Details for: BMAL1
Gene ID: 406
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BMAL1
Ensembl ID: ENSG00000133794
Description: basic helix-loop-helix ARNT like 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 12.61rCSI 45.39%PRS 31.45
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CSI 11.64rCSI 28.28%PRS 31.59
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CSI 6rCSI 9.82%PRS 39.25
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CSI 5.69rCSI 4.41%PRS 49.71
-
CSI 5.6rCSI 4.24%PRS 62.05
-
CSI 4.11rCSI 2.95%PRS 62.48
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CSI 3.37rCSI 2.73%PRS 59.13
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CSI 3.36rCSI 2.55%PRS 60.88
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CSI 3.19rCSI 18.79%PRS 34.07
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CSI 3.19rCSI 5.25%PRS 54.45
-
CSI 3.09rCSI 3.31%PRS 47.19
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CSI 2.93rCSI 11.41%PRS 57.06
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CSI 2.6rCSI 5.93%PRS 42.05
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CSI 2.51rCSI 1.74%PRS 58.37
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CSI 2.43rCSI 1.69%PRS 62.4
-
CSI 2.37rCSI 5.65%PRS 58.9
-
CSI 2.3rCSI 4.05%PRS 46.91
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CSI 2.27rCSI 54.44%PRS 32.1
-
CSI 2.25rCSI 54.32%PRS 33
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CSI 2.23rCSI 1.81%PRS 49.55
-
CSI 2.23rCSI 3.31%PRS 51.19
-
CSI 2.22rCSI 6.58%PRS 59.84
-
CSI 2.2rCSI 2.74%PRS 30.97
-
CSI 2.2rCSI 2.03%PRS 69.48
-
CSI 2.13rCSI 1.58%PRS 42.27
-
CSI 2.1rCSI 4.79%PRS 48.39
-
CSI 2rCSI 1.5%PRS 52.85
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CSI 1.99rCSI 3.16%PRS 41.75
-
CSI 1.97rCSI 2.31%PRS 64.82
-
CSI 1.93rCSI 3.88%PRS 38.66
-
CSI 1.9rCSI 1.48%PRS 66.74
-
CSI 1.89rCSI 5.92%PRS 36.31
-
CSI 1.88rCSI 4.64%PRS 46.98
-
CSI 1.83rCSI 1.53%PRS 53.94
-
CSI 1.79rCSI 2.02%PRS 65.5
-
CSI 1.79rCSI 1.65%PRS 49.82
-
CSI 1.77rCSI 2.37%PRS 50.25
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CSI 1.75rCSI 3.1%PRS 31.66
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CSI 1.72rCSI 3.01%PRS 41.23
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CSI 1.7rCSI 1.59%PRS 48.7
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CSI 1.69rCSI 1.54%PRS 63.82
-
CSI 1.64rCSI 2.95%PRS 42.31
-
CSI 1.63rCSI 2.82%PRS 39.53
-
CSI 1.61rCSI 3.65%PRS 54.2
-
CSI 1.61rCSI 2.7%PRS 32.62
-
CSI 1.59rCSI 4.57%PRS 67.42
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CSI 1.56rCSI 13.42%PRS 36.46
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CSI 1.54rCSI 1.91%PRS 60.12
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CSI 1.53rCSI 11.26%PRS 36.66
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CSI 1.52rCSI 1.96%PRS 33.6
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CSI 1.51rCSI 1.94%PRS 53.83
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CSI 1.5rCSI 2.68%PRS 47.53
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CSI 1.47rCSI 2.25%PRS 49.61
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CSI 1.41rCSI 1.63%PRS 39.11
-
CSI 1.4rCSI 1.67%PRS 32.45
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CSI 1.4rCSI 4.48%PRS 45.89
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CSI 1.4rCSI 6.69%PRS 47.82
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CSI 1.32rCSI 2.47%PRS 38.36
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CSI 1.31rCSI 1.99%PRS 45.5
-
CSI 1.27rCSI 2.04%PRS 34.81
-
CSI 1.26rCSI 1.62%PRS 43.79
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CSI 1.23rCSI 1.25%PRS 62.51
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CSI 1.22rCSI 2.48%PRS 30.9
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CSI 1.2rCSI 3.44%PRS 64.87
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CSI 1.2rCSI 3.12%PRS 48.09
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CSI 1.19rCSI 2.84%PRS 37.75
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CSI 1.15rCSI 2.57%PRS 33.44
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CSI 1.11rCSI 1.78%PRS 39.45
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CSI 1.09rCSI 2.41%PRS 36.76
