Details for: BMAL1

Gene ID: 406

Symbol: BMAL1

Ensembl ID: ENSG00000133794

Description: basic helix-loop-helix ARNT like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 146.8383
    Cell Significance Index: -22.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.8900
    Cell Significance Index: -22.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.4330
    Cell Significance Index: -19.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.4034
    Cell Significance Index: -19.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.5327
    Cell Significance Index: -22.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9101
    Cell Significance Index: -21.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8632
    Cell Significance Index: -21.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8464
    Cell Significance Index: -23.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1481
    Cell Significance Index: -6.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.0192
    Cell Significance Index: 66.1100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.9878
    Cell Significance Index: 21.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9612
    Cell Significance Index: 24.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6283
    Cell Significance Index: 326.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5383
    Cell Significance Index: 24.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2539
    Cell Significance Index: 238.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0517
    Cell Significance Index: 46.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9848
    Cell Significance Index: 37.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9517
    Cell Significance Index: 25.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9282
    Cell Significance Index: 58.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7771
    Cell Significance Index: 11.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7216
    Cell Significance Index: 71.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7017
    Cell Significance Index: 15.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6196
    Cell Significance Index: 559.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6084
    Cell Significance Index: 34.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5823
    Cell Significance Index: 208.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5306
    Cell Significance Index: 6.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4339
    Cell Significance Index: 21.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4038
    Cell Significance Index: 30.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3884
    Cell Significance Index: 63.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3638
    Cell Significance Index: 39.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3133
    Cell Significance Index: 216.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2893
    Cell Significance Index: 17.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2664
    Cell Significance Index: 6.5000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2556
    Cell Significance Index: 3.4100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2348
    Cell Significance Index: 1.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2248
    Cell Significance Index: 6.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2143
    Cell Significance Index: 11.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2042
    Cell Significance Index: 40.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2020
    Cell Significance Index: 5.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1980
    Cell Significance Index: 3.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1629
    Cell Significance Index: 22.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1503
    Cell Significance Index: 10.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1454
    Cell Significance Index: 3.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1402
    Cell Significance Index: 25.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1165
    Cell Significance Index: 3.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0936
    Cell Significance Index: 41.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0924
    Cell Significance Index: 2.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0913
    Cell Significance Index: 6.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0909
    Cell Significance Index: 4.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0830
    Cell Significance Index: 156.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0782
    Cell Significance Index: 2.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0778
    Cell Significance Index: 2.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0767
    Cell Significance Index: 9.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0478
    Cell Significance Index: 30.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0363
    Cell Significance Index: 19.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0304
    Cell Significance Index: 56.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0253
    Cell Significance Index: 1.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0227
    Cell Significance Index: 34.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0149
    Cell Significance Index: 20.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0032
    Cell Significance Index: -1.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0044
    Cell Significance Index: -0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0154
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0226
    Cell Significance Index: -16.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0293
    Cell Significance Index: -21.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0298
    Cell Significance Index: -0.5100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0335
    Cell Significance Index: -0.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0373
    Cell Significance Index: -21.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0391
    Cell Significance Index: -6.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0400
    Cell Significance Index: -25.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0459
    Cell Significance Index: -5.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0673
    Cell Significance Index: -19.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0717
    Cell Significance Index: -2.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0866
    Cell Significance Index: -8.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1035
    Cell Significance Index: -12.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1151
    Cell Significance Index: -24.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1158
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1163
    Cell Significance Index: -13.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1290
    Cell Significance Index: -1.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1362
    Cell Significance Index: -2.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1519
    Cell Significance Index: -19.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1559
    Cell Significance Index: -8.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1611
    Cell Significance Index: -4.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1661
    Cell Significance Index: -12.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1715
    Cell Significance Index: -8.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1790
    Cell Significance Index: -11.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1794
    Cell Significance Index: -18.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1837
    Cell Significance Index: -3.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1925
    Cell Significance Index: -2.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1941
    Cell Significance Index: -13.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1984
    Cell Significance Index: -4.2300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2125
    Cell Significance Index: -2.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2276
    Cell Significance Index: -3.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2345
    Cell Significance Index: -7.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2411
    Cell Significance Index: -14.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2597
    Cell Significance Index: -20.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2740
    Cell Significance Index: -3.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMAL1 is a transcription factor that belongs to the basic helix-loop-helix (bHLH) family of proteins. It is a heterodimeric protein that forms a complex with the ARNT (aryl hydrocarbon receptor nuclear translocator) protein to regulate gene expression. BMAL1 is highly expressed in the suprachiasmatic nucleus (SCN), the master biological clock of the body, as well as in other tissues such as the liver, pancreas, and brain. It is also highly conserved across species, suggesting its importance in maintaining circadian rhythm. **Pathways and Functions** BMAL1 plays a critical role in regulating the circadian clock by interacting with other proteins to activate or repress the expression of genes involved in various physiological processes. Some of the key pathways and functions of BMAL1 include: 1. **Circadian gene expression**: BMAL1 forms a complex with the NPAS2 protein to activate the expression of genes involved in the circadian clock, including PER2, PER3, and BMAL2. 2. **Metabolism**: BMAL1 regulates the expression of genes involved in glucose and lipid metabolism, including PPARα and PPARγ. 3. **Hormone secretion**: BMAL1 regulates the expression of genes involved in hormone secretion, including insulin and glucagon. 4. **Cell cycle regulation**: BMAL1 regulates the expression of genes involved in cell cycle progression, including cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). 5. **Stress response**: BMAL1 regulates the expression of genes involved in stress response, including heat shock proteins (HSPs) and antioxidant enzymes. **Clinical Significance** Dysregulation of the BMAL1 gene has been implicated in various diseases, including: 1. **Metabolic disorders**: BMAL1 mutations have been associated with metabolic disorders, including type 2 diabetes and obesity. 2. **Cardiovascular disease**: BMAL1 dysregulation has been implicated in cardiovascular disease, including hypertension and atherosclerosis. 3. **Neurodegenerative disorders**: BMAL1 dysregulation has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: BMAL1 dysregulation has been implicated in cancer, including breast cancer and colon cancer. In conclusion, the BMAL1 gene plays a critical role in regulating the body's internal clock and circadian rhythm, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which BMAL1 regulates gene expression and to develop therapeutic strategies for the treatment of diseases associated with BMAL1 dysregulation.

