Details for: LPO

Gene ID: 4025

Symbol: LPO

Ensembl ID: ENSG00000167419

Description: lactoperoxidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 12.0265
    Cell Significance Index: 250.8200
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 10.7043
    Cell Significance Index: -1.6700
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 8.6309
    Cell Significance Index: 48.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.4658
    Cell Significance Index: -1.6400
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 3.6644
    Cell Significance Index: 36.6700
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.1255
    Cell Significance Index: 9.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6586
    Cell Significance Index: 77.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3928
    Cell Significance Index: 44.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.3626
    Cell Significance Index: -1.6800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7753
    Cell Significance Index: 11.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6412
    Cell Significance Index: 122.0300
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.4502
    Cell Significance Index: 3.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4442
    Cell Significance Index: 9.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3945
    Cell Significance Index: 39.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3261
    Cell Significance Index: 294.4400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3237
    Cell Significance Index: 5.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2805
    Cell Significance Index: 16.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2662
    Cell Significance Index: 28.9500
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: 0.2376
    Cell Significance Index: 1.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2104
    Cell Significance Index: 34.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1944
    Cell Significance Index: 4.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1780
    Cell Significance Index: 3.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1658
    Cell Significance Index: 3.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1396
    Cell Significance Index: 9.6600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.1282
    Cell Significance Index: 1.5500
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.0988
    Cell Significance Index: 0.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0235
    Cell Significance Index: 0.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0211
    Cell Significance Index: 0.7400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0201
    Cell Significance Index: 0.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0199
    Cell Significance Index: 4.0000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0166
    Cell Significance Index: 0.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0130
    Cell Significance Index: 1.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0119
    Cell Significance Index: 0.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0087
    Cell Significance Index: 1.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0076
    Cell Significance Index: 0.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0076
    Cell Significance Index: 0.1900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0066
    Cell Significance Index: 0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0022
    Cell Significance Index: 0.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0010
    Cell Significance Index: 0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0006
    Cell Significance Index: 0.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0006
    Cell Significance Index: 0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0016
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0021
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0021
    Cell Significance Index: -1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0028
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0028
    Cell Significance Index: -1.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0039
    Cell Significance Index: -0.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0043
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0047
    Cell Significance Index: -0.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0056
    Cell Significance Index: -0.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0064
    Cell Significance Index: -0.2900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0071
    Cell Significance Index: -0.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0077
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0078
    Cell Significance Index: -1.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0088
    Cell Significance Index: -0.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0091
    Cell Significance Index: -1.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0095
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0104
    Cell Significance Index: -1.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0108
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0112
    Cell Significance Index: -1.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0112
    Cell Significance Index: -0.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0116
    Cell Significance Index: -1.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0125
    Cell Significance Index: -0.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0140
    Cell Significance Index: -0.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0141
    Cell Significance Index: -0.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0152
    Cell Significance Index: -1.5800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0157
    Cell Significance Index: -0.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0157
    Cell Significance Index: -0.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0174
    Cell Significance Index: -1.7800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0186
    Cell Significance Index: -0.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0198
    Cell Significance Index: -0.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0202
    Cell Significance Index: -1.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0203
    Cell Significance Index: -0.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0215
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0226
    Cell Significance Index: -0.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0243
    Cell Significance Index: -1.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0261
    Cell Significance Index: -0.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0266
    Cell Significance Index: -1.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0277
    Cell Significance Index: -0.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0278
    Cell Significance Index: -1.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0283
    Cell Significance Index: -0.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0287
    Cell Significance Index: -0.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0293
    Cell Significance Index: -1.8900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0307
    Cell Significance Index: -1.6000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0330
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0358
    Cell Significance Index: -0.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Lactoperoxidase is a heme-containing enzyme that is widely expressed in various tissues, including the salivary gland, blood vessels, lungs, colon, and small intestine. It is secreted by epithelial cells and has been implicated in several cellular processes, including the regulation of oxidative stress, the production of thiocyanate, and the modulation of immune responses. The LPO gene (ENSG00000167419) is a pseudogene that is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** Lactoperoxidase is involved in several key pathways, including: 1. **Cellular oxidant detoxification:** LPO catalyzes the oxidation of thiocyanate to hypothiocyanite, which is a potent antimicrobial agent that can inactivate pathogens and regulate oxidative stress. 2. **Immune system regulation:** LPO modulates immune responses by regulating the production of ROS and thiocyanate, which are involved in the activation of immune cells and the regulation of inflammation. 3. **Oxidative stress response:** LPO helps to regulate oxidative stress by scavenging ROS and maintaining the redox balance in cells. 4. **Bitter taste perception:** LPO is involved in the detection of chemical stimuli involved in sensory perception of bitter taste. **Clinical Significance:** Dysregulation of lactoperoxidase has been implicated in various diseases, including: 1. **Infectious diseases:** Abnormal LPO activity has been linked to the development of infectious diseases, such as respiratory tract infections and sepsis. 2. **Atherosclerosis:** LPO has been implicated in the regulation of oxidative stress and inflammation in atherosclerosis. 3. **Cancer:** LPO has been shown to have anti-tumor effects by regulating oxidative stress and inflammation in cancer cells. 4. **Neurodegenerative diseases:** LPO has been implicated in the regulation of oxidative stress and inflammation in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, lactoperoxidase is a multifunctional enzyme that plays a crucial role in various physiological and pathological processes. Its dysregulation has been implicated in various diseases, making it an important target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms of LPO and its clinical significance.

