Details for: LLGL1

Gene ID: 3996

Symbol: LLGL1

Ensembl ID: ENSG00000131899

Description: LLGL scribble cell polarity complex component 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.6255
    Cell Significance Index: -9.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.6513
    Cell Significance Index: -9.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.7935
    Cell Significance Index: -7.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.0545
    Cell Significance Index: -7.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.9322
    Cell Significance Index: -9.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4903
    Cell Significance Index: -9.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4911
    Cell Significance Index: -9.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.8309
    Cell Significance Index: 13.9100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4407
    Cell Significance Index: 7.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4037
    Cell Significance Index: 5.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4006
    Cell Significance Index: 5.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2925
    Cell Significance Index: 55.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2422
    Cell Significance Index: 5.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1692
    Cell Significance Index: 10.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1606
    Cell Significance Index: 3.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1604
    Cell Significance Index: 8.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1590
    Cell Significance Index: 8.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1433
    Cell Significance Index: 16.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1410
    Cell Significance Index: 62.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1407
    Cell Significance Index: 97.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1116
    Cell Significance Index: 3.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1073
    Cell Significance Index: 11.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0920
    Cell Significance Index: 9.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0899
    Cell Significance Index: 11.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0750
    Cell Significance Index: 12.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0700
    Cell Significance Index: 9.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0691
    Cell Significance Index: 62.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0690
    Cell Significance Index: 13.8400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0533
    Cell Significance Index: 0.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0375
    Cell Significance Index: 1.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0369
    Cell Significance Index: 0.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0355
    Cell Significance Index: 7.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0325
    Cell Significance Index: 1.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0324
    Cell Significance Index: 1.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0283
    Cell Significance Index: 10.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0260
    Cell Significance Index: 1.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0236
    Cell Significance Index: 2.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0144
    Cell Significance Index: 0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0082
    Cell Significance Index: 1.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0070
    Cell Significance Index: 0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0067
    Cell Significance Index: 3.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0031
    Cell Significance Index: 0.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0154
    Cell Significance Index: -1.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0161
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0166
    Cell Significance Index: -10.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0175
    Cell Significance Index: -7.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0209
    Cell Significance Index: -1.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0231
    Cell Significance Index: -2.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0243
    Cell Significance Index: -0.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0267
    Cell Significance Index: -7.6800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0392
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0429
    Cell Significance Index: -7.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0458
    Cell Significance Index: -6.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0485
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0518
    Cell Significance Index: -10.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0519
    Cell Significance Index: -5.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0551
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0568
    Cell Significance Index: -6.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0616
    Cell Significance Index: -0.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0625
    Cell Significance Index: -3.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0628
    Cell Significance Index: -4.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0777
    Cell Significance Index: -2.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0781
    Cell Significance Index: -1.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0782
    Cell Significance Index: -4.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0789
    Cell Significance Index: -1.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0877
    Cell Significance Index: -5.6600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0908
    Cell Significance Index: -0.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0918
    Cell Significance Index: -9.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1021
    Cell Significance Index: -4.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1047
    Cell Significance Index: -7.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1054
    Cell Significance Index: -8.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1054
    Cell Significance Index: -2.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1066
    Cell Significance Index: -8.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1069
    Cell Significance Index: -2.2900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1129
    Cell Significance Index: -0.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1162
    Cell Significance Index: -6.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1265
    Cell Significance Index: -2.7700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1517
    Cell Significance Index: -2.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1559
    Cell Significance Index: -4.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1767
    Cell Significance Index: -7.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1932
    Cell Significance Index: -2.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1965
    Cell Significance Index: -5.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2006
    Cell Significance Index: -5.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2047
    Cell Significance Index: -7.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2113
    Cell Significance Index: -8.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2165
    Cell Significance Index: -3.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2182
    Cell Significance Index: -8.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2183
    Cell Significance Index: -3.2900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2332
    Cell Significance Index: -1.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2352
    Cell Significance Index: -7.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LLGL1 is a gene that encodes a protein with a unique structure, consisting of multiple protein-protein interaction domains. These domains enable LLGL1 to interact with various proteins, including those involved in cell polarity, cytoskeletal organization, and signaling pathways. The gene is highly expressed in cells that require precise polarity, such as tracheal goblet cells and intestinal epithelial cells. LLGL1's expression is also observed in cells that undergo significant changes in their polarity, such as during development and tissue regeneration. **Pathways and Functions:** LLGL1 is involved in various cellular processes, including: 1. **Establishment of Spindle Orientation:** LLGL1 regulates the orientation of microtubules during cell division, ensuring proper spindle formation and chromosomal segregation. 2. **Cell Polarity:** LLGL1 is a key component of the scribble complex, which governs the establishment and maintenance of epithelial cell polarity. This involves regulating the localization of proteins and lipids to specific cellular compartments. 3. **Cytoskeletal Organization:** LLGL1 interacts with myosin II, a motor protein that regulates actin cytoskeleton dynamics. This interaction is essential for maintaining cellular shape and polarity. 4. **Regulation of Notch Signaling Pathway:** LLGL1 regulates the activity of the Notch signaling pathway, which plays a crucial role in cell fate determination and development. 5. **Protein Secretion and Exocytosis:** LLGL1 is involved in regulating the secretion of proteins and lipids from the Golgi apparatus, which is essential for maintaining cellular polarity and function. **Clinical Significance:** Dysregulation of LLGL1 has been implicated in various diseases, including: 1. **Cancer:** LLGL1 is often downregulated in cancer cells, leading to loss of cell polarity and increased tumorigenesis. 2. **Neurological Disorders:** LLGL1 is expressed in GABAergic interneurons, and its dysregulation has been linked to neurological disorders such as epilepsy and schizophrenia. 3. **Gastrointestinal Disorders:** LLGL1 is expressed in intestinal epithelial cells, and its dysregulation has been implicated in gastrointestinal disorders such as inflammatory bowel disease. In conclusion, LLGL1 is a gene that plays a critical role in maintaining cellular polarity and regulating various cellular processes. Its dysregulation has significant implications for human health, and further research is necessary to fully understand its role in disease.