Genular Protein ID: 4091294589

Symbol: BMAL1_HUMAN

Name: Aryl hydrocarbon receptor nuclear translocator-like protein 1

UniProtKB Accession Codes:

O00327 A2I2N6 A8K645 B5ME11 B7WPG7 D3DQW6 O00313 O00314 O00315 O00316 O00317 Q4G136 Q8IUT4 Q99631 Q99649

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 22 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 1 PDBsum 1 PIR 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 Reactome 5 RefSeq 13 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9144434

Title: cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage.

PubMed ID: 9144434

DOI: 10.1006/bbrc.1997.6371

PubMed ID: 9079689

Title: Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.

PubMed ID: 9079689

DOI: 10.1074/jbc.272.13.8581

PubMed ID: 9576906

Title: The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.

PubMed ID: 9576906

DOI: 10.1073/pnas.95.10.5474

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9616112

Title: Role of the CLOCK protein in the mammalian circadian mechanism.

PubMed ID: 9616112

DOI: 10.1126/science.280.5369.1564

PubMed ID: 11441146

Title: Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.

PubMed ID: 11441146

DOI: 10.1126/science.1060698

PubMed ID: 12738229

Title: Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2.

PubMed ID: 12738229

DOI: 10.1016/s0022-2828(03)00051-8

PubMed ID: 14645221

Title: Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.

PubMed ID: 14645221

DOI: 10.1074/jbc.m311973200

PubMed ID: 16474406

Title: Feedback repression is required for mammalian circadian clock function.

PubMed ID: 16474406

DOI: 10.1038/ng1745

PubMed ID: 18587630

Title: CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter.

PubMed ID: 18587630

DOI: 10.1007/s11010-008-9846-x

PubMed ID: 21960634

Title: Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

PubMed ID: 21960634

DOI: 10.1126/science.1206022

PubMed ID: 23576606

Title: Mechanism of the circadian clock in physiology.

PubMed ID: 23576606

DOI: 10.1152/ajpregu.00066.2013

PubMed ID: 23955654

Title: The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth.

PubMed ID: 23955654

DOI: 10.1007/s00403-013-1403-0

PubMed ID: 23785138

Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

PubMed ID: 23785138

DOI: 10.1523/jneurosci.2757-12.2013

PubMed ID: 23303907

Title: Metabolism and the circadian clock converge.

PubMed ID: 23303907

DOI: 10.1152/physrev.00016.2012

PubMed ID: 24385426

Title: Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression.

PubMed ID: 24385426

DOI: 10.1074/jbc.m113.534651

PubMed ID: 24005054

Title: A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock.

PubMed ID: 24005054

DOI: 10.1038/jid.2013.366

PubMed ID: 24728990

Title: The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor.

PubMed ID: 24728990

DOI: 10.1093/nar/gku225

PubMed ID: 23916625

Title: Molecular architecture of the mammalian circadian clock.

PubMed ID: 23916625

DOI: 10.1016/j.tcb.2013.07.002

PubMed ID: 25936801

Title: Cancer/testis antigen PASD1 silences the circadian clock.

PubMed ID: 25936801

DOI: 10.1016/j.molcel.2015.03.031

PubMed ID: 28985504

Title: CLOCK acetylates ASS1 to drive circadian rhythm of ureagenesis.

PubMed ID: 28985504

DOI: 10.1016/j.molcel.2017.09.008

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28903391

Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

PubMed ID: 28903391

DOI: 10.18632/oncotarget.18973

PubMed ID: 29626158

Title: Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1.

PubMed ID: 29626158

DOI: 10.1042/bcj20180005

PubMed ID: 30530698

Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.