Genular Protein ID: 985773821

Symbol: PERL_HUMAN

Name: N/A

UniProtKB Accession Codes:

P22079 A5JUY4 E7EMJ3 Q13408 Q3KNQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8964511

Title: Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA.

PubMed ID: 8964511

DOI: 10.1016/0378-1119(96)00078-9

PubMed ID: 19059195

Title: Molecular heterogeneity and alternative splicing of human lactoperoxidase.

PubMed ID: 19059195

DOI: 10.1016/j.abb.2008.11.015

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2222811

Title: Molecular cloning of cDNAs encoding bovine and human lactoperoxidase.

PubMed ID: 2222811

DOI: 10.1089/dna.1990.9.499

PubMed ID: 10715594

Title: Identification of lactoperoxidase in mature human milk.

PubMed ID: 10715594

DOI: 10.1016/s0955-2863(99)00082-0

PubMed ID: 12626341

Title: Lactoperoxidase and human airway host defense.

PubMed ID: 12626341

DOI: 10.1165/rcmb.2002-0152oc

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

Sequence Information:

  • Length: 712
  • Mass: 80288
  • Checksum: BC7AA410997198C0
  • Sequence:
    • MRVLLHLPAL LASLILLQAA ASTTRAQTTR TSAISDTVSQ AKVQVNKAFL DSRTRLKTAM 
SSETPTSRQL SEYLKHAKGR TRTAIRNGQV WEESLKRLRQ KASLTNVTDP SLDLTSLSLE 
VGCGAPAPVV RCDPCSPYRT ITGDCNNRRK PALGAANRAL ARWLPAEYED GLSLPFGWTP 
GKTRNGFPLP LAREVSNKIV GYLNEEGVLD QNRSLLFMQW GQIVDHDLDF APDTELGSSE 
YSKAQCDEYC IQGDNCFPIM FPPNDPKAGT QGKCMPFFRA GFVCPTPPYK SLAREQINAL 
TSFLDASFVY SSEPSLASRL RNLSSPLGLM AVNQEVSDHG LPYLPYDSKK PSPCEFINTT 
ARVPCFLAGD SRASEHILLA TSHTLFLREH NRLARELKRL NPQWDGEKLY QEARKILGAF 
VQIITFRDYL PILLGDHMQK WIPPYQGYSE SVDPRISNVF TFAFRFGHLE VPSSMFRLDE 
NYQPWGPEPE LPLHTLFFNT WRMVKDGGID PLVRGLLAKK SKLMKQNKMM TGELRNKLFQ 
PTHRIHGFDL AAINTQRCRD HGQPGYNSWR AFCDLSQPQT LEELNTVLKS KMLAKKLLGL 
YGTPDNIDIW IGAIAEPLVE RGRVGPLLAC LLGKQFQQIR DGDRFWWENP GVFTNEQKDS 
LQKMSFSRLV CDNTRITKVP RDPFWANSYP YDFVDCSAID KLDLSPWASV KN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.