Genular Protein ID: 1135981185

Symbol: L2GL1_HUMAN

Name: Lethal(2) giant larvae protein homolog 1

UniProtKB Accession Codes:

Q15334 A7MBM7 O00188 Q58F11 Q86UK6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7542763

Title: A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain.

PubMed ID: 7542763

PubMed ID: 8565641

Title: The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2.

PubMed ID: 8565641

DOI: 10.1159/000134167

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12725730

Title: Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.

PubMed ID: 12725730

DOI: 10.1016/s0960-9822(03)00244-6

PubMed ID: 15735678

Title: Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.

PubMed ID: 15735678

DOI: 10.1038/sj.onc.1208520

PubMed ID: 16170365

Title: Expression of Hugl-1 is strongly reduced in malignant melanoma.

PubMed ID: 16170365

DOI: 10.1038/sj.onc.1209008

PubMed ID: 20644714

Title: Involvement of Lgl and Mahjong/VprBP in cell competition.

PubMed ID: 20644714

DOI: 10.1371/journal.pbio.1000422

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 1064
  • Mass: 115418
  • Checksum: 9318D6736934E4D5
  • Sequence:
    • MMKFRFRRQG ADPQREKLKQ ELFAFNKTVE HGFPNQPSAL AFDPELRIMA IGTRSGAVKI 
YGAPGVEFTG LHRDAATVTQ MHFLTGQGRL LSLLDDSSLH LWEIVHHNGC AHLEEALSFQ 
LPSRPGFDGA SAPLSLTRVT VVLLVAASDI AALGTEGSSV FFLDVTTLTL LEGQTLAPGE 
VLRSVPDDYR CGKALGPVES LQGHLRDPTK ILIGYSRGLL VIWNQASQCV DHIFLGNQQL 
ESLCWGRDSS TVVSSHSDGS YAVWSVDAGS FPTLQPTVAT TPYGPFPCKA INKILWRNCE 
SGGHFIIFSG GMPRASYGDR HCVSVLRAET LVTLDFTSRI IDFFTVHSTR PEDEFDDPQA 
LAVLLEEELV VLDLQTPGWP AVPAPYLAPL HSSAITCSAH VASVPAKLWA RIVSAGEQQS 
PQPVSSALSW PITGGRNLAQ EPSQRGLLLT GHEDGTVRFW DASGVALRPL YKLSTAGLFQ 
TDCEHADSLA QAAEDDWPPF RKVGCFDPYS DDPRLGVQKV ALCKYTAQMV VAGTAGQVLV 
LELSDVPVEQ AVSVAIIDLL QDREGFTWKG HERLSPRTGP LPWPAGFQPR VLVQCLPPAA 
VTAVTLHTEW SLVAFGTSHG FGLFDYQRKS PVLARCTLHP NDSLAMEGPL SRVKSLKKSL 
RQSFRRIRKS RVSGKKRAAN ASSKLQEANA QLAEQACPHD VEMTPVQRRI EPRSADDSLS 
GVVRCLYFAD TFLRDGAHHG PTMWAGTNSG SVFAYALEVP AAAVGGEKRP EQAVEAVLGK 
EVQLMHRAPV VAIAVLDGRG RPLPEPYEAS RDLAQAPDMQ GGHAVLIASE EQFKVFTLPK 
VSAKTKFKLT AHEGCRVRKV ALATFASVAC EDYAETCLAC LTNLGDVHVF SVPGLRPQVH 
YSCIRKEDIS GIASCVFTRH GQGFYLISPS EFERFSLSAR NITEPLCSLD INWPRDATQA 
SYRIRESPKL SQANGTPSIL LAPQSLDGSP DPAHSMGPDT PEPPEAALSP MSIDSATSAD 
TTLDTTGDVT VEDVKDFLGS SEESEKNLRN LAEDEAHACA ILIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.