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CSI 1.03rCSI 1.23%PRS 69.28
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CSI 0.99rCSI 2.15%PRS 38.68
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CSI 0.96rCSI 4.82%PRS 60.46
-
CSI 0.96rCSI 4.2%PRS 46.2
-
CSI 0.91rCSI 1.87%PRS 42.19
-
CSI 0.83rCSI 2.09%PRS 39.14
-
CSI 0.81rCSI 2.78%PRS 39.69
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CSI 0.77rCSI 2.9%PRS 33.5
-
CSI 0.77rCSI 0.59%PRS 48.08
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CSI 0.73rCSI 1.16%PRS 50.2
-
CSI 0.72rCSI 2.37%PRS 37.28
-
CSI 0.71rCSI 2.22%PRS 33.96
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CSI 0.69rCSI 9.84%PRS 40.92
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CSI 0.66rCSI 2.95%PRS 34.48
-
CSI 0.61rCSI 1.76%PRS 40.02
-
CSI 0.61rCSI 3.42%PRS 35.09
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CSI 0.59rCSI 3.99%PRS 45.98
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CSI 0.54rCSI 2.05%PRS 41.62
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CSI 0.36rCSI 1%PRS 64.48
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CSI 0.35rCSI 2.19%PRS 41.29
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CSI 0.3rCSI 6.06%PRS 42.26
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CSI 0.23rCSI 4.65%PRS 40.97
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4091294589
Symbol: BMAL1_HUMAN
Name: Aryl hydrocarbon receptor nuclear translocator-like protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9144434
Title: cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage.
PubMed ID: 9144434
PubMed ID: 9079689
Title: Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
PubMed ID: 9079689
PubMed ID: 9576906
Title: The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.
PubMed ID: 9576906
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9616112
Title: Role of the CLOCK protein in the mammalian circadian mechanism.
PubMed ID: 9616112
PubMed ID: 11441146
Title: Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.
PubMed ID: 11441146
PubMed ID: 12738229
Title: Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2.
PubMed ID: 12738229
PubMed ID: 14645221
Title: Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
PubMed ID: 14645221
PubMed ID: 16474406
Title: Feedback repression is required for mammalian circadian clock function.
PubMed ID: 16474406
DOI: 10.1038/ng1745
PubMed ID: 18587630
Title: CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter.
PubMed ID: 18587630
PubMed ID: 21960634
Title: Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
PubMed ID: 21960634
PubMed ID: 23576606
Title: Mechanism of the circadian clock in physiology.
PubMed ID: 23576606
PubMed ID: 23955654
Title: The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth.
PubMed ID: 23955654
PubMed ID: 23785138
Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.
PubMed ID: 23785138
PubMed ID: 23303907
Title: Metabolism and the circadian clock converge.
PubMed ID: 23303907
PubMed ID: 24385426
Title: Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression.
PubMed ID: 24385426
PubMed ID: 24005054
Title: A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock.
PubMed ID: 24005054
DOI: 10.1038/jid.2013.366
PubMed ID: 24728990
Title: The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor.
PubMed ID: 24728990
DOI: 10.1093/nar/gku225
PubMed ID: 23916625
Title: Molecular architecture of the mammalian circadian clock.
PubMed ID: 23916625
PubMed ID: 25936801
Title: Cancer/testis antigen PASD1 silences the circadian clock.
PubMed ID: 25936801
PubMed ID: 28985504
Title: CLOCK acetylates ASS1 to drive circadian rhythm of ureagenesis.
PubMed ID: 28985504
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28903391
Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
PubMed ID: 28903391
PubMed ID: 29626158
Title: Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1.
PubMed ID: 29626158
DOI: 10.1042/bcj20180005
PubMed ID: 30530698
Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.
PubMed ID: 30530698
PubMed ID: 34545347
Title: The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells.
PubMed ID: 34545347
PubMed ID: 23229515
Title: Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.
