung cancer, suggesting its role in maintaining epithelial cell polarity and preventing cancer. 2. **Neurological Disorders:** LLGL2 has been implicated in neurological disorders, including autism and schizophrenia, suggesting its role in regulating cellular polarity and signaling in the nervous system. 3. **Gastrointestinal Diseases:** LLGL2 has been implicated in gastrointestinal diseases, including inflammatory bowel disease and colon cancer, suggesting its role in maintaining epithelial cell polarity and preventing disease. In conclusion, LLGL2 is a critical regulator of cellular polarity and signaling, and its dysregulation has been implicated in various human diseases. Further research is necessary to fully understand the intricacies of LLGL2's function and its implications in human disease.

Genular Protein ID: 1358482829

Symbol: L2GL2_HUMAN

Name: LLGL scribble cell polarity complex component 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632202

Title: Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.

PubMed ID: 15632202

DOI: 10.1074/jbc.c400440200

PubMed ID: 12725730

Title: Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.

PubMed ID: 12725730

DOI: 10.1016/s0960-9822(03)00244-6

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20644714

Title: Involvement of Lgl and Mahjong/VprBP in cell competition.

PubMed ID: 20644714

DOI: 10.1371/journal.pbio.1000422

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1020
  • Mass: 113448
  • Checksum: 9C36BFF9F94314B5
  • Sequence:
  • MRRFLRPGHD PVRERLKRDL FQFNKTVEHG FPHQPSALGY SPSLRILAIG TRSGAIKLYG 
    APGVEFMGLH QENNAVTQIH LLPGQCQLVT LLDDNSLHLW SLKVKGGASE LQEDESFTLR 
    GPPGAAPSAT QITVVLPHSS CELLYLGTES GNVFVVQLPA FRALEDRTIS SDAVLQRLPE 
    EARHRRVFEM VEALQEHPRD PNQILIGYSR GLVVIWDLQG SRVLYHFLSS QQLENIWWQR 
    DGRLLVSCHS DGSYCQWPVS SEAQQPEPLR SLVPYGPFPC KAITRILWLT TRQGLPFTIF 
    QGGMPRASYG DRHCISVIHD GQQTAFDFTS RVIGFTVLTE ADPAATFDDP YALVVLAEEE 
    LVVIDLQTAG WPPVQLPYLA SLHCSAITCS HHVSNIPLKL WERIIAAGSR QNAHFSTMEW 
    PIDGGTSLTP APPQRDLLLT GHEDGTVRFW DASGVCLRLL YKLSTVRVFL TDTDPNENFS 
    AQGEDEWPPL RKVGSFDPYS DDPRLGIQKI FLCKYSGYLA VAGTAGQVLV LELNDEAAEQ 
    AVEQVEADLL QDQEGYRWKG HERLAARSGP VRFEPGFQPF VLVQCQPPAV VTSLALHSEW 
    RLVAFGTSHG FGLFDHQQRR QVFVKCTLHP SDQLALEGPL SRVKSLKKSL RQSFRRMRRS 
    RVSSRKRHPA GPPGEAQEGS AKAERPGLQN MELAPVQRKI EARSAEDSFT GFVRTLYFAD 
    TYLKDSSRHC PSLWAGTNGG TIYAFSLRVP PAERRMDEPV RAEQAKEIQL MHRAPVVGIL 
    VLDGHSVPLP EPLEVAHDLS KSPDMQGSHQ LLVVSEEQFK VFTLPKVSAK LKLKLTALEG 
    SRVRRVSVAH FGSRRAEDYG EHHLAVLTNL GDIQVVSLPL LKPQVRYSCI RREDVSGIAS 
    CVFTKYGQGF YLISPSEFER FSLSTKWLVE PRCLVDSAET KNHRPGNGAG PKKAPSRARN 
    SGTQSDGEEK QPGLVMERAL LSDERVLKEI QSTLEGDRGS GNWRSHRAAV GCSLSNGGAE

Genular Protein ID: 2775581295

Symbol: A0PJJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 271
  • Mass: 29831
  • Checksum: 7E5675D861523139
  • Sequence:
  • VPPAERRMDE PVRAEQAKEI QLMHRAPVVG ILVLDGHSVP LPEPLEVAHD LSKSPDMQGS 
    HQLLVVSEEQ FKVFTLPKVS AKLKLKLTAL EGSRVRRVSV AHFGSRRAED YGEHHLAVLT 
    NLGDIQVVSL PLLKPQVRYS CIRREDVSGI ASCVFTKYGQ GFYLISPSEF ERFSLSTKWL 
    VEPRCLVDSA ETKNHRPGNG AGPKKAPSRA RNSGTQSDGE EKQPGLVMER ALLSDERVLK 
    EIQSTLEGDR GSGNWRSHRA AVGCSLSNGG E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.