PubMed ID: 30530698

DOI: 10.1073/pnas.1816411115

PubMed ID: 34545347

Title: The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells.

PubMed ID: 34545347

DOI: 10.1016/j.isci.2021.103144

PubMed ID: 23229515

Title: Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.

PubMed ID: 23229515

DOI: 10.1038/cr.2012.170

Sequence Information:

  • Length: 626
  • Mass: 68762
  • Checksum: 820F0E07DC6265A6
  • Sequence:
    • MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR 
LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ 
HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL 
NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC 
SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKADRKSFC TIHSTGYLKS WPPTKMGLDE 
DNEPDNEGCN LSCLVAIGRL HSHVVPQPVN GEIRVKSMEY VSRHAIDGKF VFVDQRATAI 
LAYLPQELLG TSCYEYFHQD DIGHLAECHR QVLQTREKIT TNCYKFKIKD GSFITLRSRW 
FSFMNPWTKE VEYIVSTNTV VLANVLEGGD PTFPQLTASP HSMDSMLPSG EGGPKRTHPT 
VPGIPGGTRA GAGKIGRMIA EEIMEIHRIR GSSPSSCGSS PLNITSTPPP DASSPGGKKI 
LNGGTPDIPS SGLLSGQAQE NPGYPYSDSS SILGENPHIG IDMIDNDQGS SSPSNDEAAM 
AVIMSLLEAD AGLGGPVDFS DLPWPL

Genular Protein ID: 3562297855

Symbol: A0A669KBF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A669KBF4

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 3 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 630
  • Mass: 69238
  • Checksum: A98ECCAF36F68F0A
  • Sequence:
    • MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR 
LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ 
HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL 
NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC 
SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKDRKSFCT IHSTGYLKSW PPTKMGLDED 
NEPDNEGCNL SCLVAIGRLH SHVVPQPVNG EIRVKSMEYV SRHAIDGKFV FVDQRATAIL 
AYLPQELLGT SCYEYFHQDD IGHLAECHRQ VLQTREKITT NCYKFKIKDG SFITLRSRWF 
SFMNPWTKEV EYIVSTNTVV LANVLEGGDP TFPQLTASPH SMDSMLPSGE DSFVVGGPKR 
THPTVPGIPG GTRAGAGKIG RMIAEEIMEI HRIRGSSPSS CGSSPLNITS TPPPDASSPG 
GKKILNGGTP DIPSSGLLSG QAQENPGYPY SDSSSILGEN PHIGIDMIDN DQGSSSPSND 
EAAMAVIMSL LEADAGLGGP VDFSDLPWPL

Genular Protein ID: 439758122

Symbol: A0A140VKD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VKD3

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 10 Gene3D 2 InterPro 8 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 3 RefSeq 3 SAM 1 SMART 3 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 625
  • Mass: 68691
  • Checksum: 3F3F7D5688A6FFE2
  • Sequence:
    • MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR 
LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ 
HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL 
NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC 
SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKDRKSFCT IHSTGYLKSW PPTKMGLDED 
NEPDNEGCNL SCLVAIGRLH SHVVPQPVNG EIRVKSMEYV SRHAIDGKFV FVDQRATAIL 
AYLPQELLGT SCYEYFHQDD IGHLAECHRQ VLQTREKITT NCYKFKIKDG SFITLRSRWF 
SFMNPWTKEV EYIVSTNTVV LANVLEGGDP TFPQLTASPH SMDSMLPSGE GGPKRTHPTV 
PGIPGGTRAG AGKIGRMIAE EIMEIHRIRG SSPSSCGSSP LNITSTPPPD ASSPGGKKIL 
NGGTPDIPSS GLLSGQAQEN PGYPYSDSSS ILGENPHIGI DMIDNDQGSS SPSNDEAAMA 
VIMSLLEADA GLGGPVDFSD LPWPL

Genular Protein ID: 3216779482

Symbol: B2RCL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RCL8

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 626
  • Mass: 68778
  • Checksum: 6755CFB1070FD367
  • Sequence:
    • MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM DTDKDDPHGR 
LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ 
HMKTLRGATN PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL 
NYSQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC 
SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKADRKSFC TIHSTGYLKS WPPTKMGLDE 
DNEPDNEGCN LSCLVAIGRL HSHVVPQPVN GEIRVKSMEY VSRHAIDGKF VFVDQRATAI 
LAYLPQELLG TSCYEYFHQD DIGHLAECHR QVLQTREKIT TNCYKFKIKD GSFITLRSRW 
FSFMNPWTKE VEYIVSTNTV VLANVLEGGD PTFPQLTASP HSMDSMLPSG EGGPKRTHPT 
VPGIPGGTRA GAGKIGRMIA EEIMEIHRIR GSSPSSCGSS LLNITSTPPP DASSPGGKKI 
LNGGTPDIPS SGLLSGQAQE NPGYPYSDSS SILGENPHIG IDMIDNDQGS SSPSNDEAAM 
AVIMSLLEAD AGLGGPVDFS DLPWPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.