PubMed ID: 23229515
DOI: 10.1038/cr.2012.170
Sequence Information:
- Length: 626
- Mass: 68762
- Checksum: 820F0E07DC6265A6
- Sequence:
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKADRKSFC TIHSTGYLKS WPPTKMGLDE DNEPDNEGCN LSCLVAIGRL HSHVVPQPVN GEIRVKSMEY VSRHAIDGKF VFVDQRATAI LAYLPQELLG TSCYEYFHQD DIGHLAECHR QVLQTREKIT TNCYKFKIKD GSFITLRSRW FSFMNPWTKE VEYIVSTNTV VLANVLEGGD PTFPQLTASP HSMDSMLPSG EGGPKRTHPT VPGIPGGTRA GAGKIGRMIA EEIMEIHRIR GSSPSSCGSS PLNITSTPPP DASSPGGKKI LNGGTPDIPS SGLLSGQAQE NPGYPYSDSS SILGENPHIG IDMIDNDQGS SSPSNDEAAM AVIMSLLEAD AGLGGPVDFS DLPWPL
Genular Protein ID: 3562297855
Symbol: A0A669KBF4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
Sequence Information:
- Length: 630
- Mass: 69238
- Checksum: A98ECCAF36F68F0A
- Sequence:
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKDRKSFCT IHSTGYLKSW PPTKMGLDED NEPDNEGCNL SCLVAIGRLH SHVVPQPVNG EIRVKSMEYV SRHAIDGKFV FVDQRATAIL AYLPQELLGT SCYEYFHQDD IGHLAECHRQ VLQTREKITT NCYKFKIKDG SFITLRSRWF SFMNPWTKEV EYIVSTNTVV LANVLEGGDP TFPQLTASPH SMDSMLPSGE DSFVVGGPKR THPTVPGIPG GTRAGAGKIG RMIAEEIMEI HRIRGSSPSS CGSSPLNITS TPPPDASSPG GKKILNGGTP DIPSSGLLSG QAQENPGYPY SDSSSILGEN PHIGIDMIDN DQGSSSPSND EAAMAVIMSL LEADAGLGGP VDFSDLPWPL
Genular Protein ID: 439758122
Symbol: A0A140VKD3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 625
- Mass: 68691
- Checksum: 3F3F7D5688A6FFE2
- Sequence:
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKDRKSFCT IHSTGYLKSW PPTKMGLDED NEPDNEGCNL SCLVAIGRLH SHVVPQPVNG EIRVKSMEYV SRHAIDGKFV FVDQRATAIL AYLPQELLGT SCYEYFHQDD IGHLAECHRQ VLQTREKITT NCYKFKIKDG SFITLRSRWF SFMNPWTKEV EYIVSTNTVV LANVLEGGDP TFPQLTASPH SMDSMLPSGE GGPKRTHPTV PGIPGGTRAG AGKIGRMIAE EIMEIHRIRG SSPSSCGSSP LNITSTPPPD ASSPGGKKIL NGGTPDIPSS GLLSGQAQEN PGYPYSDSSS ILGENPHIGI DMIDNDQGSS SPSNDEAAMA VIMSLLEADA GLGGPVDFSD LPWPL
Genular Protein ID: 3216779482
Symbol: B2RCL8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 626
- Mass: 68778
- Checksum: 6755CFB1070FD367
- Sequence:
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKADRKSFC TIHSTGYLKS WPPTKMGLDE DNEPDNEGCN LSCLVAIGRL HSHVVPQPVN GEIRVKSMEY VSRHAIDGKF VFVDQRATAI LAYLPQELLG TSCYEYFHQD DIGHLAECHR QVLQTREKIT TNCYKFKIKD GSFITLRSRW FSFMNPWTKE VEYIVSTNTV VLANVLEGGD PTFPQLTASP HSMDSMLPSG EGGPKRTHPT VPGIPGGTRA GAGKIGRMIA EEIMEIHRIR GSSPSSCGSS LLNITSTPPP DASSPGGKKI LNGGTPDIPS SGLLSGQAQE NPGYPYSDSS SILGENPHIG IDMIDNDQGS SSPSNDEAAM AVIMSLLEAD AGLGGPVDFS DLPWPL