Details for: LPO

Gene ID: 4025

Symbol: LPO

Ensembl ID: ENSG00000167419

Description: lactoperoxidase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.39
    Marker Score: 7726
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.14
    Marker Score: 2150
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.83
    Marker Score: 731
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.73
    Marker Score: 1542
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.51
    Marker Score: 553
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.09
    Marker Score: 3134
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.03
    Marker Score: 482.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1854
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 387
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5312
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1673
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 616
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.79
    Marker Score: 8116
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.77
    Marker Score: 1591
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10944
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.69
    Marker Score: 223
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.68
    Marker Score: 306
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.66
    Marker Score: 347.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.65
    Marker Score: 1529
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.58
    Marker Score: 555
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 447
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.52
    Marker Score: 189
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.49
    Marker Score: 546
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.45
    Marker Score: 350.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.44
    Marker Score: 137
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.43
    Marker Score: 105
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 260
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 177
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.34
    Marker Score: 132
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.32
    Marker Score: 90
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.28
    Marker Score: 62
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 114
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.2
    Marker Score: 1909
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1258
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.18
    Marker Score: 705
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.18
    Marker Score: 76
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.18
    Marker Score: 113.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.14
    Marker Score: 73
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 49.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 107
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 123
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 210
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.12
    Marker Score: 495
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 105
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.11
    Marker Score: 309.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 141
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 51.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.09
    Marker Score: 110
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 60
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.08
    Marker Score: 126
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.08
    Marker Score: 280
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 107
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.07
    Marker Score: 48.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 34

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Other Information

**Key characteristics:** - It is a glycoprotein with a molecular weight of approximately 50,000 Da. - It is found in both the cytoplasm and the extracellular space. - It is a key regulator of the immune response and is involved in the detection of chemical stimuli. **Pathways and functions:** - It is involved in cellular oxidant detoxification, the cytoplasm, defense response to bacteria, and the detection of chemical stimuli involved in sensory perception of bitter taste. - It is also involved in the thiocyanate metabolic process and the production of ROS and rns in phagocytes. **Clinical significance:** - Mutations in the LPO gene have been linked to several human diseases, including salivary gland cancer, lung cancer, and diabetes. - LPO inhibitors are being investigated as potential treatments for these diseases. **Additional information:** - It is a highly conserved protein, with a similar enzyme found in other mammals. - It is regulated by a number of factors, including the levels of copper and hydrogen peroxide. - It is a key regulator of the immune response, and its activity is increased in response to infection.

Genular Protein ID: 985773821

Symbol: PERL_HUMAN

Name: N/A

UniProtKB Accession Codes:

P22079 A5JUY4 E7EMJ3 Q13408 Q3KNQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8964511

Title: Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA.

PubMed ID: 8964511

DOI: 10.1016/0378-1119(96)00078-9

PubMed ID: 19059195

Title: Molecular heterogeneity and alternative splicing of human lactoperoxidase.

PubMed ID: 19059195

DOI: 10.1016/j.abb.2008.11.015

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2222811

Title: Molecular cloning of cDNAs encoding bovine and human lactoperoxidase.

PubMed ID: 2222811

DOI: 10.1089/dna.1990.9.499

PubMed ID: 10715594

Title: Identification of lactoperoxidase in mature human milk.

PubMed ID: 10715594

DOI: 10.1016/s0955-2863(99)00082-0

PubMed ID: 12626341

Title: Lactoperoxidase and human airway host defense.

PubMed ID: 12626341

DOI: 10.1165/rcmb.2002-0152oc

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

Sequence Information:

  • Length: 712
  • Mass: 80288
  • Checksum: BC7AA410997198C0
  • Sequence:
    • MRVLLHLPAL LASLILLQAA ASTTRAQTTR TSAISDTVSQ AKVQVNKAFL DSRTRLKTAM 
SSETPTSRQL SEYLKHAKGR TRTAIRNGQV WEESLKRLRQ KASLTNVTDP SLDLTSLSLE 
VGCGAPAPVV RCDPCSPYRT ITGDCNNRRK PALGAANRAL ARWLPAEYED GLSLPFGWTP 
GKTRNGFPLP LAREVSNKIV GYLNEEGVLD QNRSLLFMQW GQIVDHDLDF APDTELGSSE 
YSKAQCDEYC IQGDNCFPIM FPPNDPKAGT QGKCMPFFRA GFVCPTPPYK SLAREQINAL 
TSFLDASFVY SSEPSLASRL RNLSSPLGLM AVNQEVSDHG LPYLPYDSKK PSPCEFINTT 
ARVPCFLAGD SRASEHILLA TSHTLFLREH NRLARELKRL NPQWDGEKLY QEARKILGAF 
VQIITFRDYL PILLGDHMQK WIPPYQGYSE SVDPRISNVF TFAFRFGHLE VPSSMFRLDE 
NYQPWGPEPE LPLHTLFFNT WRMVKDGGID PLVRGLLAKK SKLMKQNKMM TGELRNKLFQ 
PTHRIHGFDL AAINTQRCRD HGQPGYNSWR AFCDLSQPQT LEELNTVLKS KMLAKKLLGL 
YGTPDNIDIW IGAIAEPLVE RGRVGPLLAC LLGKQFQQIR DGDRFWWENP GVFTNEQKDS 
LQKMSFSRLV CDNTRITKVP RDPFWANSYP YDFVDCSAID KLDLSPWASV KN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.